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Volumn 8, Issue 2, 2009, Pages 95-102

Hepatic encephalopathy, ammonia, glutamate, glutamine and oxidative stress

Author keywords

Brain; Excitotoxic neurotransmitter; Glutamine glutamate cycle; Hyperammonemia; Liver; Mitochondria; Reactive oxygen species

Indexed keywords

AMMONIA; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 67650538602     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31785-5     Document Type: Review
Times cited : (132)

References (61)
  • 1
    • 33744513689 scopus 로고    scopus 로고
    • Hepatic encephalopathy forward to the past
    • Blendis L. Hepatic encephalopathy forward to the past. Gastroenterology 2006; 130: 2239-2240.
    • (2006) Gastroenterology , vol.130 , pp. 2239-2240
    • Blendis, L.1
  • 2
    • 0035113807 scopus 로고    scopus 로고
    • Hepatic encephalopathy: Metabolic consequence of cirrhosis often is reversible
    • Abou-Assi S, Vlahcevic ZR. Hepatic encephalopathy. Metabolic consequence of cirrhosis often is reversible. Postgrad Med 2001; 109: 52-60, 63. (Pubitemid 32167907)
    • (2001) Postgraduate Medicine , vol.109 , Issue.2 , pp. 52-70
    • Abou-Assi, S.1    Vlahcevic, Z.R.2
  • 3
    • 0026459594 scopus 로고
    • Pallidal hyperintensity on magnetic resonance imaging in cirrhotic patients: Clinical correlations
    • Kulisevsky J, Pujol J, Balanzo J, Junque C, Deus J, Capdevilla A, et al. Pallidal hyperintensity on magnetic resonance imaging in cirrhotic patients: clinical correlations. Hepatology 1992; 16: 1382-1388.
    • (1992) Hepatology , vol.16 , pp. 1382-1388
    • Kulisevsky, J.1    Pujol, J.2    Balanzo, J.3    Junque, C.4    Deus, J.5    Capdevilla, A.6
  • 4
    • 0028020080 scopus 로고
    • Metabolic abnormalities and grade of encephalopathy in acute hepatic failure
    • Mans AM, DeJoseph MR, Hawkins RA. Metabolic abnormalities and grade of encephalopathy in acute hepatic failure. J Neurochem 1994; 63: 1829-1838. (Pubitemid 24326227)
    • (1994) Journal of Neurochemistry , vol.63 , Issue.5 , pp. 1829-1838
    • Mans, A.M.1    Dejoseph, M.R.2    Hawkins, R.A.3
  • 5
    • 0017705111 scopus 로고
    • Presence of serum creatine kinase isoenzymes in liver failure with cerebral involvement
    • Lemberg A, Werber DH, Gilardoni A, Magrino HJ. Presence of serum creatine kinase isoenzymes in liver failure with cerebral involvement. Clin Chim Acta 1977; 80: 385-390. (Pubitemid 8213666)
    • (1977) Clinica Chimica Acta , vol.80 , Issue.2 , pp. 385-390
    • Lemberg, A.1    Werber, D.H.2    Gilardoni, A.3    Magrino, H.J.4
  • 6
    • 0026583030 scopus 로고
    • Effect of ammonium ions on synaptic transmission in the mammalian central nervous system
    • Szerb JC, Butterworth RF. Effect of ammonium ions on synaptic transmission in the mammalian central nervous system. Prog Neurobiol 1992; 39: 135-153.
    • (1992) Prog Neurobiol , vol.39 , pp. 135-153
    • Szerb, J.C.1    Butterworth, R.F.2
  • 7
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine synthetase in astrocytes of rat brain
    • DOI 10.1016/0006-8993(79)90071-4
    • Norenberg MD, Martinez-Hernandez A. Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res 1979; 161: 303-310. (Pubitemid 9087410)
    • (1979) Brain Research , vol.161 , Issue.2 , pp. 303-310
    • Norenberg, M.D.1    Martinez-Hernandez, A.2
  • 8
    • 0023287036 scopus 로고
    • The role of astrocytes in hepatic encephalopathy
    • Norenberg MD. The role of astrocytes in hepatic encephalopathy. Neurochem Pathol 1987; 6: 13-33.
