Photoexcited calphostin C selectively destroys nuclear lamin B1 in neoplastic human and rat cells - A novel mechanism of action of a photodynamic tumor therapy agent

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1783, Issue 9, 2008, Pages 1642-1653

  Chiarini, Anna ^a   Whitfield, James F ^b   Pacchiana, Raffaella ^a   Armato, Ubaldo ^a   Dal Pra, Ilaria ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Calphostin C; H cervical carcinoma C4 I cell; Lamin; Rat pyF111 fibroblast; Ubiquitin proteasome system

Indexed keywords

CALPHOSTIN C; CASPASE 3; CASPASE 6; CASPASE 8; CYCLIN E; EMERIN; LAMIN A; LAMIN B; LAMIN B1; LAMIN C; PROTEASOME; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; NAPHTHALENE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL KILLING; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; UTERINE CERVIX CARCINOMA; ANIMAL; CELL LINE; CELL NUCLEUS MEMBRANE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; NEOPLASM; OXIDATIVE STRESS; PATHOLOGY; PHOTOCHEMOTHERAPY; RADIATION EXPOSURE; TUMOR CELL LINE; UBIQUITINATION;

POLYOMAVIRUS; RATTUS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; HUMANS; IMMUNOHISTOCHEMISTRY; LAMIN TYPE B; NAPHTHALENES; NEOPLASMS; NUCLEAR ENVELOPE; OXIDATIVE STRESS; PHOTOCHEMOTHERAPY; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS; UBIQUITINATION;

EID: 49149107321     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.03.014     Document Type: Article

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