Order changes within receptor systems upon ligand binding: Receptor tightening/oligomerisation and the interpretation of binding parameters

Journal of Molecular Biology

Volumn 340, Issue 2, 2004, Pages 373-383

  Williams, Dudley H ^a   O'Brien, Dominic P ^a   Sandercock, Alan M ^a   Stephens, Elaine ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

agonist; cooperativity; dynamics; enthalpy entropy compensation; GPCR, G protein coupled receptor; HD exchange, hydrogen deuterium exchange; LGICR, ligand gated ion channel receptor; receptor; T m, melting temperature

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CYTOKINE RECEPTOR; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR RECEPTOR; INTEGRIN RECEPTOR; SEROTONIN; SEROTONIN 3 RECEPTOR; T LYMPHOCYTE RECEPTOR; THYROTROPIN RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; TYROSINE KINASE RECEPTOR;

ARTICLE; BINDING KINETICS; BINDING SITE; DIMERIZATION; DISSOCIATION CONSTANT; ENTHALPY; ENTROPY; LIGAND BINDING; MOLECULAR DYNAMICS; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR BINDING; THERMODYNAMICS;

HOMO;

EID: 2942589210     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.04.056     Document Type: Article

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