An internal domain of β-tropomyosin increases myofilament Ca 2+ sensitivity

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 1, 2009, Pages

  Jagatheesan, Ganapathy ^a   Rajan, Sudarsan ^a   Schulz, Emily M ^a   Ahmed, Rafeeq P H ^a   Petrashevskaya, Natalia ^a,c   Schwartz, Arnold ^a   Boivin, Greg P ^a,d   Arteaga, Grace M ^b,e   Wang, Tao ^a   Wang, Yi Gang ^a   Ashraf, Muhammad ^a   Liggett, Stephen B ^c   Lorenz, John ^a   Solaro, R John ^b   Wieczorek, David F ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d WRIGHT STATE UNIVERSITY   (United States)

^e MAYO CLINIC   (United States)

Author keywords

Calcium sensitivity; Contractile function; Genetically altered mice

Indexed keywords

CALCIUM ION; ISOPRENALINE; MUTANT PROTEIN; TROPOMYOSIN;

ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HEART CONTRACTION; HEART MUSCLE RELAXATION; MOUSE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; SKINNED MUSCLE FIBER; THIN FILAMENT; TRANSGENIC MOUSE;

ADRENERGIC BETA-AGONISTS; AMINO ACID SUBSTITUTION; ANIMALS; BLOTTING, SOUTHERN; CALCIUM; CARDIOTONIC AGENTS; CIRCULAR DICHROISM; ECHOCARDIOGRAPHY; ISOELECTRIC FOCUSING; ISOPROTERENOL; MICE; MICROFILAMENTS; MUTATION; MYELIN SHEATH; MYOCARDIAL CONTRACTION; PROTEIN DENATURATION; RECOMBINANT PROTEINS; RNA; SARCOMERES; TROPOMYOSIN;

EID: 67650067101     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00329.2008     Document Type: Article

References (34)

