The Effect of Substrate, Dihydrobiopterin, and Dopamine on the EPR Spectroscopic Properties and the Midpoint Potential of the Catalytic Iron in Recombinant Human Phenylalanine Hydroxylase

Journal of Biological Chemistry

Volumn 276, Issue 25, 2001, Pages 22850-22856

  Hagedoorn, Peter L ^a   Schmidt, Peter P ^b   Andersson, K Kristoffer ^b   Hagen, Wilfred R ^a   Flatmark, Torgeir ^c   Martínez, Aurora ^c  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHEMICAL ACTIVATION; DIMERS; ELECTRON TRANSITIONS; ENZYMES; IRON; PARAMAGNETIC MATERIALS; PARAMAGNETIC RESONANCE; SPECTROSCOPIC ANALYSIS; THERMODYNAMICS;

BINDING AFFINITIES;

BIOCHEMISTRY;

DIHYDROBIOPTERIN; DOPAMINE; IRON; PHENYLALANINE 4 MONOOXYGENASE; RECOMBINANT ENZYME; 7,8-DIHYDROBIOPTERIN; BIOPTERIN; DRUG DERIVATIVE; LIGAND; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; ELECTRON SPIN RESONANCE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR DYNAMICS; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION;

BIOPTERIN; CATALYSIS; DOPAMINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; IRON; LIGANDS; MODELS, MOLECULAR; PHENYLALANINE HYDROXYLASE; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0035933752     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009458200     Document Type: Article

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