β-tropomyosin overexpression induces severe cardiac abnormalities

Journal of Molecular and Cellular Cardiology

Volumn 30, Issue 8, 1998, Pages 1545-1557

  Muthuchamy, Mariappan ^a,b   Boivin, Gregory P ^a   Grupp, Ingrid L ^a   Wieczorek, David F ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Contractility; Heart; Thrombi; Transgenic; Tropomyosin

Indexed keywords

TROPOMYOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOCARDIUM; HEART CONTRACTION; HEART DISEASE; HEART FUNCTION; HEART PERFORMANCE; HISTOLOGY; LETHALITY; MOUSE; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMERE; THROMBOGENESIS; TRANSGENE;

EID: 0032142736     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.1998.0720     Document Type: Article

References (36)

1. ANDERSON PAW, MALOUF NN, OAKELEY A, PAGANI ED, ALLEN PD. 1991. Troponin T isoform expression in humans: A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle. Circ Res 69: 1226-1233.
2. BEALL C, SEPANSKI M, FRYBERG E. 1989. Genetic dissection of Drosophila myofibril formation: effects of actin and myosin heavy chain null alleles. Genes Dev 3: 131-140.
3. DEPONTI-ZILLI L, SEILER-TUYNS A, PATERSON B. 1988. A 40-base-pair sequence in the 3′ end of the β-actin gene regulates β-actin mRNA transcription during myogenesis. Proc Natl Acad Sci USA 85: 1389-1393.
4. GARFINKEL L. 1982. Molecular studies of contractile proteins gene regulation during muscle differentiation and the structure of the fast muscle myosin light chain 1/3 gene. Yeshiva University.
5. GEENEN DL, MALHORTA A, LIANG D, SCHEUER J. 1991. Ventricular function and contractile proteins in the infarcted rat heart exposed to chronic pressure overload. Cardiovascular Research 25: 330-336.
6. GEISTERFER-LOWRANCE AAT, CHRISTE M, CONNER DA, INGWALL JS, SCHOEN FJ, SEIDMAN CE, SEIDMAN JG. 1996. A mouse model of familial hypertrophic cardiomyopathy. Science 272: 731-734.
7. 2+ in intact and skinned trabeculae from control and myopathic human hearts. J Clin Invest 82: 1578-1584.
8. HAMMELL RL, HITCHCOCK-DECREGORI SE. 1996. Mapping the functional domains within the carboxyl terminus of α-tropomyosin encoded by the alternatively spliced ninth exon. J Biol Chem 271: 4236-4242.
9. HILL TL, EISENBERG E, GREENE LE. 1980. Theoretical model for the cooperative equilibrium binding of myosin subfragment 1 to actin-troponin-tropomyosin. Proc Natl Acad Sci 77: 3186-3190.
10. HUNKELER NM, KULLMAN J, MURPHY AM. 1991. Troponin I isoform expressing in human heart. Circ Res 69: 1409-1414.
11. HUXLEY HE. 1972. Structural changes in the actin- and myosin-containing filaments during contraction. Cold Spring Harbor Symp Quant Biol 37: 361-376.
12. KOSS K, PONNIAH S, JONES K, GRUPP I, KRANIAS EG. 1995. Differential phospholamban gene expression in murine cardiac compartments. Molecular and physiological analyses. Circ Res 77: 342-353.
13. KUMAR A, CRAWFORD K, CLOSE L, MADISON M, ABBAS Z, LORENZ J, DOETSCHMAN T, PAWLAWSKI S, DUFFY J, NEUMANN J, ROBBINS J, BOIVIN G, O'TOOLE B, LESSARD J. 1997. Rescue of cardiac actin deficient mice by enteric actin. Proc Natl Acad Sci USA 94: 4406-4411.
14. LAING NG, WILTON SD, AKKARI PA, DOROSZ S, BOUNDY K, KNEEBONE C, BLUMBERGS P, WHITE S, WATKINS H, LOVE DR, HAAN E. 1995. A mutation in the α-tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. Nature Genetics 9: 75-79.
