Design, synthesis, and investigation of protein kinase C inhibitors: Total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones

Journal of the American Chemical Society

Volumn 131, Issue 26, 2009, Pages 9413-9425

  Morgan, Barbara J ^a   Dey, Sangeeta ^a   Johnson, Steven W ^a   Kozlowski, Marisa C ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELL LINES; CERCOSPORIN; CUPRATE; ENANTIOSELECTIVE; FLEXIBLE STRATEGIES; NATURAL PRODUCTS; PHLEICHROME; PROTEIN KINASE C INHIBITORS; SELECTIVE SYNTHESIS; STRUCTURAL FEATURE; TOTAL SYNTHESIS;

CELL CULTURE; COPPER COMPOUNDS; STEREOCHEMISTRY;

SYNTHESIS (CHEMICAL);

ANTINEOPLASTIC AGENT; CALPHOSTIN D; CERCOSPORIN; ELSINOCHROME; HYPOCRELLIN A; PERYLENEQUINONE DERIVATIVE; PHLEICHROME; PROTEIN KINASE C INHIBITOR; SCUTIAQUINONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HUMAN; HUMAN CELL; STEREOISOMERISM; SUZUKI REACTION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NAPHTHALENES; PERYLENE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; QUINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649989349     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja902324j     Document Type: Article

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