On the origins of enzyme inhibitor selectivity and promiscuity: A case study of protein kinase binding to staurosporine

Chemical Biology and Drug Design

Volumn 74, Issue 1, 2009, Pages 16-24

  Tanramluk, Duangrudee ^a   Schreyer, Adrian ^a   Pitt, William R ^a,b   Blundell, Tom L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UCB PHARMA   (Belgium)

Author keywords

ATP binding site; Kinase selectivity; Mantel test; Staurosporine; Structural analysis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ASPARTIC ACID; GLYCINE; METHYLAMINE; PROTEIN KINASE; STAUROSPORINE;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ASSAY; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; HINGE REGION; HYDROGEN BOND; INTERNET; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; BINDING SITES; COMPUTER SIMULATION; DATABASES, PROTEIN; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STAUROSPORINE;

PYRONIA TITHONUS;

EID: 67650457580     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2009.00832.x     Document Type: Article

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