A synthetic peptide derived from glycine-gated Cl- channel induces transepithelial Cl- and fluid secretion

American Journal of Physiology - Cell Physiology

Volumn 272, Issue 5 41-5, 1997, Pages

  Wallace, Darren P ^a   Tomich, John M ^b   Iwamoto, Takeo ^b   Henderson, Kyle ^a   Grantham, Jared J ^a   Sullivan, Lawrence P ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

chloride channels; chloride transport; cystic fibrosis; epithelial monolayers; fluid transport; Mardin Darby canine kidney cells; synthetic channels

Indexed keywords

CHLORIDE CHANNEL; CHLORIDE CHANNEL BLOCKING AGENT; CHLORIDE ION; GLYCINE; GLYCINE RECEPTOR; SYNTHETIC PEPTIDE; WATER;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; CHANNEL GATING; CHLORIDE CURRENT; CONTROLLED STUDY; CYSTIC FIBROSIS; DOG; EPITHELIUM CELL; NONHUMAN; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; SECOND MESSENGER;

ANIMALIA; CANIS FAMILIARIS;

EID: 0031011840     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1997.272.5.c1672     Document Type: Article

References (27)

1. Chao, A. C., and H. Mochizuki. Niflumic and flufenamic acids are potent inhibitors of chloride secretion in mammalian airway. Life Sci. 51: 1453-1457, 1992.
2. El-Etri, M., and J. Cuppoletti. Metalloporphyrin chloride ionophores: induction of increased anion permeability in lung epithelial cells. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L386-L392, 1996.
3. Grantham, J. J., M. Uchic, E. J. Cragoe, Jr., J. Kornhaus, J. A. Grantham, V. Donoso, R. Mangoo-Karim, A. Evan, and J. McAteer. Chemical modification of cell proliferation and fluid secretion in renal cysts. Kidney Int. 35: 1379-1389, 1989.
4. Grantham, J. J., M. Ye, V. H. Gattone II, and L. P. Sullivan. In vitro fluid secretion by epithelium from polycystic kidneys. J. Clin. Invest. 95: 195-202, 1995.
5. Haas, M. The Na-K-Cl cotransporters. Am. J. Physiol. 267 (Cell Physiol. 36): C869-C885, 1994.
6. Haas, M., D. G. McBrayer, and J. R. Yankaskas. Dual mechanism for Na-K-Cl cotransport regulation in airway epithelial cells. Am. J. Physiol. 264 (Cell Physiol. 33): C189-C200, 1993.
7. Hucho, F., W. Oberthür, and F. Lottspeich. The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits. FEBS Lett. 205: 137-142, 1986.
8. Imoto, K., C. Methfessel, B. Sakmann, M. Mishina, Y. Mori, T. Konno, K. Fukuda, M. Kurasaki, H. Bujo, Y. Fujita, and S. Numa. Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel. Nature 324: 670-674, 1986.
9. Krishna, A., and P. F. Terranova. Relationships between LH stimulation in vitro and progesterone, androstenedione and cyclic AMP synthesis in preantral follicles of the cyclic hamster. J. Endocrinol. 114: 55-63, 1987.
10. Lang, F., and M. Paulmichl. Properties and regulation of ion channels in MDCK cells. Kidney Int. 48: 1200-1205, 1995.
11. Langosh, D., K. Hartung, E. Grell, E. Bamberg, and H. Betz. Ion channel formation by synthetic transmembrane segments of the inhibitory glycine receptor: a model study. Biochim. Biophys. Acta 1063: 36-44, 1991.
12. Liedtke, C. M. Regulation of chloride transport in epithelia. Annu. Rev. Physiol. 51: 143-160, 1989.
13. Lytle, C., and B. Forbush III. Na-K-Cl cotransport in the shark rectal gland. II. Regulation in isolated tubules. Am. J. Physiol. 262 (Cell Physiol. 31): C1009-C1017, 1992.
14. Mangoo-Karim, R., M. Ye, D. P. Wallace, J. J. Grantham, and L. P. Sullivan. Anion secretion drives fluid secretion by monolayers of cultured human polycystic cells. Am. J. Physiol. 269 (Renal Fluid Electrolyte Physiol. 38): F381-F388, 1995.
15. Neufeld, T. K., M. E. Grant, and J. J. Grantham. A method to measure the rate of net fluid secretion by monolayers of cultured renal epithelial cells. J. Tissue Cult. Methods 13: 229-234, 1991.
16. Pewitt, E. B., R. S. Hegde, M. Haas, and H. C. Palfrey. The regulation of Na/K/2Cl cotransport and bumetanide binding by protein phosphorylation and dephosphorylation. J. Biol. Chem. 265: 20747-20756, 1990.
17. Reddy, G. L., T. Iwamoto, J. M. Tomich, and M. Montal. Synthetic peptides and four-helix bundle proteins as model systems for the pore-forming structure of channel proteins. II. Transmembrane segment M2 of the brain glycine receptor is a plausible candidate for the pore-lining structure. J. Biol. Chem. 268: 14608-14615, 1993.
18. Reeves, W. B., and T. E. Andreoli. Renal epithelial chloride channels. Annu. Rev. Physiol. 54: 29-50, 1992.
19. - secretion. Exp. Physiol. 78: 117-137, 1993.
20. Sullivan, L. P., D. P. Wallace, and J. J. Grantham. Coupling of cell volume and membrane potential changes to fluid secretion in a model of renal cysts. Kidney Int. 45: 1369-1380, 1994.
21. Tomich, J. M., G. Radke, R. Brandt, and T. Iwamoto. Aqueous solubilization of transmembrane peptide sequences with retention of membrane binding and insertion (Abstract). Protein Sci. 5, Suppl. 1: 150, 1996.
22. Twyman, R. E., and R. L. MacDonald. Kinetic properties of the glycine receptor main- and sub-conductance states of mouse spinal cord neurones in culture. J. Physiol. (Lond.) 435: 303-331, 1991.
23. Wallace, D., K. Henderson, J. Tomich, T. Iwamoto, J. Grantham, and L. Sullivan. Modification of a synthetic chloride channel-forming peptide, M2GlyR, to improve solubility and effectiveness (Abstract). J. Am. Soc. Nephrol. 7: 1294, 1996.
24. Wallace, D. P., J. J. Grantham, and L. P. Sullivan. Chloride and fluid secretion by cultured human polycystic kidney cells. Kidney Int. 50: 1327-1336, 1996.
25. Wallace, D. P., J. M. Tomich, T. Iwamoto, J. J. Grantham, and L. P. Sullivan. A synthetic chloride channel-forming peptide, M2GlyR, induces chloride and fluid secretion by cultured epithelial cells (Abstract). FASEB J. 10: A73, 1996.
26. - channel blockers in the thick ascending limb of the loop of Henle: structure activity relationship. Pflügers Arch. 407, Suppl. 2: S128-S141, 1986.
27. Welsh, M. J. Electrolyte transport by airway epithelia. Physiol. Rev. 67: 1143-1184, 1987.