A 5th type of hypersensitivity reaction: Does incidental recruitment of autoreactive effector memory T-cells in response to minute amounts of PAMPs or DAMPs, underlie inflammatory episodes in the seronegative arthropathies and acute anterior uveitis?

Medical Hypotheses

Volumn 73, Issue 3, 2009, Pages 284-291

  Gray, P E A ^a  

^a SYDNEY CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DAMAGE ASSOCIATED MOLECULAR PATTERN MOLECULE; HLA B27 ANTIGEN; PATHOGEN ASSOCIATED MOLECULAR PATTERN MOLECULE; PATTERN RECOGNITION RECEPTOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANKYLOSING SPONDYLITIS; ANTIGEN PRESENTATION; ARTHROPATHY; ARTICLE; AUTOIMMUNE DISEASE; ENTERITIS; HUMAN; HYPERSENSITIVITY REACTION; INFECTION; INFLAMMATION; INNATE IMMUNITY; INTESTINE LIPODYSTROPHY; IRIDOCYCLITIS; MEMORY T LYMPHOCYTE; MOLECULAR MIMICRY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSORIATIC ARTHRITIS; REACTIVE ARTHRITIS; T LYMPHOCYTE ACTIVATION;

ACUTE DISEASE; ANIMALS; DISORDERS OF EXCESSIVE SOMNOLENCE; HUMANS; JOINT DISEASES; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES; UVEITIS;

EID: 67649866386     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2009.03.040     Document Type: Article

References (83)

