Delivery of nascent polypeptides to the mitochondrial surface

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1592, Issue 1, 2002, Pages 35-39

  Beddoe, Travis ^a   Lithgow, Trevor ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Mitochondrion; Molecular chaperone; mRNA localisation; Polypeptide synthesis; Protein import; Ribosome

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; CELL PROTEIN; CHAPERONE; CYTOPLASM PROTEIN; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; ISOPROTEIN; MITOCHONDRIAL IMPORT STIMULATION FACTOR; NASCENT ASSOCIATED POLYPEPTIDE COMPLEX; POLYPEPTIDE; PROTEIN MOD5P; RIBOSOME ASSOCIATED COMPLEX; TRANSLOCASE OF THE OUTER MEMBRANE; UNCLASSIFIED DRUG;

CYTOPLASM; HYDROPHOBICITY; MITOCHONDRION; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; RIBOSOME;

CARRIER PROTEINS; CYTOPLASM; EUKARYOTIC CELLS; INTRACELLULAR MEMBRANES; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR CHAPERONES; PEPTIDES; PROTEIN BIOSYNTHESIS; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RIBOSOMES;

EID: 0037009090     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(02)00262-8     Document Type: Review

References (48)

1. Protein import into mitochondria
2. Versatility of the mitochondrial protein import machinery
3. Limitations to in vivo import of hydrophobic proteins into yeast mitochondria. The case of a cytoplasmically synthesized apocytochrome b
4. Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria
5. Polypeptides traverse the mitochondrial envelope in an extended state
6. Transport of proteins into mitochondria: Translocational intermediates spanning contact sites between outer and inner membranes
7. New insights into signal recognition and elongation arrest activities of the signal recognition particle
8. Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane
9. The products of mitochondria-bound cytoplasmic polysomes in yeast
10. Overexpression of yeast karyopherin Pse1p/Kap121p stimulates the mitochondrial import of hydrophobic proteins in vivo
11. Translatable mRNAs for imported mitochondrial proteins are present in free as well as mitochondria-bound cytoplasmic polysomes
12. The single translation product of the FUM1 gene (fumarase) is processed in mitochondria before being distributed between the cytosol and mitochondria in Saccharomyces cerevisiae
13. Import into mitochondria, folding and retrograde movement of fumarase in yeast
14. MRNA encoding the beta-subunit of the mitochondrial F1-ATPase complex is a localized mRNA in rat hepatocytes
15. Subcellular structure containing mRNA for the beta subunit of mitochondrial H+-ATP synthase in rat hepatocytes is translationally active
16. In yeast, the 3′ untranslated region or the presequence of ATM1 is required for the exclusive localization of its mRNA to the vicinity of the mitochondria
17. Mitochondrial precursor protein. Effects of 70-kilodalton heat shock protein on polypeptide folding, aggregation, and import competence
18. Role of heat shock cognate 70 protein in import of ornithine transcarbamylase precursor into mammalian mitochondria
19. Interaction of HSp70 with newly synthesised proteins: Implication for folding and assembly
20. Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones [see comments]
21. Partner proteins determine multiple functions of Hsp70
22. The translation machinery and 70 kd heat shock protein cooperate in protein synthesis
23. The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex
24. RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin
25. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
26. 70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria
27. Functional interaction of cytosolic hsp70 and a DnaJ-related protein, Ydj1p, in protein translocation in vivo
28. Regulation of Hsp70 function by a eukaryotic DnaJ homolog
29. MAS5, a yeast homolog of DnaJ involved in mitochondrial protein import
30. YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism
31. A protein complex required for signal-sequence-specific sorting and translocation
32. The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo
33. Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria
34. A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins
35. MSF, a novel cytoplasmic chaperone which functions in precursor targeting to mitochondria
36. Binding of mitochondrial precursor proteins to the cytoplasmic domains of the import receptors Tom70 and Tom20 is determined by cytoplasmic chaperones
37. Reconstitution of the initial steps of mitochondrial protein import
38. Two nuclear mutations that block mitochondrial protein import in yeast
39. The amino terminus of the yeast F1-ATPase beta-subunit precursor functions as a mitochondrial import signal
40. A toxic fusion protein accumulating between the mitochondrial membranes inhibits protein assembly in vivo
41. Mitochondrial protein import: Isolation and characterization of the Saccharomyces cerevisiae MFT1 gene
42. Mft52, an acid-bristle protein in the cytosol that delivers precursor proteins to yeast mitochondria
43. A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae
44. Mutations altering the mitochondrial-cytoplasmic distribution of Mod5p implicate the actin cytoskeleton and mRNA 3′ ends and/or protein synthesis in mitochondrial delivery
45. Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast
46. Pan1p, End3p and Sla1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis
47. The mitochondrial protein targeting suppressor (mts1) mutation maps to the mRNA-binding domain of Npl3p and effects translation on cytoplasmic ribosomes
48. Highways for protein delivery to the mitochondria