    • (1987) Neurochem Pathol , vol.6 , pp. 13-33
    • Norenberg, M.D.1
  • 9
    • 0019471152 scopus 로고
    • Effects of low ammonia levels on NAD(P)H levels and glutamate secretion during calcium-dependent depolarization of CNS slices
    • DOI 10.1002/jnr.490060208
    • Cummins JT, Hamberger A, Nystrom B. Effects of low ammonia levels on NAD [P]H levels and glutamate secretion during cal cium-dependent depolarization of CNS slices. J Neurosci Res 1981; 6: 217-224. (Pubitemid 11098418)
    • (1981) Journal of Neuroscience Research , vol.6 , Issue.2 , pp. 217-224
    • Cummins, J.T.1    Hamberger, A.2    Nystrom, B.3
  • 10
    • 0022972426 scopus 로고
    • Brain α-ketoglutarate dehydrogenase complex: Kinetic properties, regional distribution, and effects of inhibitors
    • DOI 10.1111/j.1471-4159.1986.tb00768.x
    • Lai JC, Cooper AJ. Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors. J Neurochem 1986; 47: 1376-1386. (Pubitemid 17174649)
    • (1986) Journal of Neurochemistry , vol.47 , Issue.5 , pp. 1376-1386
    • Lai, J.C.K.1    Cooper, A.J.L.2
  • 11
    • 36048989392 scopus 로고    scopus 로고
    • Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions
    • Vaquero J, Butterworth RF. Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions. Neurol Res 2008; 29: 683-690.
    • (2008) Neurol Res , vol.29 , pp. 683-690
    • Vaquero, J.1    Butterworth, R.F.2
  • 15
    • 0025079063 scopus 로고
    • Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation
    • DOI 10.1007/BF00996975
    • Schmidt W, Wolf G, Grungreiff K, Meier M, Reum T. Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation. Metab Brain Dis 1990; 5: 19-31. (Pubitemid 20251342)
    • (1990) Metabolic Brain Disease , vol.5 , Issue.1 , pp. 19-31
    • Schmidt, W.1    Wolf, G.2    Grungreiff, K.3    Meier, M.4    Reum, T.5
  • 16
    • 0342314620 scopus 로고    scopus 로고
    • Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle
    • Desjardins P, Rao KV, Michalak A, Rose C, Butterworth RF. Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle. Metab Brain Dis 1999; 14: 273-280. (Pubitemid 30337701)
    • (1999) Metabolic Brain Disease , vol.14 , Issue.4 , pp. 273-280
    • Desjardins, P.1    Rama Rao, K.V.2    Michalak, A.3    Rose, C.4    Butterworth, R.F.5
  • 17
    • 0034708716 scopus 로고    scopus 로고
    • Modulation of glutamate transporters (GLAST, GLT-1 and EAAC1) in the rat cerebellum following portocaval anastomosis
    • DOI 10.1016/S0006-8993(00)01993-4, PII S0006899300019934
    • Suarez I, Bodega G, Fernandez B. Modulation of glutamate transporters [GLAST, GLT-1 and EAAC1] in the rat cerebellum following portocaval anastomosis. Brain Res 2000; 859: 293-302. (Pubitemid 30136101)
    • (2000) Brain Research , vol.859 , Issue.2 , pp. 293-302
    • Suarez, I.1    Bodega, G.2    Fernandez, B.3
  • 18
    • 0029877408 scopus 로고    scopus 로고
    • Effects of ammonia on L-glutamate uptake in cultured astrocytes
    • DOI 10.1007/BF02527755
    • Bender AS, Norenberg MD. Effects of ammonia on L-glutamate uptake in cultured astrocytes. Neurochem Res 1996; 21: 567-573. (Pubitemid 26151002)
    • (1996) Neurochemical Research , vol.21 , Issue.5 , pp. 567-573
    • Bender, A.S.1    Norenberg, M.D.2
  • 19
    • 0032702799 scopus 로고    scopus 로고
    • Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy
    • DOI 10.1023/A:1022532623281
    • Chan H, Butterworth RF. Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy. Neurochem Res 1999; 24: 1397-1401. (Pubitemid 29505949)
    • (1999) Neurochemical Research , vol.24 , Issue.11 , pp. 1397-1401
    • Chan, H.1    Butterworth, R.F.2
  • 20
    • 0036894510 scopus 로고    scopus 로고
    • Cerebral microdialysis in patients with fulminant hepatic failure
    • DOI 10.1053/jhep.2002.36944
    • Tofteng F, Jorgensen L, Hansen BA, Ott P, Kondrup J, Larsen FS. Cerebral microdialysis in patients with fulminant hepatic failure. Hepatology 2002; 36: 1333-1340. (Pubitemid 35403522)
