Can thermodynamic measurements of receptor binding yield information on drug affinity and efficacy?

Biochemical Pharmacology

Volumn 60, Issue 11, 2000, Pages 1549-1556

  Borea, Pier Andrea ^a   Dalpiaz, Alessandro ^b   Varani, Katia ^a   Gilli, Paola ^c   Gilli, Gastone ^c  

^a Dipartimento di Medicina Clinica e Sperimentale   (Italy)

^b Dipartimento di Scienze Farmaceutiche   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

Author keywords

Agonist antagonist discrimination; Binding thermodynamics; Enthalpy entropy compensation; G protein coupled receptors; Ligand gated ion channel receptors; Solvent reorganization

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; BENZODIAZEPINE RECEPTOR; BETA ADRENERGIC RECEPTOR; DOPAMINE 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; SEROTONIN 1A RECEPTOR; SOLVENT;

BINDING AFFINITY; CHANNEL GATING; DRUG EFFICACY; DRUG RECEPTOR BINDING; ENTHALPY; PRIORITY JOURNAL; REVIEW; THERMODYNAMICS;

EID: 0034571319     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00368-3     Document Type: Article

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