Lipoxygenase inhibitors prevent lung carcinogenesis and inhibit non- small cell lung cancer growth

Experimental Lung Research

Volumn 24, Issue 4, 1998, Pages 617-628

  Moody, T W ^a,c   Leyton, J ^a   Martinez, A ^a   Hong, S ^a   Malkinson, A ^b   Mulshine, J L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c Medicine Branch   (United States)

Author keywords

A J mice; Apoptosis; Lipoxygenase inhibitors; Lung carcinogenesis; Non small cell lung cancer

Indexed keywords

LIPOXYGENASE INHIBITOR;

AMINO ACID METABOLISM; ANIMAL CELL; CANCER GROWTH; CONFERENCE PAPER; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; LUNG BIOPSY; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0031803405     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.3109/01902149809087390     Document Type: Conference Paper

References (29)

1. Moody TW, Cuttitta F. Growth factors and receptors in lung cancer. Life Sci. 1993;52:1161-1173.
2. Moody TW. Peptides and growth factors in non-small cell lung cancer. Peptides. 1996; 17:545-555.
3. Moody TW, Murphy A, Mahmoud S, Fiskum G. Bombesin-like peptides elevate cytosolic calcium in small cell lung cancer cells, Biochem Biophys Res Commun. 1987;147:189-195.
4. Trepel J, Moyer J, Cuttitta F, et al. A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line. Biochem Biophys Res Commun 1988;156;1383-1389.
5. Nakanishi Y, Mulshine J, Kasprzyk P, et al. Insulin-like growth factor-1 can stimulate the proliferation of human small cell lung cancer lines. J Clin Invest. 1988;82:354-359.
6. Zia F, Jacobs S, Kull F Jr, Cuttitta F, Mulshine J, Moody TW. Monoclonal antibody αIR-3 inhibits non-small cell lung cancer growth in vitro and in vivo. J Cell Biochem. 1996;24s:269-275.
7. Rechler MW, Nissley SP. The nature and regulation of the receptor for insulin-like growth factors, Annu Rev Physiol. 1994;47:425-442.
8. Moody TW, Zia F, Venugopal R, Fagarasan M, Oie H, Hu V. GRP receptors are present on non-small cell lung cancer cell lines. J Cell Biochem. 1996,24s:247-256.
9. Millar J, Rozengurt E. Arachidonic acid release by bombesin. J Biol Chem. 1990;265:19973-19979.
10. Dewitt DL. Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim Biophys Acta. 1991;1083:121-134.
11. Hubbard WC, Alley MC, Gray GN, Green KC, McLemore TL, Boyd MR. Evidence for prostanoid biosynthesis as a biochemical feature of certain subclasses of non-small cell carcinomas of the lung as determined in established cell lines derived from human lung tumors. Cancer Res. 1989;49:826-832.
12. Duperron C, Castonguay A. Inhibition of lung tunorigenesis by aspirin in A/J mice. Cancer Res Proc. 1996;36:592.
13. Samuelsson B, Dahlen SE, Lindren JA, Rouzer CA, Serhan CN. Leukotrienes and lipoxins: structures, biosynthesis and biological effects. Science. 1987:237;1171-1176.
14. Avis IM, Jett M, Boyle T, et al. Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signalling. J Clin Invest. 1996;97:806-813.
15. Carney DN, Gazdar AF, Bepler G, et al. Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res. 1985;45:2913-2923.
16. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 1979;18:5294-5299.
17. Davis L, Dibner M, Battey JF. Basic Methods in Molecular Biology. New York: Elsevier; 1986.
18. 13,14) Bombesin analogues inhibit the growth of small cell lung cancer in vitro and in vivo. Cancer Res. 1991;51:1798-1802.
19. Malkinson AM. Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma. Cancer Res. 1992;52:2670s-2676s.
20. Dixon RAF, Diehl, RE, Opas E, et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature. 1990;343:282-284.
21. Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B. Molecular cloning and amino acid sequence of human 5-lipoxygenase. Proc Natl Acad Sci USA. 1988;85:26-30.
22. Rouzer CA, Ford-Hutchinson AW, Morton H, Gillard J. MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes. J Biol Chem. 1990;265:1436-1442.
23. Rozengurt E, Sinett-Smith J. Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells. Proc Natl Acad Sci USA. 1993;80:2936-2940.
24. Marquez C, Treston A, You L, et al. Chemoprevention of lung adenomas by BW2258U89. Cancer Res Proc. 1996;37:270.
25. Lee M, Draoui M, Zia F, et al. Epidermal growth factor receptor monoclonal antibodies inhibit the growth of lung cancer cell lines. JNCI Monogr. 1992;13:117-123.
26. Moody TW, Zia F, Draoui M, et al. A novel VIP antagonist inhibits non-small cell lung cancer growth. Proc Natl Acad Sci USA. 1993;90:4345-4349.
27. Rioux N, Castonguay A. A new class of cancer chemopreventive agents: 5-lipoxygenase inhibitors. Cancer Res Proc. 1997;38:262.
28. Hubbard WC, Litterist CL, Liu MC, et al. Profiling of prostaglandin biosynthesis in biopsy fragments of human lung carcinomas and normal human lung by capillary gas chromatography-negative ion chemical ionization mass spectrometry. Prostaglandins. 1986;32:889-906.
29. 2 and the growth of non-small cell lung cancer cells. Cancer Res Proc. 1995;36:601.