1. Bing W, Knott A, Redwood C, Esposito G, Purcell I, Watkins H, Marston S. Effect of hypertrophic cardiomyopathy mutations in human cardiac muscle alpha-tropomyosin (Asp175Asn and Glu180Gly) on the regulatory properties of human cardiac troponin determined by in vitro motility assay. J Mol Cell Cardiol 32: 1489-1498, 2000.
2. Chang AN, Harada K, Ackerman MJ, Potter JD. Functional consequences of hypertrophic and dilated cardiomyopathy-causing mutations in alpha-tropomyosin. J Biol Chem 280: 34343-34349, 2005.
3. Conway JF, Parry DA. Structural features in the heptad substructure and longer range repeats of two-stranded alpha-fibrous proteins. Int J Biol Macromol 12: 328-334, 1990.
4. Davis KL, Mehlhorn U, Schertel ER, Geissler HJ, Trevas D, Laine GA, Allen SJ. Variation in tau, the time constant for isovolumic relaxation, along the left ventricular base-to-apex axis. Basic Res Cardiol 94:41-48, 1999.
5. Elliott K, Watkins H, Redwood CS. Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy. J Biol Chem 275: 22069-22074, 2000.
6. Galinska-Rakoczy A, Engel P, Xu C, Jung H, Craig R, Tobacman LS, Lehman W. Structural basis for the regulation of muscle contraction by troponin and tropomyosin. J Mol Biol 379: 929-935, 2008.
7. Golitsina N, An Y, Greenfield NJ, Thierfelder L, Iizuka K, Seidman JG, Seidman CE, Lehrer SS, Hitchcock-DeGregori SE. Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function. Biochemistry 38: 3850, 1999.
8. 2+ sensitivity and tropomyosin N-domain flexibility. J Biol Chem 278: 41742-41748, 2003.
9. Horton RM, Hunt HD, Ho SN, Pullen JK, Pease LR. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77: 61-68, 1989.
10. Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga G, de Tombe PP, Solaro RJ, Wieczorek DF. Physiological significance of troponin T binding domains in striated muscle tropomyosin. Am J Physiol Heart Circ Physiol 287: H1484-H1494, 2004.
11. Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga GM, Solaro RJ, Liggett SB, Wieczorek DF. Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Am J Physiol Heart Circ Physiol 293: H949-H958, 2007.
12. Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Vahebi S, DeTombe P, Solaro RJ, Labitzke E, Hilliard G, Wieczorek DF. Functional importance of the carboxyl-terminal region of striated muscle tropomyosin. J Biol Chem 278: 23204-23211, 2003.
13. Michele DE, Coutu P, Metzger JM. Divergent abnormal muscle relaxation by hypertrophic cardiomyopathy and nemaline myopathy mutant tropomyosins. Physiol Genomics 9: 103-111, 2002.
14. Mirza M, Robinson P, Kremneva E, Copeland O, Nikolaeva O, Watkins H, Levitsky D, Redwood C, El-Mezgueldi M, Marston S. The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments. J Biol Chem 282: 13487-13497, 2007.
15. Monteiro PB, Lataro RC, Ferro JA, de Castro Reinach F. Functional alpha-tropomyosin produced in Escherichia coli: a dipeptide extension can substitute the amino-terminal acetyl group. J Biol Chem 269: 10461-10466, 1994.
16. Murakami K, Stewart M, Nozawa K, Tomii K, Kudou N, Igarashi N, Shirakihara Y, Wakatsuki S, Yasunaga T, Wakabayashi T. Structural basis for tropomyosin overlap in thin (actin) filaments and the generation of a molecular swivel by troponin-T. Proc Natl Acad Sci USA 105: 7200-7205, 2008.
17. Muthuchamy M, Boivin GP, Grupp IL, Wieczorek DF. Beta-tropomyosin overexpression induces severe cardiac abnormalities. J Mol Cell Cardiol 30: 1545-1557, 1998.
18. Muthuchamy M, Grupp IL, Grupp G, O'Toole BA, Kier AB, Boivin GP, Neumann J, Wieczorek DF. Molecular and physiological effects of overexpressing striated muscle beta-tropomyosin in the adult murine heart. J Biol Chem 270: 30593-30603, 1995.
19. Muthuchamy M, Pieples K, Rethinasamy P, Hoit B, Grupp IL, Boivin GP, Wolska B, Evans C, Solaro RJ, Wieczorek DF. Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction. Circ Res 85: 47-56, 1999.
20. Neefjes JJ, Breur-Vriesendorp BS, van Seventer GA, Ivanyi P, Ploegh HL. An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes. Hum Immunol 16: 169-181, 1986.
21. 2+, strong cross-bridge binding, and protein phosphorylation. J Biol Chem 271: 11611-11614, 1996.
22. 2+ sensitivity and cooperativity. J Biol Chem 258: 2534-2542, 1983.
23. Perry SV. Vertebrate tropomyosin: distribution, properties and function. J Muscle Res Cell Motil 22: 5-49, 2001.
24. 2+ activation. Am J Physiol Heart Circ Physiol 283: H1344-H1353, 2002.
25. Pieples K, Wieczorek DF. Tropomyosin 3 increases striated muscle isoform diversity. Biochemistry 39: 8291-8297, 2000.
26. Prabhakar R, Boivin GP, Grupp IL, Hoit B, Arteaga G, Solaro JR, Wieczorek DF. A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice. J Mol Cell Cardiol 33: 1815-1828, 2001.
27. Prabhakar R, Petrashevskaya N, Schwartz A, Aronow B, Boivin GP, Molkentin JD, Wieczorek DF. A mouse model of familial hypertrophic cardiomyopathy caused by a alpha-tropomyosin mutation. Mol Cell Biochem 251: 33-42, 2003.
28. Rajan S, Ahmed RP, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res 101: 205-214, 2007.
29. 2+ regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein. Circ Res 86: 1146-1152, 2000.
30. Robinson P, Mirza M, Knott A, Abdulrazzak H, Willott R, Marston S, Watkins H, Redwood C. Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy. J Biol Chem 277: 40710-40716, 2002.
31. Singh A, Hitchcock-DeGregori SE. Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding. Biochemistry 42: 14114-14121, 2003.
32. White SP, Cohen C, Phillips GN Jr. Structure of co-crystals of tropomyosin and troponin. Nature 325: 826-828, 1987.
33. 2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express beta-tropomyosin. Circ Res 84: 745-751, 1999.
34. Zot AS, Potter JD. Structural aspects of troponin-tropomyosin regulation of skeletal muscle contraction. Annu Rev Biophys Biophys Chem 16: 535-559, 1987.