Activated calphostin C cytotoxicity is independent of p53 status and in vivo metastatic potential

Clinical Cancer Research

Volumn 4, Issue 10, 1998, Pages 2391-2398

  Dubauskas, Zita ^a   Beck, Traci P ^a   Chmura, Steven J ^a   Kovar, David A ^a   Kadkhodaian, Mithra M ^a   Shrivastav, Maneesh ^a   Chung, Theodore ^a,b   Stadler, Walter M ^b   Rinker Schaeffer, Carrie W ^a,b,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b University of Chicago   (United States)

^c Section of Urology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALPHOSTIN C; PHOTOSENSITIZING AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; MALE; METASTASIS; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROSTATE CANCER; TUMOR SUPPRESSOR GENE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BIOTRANSFORMATION; HUMANS; LIGHT; MALE; NAPHTHALENES; NEOPLASM METASTASIS; RATS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031754283     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995.
2. Weil, M., Jacobson, M. D., Coles, H. S. R., Davies, T. J., Gardner, R. L., Raff, K. D., and Raff, M. C. Constitutive expression of the machinery for programmed cell death. J. Cell Biol., 133: 1053-1059, 1996.
3. Grant, S., and Jarvis, W. D. Modulation of drug-induced apoptosis by interruption of protein kinase C signal transduction pathway: a new therapeutic strategy. Clin. Cancer Res., 2: 1915-1920, 1996.
4. Lowe, S. W. Cancer therapy and p53. Curr. Opin. Oncol., 7: 547-553, 1995.
5. McConkey, D. J., Greene, G., and Pettaway, C. A. Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line. Cancer Res., 56: 5594-5599, 1996.
6. Fidler, I. J., and Kozlowski, J. M. The heterogeneous nature of metastatic neoplasms: implications for the treatment of cancer. Urology, 23: 29-38, 1984.
7. Kobayashi, E., Nakano, H., Morimoto, M., and Tamaoki, T. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem. Biophys. Res. Commun., 159: 548-553, 1989.
8. Weller, M., Trepel, M., Grimmel, C., Schabet, M., Bremen, D., Krajewski, S., and Reed, J. C. Hypericin-induced apoptosis of human malianant glioma cells is light-dependent, independent of bcl-2 expression, does not require wild-type p53. Neurol. Res., 19: 459-470, 1997.
9. Bruns, R. F., Miller, F. D., Merriman, R. L., Howbert, J. J., Heath, W. F., Kobayashi, E., Takahashi, I., Tamaoki, T., and Nakano, H. Inhibition of protein kinase C by calphostin C is light-dependent. Biochem Biophys Res Commun., 176: 288-93, 1991.
10. Jarvis, W. D., Turner, A. J., Povirk, L. F., Traylor, R. S., and Grant, S. Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res., 54: 1707-1714, 1994.
11. Pollack, I. F., and Kawecki, S. The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J. Neurooncol., 31: 255-266, 1997.
12. Diwu, Z., and Lown, W. J. Photosensitization with anticancer agents. 19. EPR studies of photodynamic action of calphostin C: formation of semiquinone radical and activated oxygen on illumination with visible light. Free Radical Biol. Med., 16: 645-652, 1994.
13. Kobayashi, E., Ando, K., Nakano, H., Iida, T., Ohno, H., Morimoto, M., and Tamaoki, T. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J. Antibiot., 42: 1470-1474, 1989.
14. Diwu, Z. J., and Lown, J. W. The photodynamic potential of alternative photosensitizers to porphyrins. Pharmacol. Ther., 63: 1-35, 1994.
15. Furuya, Y., Lundmo, P., Short, A. D., Gill, D. L., and Isaacs, J. T. The role of calcium, Ph, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin. Cancer Res., 54: 6167-6175, 1994.
16. Isaacs, W. B., Carter, B. S., and Ewing, C. M. Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles. Cancer Res., 51: 4716-4720, 1991.
17. Bookstein, R., Shew, J. Y., Chen, P. L., Scully, P., and Lee, W. H. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science (Washington DC), 247: 712-715, 1990.
18. Carroll, A. G., Voeller, H. J., Sugars, L., and Gelmann, E. P. p53 oncogene mutations in three human prostate cancer cell lines. Prostate, 23: 123-134, 1993.
19. Isaacs, J. T., Isaacs, W. B., Feitz, W. F., and Scheres, J. Establishment and characterization of seven Dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers. Prostate, 9: 261-281, 1986.
