Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure

Hepatology

Volumn 31, Issue 4, 2000, Pages 872-877

  Rose, Christopher ^a   Michalak, Adrianna ^a   Pannunzio, Marc ^a   Chatauret, Nicolas ^a   Rambaldi, Andrea ^a   Butterworth, Roger F ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIA; GLUTAMIC ACID;

AMINO ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; BODY TEMPERATURE; BRAIN EDEMA; BRAIN PROTECTION; CEREBROSPINAL FLUID LEVEL; CONTROLLED STUDY; DISEASE COURSE; HEPATIC COMA; HEPATIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; LIVER FAILURE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

EID: 0034102769     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/he.2000.5923     Document Type: Article

References (5)

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2. Makin AJ, Wendon J, Williams R. A 7-year experience of severe acetaminophen-induced hepatotoxicity (1987-1993). Gastroenterology 1995;109:1907-1916.
3. Holmin T, Agardh CD, Alinger G, Herlin P, Hultberg B. The influence of total hepatectomy on cerebral energy state, ammonia-related amino acids of the brain and plasma amino acids in the rat. Eur J Clin Invest 1983;13:215-220.
4. Mans AM, Saunders SJ, Kirsch RE, Biebuyck R. Correlation of plasma and brain amino acid and putative neurotransmitter alterations during acute hepatic coma in the rat. J Neurochem 1979;32:285-292.
5. Swain M, Butterworth RF, Blei AT. Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats. HEPATOLOGY 1992;15:449-453.