Trovafloxacin enhances the inflammatory response to a gram-negative or a gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 330, Issue 1, 2009, Pages 72-78

  Shaw, Patrick J ^a   Ganey, Patricia E ^a   Roth, Robert A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; CHEMOKINE; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOTEICHOIC ACID; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; PEPTIDOGLYCAN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TROVAFLOXACIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HISTOPATHOLOGY; IMMUNE RESPONSE; LIVER FUNCTION; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; FLUOROQUINOLONES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEPATITIS, TOXIC; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NAPHTHYRIDINES; NEUTROPHILS;

EID: 67649881064     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.151068     Document Type: Article

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