On the design of an in-line control system for a Vial Freeze-drying process: The role of Chamber pressure

Chemical Product and Process Modeling

Volumn 4, Issue 2, 2009, Pages

  Fissore, Davide ^a   Pisano, Roberto ^a   Barresi, Antonello A ^a  

^a POLITECNICO DI TORINO   (Italy)

Author keywords

Control; Freeze drying; Monitoring; Optimization

Indexed keywords

CONTROL; CONTROL SYSTEMS; CONTROLLERS; LOW TEMPERATURE DRYING; MONITORING; OPTICAL VARIABLES MEASUREMENT; OPTIMIZATION;

CHAMBER PRESSURE; CLOSED LOOP CONTROLLERS; CONTROLLED VARIABLES; DYNAMIC PARAMETERS; FLUID TEMPERATURES; FREEZE DRYING; FREEZE-DRYING PROCESS; OPEN LOOP CONTROLLERS;

DRYING;

EID: 67650504810     PISSN: 19342659     EISSN: None     Source Type: Journal    
DOI: 10.2202/1934-2659.1286     Document Type: Article

References (26)

1. Barresi, A. A., Baldi, G., Parvis, M., Vallan, A., Velardi, S. A., Hammouri, H. (2007). Optimization and control of the freeze-drying process of pharmaceutical products. International patent application No PCT/IB2007/051276. International Publication No. WO2007/116371 A2 (18 October 2007).
2. Barresi A. A., Pisano R., Rasetto V., Fissore D., Galan, M. (2008). Model-based monitoring and controlling of industrial freeze-drying processes. Proceedings of Drying 2008 - 16th International Drying Symposium (edited by Department of Chemical Engineering, Institute of Chemical Technology, University of Mumbay, India), November 9-12, Ramoji Film City (Hyderabad), India, Vol. B, pp. 746-754.
3. Barresi A. A., Pisano R., Fissore D., Rasetto V., Velardi S. A., Vallan A., Parvis M., Galan, M. (2009a). Monitoring of the primary drying of a freeze-drying process in vials. Chemical Engineering & Processing, 48, 849-861.
4. Barresi A. A., Velardi S. A., Pisano, R., Rasetto V., Vallan A., Galan M. (2009b). In-line control of the lyophilization process. A gentle PAT approach using software sensors, International Journal of Refrigeration. Forthcoming. [DOI: 10.1016/j.ijrefrig.2008.10.012]
5. Barresi, A. A., Velardi, S. A., Fissore D., Pisano R. (2009c). Monitoring and controlling processes with complex dynamics using soft-sensors. In: Modeling, Control, Simulation and Diagnosis of Complex Industrial and Energy Systems (L. Ferrarini, C. Veber Eds.), Chapter 7, 139-162. Ottawa (Canada): O3NEDIA - ISA Series on Industrial Automation. [ISBN: 978-1-934394-90-8.]
6. Boss, E. A., Filho, R. M., Vasco de Toledo, E. C. (2004). Freeze drying process: real time model and optimization. Chemical Engineering and Processing, 43, 1475-1485.
7. Chouvenc, P., Vessot, S., Andrieu, J., Vacus, P. (2004). Optimization of the freeze-drying cycle: a new model for pressure rise analysis. Drying Technology, 22, 1577-1601.
8. Fissore D., Velardi, S. A., Barresi A. A. (2008). In-line control of a freeze-drying process in vials. Drying Technology, 26, 685-694.
9. Gan, K. H., Bruttini, R., Crosser, O. K., Liapis, A. I. (2004). Heating policies during the primary and secondary drying stages of the lyophilization process in vials: Effects of the arrangement of vials in clusters of square and hexagonal arrays on trays. Drying Technology, 22, 1539-1575.
10. Gan, K. H., Crosser, O. K., Liapis, A. I., Bruttini, R. (2005). Lyophilization in vials on trays: Effects of tray side. Drying Technology, 23, 341-363.
11. Liapis, A. I., Litchfield, R. J. (1979). Optimal control of a freeze dryer - I. Theoretical development and quasi steady-state analysis. Chemical Engineering Science, 34, 975-981.
12. Liapis, A. I., Pikal, M. J., Bruttini, R. (1996). Research and development needs and opportunities in freeze-drying. Drying Technology, 14, 1265-1300.
13. Liapis, A. I., Sadikoglu, H. (1998). Dynamic pressure rise in the drying chamber as a remote sensing method for monitoring the temperature of the product during the primary drying stage of freeze-drying. Drying Technology, 16, 1153-1171.
14. Lombraña, J. I., Diaz, J. M. (1987a). Heat programming to improve efficiency in a batch freeze-dryer. The Chemical Engineering Journal, 35, B23-B30.
15. Lombraña, J. I., Diaz, J. M. (1987b). Coupled vacuum and heating power control for freeze-drying time reduction of solutions in phials. Vacuum, 37, 473-476.
16. Lombraña, J. I., De Elvira, C., Villaran, M. C. (1997). Analysis of operating strategies in the production of special foods in vial by freeze-drying. International Journal of Food Science and Technology, 32, 107-115.
17. Milton, N., Pikal, M. J., Roy, M. L., Nail, S. L. (1997). Evaluation of Manometric Temperature Measurement as a method of monitoring product temperature during lyophilization. PDA Journal of Pharmaceutical Science & Technology, 51, 7-16.
18. Oetjen, G. W. (1999). Freeze-drying. Weinheim: Wiley-VCH Verlag.
19. Oetjen, G. W., Haseley, P. (2004). Freeze-Drying - Second edition. Weinheim: Wiely-VHC.
20. Pikal, M. J., Tang, X., Nail, S. L. (2005). Automated process control using manometric temperature measurement. United States Patent n. 6,971,187 B1.
21. Rene, F., Wolff, E., Rodolphe, F. (1993). Vacuum freeze-drying of a liquid in a vial: determination of heat and mass-transfer coefficients and optimisation of operating pressure. Chemical Engineering and Processing, 32, 245-251.
22. Sadikoglu, H., Ozdemir, M., Seker, M. (2006). Freeze-drying of pharmaceutical products: Research and development needs. Drying Technology, 24, 849-861.
23. Schneid, S., Gieseler, H. (2008). Evaluation of a new wireless temperature remote interrogation system (TEMPRIS) to measure product temperature during freeze drying. AAPS Pharmaceutical Science & Technology, 9, 729-739.
24. Tang, X. C., Nail, S. L., Pikal, M. J. (2005). Freeze-drying process design by manometric temperature measurement: design of a smart freeze-dryer. Pharmaceutical Research, 22, 685-700.
25. Velardi, S. A., Barresi, A. A. (2008). Development of simplified models for the freeze-drying process and investigation of the optimal operating conditions. Chemical Engineering Research &. Design, 86, 9-22.
26. Velardi, S. A., Rasetto, V., Barresi, A. A. (2008). Dynamic Parameters Estimation method: advanced Manometric Temperature Measurement approach for freeze-drying monitoring of pharmaceutical solutions. Industrial & Engineering Chemistry Research, 47, 8445-8457.