The features of arthritis induced by CpG motifs in bacterial DNA

Arthritis and Rheumatism

Volumn 43, Issue 2, 2000, Pages 356-364

  Deng, Guo Min ^a   Tarkowski, Andrej ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; INTERLEUKIN 12; INTERLEUKIN 1BETA; RANTES; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; BACTERIAL ARTHRITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GENE EXPRESSION; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; METHYLATION; MOUSE; NONHUMAN; OLIGONUCLEOTIDE PROBE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; T LYMPHOCYTE;

ANIMALS; ARTHRITIS, INFECTIOUS; AUTOANTIBODIES; CHEMOKINES; CPG ISLANDS; DNA, BACTERIAL; DRUG SYNERGISM; IMMUNOGLOBULINS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN-6; JOINTS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034042678     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200002)43:2<356::AID-ANR15>3.0.CO;2-J     Document Type: Article

References (64)

1. Goldenberg DL. Septic arthritis. Lancet 1998;351:197-202.
2. Tarkowski A, Wagner H. Arthritis and sepsis caused by Staphylococcus aureus: can the tissue injury be reduced by modulating the host's immune system? Mol Med Today 1998;4:15-8.
3. Shimada S, Yano O, Inoue H, Kuramoto E, Fukuda T, Yamamoto H, et al. Antitumor activity of the DNA fraction from Mycobacterium bovis BCG. II. Effects on various syngeneic mouse tumors. J Natl Cancer Inst 1985;74:681-8.
4. Yamamoto S, Yamamoto T, Kataoka T, Kuramoto E, Yano O, Tokunaga T. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN (correction of IFN) and augment IFN-mediated (correction of IFN) natural killer activity. J Immunol 1992;148:4072-6.
5. Messina JP, Gilkeson GS, Pisetsky DS. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J Immunol 1991;147:1759-64.
6. Bird AP. CpG-rich islands and the function of DNA methylation. Nature 1986;321:209-13.
7. Sved J, Bird A. The expected equilibrium of the CpG dinucleotide in vertebrate genomes under a mutation model. Proc Natl Acad Sci U S A 1990;87:4692-6.
8. Krieg AM, Yi AK, Matson S, Waldschmidt TJ, Bishop GA, Teasdale R, et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995;374:546-9.
9. Pisetsky DS. Immune activation by bacterial DNA: a new genetic code. Immunity 1996;5:303-10.
10. Bennett RM, Gabor GT, Merritt MM. DNA binding to human leukocytes. J Clin Invest 1985;76:2182-90.
11. Zhao Q, Song X, Waldschmidt T, Fisher E, Krieg AM. Oligonucleotide uptake in human hematopoietic cells is increased in leukemia and is related to cellular activation. Blood 1996;88:1788-95.
12. Bremell T, Abdelnour A, Tarkowski A. Histopathological and serological progression of experimental Staphylococcus aureus arthritis. Infect Immun 1992;60:2976-85.
13. Sparwasser T, Miethke T, Lipford G, Borschert K, Hacker H, Heeg K, et al. Bacterial DNA causes septic shock. Nature 1997; 386:336-7.
14. Jonsson R, Tarkowski A, Klareskog LA. Demineralization procedure for immunohistopathological use. J Immunol Methods 1986; 88:109-14.
15. Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 1965;58:577-81.
16. Carlsten H, Tarkowski A, Jonsson R, Nilsson LÅ. Expression of heterozygous lpr gene in MRL mice. II. Acceleration of glomerulonephritis, sialadenitis and autoantibody production. Scand J Immunol 1990;32:21-8.
17. Helle M, Boeije L, Aarden LA. Functional discrimination between interleukin-6 and interleukin-1. Eur J Immunol 1988;18:1535-40.
18. Zhao Y-X, Ljungdahl Å, Olsson T, Tarkowski A. In situ hybridization analysis of synovial and systemic cytokine messenger RNA expression in superantigen-mediated Staphylococcus aureus arthritis. Arthritis Rheum 1996;39:959-67.
19. Rollins BJ, Morrison ED, Stiles CD. Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc Natl Acad Sci U S A 1988;85:3738-42.
20. Tekamp-Olson P, Gallegos C, Bauer D, McClain J, Sherry B, Fabre M, et al. Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. J Exp Med 1990;172:911-9.
21. Schall TJ, Simpson HJ, Mak JY. Molecular cloning and expression of the murine RANTES cytokine: structural and functional conservation between mouse and man. Eur J Immunol 1992;22:1477-81.
22. Stacey KJ, Sweet MJ, Hume DA. Macrophages ingest and are activated by bacterial DNA. J Immunol 1996;157:2116-22.
23. Sparwasser T, Miethke T, Lipford G, Borschert K, Hacker H, Heeg K, et al. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur J Immunol 1998;27:1671-9.
24. Klinman DM, Yi AK, Beaucage SL, Conover J, Krieg AM. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ. Proc Natl Acad Sci U S A 1996;93:2879-83.
25. Stein CA, Cheng YC. Antisense oligonucleotides as therapeutic agents: is the bullet really magical? Science 1993;261:1004-12.
26. Bird AP. CpG islands as gene markers in the vertebrate nucleus. Trends Genet 1987;3:342-7.
27. Wright SD, Ramos RA, Tobias PS, Vlevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990;249:1431-3.
28. Deng GM, Nilsson IM, Verdrengh M, Collins LV, Tarkowski A. Intraarticularly localized bacterial DNA containing CpG motifs induces arthritis. Nat Med 1999;5:702-5.
