Skin solubility determines maximum transepidermal flux for similar size molecules

Pharmaceutical Research

Volumn 26, Issue 8, 2009, Pages 1974-1985

  Zhang, Qian ^a,d   Grice, Jeffrey E ^a   Li, Peng ^a   Jepps, Owen G ^c   Wang, Guang Ji ^b   Roberts, Michael S ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c GRIFFITH UNIVERSITY   (Australia)

^d UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

Maximum flux; Structure penetration relationships; Transdermal permeation

Indexed keywords

2 NAPHTHOL; 4 N BUTYLPHENOL; 4 PROPOXYPHENOL; CHLOROCRESOL; CHLOROXYLENOL; ISO THYMOL; METHYL PARABEN; OCTANOL; PHENOL DERIVATIVE; SALICYLIC ACID METHYL ESTER; TERT BUTYLPHENOL; THYMOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; DRUG SOLUBILITY; DRUG STRUCTURE; EPIDERMIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR WEIGHT; MOLECULE; NORMAL HUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SKIN; SKIN PERMEABILITY; STRATUM CORNEUM;

HUMANS; PERMEABILITY; PHARMACOKINETICS; SKIN; SKIN ABSORPTION; SOLUBILITY;

EID: 67650021919     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9912-4     Document Type: Article

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