Synthesis and evaluation of 1-(benzo[b]thiophen-2-yl)ethanone analogues as novel anti-osteoporosis agents acting on BMP-2 promotor

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4167-4170

  Liu, Zong ying ^a   He, Xiao bo ^a   Yang, Zhao yong ^a   Shao, Hua yi ^a   Li, Xue ^a   Guo, Hui fang ^a   Zhang, Yue qin ^a   Si, Shu yi ^a   Li, Zhuo rong ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

Anti osteoporosis; BMP 2 promotor; Synthesis

Indexed keywords

1 (BENZO[B]THIOPHEN 2 YL)ETHANONE DERIVATIVE; BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN 2; RALOXIFENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; MORPHOMETRICS; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MICE; MODELS, CHEMICAL; OSTEOPOROSIS; OVARIECTOMY; PROMOTER REGIONS, GENETIC; RATS; THIOPHENES;

RATTUS;

EID: 67649959386     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.118     Document Type: Article

References (24)

1. Rodan G.A., and Martin T.J. Science 289 (2000) 1508
2. Xiong Y., Zhao M., Wang C., Chang H.W., and Peng S. J. Med. Chem. 50 (2007) 3340
3. Xie Y., Ding H., Qian L., Yan X., and Yang C. Bioorg. Med. Chem. Lett. 15 (2005) 3267
4. Woo J.T., Yonezawa T., Cha B.Y., Teruya T., and Nagai K. J. Pharmacol. Sci. 106 (2008) 547
5. Kuo P.L., Huang Y.T., Chang C.H., and Chang J.K. Biol. Pharm. Bull. 29 (2006) 119
6. Rubin M.R., and Bilezikian J.P. Endocrinol. Metab. Clin. North Am. 32 (2003) 285
7. Soper D.L., Milbank J.B., Mieling G.E., Dirr M.J., Kende A.S., Cooper R., Jee W.S., Yao W., Chen J.L., Bodman M., Lundy M.W., De B., Stella M.E., Ebetino F.H., Wang Y., de Long M.A., and Wos J.A. J. Med. Chem. 44 (2001) 4157
8. Tang C.H., Yang R.S., Chien M.Y., Chen C.C., and Fu W.M. Eur. J. Pharmacol. 579 (2008) 40
9. Wu J.B., Fong Y.C., Tsai H.Y., Chen Y.F., Tsuzuki M., and Tang C.H. Eur. J. Pharmacol. 588 (2008) 333
10. Zhou S., Turgeman G., Harris S.E., Leitman D.C., Komm B.S., Bodine P.V., and Gazit D. Mol. Endocrinol. 17 (2003) 56
11. Jones A.L., Bucholz R.W., Bosse M.J., Mirza S.K., Lyon T.R., Webb L.X., Pollak A.N., Golden J.D., and Valentin-Opran A. J. Bone Joint Surg. Am. 88 (2006) 1431
12. Alt V., and Heissel A. Curr. Med. Res. Opin. 22 (2006) S19
13. Swiontkowski M.F., Aro H.T., Donell S., Esterhai J.L., Goulet J., Jones A., Kregor P.J., Nordsletten L., Paiement G., and Patel A. J. Bone Joint Surg. Am. 88 (2006) 1258
14. Mundy G., Garrett R., Harris S., Chan J., Chen D., Rossini G., Boyce B., Zhao M., and Gutierrez G. Science 286 (1999) 1946
15. Kagano, H.; Goda, H.; Yoshida, K.; Nakano, M. EP Patent 0572,712, 1993
16. Gallagher T., Pardoe D.A., and Porter R.A. Tetrahedron Lett. 41 (2000) 5415
17. Yazawa, N.; Saito, Y.; Hiyoshi, H. U.S. Patent 5266,705, 1993.
18. Chen S., Guttridge D.C., Tang E., Shi S., Guan K., and Wang C.Y. J. Biol. Chem. 276 (2001) 39259
19. Vaes B.L., Dechering K.J., Feijen A., Hendriks J.M., Lefevre C., Mummery C.L., Olijve W., van Zoelen E.J., and Steegenga W.T. J. Bone Miner. Res. 17 (2002) 2106
20. Liu Z., Shi W., Ji X., Sun C., Jee W.S., Wu Y., Mao Z., Nagy T.R., Li Q., and Cao X. J. Biol. Chem. 279 (2004) 11313
21. Evans G., Bryant H.U., Magee D., Sato M., and Turner R.T. Endocrinology 134 (1994) 2283
22. Evans G.L., Bryant H.U., Magee D.E., and Turner R.T. Endocrinology 137 (1996) 4139
23. Zhao Y., Zou B., Shi Z., Wu Q., and Chen G.Q. Biomaterials 28 (2007) 3063
24. Kimmel D.B., and Jee W.S. Calcified Tissue Int. 32 (1980) 113