20. Isaacs, J. T., Yu, G. W., and Coffey, D. S. The characterization of a newly identified, highly metastatic variety of Dunning R 3327 rat prostatic adenocarcinoma system: the MAT LyLu tumor. Invest. Urol., 19: 20-23, 1981.
21. Ichikawa, T., Ichikawa, Y., Dong, J., Hawkins, A. L., Griffin, C. A., Isaacs, W. B., Oshimura, M., Barrett, J. C., and Isaacs, J. T. Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11. Cancer Res., 52: 3486-3490, 1992.
22. Kaighn, M. E., Narayan, K. S., Ohnuki, Y., Lechner, J. F., and Jones, L. W. Establishment and characterization of human prostatic carcinoma cell line (PC-3). Invest. Urol., 17: 16-23, 1979.
23. Iizumi, T., Yazaki, T., Kanoh, S., Kondon, I., and Koiso, K. Establishment of a new prostatic carcinoma cell line (TSU-Pr1). J. Urol., 137: 1304-1306, 1987.
24. Stone, K. R., Mickey, D. D., Wunderli, H., Mickey, G. H., and Paulson, D. F. Isolation of a human prostate carcinoma cell line (DU 145). Int. J. Cancer, 21: 274-281, 1978.
25. Gingrich, J. R., Tucker, J. A., Walther, P. J., Day, J. W., Poulton, S. H., and Webb, K. S. Establishment and characterization of anew prostatic carcinoma cell line (DuPro-1). J. Urol., 146: 915-919, 1991.
26. Gomer, C. J., Rucker, N., Ferrario, A., and Wong, S. Properties and applications of photodynamic therapy. Radiat. Res., 120: 1-18, 1989.
27. Espinosa, R. I., and LeBeau, M. M. Gene mapping by FISH. Methods Mol. Biol., 68: 53-76, 1997.
28. Mossman, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65: 55-63, 1983.
29. Perez, C. A., and Brady, L. W. Overview. In: C. A. Perez and L. W. Brady (eds.), Principles and Practice of Radiation Oncology, pp. 25-27. Philadelphia: J. B. Lippincott Co., 1992.
30. Diwu, Z., and Lown, J. W. Phototherapeutic potential of alternative photosensitizers to porphyrins. Pharmacol. Ther., 63: 1-35, 1994.
31. Diwu, Z., and Lown, J. W. Photosensitization with anticancer agents 15. Perylenequinoid pigments as potential photodynamic therapeutic agents: formation of semiquinone radicals and reactive oxygen species on illumination. J. Photochem. Photobiol. B Biol., 18: 131-143, 1993.
32. Gopalakrishna, R., Chen, Z. H., and Gundimeda, U. Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett., 314: 149-154, 1992.
33. Chmura, S. J., Mauceri, H. J., Advani, S., Heimann, R., Beckett, M. A., Nodzenski, E., Quintans, J., Kufe, D. W., and Weichselbaum, R. R. Decreasing the apoptotic threshold of tumor cells through protein kinase C inhibition and sphineomyelinase activation increases tumor killing by ionizing radiation. Cancer Res., 57: 4340-4347, 1997.
34. Haimovitz-Friedman, A., Kan, C. C., Ehleiter, D., Persaud, R. S., McLoughlin, M., Fuks, Z., and Kolesnick, R. N. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med., 180: 525-535, 1994.
35. Jarvis, W. D., Povirk, L. F., Turner, A. J., Traylor, R. S., Gewirtz, D. A., Pettit, G. R., and Grant, S. Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-D-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells. Biochem. Pharmacol., 47: 839-852, 1994.
36. Gamou, S., and Shimizu, N. Light-dependent induction of early-response gene expression by calphostin-C. Cell Struct. Funct., 19: 195-200, 1994.
37. Ohta, H., Yatomi, Y., Sweeney, E. A., Hakomori, S., Igarashi, Y. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-α in human neutrophils. FEBS Lett., 355: 267-270, 1994.
38. Pushkareva, M., Chao, R., Bielawska, A., Merrill, A. H., Jr., Crane, H. M., Lagu, B., Liotta, D., and Hannun, Y. A. Stereoselectivity of induction of the retinoblastoma gene product (pRb) dephosphorylation by D-erythro-sphingosine supports a role for pRb in growth suppression by sphingosine. Biochemistry, 34: 1885-1892, 1995.
39. Jarvis, W. D., Fornari, F. A., Traylor, R. S., Martin, H. A., Kramer, L. B., Erukulla, R. K., Bittman, R., and Grant, S. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. J. Biol. Chem., 271: 8275-8284, 1996.
40. Chmura, S. J., Nodzenski, E., Weichselbaum, R. R., and Quintans, J. Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase. Cancer Res., 56: 2711-2714, 1996.