Hyperglycemia regulates RUNX2 activation and cellular wound healing through the aldose reductase polyol pathway

Journal of Biological Chemistry

Volumn 284, Issue 27, 2009, Pages 17947-17955

  D'Souza, David R ^a   Salib, Maryann M ^a   Bennett, Jessica ^a   Mochin Peters, Maria ^a   Asrani, Kaushal ^a   Goldblum, Simeon E ^b   Renoud, Keli J ^a   Shapiro, Paul ^c   Passaniti, Antonino ^a,b  

^a UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSE REDUCTASE; ANGIOGENESIS; DIABETES MELLITUS; DNA BINDING; MICROVASCULAR; PHYSIOLOGICAL LEVELS; RECEPTOR ACTIVATION; TRANSCRIPTIONAL ACTIVITY; VASCULAR DAMAGE; VASCULAR ENDOTHELIAL CELLS; VASCULAR REMODELING; WOUND HEALING;

ANIMALS; CELL MEMBRANES; ELECTRIC CONDUCTIVITY MEASUREMENT; ENDOTHELIAL CELLS; GLUCOSE; MONOLAYERS; NUCLEIC ACIDS; SUGAR (SUCROSE); TRANSCRIPTION FACTORS;

ARGON;

ALDEHYDE REDUCTASE; DNA; GLUCOSE; POLYOL; SOMATOMEDIN C; SOMATOMEDIN RECEPTOR; TRANSCRIPTION FACTOR RUNX2;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; AUTOCRINE EFFECT; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC MICROANGIOPATHY; DNA BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; GENETIC TRANSCRIPTION; HYPERGLYCEMIA; MONOLAYER CULTURE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RECEPTOR UPREGULATION; VASCULAR ENDOTHELIUM; WOUND HEALING;

ALDEHYDE REDUCTASE; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; HUMANS; HYPERGLYCEMIA; INSULIN-LIKE GROWTH FACTOR I; OXIDATIVE STRESS; RECEPTOR, IGF TYPE 1; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; WOUND HEALING;

ANIMALIA;

EID: 67650519130     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.002378     Document Type: Article

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