Structure-function analysis of the α5 and the α13 helices of human glucokinase: Description of two novel activating mutations

Protein Science

Volumn 14, Issue 8, 2005, Pages 2080-2086

  Pedelini, Leda ^a   Garcia Gimeno, Maria Adelaida ^a   Marina, Alberto ^a   Gomez Zumaquero, Juan M ^b   Rodriguez Bada, Pablo ^b   López Enriquez, Soledad ^b   Soriguer, Federico C ^c   Cuesta Muñoz, Antonio L ^b   Sanz, Pascual ^a  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^b Hospital University Carlos Haya de Málaga   (Spain)

^c HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

Author keywords

Activating mutation; Enzyme kinetics; GKAs; Glucokinase; Glucose signaling

Indexed keywords

AMINO ACID; GLUCOKINASE; GLUCOSE;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME KINETICS; GENE MUTATION; NONHUMAN; PARAMETER; PRIORITY JOURNAL; PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; WILD TYPE;

AMINO ACID SEQUENCE; GLUCOKINASE; GLUCOSE; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23644449095     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.051485205     Document Type: Article

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