Physico-chemical determinants of dermal drug delivery: Effects of the number and substitution pattern of polar groups

European Journal of Pharmaceutical Sciences

Volumn 16, Issue 3, 2002, Pages 107-112

  Du Plessis, Jeanetta ^a   Pugh, W John ^b   Judefeind, Anja ^b   Hadgraft, Jonathan ^b,c  

^a NORTH WEST UNIVERSITY   (South Africa)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF GREENWICH   (United Kingdom)

Author keywords

Dipolar bonding; Hydrogen bonding; Phenols; Skin permeability; Solubility parameters

Indexed keywords

DIFFUSION; HYDROGEN BONDS; MECHANICAL PERMEABILITY; PHENOLS; SUBSTITUTION REACTIONS;

COMBINED SOLUBILITY PARAMETERS; DERMAL DRUG DELIVERY;

DRUG PRODUCTS;

1,2,4 BENZENETRIOL; HYDROXIDE; OCTANOL; PHENOL DERIVATIVE; PHLOROGLUCINOL; WATER; HYDROXIDE ION;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG SOLUBILITY; HUMAN; HUMAN TISSUE; HYDROGEN BOND; PARAMETER; PARTITION COEFFICIENT; PRIORITY JOURNAL; SKIN PERMEABILITY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; EPIDERMIS; FEMALE; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; PERMEABILITY; PHYSICAL CHEMISTRY;

ADMINISTRATION, CUTANEOUS; CHEMISTRY, PHYSICAL; EPIDERMIS; FEMALE; HUMAN; HYDROGEN BONDING; HYDROXIDES; MOLECULAR STRUCTURE; PERMEABILITY; PHENOLS; SUPPORT, NON-U.S. GOV'T; HUMANS;

EID: 0035997050     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00085-4     Document Type: Article

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