Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 14, 2009, Pages 5139-5145

  Zhu, Ping Jun ^a   Hobson, John P ^b   Southall, Noel ^a   Qiu, Cunping ^b   Thomas, Craig J ^a   Lu, Jiamo ^c   Inglese, James ^a   Zheng, Wei ^a   Leppla, Stephen H ^c   Bugge, Thomas H ^b   Austin, Christopher P ^a   Liu, Shihui ^c  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Anthrax; Anthrax lethal factor; Diphyllin; Endocytosis; Niclosamide; Quantitative high throughput screening

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENOSINE TRIPHOSPHATASE; ANTHRAX INDUCED CELL DEATH INHIBITOR; ANTHRAX TOXIN; ANTIGEN; ANTITOXIN; BETA LACTAMASE; CAPILLARY MORPHOGENESIS GENE 2 RECEPTOR; CELL RECEPTOR; CHROMENO[4,3 C]PYRAZOL 4(1H) ONE DERIVATIVE; DIPHTHERIA TOXIN; DIPROPHYLLINE; HYBRID PROTEIN; NCGC 00084148; NICLOSAMIDE; PSEUDOMONAS EXOTOXIN; TUMOR ENDOTHELIAL CELL MARKER 8 RECEPTOR; UNCLASSIFIED DRUG;

ACIDIFICATION; ANIMAL CELL; ANTHRAX; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; ENDOCYTOSIS; ENDOSOME; ENZYME INHIBITION; GENE TRANSLOCATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LETHAL GENE; MACROPHAGE; NONHUMAN; QUANTITATIVE ANALYSIS; TOXIN INTERNALIZATION;

ANIMALS; ANTHRAX; ANTI-BACTERIAL AGENTS; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL DEATH; CHO CELLS; CORYNEBACTERIUM DIPHTHERIAE; CRICETINAE; CRICETULUS; DIPHTHERIA TOXIN; ENDOCYTOSIS; EXOTOXINS; MACROPHAGES; MICE; PSEUDOMONAS; SMALL MOLECULE LIBRARIES;

PSEUDOMONAS EXOTOXIN;

EID: 67650080312     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.054     Document Type: Article

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