1. Chang J.H., McCluskey P.J., and Wakefield D. Acute anterior uveitis and HLA B27. Surveys Ophthalmol 50 4 (2005) 364-388
2. Monnet D., Breban M., Hudry C., et al. Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis. Ophthalmology 111 (2004) 802-809
3. Tay-Kearney M.L., Schwam B.L., Lowder C., et al. Clinical features and associated systemic diseases of HLA B27 uveitis. Am J Ophthalmol 121 (1996) 47-56
4. Gran J.T., and Husby G. Ankylosing spondylitis. In: Klippel J.H., and Dieppe P.A. (Eds). Prevalence and demography in rheumatology. 2nd ed. (1998), Mosby Int'l Press
5. Dobbins W.O. HLA antigens in Whipple's disease. Arthritis Rheum 30 1 (1986) 102-105
6. Pacheco-Tena C., Zhang X., Stone M., et al. Innate immunity in host-microbial interactions: beyond B27 in the spondyloarthropathies. Curr Opin Rheum 14 (2002) 373-382
7. Dobbins W.O. The diagnosis of Whipple's disease. New Engl J Med 332 (1995) 390-392
8. Rashid T., and Ebringer A. Ankylosing spondylitis is linked to Klebsiella - the evidence. Clin Rheumatol 26 6 (2007) 858-864
9. Huhtinen M., Laasila K., Granfors K., et al. Infectious background of patients with a history of acute anterior uveitis. Ann Rheum Dis 61 (2002) 1012-1016
10. Leirisalo-Repo M., Turunen V., Stenman S., et al. High frequency of silent inflammatory bowel disease in spondyloarthropathy. Arthritis Rheum 37 (1994) 23-35
11. Banares A.A., Jover J.A., Fernandez-Gutierrez B., et al. Bowel inflammation in anterior uveitis and spondyloarthropathies. J Rheumatol 22 (1995) 1112-1117
12. Jun J.B., Kim T.H., Jung S.S., et al. Seronegative spondyloarthropathy initiated by physical trauma. Clin Rheumatol 19 (2000) 348-351
13. Pattison EJ, Harrison BJ, Griffiths CEM, et al. Environmental risk factors for the development of psoriatic arthritis: results from a case control study. Ann Rheum Dis 2007; 19 Nov 2007 - online publication.
14. Bollow M., Fischer T., Reisshauer H., et al. Quantitative analyses of sacroiliac biopsies in spondyloarthropathies: T-cells and macrophages predominate in early and active sacroiliitis-cellularity correlates with the degree of enhancement detected by magnetic resonance imaging. Ann Rheum Dis 59 (2000) 135-140
15. Fiorillo M.T., Marango M., Butler R., et al. CD8+ T-cell autoreactivity to an HLA B27-restricted self-epitope correlates with ankylosing spondylitis. J Clin Invest 106 (2000) 47-53
16. Baeten D., Demetter P., Cuvelier C., et al. Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity. Ann Rheum Dis 59 (2000) 945-953
17. Hoentjen F., Tonkonogy S.L., Liu B., et al. Adoptive transfer of nontransgenic mesenteric lymph node cells induces colitis in athymic HLA-B27 transgenic nude rats. Clin Exp Immunol 143 3 (2006) 474-483
18. Breban M., Fernandez-Sueiro J.L., Richardson J.A., et al. T-cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J Immunol 156 (1996) 794-803
19. Smith J.A., Marker-Hermann E., and Colbert R.A. Pathogenesis of ankylosing spondylitis: current concepts. Best Pract Res Clin Rheumatol 20 3 (2006) 571-591
20. Gerard H.C., Branigan P.J., Schumacher Jr. H.R., et al. Synovial Chlamydia trachomatis in patients with reactive arthritis/Reiters syndrome are viable but show aberrant gene expression. J Rheumatol 25 (1998) 734-742
21. Taylor-Robinson D., Gilroy C.B., Thomas B.J., et al. Detection of Chlamydia trachomatis DNA in joints of reactive arthritis patients by polymerase chain reaction. Lancet 340 (1992) 81-82
22. Lo W.F., Woods A.S., DeCloux A., et al. Molecular mimicry mediated by MHC class Ib molecules after infection with gram-negative pathogens. Nature Med 6 2 (2000) 215-218
23. Allen R.L., O'Callaghan C.A., McMichael A.J., and Bowness P. Cutting edge: HLA B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure. J Immunol 162 (1999) 5045-5048
24. Medzhitov R., and Janeway Jr. C.A. Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 91 1 (1997) 4-9
25. Iwasaki A., and Medzhitov R. Toll-like receptor control of the adaptive immune response. Nature Immunol 5 10 (2004) 987-995
26. Foell D., Wittkowski H., and Roth J. Mechanisms of disease: a 'DAMP' view of inflammatory arthritis. Nat Clin Pract Rheumatol 3 7 (2007) 382-390
27. Foell D., Wittkowski H., Vogl T., and Roth J. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukocyte Biol 81 1 (2007) 28-37
28. Bianchi M.E. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukocyte Biol 81 1 (2007) 1-5
29. Rubartelli A., and Lotze M.T. Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox. Trends Immunol 28 10 (2007) 429-436
