Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy

Neurochemical Research

Volumn 24, Issue 11, 1999, Pages 1397-1401

  Chan, Helen ^a   Butterworth, Roger F ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Acute liver failure; GLT 1; Glutamate; Glutamate transport; Hepatic encephalopathy; 3H D Aspartate

Indexed keywords

AMMONIA; CARRIER PROTEIN; GLUTAMIC ACID;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN EDEMA; BRAIN SLICE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; EXCITABILITY; GENE EXPRESSION; HEPATIC ENCEPHALOPATHY; LIVER FAILURE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID TRANSPORT SYSTEM X-AG; AMMONIA; ANIMALS; ASTROCYTES; ATP-BINDING CASSETTE TRANSPORTERS; BRAIN; GENE EXPRESSION; GLUTAMIC ACID; HEPATIC ENCEPHALOPATHY; HUMANS;

ANIMALIA;

EID: 0032702799     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1022532623281     Document Type: Article

References (31)

1. Record, C. O., Buxton, B., Chase, R., Curzon, G., Murray-Lyon, I. M., and Williams, R. 1976. Plasma and brain amino acids in fulminant hepatic failure and their relationship to hepatic encephalopahy. Eur. J. Clin. Invest. 6:387-394.
2. Lavoie, J., Giguère, J. F., Layrargues, G. P., and Butterworth, R. F. 1987. Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy. J. Neurochem. 9:692-697.
3. Swain, M., Bergeron, M., Audet, R., Blei, A. T., and Butterworth, R. F. 1992. Monitoring of neurotransmitter amino acids by means an indwelling cisterna magna catheter: a comparison of two rodent models of fulminant hepatic failure. Hepatology 16:1028-1035.
4. Mans, A. M., DeJoseph, M. R., and Hawkins, R. A. 1994. Metabolic abnormalities and grade of encephalopathy in acute hepatic failure. J. Neurochem. 63:1829-183.
5. Bosman, D. K., Deutz, N. E. P., Maas, M. A. W. van Eijk, H. M. H., Smit, J. J. H., de Haan, J. G., and Chamuleau, R. A. F. M. 1992. Amino acid release from cerebral cortex in experimental acute liver failure, studied by in vivo microdialysis. J. Neurochem. 59:591-599.
6. Michalak, A., Rose, C., Butterworth, J., and Butterworth, R. F. 1996. Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure. Hepatology 24:908-913.
7. De Kneght, R. J., Schalm, S.W., Van Der Rijt, C. C. D., Fekkes, D., Dalm, E., and Hekking-Weyma, I. 1994. Extracellular brain glutamate during acute liver failure and during acute hyperammonemia stimulating acute liver failure: An experimental study based on in vivo brain dialysis. J. Hepatol. 20:19-26.
8. Oppong, K. N. W., Bartlett, K., Record, C. O., and Al Mardini, H. 1995. Synaptosomal glutamate transport in thioacetamide-induced hepatic encephalopathy in the rat. Hepatology 22:53-558.
9. Moroni, F., Lombardi, G., Moneti, G., and Cortesini, C. 1983. The release and the neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy. J. Neurochem. 40:850-854.
10. Tossman, U., Delin, A., Eriksson, L. S., and Ungerstedt, U. 1987. Brain cortical amino acids measured by intracerebral dialysis in portacaval shunted rats. Neurochem. Res. 12:265-269.
11. Tossman, U., Eriksson, S., Delin, A., Hagenfeldt, L., Law, D., and Ungerstedt, U. 1983. Brain amino acids measured by intracerebral dialysis in portacaval shunted rats. J. Neurochem. 41:106-1051.
12. Raghavendra Rao, V. L., Audet, R. M., and Butterworth, R. F. 1995. Selective alterations of extracellular brain amino acids in relation to function in experimental portal-systemic encephalopathy: results of an in vivo microdialysis study. J. Neurochem. 65:1221-1228.