    • (2002) Hepatology , vol.36 , Issue.6 , pp. 1333-1340
    • Tofteng, F.1    Jorgensen, L.2    Adel Hansen, B.3    Ott, P.4    Kondrup, J.5    Larsen, F.S.6
  • 21
    • 29144519910 scopus 로고    scopus 로고
    • Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure
    • DOI 10.1038/sj.jcbfm.9600168
    • Tofteng F, Hauerberg J, Hansen BA, Pedersen CB, Jorgensen L, Larsen FS. Persistent arterial hyperammonemia increases the concentration of glutamine and alanine in the brain and correlates with intracranial pressure in patients with fulminant hepatic failure. J Cereb Blood Flow Metab 2006; 26: 21-27. (Pubitemid 41818066)
    • (2006) Journal of Cerebral Blood Flow and Metabolism , vol.26 , Issue.1 , pp. 21-27
    • Tofteng, F.1    Hauerberg, J.2    Hansen, B.A.3    Pedersen, C.B.4    Jorgensen, L.5    Larsen, F.S.6
  • 22
    • 0018965495 scopus 로고
    • Hippocampal glutamate release after porta cava anastomosis: Reduced sensitivity to ammonia inhibition
    • DOI 10.1002/jnr.490050408
    • Hamberger A, Hedquist B, Lundborg H, Nystrom B. Hippocampal glutamate release after porta cava anastomosis: reduced sensitivity to ammonia inhibition. J Neurosci Res 1980; 5: 313-322. (Pubitemid 10029320)
    • (1980) Journal of Neuroscience Research , vol.5 , Issue.4 , pp. 313-322
    • Hamberger, A.1    Hedquist, B.2    Lundborg, H.3    Nystrom, B.4
  • 23
    • 0030469920 scopus 로고    scopus 로고
    • Flumazenil does not affect the increase in rat hippocampal extracellular glutamate concentration produced during thioacetamide-induced hepatic encephalopathy
    • DOI 10.1007/BF02029494
    • McArdle P, Penning DH, Dexter F, Reynolds JD. Flumazenil does not affect the increase in rat hippocampal extracellular glutamate concentration produced during thioacetamide-induced hepatic encephalopathy. Metab Brain Dis 1996; 11: 329-342. (Pubitemid 27004858)
    • (1996) Metabolic Brain Disease , vol.11 , Issue.4 , pp. 329-342
    • McArdle, P.1    Penning, D.H.2    Dexter, F.3    Reynolds, J.D.4
  • 24
    • 0028139971 scopus 로고
    • Extracellular brain glutamate during acute liver failure and during acute hyperammonemia stimulating acute liver failure: An experimental study based on in vivo brain dialysis
    • de Knegt RJ, Schalm SW, van der Rijt CC, Fekkes D, Dalm E, Hekking-Weyma I. Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. J Hepatol 1994; 20: 19-26. (Pubitemid 24043081)
    • (1994) Journal of Hepatology , vol.20 , Issue.1 , pp. 19-26
    • De Knegt, R.J.1    Schalm, S.W.2    Van Der Rijt, C.C.D.3    Fekkes, D.4    Dalm, E.5    Hekking-Weyma, I.6
  • 26
    • 0034102769 scopus 로고    scopus 로고
    • Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure
    • Rose C, Michalak A, Pannunzio M, Chatauret N, Rambaldi A, Butterworth RF. Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Hepatology 2000; 31: 872-877. (Pubitemid 30169933)
    • (2000) Hepatology , vol.31 , Issue.4 , pp. 872-877
    • Rose, C.1    Michalak, A.2    Pannunzio, M.3    Chatauret, N.4    Rambaldi, A.5    Butterworth, R.F.6
  • 27
    • 20444366546 scopus 로고    scopus 로고
    • Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH
    • DOI 10.1074/jbc.M412448200
    • Rose C, Kresse W, Kettenmann H. Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH. J Biol Chem 2005; 280: 20937-20944. (Pubitemid 40805650)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.22 , pp. 20937-20944
    • Rose, C.1    Kresse, W.2    Kettenmann, H.3
  • 28
    • 33846192274 scopus 로고    scopus 로고
    • Contribution of altered signal transduction associated to glutamate receptors in brain to the neurological alterations of hepatic encephalopathy
    • Felipo V. Contribution of altered signal transduction associated to glutamate receptors in brain to the neurological alterations of hepatic encephalopathy. World J Gastroenterol 2006; 12: 7737-7743. (Pubitemid 46099939)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.48 , pp. 7737-7743
    • Felipo, V.1
  • 30
    • 1842430709 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures
