Prevalence, clinical relevance and characterization of circulating cytotoxic CD4+CD28- T cells in ankylosing spondylitis

Arthritis Research and Therapy

Volumn 5, Issue 5, 2003, Pages

  Duftner, Christina ^a   Goldberger, Christian ^a   Falkenbach, Albrecht ^b   Würzner, Reinhard ^a   Falkensammer, Barbara ^a   Pfeiffer, Karl P ^a   Maerker Hermann, Elisabeth ^c   Schirmer, Michael ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b Gasteiner Heilstollen Hospital   (Austria)

^c HSK Aukammallee   (Germany)

Author keywords

ankylosing spondylitis; CD28 molecule; CD4+ T cells; cytotoxicity; HLA B27

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; HLA B27 ANTIGEN;

ANKYLOSING SPONDYLITIS; APOPTOSIS; ARTICLE; BIOSYNTHESIS; BLOOD; CELL CULTURE; CELL LINE; CHEMISTRY; CYTOTOXIC T LYMPHOCYTE; GENETIC TRANSFECTION; HUMAN; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; NATURAL KILLER CELL; PATHOLOGY; PHYSIOLOGY; PREVALENCE; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD28; ANTIGENS, CD4; APOPTOSIS; CELL LINE; CELLS, CULTURED; HLA-B27 ANTIGEN; HUMANS; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; MIDDLE AGED; PREVALENCE; SPONDYLITIS, ANKYLOSING; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 2342596557     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar793     Document Type: Article

References (42)