13. Hamberger, A., Lindroth, B., and Nystrom, B. 1982. Regulation of glutamate biosynthesis and release in vitro by low levels of ammonium ions. Brain Res. 237:339-350.
14. Butterworth, R. F. Girard, G., and Giguère, J. F. 1988. Regional differences in the capacity for ammonia removal by brain following portacaval anastomosis. Neurochem. 51:486-490.
15. Lockwood, A. H., Yap, E. W. H., and Wong, W.-H. 1991. Cerebral ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy. J. Cerebral Blood Flow Metab. 11:337-341.
16. Hamberger, A., Hedquist, B., and Nystrom, B. 1979. Ammonium ion inhibition of evoked release of endogenous glutamate from hippocampal slices. J. Neurochem. 33:1295-1302.
17. Erecinska, M., Pastuszko, A., Wilson, D. F., and Nelson, D. 1987. Ammonia-induced release of neurotransmitters from rat brain synaptosomes: Differences between the effects on amines and amino acids. J. Neurochem. 49:1258-1265.
18. 3H]L-glutamate uptake in a rat model of chronic hepatic encephalopathy. Neurochem. Int. 28:89-93.
19. Michalak, A., Rose, C., and Butterworth, R. F. 1998. Further evidence for decreased expression of glutamate and noradrenaline transporters in cortical and sub-cortical structures in acute liver failure. Hepatology, 28(4), pt. 2, #688 (abstract).
20. Schmidt, W., Wolf, G., Grungreiff, K., Meier, M., and Reum, T. 1990. Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation. Metab. Brain Dis. 5:19-31.
21. Bender, A. S., and Norenberg, M. D. 1996. Effects of ammonia on L-glutamate uptake in cultured astrocytes. Neurochem. Res. 21:567-573.
22. Mena, E. E., and Cotman, C. W. 1985. Pathologic concentrations of ammonium ions block L-glutamate uptake. Exp. Neurol. 89:259-263.
23. Chaudhry, F. A., Lehre, K. P., van Lookeren Campagne, M., Ottersen, O. P., Danbolt, N. C., and Storm-Mathisen, J. 1995. Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron, 1:711-720.
24. Rothstein, J. D., Martin, L., Levey, A. I., Dykes-Hoberg, M., Jin, L., Wu, D., Nash, N., and Kuncl, R. W. 1994. Localization of neuronal and glial glutamate transporters. Neuron, 13:713-725.
25. Robinson, M. B. 1998. The family of sodium-dependent glutamate transporters: a focus on the GLT-1/EAAT2 subtype. Neurochem. Int. 33:479-491, 1998.
26. Tanaka, K., Watase, K., Manabe, T., Yamada, K., Watanabe, M., Takahashi, K., Iwama, H., Nishikawa, T., Ichihara, N., Kikuchi, T., Okuyama, S., Kawashima, N., Hori, S., Takimoto, M., and Wada, K. 1997. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276:1699-1702.
27. Knecht, K., Michalak, A., Rose, C., Rothstein, J. D., and Butterworth, R. F. 1997. Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure. Neurosci. Left. 229:201-203.
28. Norenberg, M. D., Huo, Z., Neary, J. T., and Roig-Cantesano, A. 1997. The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: Relation to energy metabolism and glutamatergic neurotransmission. Glia 21:124-133.
29. Chan, H., Desjardins, P., Hazell, A. S., and Butterworth, R. F. 1999. Effects of ammonia on glutamate (GLT-1 and GLAST) transporter expression in cultured astrocytes. J. Neurochem. 72, suppl., #S56A.
30. Gegelashvili, G., and Schousboe, A. 1997. High affinity glutamate transporters: Regulation of expression and activity. Mol. Pharmacol. 52:6-15
31. Thorlin, T., Roginski, R. S., Choudhury, K. Nilsson, M., Rönnâck, L., Hansson, E., and Eriksson, P. S. 1998. Regulation of the glial glutamate transporter GLT-1 by glutamate and δ-opioid receptor stimulation. FEBS Letters 425:43-459.