A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2

Oncogene

Volumn 27, Issue 21, 2008, Pages 2969-2977

  Han, X ^a,b   Saito, H ^c   Miki, Y ^a,c   Nakanishi, A ^c,d  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b YANBIAN UNIVERSITY   (China)

^c CANCER INSTITUTE   (Japan)

^d THE UNIVERSITY OF TOKYO   (Japan)

Author keywords

BRCA2; Breast cancer; Centrosome; Leptomycin B; Microinjection; Nuclear export

Indexed keywords

ALANINE; BRCA2 PROTEIN; EXPORTIN 1; GREEN FLUORESCENT PROTEIN; LEPTOMYCIN B; LEUCINE; PEPTIDE;

ANIMAL CELL; ARTICLE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL NUCLEUS; CENTROSOME; CYTOPLASM; GENE AMPLIFICATION; GENE DISRUPTION; GENE MUTATION; GENE SEQUENCE; HELA CELL; HUMAN; HUMAN CELL; MICROINJECTION; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN SYNTHESIS INHIBITION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRCA2 PROTEIN; CENTROSOME; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOPLASM; DNA PRIMERS; FATTY ACIDS, UNSATURATED; HELA CELLS; HUMANS; KARYOPHERINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR EXPORT SIGNALS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 43449099740     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210968     Document Type: Article

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