29. Zhao Q, Waldschmidt T, Fisher E, Herrera CJ, Krieg AM. Stage-specific oligonucleotide uptake in murine hone marrow B-cell precursors. Blood 1994;84:3660-6.
30. Gesclowitz DA, Neckers LM. Analysis of oligonucleotide binding, internalization, and intracellular trafficking utilizing a novel radio-labeled crosslinker. Antisense Res Dev 1992;2:17-26.
31. Häcker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T, et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 1998;17:6230-40.
32. Baeuerle PA, Henkel T. Function and activation of NF-κB in the immune system. Annu Rev Immunol 1994;12:141-79.
33. Hultgren O, Eugster HP, Sedgwick JD, Körner H, Tarkowski A. TNF/lymphotoxin-α double mutant mice resist septic arthritis but display increased mortality in response to Staphylococcus aureus. J Immunol 1998;161:5937-42.
34. Thomas BM, Mundy GR, Chambers JJ. Tumor necrosis factor α and β induce osteoblastic cells to stimulated osteoclast bone resorption. J Immunol 1987;138:775-9.
35. Joosten LAB, Lubberts E, Helsen MMA, van den Berg WB. Dual role of IL-12 in early and late stages of murine collagen type II arthritis. J Immunol 1997;159:4094-102.
36. Tracey K. Tumor necrosis factor-α. In: Handbook of cytokines. London: Academic Press; 1994. p. 34-65.
37. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood 1991;77:45-56.
38. Van Snick J. Interleukin-6: an overview. Annu Rev Immunol 1990;8:253-78.
39. Brouckaert P, Spriggs D, Demetri G, Kufe D, Fiers W. Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon γ. J Exp Med 1989;169:2257-62.
40. Libert C, Brouckaert P, Shaw A, Fiers W. Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice. Eur J Immunol 1990;20:691-4.
41. Feldmann M, Brennan F, Maini R. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 1996;14:397-440.
42. Miossec P. Cytokine abnormalities in inflammatory arthritis. Baillieres Clin Rheumatol 1992;6:373-92.
43. Dayer JM, Fenner H. The role of cytokines and their inhibitors in arthritis. Baillieres Clin Rheumatol 1992;6:485-516.
44. Pettipher ER, Higgs GA, Henderson B. Interleukin 1 induced leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint. Proc Natl Acad Sci U S A 1986;83:8749-53.
45. Henderson B, Pettipher ER. Arthritogenic actions of recombinant IL-1 and tumor necrosis factor α in the rabbit: evidence for synergistic interactions between cytokines in vivo. Clin Exp Immunol 1989;75:306-10.
46. Van den Berg WB, Joostens LAB, Helsen M, van de Loo FAJ. Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment. Clin Exp Immunol 1994;95:237-43.
47. Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci U S A 1992;89:9784-8.
48. Rollins BJ. Chemokines. Blood 1997;90:909-28.
49. Matsushima K, Larsen CG, Dubois GC, Oppenheim JJ. Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J Exp Med 1989;169:1485-90.
50. Allavena P, Bianchi G, Zhou D, van Damme J, Jilek P, Sozzani S, et al. Induction of natural killer cell migration by monocyte chemotactic protein-1, -2, and -3. Eur J Immunol 1994;24:3233-6.
51. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein-1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A 1994;91:3652-6.
52. Yla-Herttuala S, Lipton BA, Rosenfeld ME, Sarkioja T, Yoshimura T, Leonard EJ, et al. Expression of monocyte chemoattractant protein 1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc Natl Acad Sci U S A 1991;88:5252-6.
53. Koch AE, Kunkel SJ, Harlow LA, Johnson B, Evanoff HL, Haines GK, et al. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J Clin Invest 1992;90:772-9.
54. Ransohoff RM, Hamilton TA, Tani M, Stoler MH, Shick HE, Major JA, et al. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis. FASEB J 1993;7:592-600.
55. Fuentes ME, Durham SK, Swerdel MR, Lewin AC, Barton DS, Megill JR, et al. Controlled recruitment of monocytes/macrophages to specific organs through transgenic expression of MCP-1. J Immunol 1995;155:5769-76.
56. Lu B, Rutledge BJ, Gu L, Fiorillo J, Lukacs NW, Kunkel SL, et al. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 1998;187:601-8.
57. Schall TJ. Biology of the RANTES/SIS cytokine family. Cytokine 1991;3:165-83.
58. Schall TJ, Bacon K, Toy KJ, Goeddel DV. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990;347:669-71.
59. Ryan MJ, Kavanaugh R, Wall PG, Hazelman BL. Bacterial joint infections in England and Wales: analysis of bacterial isolates over a four year period. Br J Rheumatol 1997;36:370-3.
60. Cowdery JS, Chace JH, Yi AK, Kreig AM. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharide. J Immunol 1996;156:4570-5.
61. Ike RW. Tidal irrigation in septic arthritis of the knee: a potential alternative to surgical drainage. J Rheumatol 1993;20:2104-11.
62. Shirai T, Shimizu N, Horiguchi S, Ito H. Rat TNF alpha. Agric Biol Chem 1989;53:1733-6.
63. Schoenhaut DS, Chua AO, Wolitzky AG, Quinn PM, Dwyer CM, McComas W, et al. Cloning and expression of murine IL-12. J Immunol 1992;148:3433-40.
64. Dijkema R, van der Meide PH, Dubbeld M, Caspers M, Wubben J, Schellekens H. Cloning, expression and purification of rat IFN-γ. Methods Enzymol 1986;119:453-64.