1. Khare SD, Luthra HS, David CS: Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies. J Exp Med. 1995, 182: 1153-1158. 10.1084/jem.182.4.1153. DOI: 10.1084/jem.182.4.1153
2. Scofield RH, Kurien B., Gross T, Warren WL, Harley JB: HLA-B27 binding of peptide from its own sequence and similar peptides from bacteria: implications for spondyloarthropathies. Lancet. 1995, 345: 1542-1544. 10.1016/S0140-6736(95)91089-1. DOI: 10.1016/S0140-6736(95)91089-1
3. Hermann E, Yu DT, Meyer zum Buschenfelde KH, Fleischer B: HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet. 1993, 342: 646-650. 10.1016/0140-6736(93)91760-J. DOI: 10.1016/0140-6736(93)91760-J
4. Ugrinovic S, Mertz A, Wu P, Braun J, Sieper J: A single nonamer from the Yersinia 60-kDA heat shock protein is the target of HLA-B27 restricted CTL response in Yersinia-induced reactive arthritis. J Immunol. 1997, 159: 5715-5723.
5. Schirmer M, Goldberger C, Wurzner R, Duftner C, Pfeiffer KP, Clausen J, Neumayr G, Falkenbach A: Circulating cytotoxic CD8+ CD28- T cells in ankylosing spondylitis. Arthritis Res. 2002, 4: 71-76. 10.1186/ar386. DOI: 10.1186/ar386
6. Boyle LH, Goodall JC, Opat SS, Gaston JS: The recognition of HLA-B27 by human CD4+ T lymphocytes. J Immunol. 2001, 167: 2619-2624. DOI: 10.4049/jimmunol.167.5.2619
7. Turner MJ, Colbert RA: HLA-B27 and pathogenesis of spondyloarthropathies. Curr Opin Rheumatol. 2002, 14: 367-372. 10.1097/00002281-200207000-00006. DOI: 10.1097/00002281-200207000-00006
8. Breban M, Hammer RE, Richardson JA, Taurog JD: Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J Exp Med. 1993, 178: 1607-1616. 10.1084/jem.178.5.1607. DOI: 10.1084/jem.178.5.1607
9. Breban M, Fernandez-Sueiro JL, Richardson JA, Hadavand RR, Maika SD, Hammer RE, Taurog JD: T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of HLA-B27 transgenic rats. J Immunol. 1996, 157: 794-803.
10. O'Sullivan FX, Vogelweid CM, Besch-Williford CL, Walker SE: Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. J Autoimmun. 1995, 8: 163-175. 10.1006/jaut.1995.0013. DOI: 10.1006/jaut.1995.0013
11. Khare SD, Bull MJ, Hanson J, Luthra HS, David CS: Spontaneous inflammatory disease in HLA-B27 transgenic mice is independent of MHC class II molecules: a direct role for B27 H chains and not B27-derived peptides. J Immunol. 1998, 160: 101-106.
12. Brand JM, Neustock P, Kruse A, Alvarez-Ossorio L, Schnabel A, Kirchner H: Stimulation of whole blood cultures in patients with ankylosing spondylitis by a mitogen derived from Mycoplasma arthritidis (MAS) and other mitogens. Rheumatol Int. 1997, 16: 207-211. 10.1007/BF01330297. DOI: 10.1007/BF01330297
13. Braun J, Bollow M, Neure L, Seipelt E, Seyrekbasan F, Herbst H, Eggens U, Distler A, Sieper J: Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis. Arthritis Rheum. 1995, 38: 499-505. DOI: 10.1002/art.1780380407
14. Hermann E, Fleischer B, Mayet WJ, Poralla T, Meyer zum Buschenfelde KH: Response of synovial fluid T cell clones to Yersinia enterocolitica antigens in patients with reactive Yersinia arthritis. Clin Exp Immunol. 1989, 75: 365-370.
15. Viner NJ, Bailey LC, Life PF, Bacon PA, Gaston JS: Isolation of Yersinia-specific T cell clones from the synovial membrane and synovial fluid of a patient with reactive arthritis. Arthritis Rheum. 1991, 34: 1151-1157. DOI: 10.1002/art.1780340911
16. Hermann E, Mayet WJ, Thomssen H, Sieper J, Poralla T, Meyer zum Buschenfelde KH, Fleischer B: HLA-DP restricted Chlamydia trachomatis specific synovial fluid T cell clones in Chlamydia-induced Reiter's disease. J Rheumatol. 1992, 19: 1243-1246.
17. Schmidt D, Goronzy JJ, Weyand CM: CD4+CD7-CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest. 1996, 97: 2027-2037. DOI: 10.1172/JCI118638
18. Markovic-Plese S, Cortese I, Wandinger KP, McFarland HF, Martin R: CD4+CD28- costimulation-independent T cells in multiple sclerosis. J Clin Invest. 2001, 108: 1185-1194. 10.1172/JCI200112516. DOI: 10.1172/JCI200112516
19. Lamprecht P, Moosig F, Csernok E, Seitzer U, Schnabel A, Mueller A, Gross WL: CD28 negative T cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis. Thorax. 2001, 56: 751-757. 10.1136/thorax.56.10.751. DOI: 10.1136/thorax.56.10.751
20. Moosig F, Csernok E, Wang G, Gross WL: Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells. Clin Exp Immunol. 1998, 114: 113-118. 10.1046/j.1365-2249.1998.00695.x. DOI: 10.1046/j.1365-2249.1998.00695.x
21. Park W, Weyand CM, Schmidt D, Goronzy JJ: Co-stimulatory pathways controlling activation and peripheral tolerance of human CD4+ CD28- T cells. Eur J Immunol. 1997, 27: 1082-1090. DOI: 10.1002/eji.1830270507