    • DOI 10.2174/1566524043479239
    • Nicholls DG. Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures. Curr Mol Med 2004; 4: 149-177. (Pubitemid 38425912)
    • (2004) Current Molecular Medicine , vol.4 , Issue.2 , pp. 149-177
    • Nicholls, D.G.1
  • 33
    • 20544452196 scopus 로고    scopus 로고
    • Ammonia effects on pyruvate/lactate production in astrocytes - Interaction with glutamate
    • DOI 10.1016/j.neuint.2005.04.001, PII S0197018605000860
    • Kala G, Hertz L. Ammonia effects on pyruvate/lactate production in astrocytes-interaction with glutamate. Neurochem Int 2005; 47: 4-12. (Pubitemid 40848687)
    • (2005) Neurochemistry International , vol.47 , Issue.1-2 SPEC. ISS , pp. 4-12
    • Kala, G.1    Hertz, L.2
  • 35
    • 0034098766 scopus 로고    scopus 로고
    • Transport of glutamate and other amino acids at the blood-brain barrier
    • Smith QR. Transport of glutamate and other amino acids at the blood-brain barrier. J Nutr 2000; 130: 1016S-22S. (Pubitemid 30173636)
    • (2000) Journal of Nutrition , vol.130 , Issue.4 SUPPL.
    • Smith, Q.R.1
  • 37
    • 33645526455 scopus 로고    scopus 로고
    • Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered
    • Eizayaga F, Scorticati C, Prestifilippo JP, Romay S, Fernandez MA, Castro JL, et al. Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered. World J Gastroenterol 2006; 12: 1367-1372.
    • (2006) World J Gastroenterol , vol.12 , pp. 1367-1372
    • Eizayaga, F.1    Scorticati, C.2    Prestifilippo, J.P.3    Romay, S.4    Fernandez, M.A.5    Castro, J.L.6
  • 38
    • 0034957318 scopus 로고    scopus 로고
    • Glutamine as a pathogenic factor in hepatic encephalopathy
    • Albrecht J, Dolinska M. Glutamine as a pathogenic factor in hepatic encephalopathy. J Neurosci Res 2001; 65: 1-5.
    • (2001) J Neurosci Res , vol.65 , pp. 1-5
    • Albrecht, J.1    Dolinska, M.2
  • 39
    • 0030448092 scopus 로고    scopus 로고
    • Astrocytic-ammonia interactions in hepatic encephalopathy
    • Norenberg MD. Astrocytic-ammonia interactions in hepatic encephalopathy. Semin Liver Dis 1996; 16: 245-253.
    • (1996) Semin Liver Dis , vol.16 , pp. 245-253
    • Norenberg, M.D.1
  • 41
    • 0032867674 scopus 로고    scopus 로고
    • Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis
    • DOI 10.1002/hep.510300428
    • Master S, Gottstein J, Blei AT. Cerebral blood flow and the development of ammonia-induced brain edema in rats after portacaval anastomosis. Hepatology 1999; 30: 876-880. (Pubitemid 29458274)
    • (1999) Hepatology , vol.30 , Issue.4 , pp. 876-880
    • Master, S.1    Gottstein, J.2    Blei, A.T.3
  • 42
    • 84989509425 scopus 로고
    • Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis
    • DOI 10.1016/0270-9139(94)90240-2
    • Blei AT, Olafsson S, Therrien G, Butterworth RF. Ammoniainduced brain edema and intracranial hypertension in rats after portacaval anastomosis. Hepatology 1994; 19: 1437-1444. (Pubitemid 24166466)
    • (1994) Hepatology , vol.19 , Issue.6 , pp. 1437-1444
    • Blei, A.T.1    Olafsson, S.2    Therrien, G.3    Butterworth, R.F.4
  • 43
    • 0027474144 scopus 로고
    • Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy
    • Hawkins RA, Jessy J, Mans AM, De Joseph MR. Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy. J Neurochem 1993; 60: 1000-1006. (Pubitemid 23066720)
    • (1993) Journal of Neurochemistry , vol.60 , Issue.3 , pp. 1000-1006
    • Hawkins, R.A.1    Jessy, J.2    Mans, A.M.3    De Joseph, M.R.4
  • 44
    • 0342680135 scopus 로고    scopus 로고
    • Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues
    • DOI 10.1016/S0197-0186(99)00142-4, PII S0197018699001424
    • Albrecht J, Dolinska M, Hilgier W, Lipkowski AW, Nowacki J. Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues. Neurochem Int 2000; 36: 341-347. (Pubitemid 30101575)
    • (2000) Neurochemistry International , vol.36 , Issue.4-5 , pp. 341-347
    • Albrecht, J.1    Dolinska, M.2    Hilgier, W.3    Lipkowski, A.W.4    Nowacki, J.5
