Leukotriene A4 hydrolase: Identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates

Journal of Biological Chemistry

Volumn 279, Issue 26, 2004, Pages 27376-27382

  Rudberg, Peter C ^a   Tholander, Fredrik ^a   Andberg, Martina ^a   Thunnissen, Marjolein M G M ^b   Haeggström, Jesper Z ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; ENZYMES; ZINC COMPOUNDS;

AMINOPEPTIDASE SUBSTRATES; BINDING STRENGTH;

BIOCHEMISTRY;

ALANINE; ALANINE 4 NITROANILIDE; AMINOPEPTIDASE; ANILIDE; ANION; ARGININE; CARBOXYLIC ACID; CHEMOATTRACTANT; EPOXIDE HYDROLASE; LEUKOTRIENE A4; LEUKOTRIENE A4 HYDROLASE; LEUKOTRIENE B4; LYSINE; METALLOPROTEIN; METHIONINE; MUTANT PROTEIN; UNCLASSIFIED DRUG; ZINC; ENZYME INHIBITOR; HYDROXAMIC ACID; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; MICHAELIS CONSTANT; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; PRIORITY JOURNAL; SURFACE CHARGE; X RAY ANALYSIS; AMINO ACID SEQUENCE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ELECTRICITY; ESCHERICHIA COLI; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; ARGININE; BINDING SITES; CARBOXYLIC ACIDS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENZYME INHIBITORS; EPOXIDE HYDROLASES; ESCHERICHIA COLI; HUMANS; HYDROXAMIC ACIDS; LEUKOTRIENE A4; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

EID: 3042549380     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401031200     Document Type: Article

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