Ammonia and glutamine metabolism during liver insufficiency: The role of kidney and brain in interorgan nitrogen exchange

Scandinavian Journal of Gastroenterology, Supplement

Volumn 31, Issue 218, 1996, Pages 61-77

  Dejong, C H C ^a,b   Deutz, N E P ^a   Soeters, P B ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Sittard Geleen Heerlen   (Netherlands)

Author keywords

Ammonia; Brain; Flux; Glutamine; Kidney; Liver disease; Metabolism; Nitrogen; Review

Indexed keywords

AMMONIA; GLUTAMINE; NITROGEN;

ACID BASE BALANCE; AMMONIA FORMATION; BRAIN FUNCTION; CONFERENCE PAPER; DETOXIFICATION; HYPERAMMONEMIA; KIDNEY FUNCTION; LIVER FAILURE; NITROGEN METABOLISM; PRIORITY JOURNAL; UREA CYCLE; ANIMAL; BRAIN; HUMAN; KIDNEY; METABOLISM; PATHOPHYSIOLOGY; REVIEW;

AMMONIA; ANIMALS; BRAIN; GLUTAMINE; HUMANS; KIDNEY; LIVER FAILURE, ACUTE; NITROGEN;

EID: 0029785988     PISSN: 00855928     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (11)

1. Zieve L. Palhogcnesis of hepatic encephalopathy. Metab Brain Dis 1987;2:147-65.
2. Meijer AJ, Lamers WH, Chamuleau RAFM. Nitrogen metabolism and ornithine cycle function. Physiol Rev 1990;70:701-48.
3. Duffy TE, Plum F. Hepatic encephalopathy. In: Arias I, Popper H, Schachter D, Shafritz DA, editors. The liver: biology and pathobiology. New York: Raven Press, 1982:693-715.
4. Rudman D, DiFulco TJ, Galambos JT, Smith RB, Salam AA, Warren WD. Maximal rates of excretion and synthesis of urea in normal and cirrhotic subjects. J Clin Invest 1973;52:2241-9.
5. Haüssinger D, Kaiser S, Stehle T, Gerok W. Structural and functional organization of hepatic ammonia metabolism: pathophysiological consequences. In: Soeters PB, Wilson JHP, Meijer AJ, Holm E, editors. Advances in ammonia metabolism and hepatic encephalopathy. Amsterdam: Excerpta Medica, 1988:26-36.
6. Kaiser S, Gerok W, Haüssinger D. Ammonia and glutamine metabolism in human liver slices: new aspects on the pathogenesis of hyperammonemia in chronic liver disease. Eur J Clin Invest 1988;18:535-42.
7. Deutz NEP, Dejong CHC, Soeters PB. Ammonia and glutamine metabolism during liver insufficiency: the muscle gut liver axis. It J Gastroenterol 1993;25:79-86.
8. Deutz NEP, Dejong CHC, Reijven PLM, Soeters PB. In vivo ammonia and glutamine flux measurements during hyperammonemia in rats and pigs. In: Bengtsson F, Jeppsson B, Almdal T, Vilstrup H, editors. Progress in hepatic encephalopathy and metabolic nitrogen exchange. Boca Raton: CRC Press, 1991:329-39.
9. Dejong CHC, Kampman MT, Deutz NEP, Soeters PB. Altered glutamine metabolism in rat portal drained viscera and hindquarter. Gastroenterology 1992;102:936-48.
10. Dejong CHC. Ammonia and glutamine metabolism during liver failure. Thesis, Maastricht, The Netherlands, 1993.
11. Dejong CHC, Deutz NEP, Soeters PB. Muscle ammonia and glutamine exchange during chronic liver insufficiency in the rat. J Hepatol 1994;21:299-307.