  • 46
    • 33750608704 scopus 로고    scopus 로고
    • Glutamine: A Trojan horse in ammonia neurotoxicity
    • DOI 10.1002/hep.21357
    • Albrecht J, Norenberg MD. Glutamine: a Trojan horse in ammonia neurotoxicity. Hepatology 2006; 44: 788-794. (Pubitemid 46489541)
    • (2006) Hepatology , vol.44 , Issue.4 , pp. 788-794
    • Albrecht, J.1    Norenberg, M.D.2
  • 47
    • 33845895245 scopus 로고    scopus 로고
    • Brain edema and intracranial hypertension in fulminant hepatic failure: Pathophysiology and management
    • Detry O, De Roover A, Honore P, Meurisse M. Brain edema and intracranial hypertension in fulminant hepatic failure: pathophysiology and management. World J Gastroenterol 2006; 12: 7405-7412. (Pubitemid 46017735)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.46 , pp. 7405-7412
    • Detry, O.1    De Roover, A.2    Honore, P.3    Meurisse, M.4
  • 48
    • 0029785988 scopus 로고    scopus 로고
    • Ammonia and glutamine metabolism during liver insufficiency: The role of kidney and brain in interorgan nitrogen exchange
    • Dejong CH, Deutz NE, Soeters PB. Ammonia and glutamine metabolism during liver insufficiency: the role of kidney and brain in interorgan nitrogen exchange. Scand J Gastroenterol Suppl 1996; 218: 61-77. (Pubitemid 26261855)
    • (1996) Scandinavian Journal of Gastroenterology, Supplement , vol.31 , Issue.218 , pp. 61-77
    • Dejong, C.H.C.1    Deutz, N.E.P.2    Soeters, P.B.3
  • 49
    • 0025878379 scopus 로고
    • Astroglial processes around identified glutamatergic synapses contain glutamine synthetase: Evidence for transmitter degradation
    • Derouiche A, Frotscher M. Astroglial processes around identified glutamatergic synapses contain glutamine synthetase: evidence for transmitter degradation. Brain Res 1991; 552: 346-350.
    • (1991) Brain Res , vol.552 , pp. 346-350
    • Derouiche, A.1    Frotscher, M.2
  • 50
    • 0037311146 scopus 로고    scopus 로고
    • 13C] nuclear magnetic resonance study
    • DOI 10.1053/jhep.2003.50052
    • Zwingmann C, Chatauret N, Leibfritz D, Butterworth RF. Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study. Hepatology 2003; 37: 420-428. (Pubitemid 36152542)
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 420-428
    • Zwingmann, C.1    Chatauret, N.2    Leibfritz, D.3    Butterworth, R.F.4
  • 51
    • 0035888288 scopus 로고    scopus 로고
    • Ammonia-induced production of free radicals in primary cultures of rat astrocytes
    • DOI 10.1002/jnr.1222
    • Murthy CR, Rama Rao KV, Bai G, Norenberg MD. Ammoniainduced production of free radicals in primary cultures of rat astrocytes. J Neurosci Res 2001; 66: 282-288. (Pubitemid 32912297)
    • (2001) Journal of Neuroscience Research , vol.66 , Issue.2 , pp. 282-288
    • Murthy, C.R.K.1    Rama Rao, K.V.2    Bai, G.3    Norenberg, M.D.4
  • 52
    • 0037096037 scopus 로고    scopus 로고
    • GeneChip analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats
    • DOI 10.1002/jnr.10268
    • Song G, Dhodda VK, Blei AT, Dempsey RJ, Rao VL. GeneChip analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats. J Neurosci Res 2002; 68: 730-737. (Pubitemid 34594989)
    • (2002) Journal of Neuroscience Research , vol.68 , Issue.6 , pp. 730-737
    • Song, G.1    Dhodda, V.K.2    Blei, A.T.3    Dempsey, R.J.4    Rao, V.L.R.5
  • 53
    • 0032005805 scopus 로고    scopus 로고
    • 4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes
    • DOI 10.1002/(SICI)1098-1136(199802)22:2<149::AID-GLIA6>3.0.CO;2-2
    • Blanc EM, Keller JN, Fernandez S, Mattson MP. 4- hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes. Glia 1998; 22: 149-160. (Pubitemid 28084387)
    • (1998) GLIA , vol.22 , Issue.2 , pp. 149-160
    • Blanc, E.M.1    Keller, J.N.2    Fernandez, S.3    Mattson, M.P.4
  • 54
    • 0029849790 scopus 로고    scopus 로고
    • Oxidative stress and liver disease
    • Kaplowitz N, Tsukamoto H. Oxidative stress and liver disease. Prog Liver Dis 1996; 14: 131-159.
