Ftz modulates Runt-dependent activation and repression of segment-polarity gene transcription

Development

Volumn 131, Issue 10, 2004, Pages 2281-2290

  Swantek, Deborah ^a   Gergen, J Peter ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Drosophila; Engrailed; Hox; Runx; Segmentation; Sloppy paired I; Wingless; Zic

Indexed keywords

DROSOPHILA PROTEIN; PROTEIN RUNT; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FTZ; UNCLASSIFIED DRUG; WNT1 PROTEIN; ZINC FINGER PROTEIN;

ARTICLE; BLASTODERM; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO POLARITY; EMBRYO SEGMENTATION; GENE CONTROL; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE INTERACTION; GENETIC MANIPULATION; IN SITU HYBRIDIZATION; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; BLASTODERM; BODY PATTERNING; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; FEMALE; FUSHI TARAZU TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EUKARYOTA; HEXAPODA;

EID: 3042753813     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01109     Document Type: Article

References (42)

1. Barolo, S. and Levine, M. (1997). Hairy mediates dominant repression in the Drosophila embryo. EMBO J. 16, 2883-2891.
2. Baumgartner, S., Bopp, D., Burri, M. and Noll, M. (1987). Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis. Genes Dev. 1, 1247-1267.
3. Benedyk, M. J., Mullen, J. R. and DiNardo, S. (1994). odd-paired: a zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos. Genes Dev. 8, 105-117.
4. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
5. Cadigan, K. M., Grossniklaus, U. and Gehring, W. J. (1994). Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments. Genes Dev. 8, 899-913.
6. Canon, J. and Banerjee, U. (2003). In vivo analysis of a developmental circuit for direct transcriptional activation and repression in the same cell by a Runx protein. Geves Dev. 17, 838-843.
7. Carroll, S. B. and Scott, M. P. (1986). Zygotically active genes that affect the spatial expression of the fushi tarazu segmentation gene during early Drosophila embryogenesis. Cell 45, 113-126.
8. Cimbora, D. M. and Sakonju, S. (1995). Drosophila midgut morphogenesis requires the function of the segmentation gene odd-paired. Dev. Biol. 169, 590-595.
9. Coffman, C. A. (2003). Runx transcription factors and the developmental balance between cell proliferation and differentiation. Cell Biol. Int. 27, 315-324.
10. DiNardo, S. and O'Farrell, P. H. (1987). Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes. Genes Dev. 1, 1212-1225.
11. Duffy, J. B. and Gergen, J. P. (1994). Sex, segments, and the central nervous system: common genetic mechanisms of cell fate determination. Adv. Genet. 31, 1-28.
12. Florence, B., Guichet, A., Ephrussi, A. and Laughon, A. (1997). Ftz-F1 is a cofactor in Ftz activation of the Drosophila engrailed gene. Development 124, 839-947.
13. Frasch, M. and Levine, M. (1987). Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila. Genes Dev. 1, 981-995.
14. Gergen, J. P. and Wieschaus, E. (1986). Dosage requirements for runt in the segmentation of Drosophila embryos. Cell 45, 289-299.
15. Grossniklaus, U., Pearson, R. K. and Gehring, W. J. (1992). The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes Dev. 6, 1030-1051.
16. Ingham, P. and Gergen, P. (1988). Interactions between the pair-rule genes runt, hairy, even-skipped and fushi tarazu and the establishment of periodic pattern in the Drosophila embryo. Development Suppl. 104, 51-60.
17. Ish-Horowicz, D. and Pinchin, S. M. (1987). Pattern abnormalities induced by ectopic expression of the Drosophila gene hairy are associated with repression of ftz transcription. Cell 51, 405-415.
18. Jimenez, G., Paroush, Z. and Ish-Horowicz, D. (1997). Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed. Genes Dev. 11, 3072-3082.