15. 2+ or myosin heads? J Muscle Res Cell Moltil 15: 232-236.
16. LEMANSK L. 1973. Morphology of developing heart in cardiac lethal mutant Mexican axolotls, Ambystoma Mexicanum. Dev Biol 33: 312-333.
17. MALHOTRA A. 1990. Regulatory proteins in hamster cardiomyopathy. Circ Res 66: 1302-1309.
18. MALHOTRA A, SIRI FM, ARONSON R. 1992. Cardiac contractile proteins in hypertrophied and failing guinea pig heart. Cardiovascular Research 26: 153-161.
19. MCKILLOP DF, GEEVES MA. 1993. Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of thinfilament. Biophys J 65: 693-701.
20. 2-adrenergic receptor. Science 264: 582-586.
21. MUTHUCHAMY M, PAJAK L, HOWLES P, DOETSCHMAN T, WIECZOREK D. 1993. Developmental analysis of TM gene expression in embryonic stem cells and mouse embryos. Mol Cell Biol 13: 3311-3323.
22. MUTHUCHAMY M, GRUPP I, GRUPP G, O'TOOLE B, KIER A, BOIVIN G, NEUMANN J, WIECZOREK D. 1995. Molecular and physiological effects of overexpressing striated muscle β-TM in the adult murine heart. J Biol Chem 270: 30593-30603.
23. NG WA, GRUPP IL, SUBRAMANIAM A, ROBBINS J. 1991. Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart. Circ Res 68: 1742-1750.
24. PALERMO J, GULICK J, COLBERT M, FEWELL J, ROBBINS J. 1996. Transgenic remodeling of the contractile apparatus in the mammalian heart. Circ Res 78: 504-509.
25. 2+, strong cross-bridge binding, and protein phosphorylation. J Biol Chem 271: 11611-11614.
26. PARKER TG, SCHNEIDER MD. 1991. Growth factors, proto-oncogenes, and plasticity of the cardiac phenotype. Annu Rev Physiol 53: 179-200.
27. RETHINASAMY P, MUTHUCHAMY M, BOIVIN G, WIECZOREK D. 1998. Development and rescue of murine cardiomyopathy in a controlled transgenic system. Mol Biol Cardiovasc System, Keystone Symposium 62: 342 a.
28. RETHINASAMY P, MUTHUCHAMY M, HEWETT T, BOIVIN G, WOLSKA B, EVANS C, SOLARO RJ, WIECZOREK D. 1998. Molecular and physiological effects of α-tropomyosin ablation in the mouse. Circ Res 82: 116-123.
29. SHARP S, KOST T, HUGHES S, DAVIDSON N. 1989. Regulation of chicken α and β actin genes and their hybrids inserted into myogenic mouse cells. Gene 80: 293-304.
30. SMILLIE L. 1996. Tropomyosin. In Barany M, ed. Biochemistry of Smooth Muscle Contraction, San Diego, Academic Press, pp. 63-75.
31. SOLARO RJ, VAN EYK J. 1996. Altered interactions among thin filament proteins modulate cardiac function. J Mol Cell Cardiol 28: 217-230.
32. SPIRITO P, SEIDMAN C, MCKENNA W, MARON B. 1997. The management of hypertrophic cardiomyopathy. New Engl J Med 336: 775-785.
33. SUBRAMANIAM A, JONES K, GULICK J, WERT S, NEUMANN J, ROBBINS J. 1991. Tissue-specific regulation of the α-myosin heavy chain gene promoter in transgenic mice. J Biol Chem 266: 24613-24620.
34. TANSEY T, MIKEY MD, DUMOULIN M, STORTI RV. 1987. Transformation and rescue of a flightless Drosophila tropomyosin mutant. EMBO J 6: 1375-1385.
35. THIERFELDER L, WATKINS H, MACRAE C, LAMAS R, MCKENNA W, VOSBERG HP, SEIDMAN CE, SEIDMAN JG. 1994. α-tropomyosin and cardiac troponin T mutations cause familial hypertrophic cardiomyopathy: A disease of the sarcomere. Cell 77: 701-712.
36. WESTFALL MV, SOLARO RJ. 1992. Alterations in myofibrillar functions and protein profiles following global ischemia in rat hearts. Circ Res 70: 302-313.