22. Vallejo AN, Mugge LO, Klimiuk PA, Weyand CM, Goronzy JJ: Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells. J Immunol. 2000, 164: 2947-2954. DOI: 10.4049/jimmunol.164.6.2947
23. Namekawa T, Snyder MR, Yen JH, Goehring BE, Leibson PJ, Weyand CM, Goronzy JJ: Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in Rheumatoid Arthritis. J Immunol. 2000, 165: 1138-1145. DOI: 10.4049/jimmunol.165.2.1138
24. Yen JH, Moore BE, Nakajima T, Scholl D, Schaid DJ, Weyand CM, Goronzy JJ: Major histocompatibility complex class I recognizing receptors are disease risk genes in RA. J Exp Med. 2001, 193: 1159-1167. 10.1084/jem.193.10.1159. DOI: 10.1084/jem.193.10.1159
25. Snyder MR, Muegge LO, Offord C, O'Fallon WM, Bajzer Z, Weyand CM, Goronzy JJ: Formation of the killer Ig-like receptor repertoire on CD4+CD28 null T cells. J Immunol. 2002, 168: 3839-3846. DOI: 10.4049/jimmunol.168.8.3839
26. Mandelboim O, Davis DM, Reyburn HT, Vales-Gomez M, Sheu EG, Pazmany L, Strominger JL: Enhancement of class II-restricted T cell responses by co-stimulatory NK receptors for class I MHC proteins. Science. 1996, 274: 2097-2100. 10.1126/science.274.5295.2097. DOI: 10.1126/science.274.5295.2097
27. van der Linden S, Valkenburg HA, Cats A: Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984, 27: 361-368. DOI: 10.1002/art.1780270401
28. Daltroy LH, Larson MG, Roberts NW, Liang MH: A modification of the Health Assessment Questionnaire for the spondyloarthropathies. J Rheumatol. 1990, 17: 946-950.
29. Jenkinson TR, Mallorie PA, Whitelock HC, Kennedy LG, Garrett SL, Calin A: Defining spinal mobility in ankylosing spondylitis (AS). The Bath AS Metrology Index. J Rheumatol. 1994, 21: 1694-1698.
30. Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P, Jenkinson T: A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol. 1994, 21: 2281-2285.
31. Kollnberger S, Bird L, Sun MY, Retiere C, Braud VM, McMichael A, Bowness P: Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. Arthritis Rheum. 2002, 46: 2972-2982. 10.1002/art.10605. DOI: 10.1002/art.10605
32. Reinhold U, Abken H: CD4+CD7- T cells: a separate subpopulation of memory T cells?. J Clin Immunol. 1997, 17: 265-271. 10.1023/A:1027318530127. DOI: 10.1023/A:1027318530127
33. Brumbaugh KM, Perez-Villar JJ, Dick CJ, Schoon RA, Lopez-Botet M, Leibson PJ: Clonotypic differences in signaling from CD94 (kp43) on NK cells lead to divergent cellular responses. J Immunol. 1996, 157: 2804-2812.
34. Weyand CM, Brandes JC, Schmidt D, Fulbright JW, Goronzy JJ: Functional properties of CD4+CD28- T cells in the aging immune system. Mech Ageing Dev. 1998, 102: 131-147. 10.1016/S0047-6374(97)00161-9. DOI: 10.1016/S0047-6374(97)00161-9
35. O'Shea JJ, Ma A, Lipsky P: Cytokines and autoimmunity. Nat Rev Immunol. 2002, 2: 37-45. 10.1038/nri702. DOI: 10.1038/nri702
36. Martens PB, Goronzy JJ, Schaid D, Weyand CM: Expansion of unusual CD4+ T cells in severe rheumatoid arthritis. Arthritis Rheum. 1997, 40: 1106-1114. DOI: 10.1002/art.1780400615
37. Brooks JM, Murray RJ, Thomas WA, Kurilla MG, Rickinson AB: Different HLA-B27 subtypes present the same immunodominant Epstein–Barr virus peptide. J Exp Med. 1993, 178: 879-887. 10.1084/jem.178.3.879. DOI: 10.1084/jem.178.3.879
38. Hooper M, Kallas EG, Coffin D, Campbell D, Evans TG, Looney RJ: Cytomegalovirus seropositivity is associated with the expansion of CD4+CD28- and CD8+CD28- T cells in rheumatoid arthritis. J Rheumatol. 1999, 26: 1452-1457.
39. Namekawa T, Wagner UG, Goronzy JJ, Weyand CM: Functional subsets of CD4 T cells in rheumatoid synovitis. Arthritis Rheum. 1998, 41: 2108-2116. 10.1002/1529-0131(199812)41:12<2108::AID-ART5>3.3.CO;2-H. DOI: 10.1002/1529-0131(199812)41:12<2108::AID-ART5>3.0.CO;2-Q
40. Bix M, Locksley RM: Natural T cells. Cells that co-express NKRP-1 and TCR. J Immunol. 1995, 155: 1020-1022.
41. Dulphy N, Rabian C, Douay C, Flinois O, Laoussadi S, Kuipers J, Tamouza R, Charron D, Toubert A: Functional modulation of expanded CD8+ synovial fluid T cells by NK cell receptor expression in HLA-B27-associated reactive arthritis. Int Immunol. 2002, 14: 471-479. 10.1093/intimm/14.5.471. DOI: 10.1093/intimm/14.5.471
42. Warrington KJ, Takemura S, Goronzy JJ, Weyand CM: CD4+, CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. Arthritis Rheum. 2001, 44: 13-20. 10.1002/1529-0131(200101)44:1<13::AID-ANR3>3.0.CO;2-6. DOI: 10.1002/1529-0131(200101)44:1<13::AID-ANR3>3.0.CO;2-6