    • (1996) Prog Liver Dis , vol.14 , pp. 131-159
    • Kaplowitz, N.1    Tsukamoto, H.2
  • 55
    • 0034116643 scopus 로고    scopus 로고
    • Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death
    • DOI 10.1016/S0306-4522(00)00028-2, PII S0306452200000282
    • Tirosh O, Sen CK, Roy S, Packer L. Cellular and mitochondrial changes in glutamate-induced HT4 neuronal cell death. Neuroscience 2000; 97: 531-541. (Pubitemid 30320759)
    • (2000) Neuroscience , vol.97 , Issue.3 , pp. 531-541
    • Tirosh, O.1    Sen, C.K.2    Roy, S.3    Packer, L.4
  • 57
    • 0037310995 scopus 로고    scopus 로고
    • Oxidative and nitrosative stress in ammonia neurotoxicity
    • DOI 10.1053/jhep.2003.50087
    • Norenberg MD. Oxidative and nitrosative stress in ammonia neurotoxicity. Hepatology 2003; 37: 245-248. (Pubitemid 36152521)
    • (2003) Hepatology , vol.37 , Issue.2 , pp. 245-248
    • Norenberg, M.D.1
  • 58
    • 37549061746 scopus 로고    scopus 로고
    • Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics
    • Lemberg A, Schreier L, Romay S, Fernandez MA, Rosello D, Gonzales S, et al. Involvement of serum apolipoprotein AI and B100 and lecithin cholesterol acyl transferase in alcoholic cirrhotics. Ann Hepatol 2007; 6: 227-232.
    • (2007) Ann Hepatol , vol.6 , pp. 227-232
    • Lemberg, A.1    Schreier, L.2    Romay, S.3    Fernandez, M.A.4    Rosello, D.5    Gonzales, S.6
  • 59
    • 0024364138 scopus 로고
    • 31P nuclear magnetic resonance study
    • DOI 10.1111/j.1471-4159.1989.tb07300.x
    • Bates TE, Williams SR, Kauppinen RA, Gadian DG. Observation of cerebral metabolites in an animal model of acute liver failure in vivo: a 1H and 31P nuclear magnetic resonance study. J Neurochem 1989; 53: 102-110. (Pubitemid 19158115)
    • (1989) Journal of Neurochemistry , vol.53 , Issue.1 , pp. 102-110
    • Bates, T.E.1    Williams, S.R.2    Kauppinen, R.A.3    Gadian, D.G.4
  • 60
    • 0029621974 scopus 로고
    • Accumulation of manganese and copper in pallidum of cirrhotic patients: Role in the pathogenesis of hepatic encephalopathy?
    • DOI 10.1007/BF02109365
    • Layrargues GP, Shapcott D, Spahr L, Butterworth RF. Accumulation of manganese and copper in pallidum of cirrhotic patients: role in the pathogenesis of hepatic encephalopathy? Metab Brain Dis 1995; 10: 353-356. (Pubitemid 26042543)
    • (1995) Metabolic Brain Disease , vol.10 , Issue.4 , pp. 353-356
    • Layrargues, G.P.1    Shapcott, D.2    Spahr, L.3    Butterworth, R.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.