30. Osterloh A, Breloer M. Heat shock proteins: linking danger and pathogen recognition. Med Microbiol Immunol 2008;197(1):1-8.
31. Termeer C., Benedix F., Sleeman J., et al. Oligosaccharides of hyaluronan activates dendritic cells via toll-like receptor 4. J Exp Med 195 1 (2002) 99-111
32. Ohashi K., Burkart V., Flohe S., and Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164 (2000) 558-561
33. Sallusto F. Central memory and effector memory T-cell subsets: function, generation and maintenance. Annu Rev Immunol 22 (2004) 745-763
34. Geginat J., Lanzavecchia A., and Sallusto F. Blood 101 (2003) 4260-4266
35. Bradley L.M. Migration and T-lymphocyte effector function. Curr Opin Immunol 15 (2003) 343-348
36. Rickman L.S., Freeman W.R., Green W.R., et al. Uveitis caused by Tropheryma whippelii (Whipple's bacillus). N Engl J Med 332 (1995) 363-366
37. Vaile J.H., Meddings, Yacyshyn B.R., et al. Bowel permeability and CD45RO expression on circulating CD20+ B cells in patients with ankylosing spondylitis and their relatives. J Rheumatol 26 1 (1999) 128-135
38. Wakefield D., McCluskey P., Verma M., et al. Ciprofloxacin treatment does not influence the course or relapse rate of reactive arthritis and anterior uveitis. Arthritis Rheum 42 9 (1999) 1894-1897
39. Saarinen M., Ekman P., Ikeda M., et al. Invasion of Salmonella into human intestinal epithelial cells is modulated by HLA B27. Rheumatology 41 (2002) 651-657
40. Appel H., Kuon W., Kuhne M., et al. Use of HLA B27 tetramers to identify low-frequency antigen-specific T-cells in Chlamydia-triggered reactive arthritis. Arthritis Res Ther 6 6 (2004) R521-R534
41. Chen J., Fujino Y., and Takahashi T. Jpn J Ophthalmol 43 5 (1999) 368-374
42. Deng G., and Tarkowski A. The features of arthritis induced by CpG motifs in bacterial DNA. Arthritis Rehum 43 2 (2000) 356-364
43. Merino G., Fulino Y., and Hanashiro R.K. Lipotechoic acid as an inducer of acute uveitis in the rat. Invest Ophthalmol Vis Sci 39 7 (1998) 1251-1256
44. Rosenbaum J.T., Hendricks P.A., Shively J.E., and McDougall I.R. Distribution of radiolabeled endotoxin with particular reference to the eye: concise communication. J Nucl Med 24 1 (1983) 29-33
45. Howes E.L., Wong K.L., Hartiala K.T., et al. Complement and polymorphonuclear leukocytes do not determine the vascular permeability induced by intraocular LPS. Am J Pathol 118 (1985) 35-42
46. Lang K.S., Reacher M., Junt T., et al. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nature Med 11 2 (2005) 138-145
47. Yoshino S., and Ohsawa M. The role of lipopolysaccharide injected systemically in the reactivation of collagen-induced arthritis in mice. Brit J Pharmacol 129 (2000) 1309-1314
48. Chan C.C., Hikita N., Dastgheib K., et al. Experimental melanin-protein-induced uveitis in the Lewis rat: immunopathologic processes. Ophthalmology 101 (1994) 1275-1280
49. Nogai A., Siffrin V., Bonhagen K., et al. Lipopolysaccharide injection induces relapses of experimental autoimmune encephalomyelitis in nontransgenic mice via bystander activation of autoreactive CD4 cells. J Immunol 175 (2005) 959-966
50. Yoshino S., Sasatomi E., Mori Y., and Sagai M. Oral administration of lipopolysaccharide exacerbates collagen-induced arthritis in mice. J Immunol 163 (1999) 3417-3422
51. Gastpar R., Gross C., Rossbacher L., et al. The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells. J Immunol 172 2 (2004) 972-980
52. Taurog J.D., Richardson J.A., Croft J.T., et al. The germ-free state prevents the development of gut and joint inflammatory disease in HLA B27 transgenic rats. J Exp Med 180 (1994) 2359-2364
53. May E., Dorris M.L., Satumtira N., et al. CD8 T-cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats. J Immunol 170 (2003) 1099-1105
54. Schirmer M., Goldberger C., Wurzner, et al. Circulating cytotoxic CD8+ CD28- T-cells in ankylosing spondylitis. Arthritis Res 4 (2002) 71-76
55. Duftner C., Goldberger C., Falkenbach A., et al. Prevalence, clinical relevance, and characterisation of circulating cytotoxic CD4+ CD28- T-cells in ankylosing spondylitis. Arthritis Res Ther 5 5 (2003) 292-300
56. Costello P, Bresnihan B, O'Farrelly C, Fitzgerald O. Predominance of CD8+ T lymphocytes in psoriatic arthritis. J Rheumatol 1999;26(5):1117-24.
57. Taylor P.C., Plater-Zyberk C., and Maini R.N. The role of Bcells in the adoptive transfer of collagen-induced arthritis from DBA/1 (H-2q) to SCID (H-2d) mice. Eur J Immunol 25 (1995) 763-769
58. Wendling D., Radacot E., and Viel J.F. Soluble IL2 receptor in patients with ankylosing spondylitis. Arthritis Rheum 34 (1991) 1622-1623
