Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4196-4200

  Orvieto, Federica ^a   Branca, Danila ^a   Giomini, Claudia ^a   Jones, Philip ^a   Koch, Uwe ^a   Ontoria, Jesus M ^a   Palumbi, Maria Cecilia ^a   Rowley, Michael ^a   Toniatti, Carlo ^a   Muraglia, Ester ^a  

^a IRBM   (Italy)

Author keywords

PARP 1 inhibitor; Pyrazole

Indexed keywords

5 OXO 4,5 DIHYDROPYRAZOLO[1,5 A]QUINAZOLINE 2 CARBOXYLIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRAZOLO[1,5 A]QUINAZOLIN 5(4H) ONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

AMIDES; CHEMISTRY, ORGANIC; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MOLECULAR STRUCTURE; POLY(ADP-RIBOSE) POLYMERASES; PYRAZOLES; QUINAZOLINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649971777     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.113     Document Type: Article

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