19. Kania, M. A., Bonner, A. S., Duffy, J. B. and Gergen, J. P. (1990). The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system. Genes Dev. 4, 1701-1713.
20. Klingler, M. and Gergen, J. P. (1993). Regulation of runt transcription by Drosophila segmentation genes. Mech. Dev. 43, 3-19.
21. Komori, T. (2002). Runx2, a multifunctional transcription factor in skeletal development. J. Cell Biochem. 87, 1-8.
22. Kosman, D., Small, S. and Reinitz, J. (1998). Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins. Dev. Genes Evol. 208, 290-294.
23. Kramer, S. G., Jinks, T. M., Schedl, P. and Gergen, J. P. (1999). Direct activation of Sex-lethal transcription by the Drosophila runt protein. Development 126, 191-200.
24. Li, L. H. and Gergen, J. P. (1999). Differential interactions between Brother proteins and Runt domain proteins in the Drosophila embryo and eye. Development 126, 3313-3322.
25. Manoukian, A. S. and Krause, H. M. (1992). Concentration-dependent activities of the even-skipped protein in Drosophila embryos. Genes Dev. 6, 1740-1751.
26. Manoukian, A. S. and Krause, H. M. (1993). Control of segmental asymmetry in Drosophila embryos. Development 118, 785-796.
27. Morrissey, D., Askew, D., Raj, L. and Weir, M. (1991). Functional dissection of the paired segmentation gene in Drosophila embryos. Genes Dev. 5, 1684-1696.
28. Mullen, J. R. and DiNardo, S. (1995). Establishing parasegments in Drosophila embryos: roles of the odd-skipped and naked genes. Dev. Biol. 169, 295-308.
29. Nusslein-Volhard, C., Wieschaus, E. and Kluding, H. (1984). Mutations affecting the pattern of teh larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch. Dev. Biol. 193, 267-282.
30. O'Neill, J. W. and Bier, E. (1994). Double-label in situ hybridization using biotin and digoxigenin-tagged RNA probes. Biotechniques 17, 870-875.
31. Pepling, M. E. and Gergen, J. P. (1995). Conservation and function of the transcriptional regulatory protein Runt. Proc. Natl. Acad. Sci. USA 92, 9087-9091.
32. Poortinga, G., Watanabe, M. and Parkhurst, S. M. (1998). Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression. EMBO J. 17, 2067-2078.
33. Robertson, H. M., Preston, C. R., Phillis, R. W., Johnson-Schlitz, D. M., Benz, W. K. and Engels, W. R. (1988). A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118, 461-470.
34. Shapiro, I. M. (1999). Discovery: Osf2/Cbfa1, a master gene of bone formation. Clin. Orthod. Res. 2, 42-46.
35. Speck, N. A., Stacy, T., Wang, Q., North, T., Gu, T. L., Miller, J., Binder, M. and Marin-Padilla, M. (1999). Core-binding factor: a central player in hematopoiesis and leukemia. Cancer Res. 59, S1789-S1793.
36. Tracey, W. D., Jr, Ning, X., Klingler, M., Kramer, S. G. and Gergen, J. P. (2000). Quantitative analysis of gene function in the Drosophila embryo. Genetics 154, 273-284.
37. Tsai, C. and Gergen, J. P. (1994). Gap gene properties of the pair-rule gene runt during Drosophila segmentation. Development 120, 1671-1683.
38. Tsai, C. and Gergen, P. (1995). Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy. Development 121, 453-462.
39. Tsai, C. C., Kramer, S. G. and Gergen, J. P. (1998). Pair-rule gene runt restricts orthodenticle expression to the presumptive head of the Drosophila embryo. Dev. Genet. 23, 35-44.
40. van Doren, M., Bailey, A. M., Esnayra, J., Ede, K. and Posakony, J. W. (1994). Negative regulation of proneural gene activity: hairy is a direct transcriptional repressor of achaete. Genes Dev. 8, 2729-2742.
41. Wheeler, J. C., Shigesada, K., Gergen, J. P. and Ito, V. (2000). Mechanisms of transcriptional regulation by Runt domain proteins. Semin. Cell Der. Biol. 11, 369-375.
42. Wheeler, J. C., VanderZwan, C., Xu, X., Swantek, D., Tracey, W. D. and Gergen, J. P. (2002). Distinct in vivo requirements for establishment versus maintenance of transcriptional repression. Nat. Genet. 32, 206-210.