59. Steiner G., Studnicka-Benke A., Witzmann G., et al. Soluble receptors for tumor necrosis factor and interleukin-2 in serum and synovial fluid of patients with rheumatoid arthritis, reactive arthritis and osteoarthritis. J Rheumatol 22 3 (1995) 406-412
60. Brandt J. Ankylosing spondylitis: new treatment modalities. Best Prac Res Clin Rheumatol 20 3 (2006) 559-570
61. Beacock-Sharp H., Young J.L., and Gaston J.S. Analysis of T-cell subsets present in the peripheral blood and synovial fluid of reactive arthritis patients. Ann Rheum Dis 57 (1998) 100-106
62. Durand D., Lecomte C., Cathebras P., et al. Whipple disease: clinical review of 52 cases. Medicine 76 3 (1997) 170
63. Bodaghi B., Dauga C., Cassoux N., et al. Whipple's syndrome (Uveitis, B27-negative spondyloarthropathy, meningitis and lymphadenopathy) associated with Arthrobacter sp. infection. Ophthalmology 105 (1998) 1891-1896
64. Clegg D.O., Reda D.J., and Abdellatif M. Comparison of sulfasalazine and placebo for the treatment of axial and peripheral articular manifestations of the seronegative spondylarthropathies: a Department of Veterans Affairs cooperative study. Arthritis Rheum 42 11 (1999) 2325-2329
65. Calin A. Is there an association between ankylosing spondylitis and multiple sclerosis. Ann Rheum Dis 48 12 (1989) 971-972
66. Niederwieser G., Bonelli R.M., Pongratz R., et al. Cerebral vasculitis associated with Reiter's syndrome. J Neurol 248 11 (2001) 988-989
67. Toris C.B., Gregerson D.S., and Pederson J.E. Uveoscleral outflow using different-sized fluorescent tracers in normal and inflamed eyes. Exp Eye Res 45 4 (1987) 525-532
68. Lebre MC, van der Aar AMG, van Baarsen L, et al. Human keratinocytes express functional toll-like receptor 3, 4, 5 and 9. J Invest Dermatol 2007;127(2):331-41.
69. Abreu M.T., Arnold E.T., Thomas L.S., et al. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem 277 (2002) 20431-20437
70. Bruce I.N., and Silman A.J. The aetiology of psoriatic arthritis. Rheumatology 40 (2001) 363-366
71. Nash P., and Clegg D.O. Psoriatic arthritis therapy: NSAIDs and traditional DMARDs. Ann Rheum Dis 64 Suppl 2 (2005) ii74-ii77
72. Helliwell P.S., Hetthen J., Sokoll K., et al. Joint symmetry in early and late rheumatoid arthritis and psoriatic arthritis: comparison and mathematical model. Arthritis Rheum 43 4 (2000) 865-871
73. Suhler E.B., Martin T., and Rosenbaum J.T. HLA-B27-associated uveitis: overview and perspectives. Curr Opin Ophthalmol 14 (2003) 378-383
74. Francois R.J., Gardner D.L., Degrave E.J., and Bywaters E.G. Histopathologic evidence that sacroiliitis in ankylosing spondylitis is not merely enthesitis. Arthritis Rheum 43 (2000) 2011-2024
75. De Rycke L., Vandooren B., Kruithof E., et al. Tumour necrosis factor alpha blockade treatment down-regulates the increased systemic and local expression of toll-like receptor 2 and toll-like receptor 4 in spondyloarthropathy. Arthritis Rheum 52 (2005) 2146-2158
76. Masopust D, Vezys V, Marzo AL, Lefrancois L. Preferential localisation of effector memory cells in nonlymphoid tissue. www.sciencexpress.org/1March2001/Page1/10.1126/science.1058867.
77. Hogan R.J., Usherwood E.J., Zhong W., et al. Activated antigen-specific CD8+ T-cells persist in the lungs following recovery from respiratory virus infections. J Immunol 166 (2001) 1813-1822
78. Ugrinovic S., Mertz A., Wu P., et al. A single monomer from the Yersinia 60 kDa heat shock protein is the target of HLA B27-restricted CTL response in Yersinai-induced reactive arthritis. J Immunol 159 (1997) 5715-5723
79. Schofield R.H., Kurien B., Gross T., et al. HLA B27 binding of peptide from its own sequence and similar peptides from bacteria: implications for spondyloarthropathies. Lancet 345 (1995) 1542-1544
80. Qian B.F., Tonkonogy S.L., and Balfour Sartor R. Luminal bacterial antigen-specific CD4+ T-cell responses in HLA B27 transgenic rats with chronic colitis are mediated by both major histocompatibility class II and HLA B27 molecules. Immunology 117 3 (2006) 319-328
81. Koivuranta-Varra P., Repo H., Leirsalo M., et al. Enhanced neutrophil migration in vivo HLA B27 positive subjects. Ann Rheum Dis 43 2 (1984) 181-185
82. Colbert R.A. HLA B27 misfolding: a solution to the spondyloarthropathy conundrum?. Mol Med Today 6 (2000) 224-230
83. Kollnberger S., Bird L.A., Sun M.Y., et al. Cell-surface expression and immune receptor recognition of HLA B27 homodimers. Arthritis Rheum 46 11 (2002) 2972-2982