The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice

Journal of Biological Chemistry

Volumn 284, Issue 19, 2009, Pages 12680-12690

  Funakoshi Tago, Megumi ^a   Tago, Kenji ^b   Sumi, Kazuya ^a   Abe, Miyuki ^a   Aizu Yokota, Eriko ^a   Oshio, Tomoyuki ^a   Sonoda, Yoshiko ^a   Kasahara, Tadashi ^a  

^a KEIO UNIVERSITY   (Japan)

^b NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

, INHIBITOR; ACUTE LYMPHOBLASTIC LEUKEMIA; ANTI-APOPTOTIC PROTEIN; ANTIAPOPTOTIC; APOPTOSIS; APOPTOTIC CELL DEATH; CELL MIGRATION; CELLULAR PROCESS; CYTOKINE; HEMATOPOIETIC CELL; IN-VITRO; INHIBITOR OF APOPTOSIS PROTEINS; NUDE MICE; ONCOGENIC ACTIVITIES; POINT MUTATIONS; SIGNALING PATHWAYS; TUMORIGENESIS; X CHROMOSOMES;

CELL GROWTH; GROWTH KINETICS;

CELL DEATH;

INHIBITOR OF APOPTOSIS PROTEIN; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN BCL XL; PROTEIN KINASE B; STAT5 PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CELL DEATH; CELL GROWTH; CELL PROTECTION; CONTROLLED STUDY; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CYTOKINES; FLOW CYTOMETRY; GENETIC VECTORS; HEMATOPOIETIC STEM CELLS; JANUS KINASE 2; LIVER NEOPLASMS, EXPERIMENTAL; LYMPHATIC METASTASIS; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; PHOSPHORYLATION; POINT MUTATION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPLENIC NEOPLASMS; STAT5 TRANSCRIPTION FACTOR; TRANSFECTION; TYRPHOSTINS;

MURINAE; MUS; MUS MUSCULUS;

EID: 67649803143     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808879200     Document Type: Article

References (32)

1. Baker, S. J., Rane, S. G., and Reddy, E. P. (2007) Oncogene 26, 6724-6737
2. Schindler, C., Levy, D. E., and Decker, T. (2007) J. Biol. Chem. 282, 20059-20063
3. O'Sullivan, L. A., Liongue, C., Lewis, R. S., Stephenson, S. E., and Ward, A. C. (2007) Mol. Immunol. 44, 2497-2506
4. Ihle, J. N., and Gilliland, D. G. (2007) Curr. Opin. Genet. Dev. 17, 8-14
5. Lacronique, V., Boureux, A., Valle, V. D., Poirel, H., Quang, C. T., Mauchauffé, M., Berthou, C., Lessard, M., Berger, R., Ghysdael, J., and Bernard, O. A. (1997) Science 278, 1309-1312
6. Lindauer, K., Loerting, T., Liedl, K. R., and Kroemer, R. T. (2001) Protein Eng. 14, 27-37
7. Feng, J., Witthuhn, B. A., Matsuda, T., Kohlhuber, F., Kerr, I. M., and Ihle, J. N. (1997) Mol. Cell. Biol. 17, 2497-2501
8. Saharinen, P., and Silvennoinen, O. (2002) J. Biol. Chem. 277, 47954-47963
9. Saharinen, P., Vihinen, M., and Silvennoinen, O. (2003) Mol. Biol. Cell 14, 1448-1459
10. James, C., Ugo, V., Le Couédic, J. P., Staerk, J., Delhommeau, F., Lacout, C., Garco̧n, L., Raslova, H., Berger, R., Bennaceur-Griscelli, A., Villeval, J. L., Constantinescu, S. N., Casadevall, N., and Vainchenker, W. (2005) Nature 434, 1144-1148
11. Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., Adelsperger, J., Koo, S., Lee, J. C., Gabriel, S., Mercher, T., D'Andrea, A., Fröhling, S., Döhner, K., Marynen, P., Vandenberghe, P., Mesa, R. A., Tefferi, A., Griffin, J. D., Eck, M. J., Sellers, W. R., Meyerson, M., Golub, T. R., Lee, S. J., and Gilliland, D. G. (2005) Cancer Cell 7, 387-397
12. Kralovics, R., Passamonti, F., Buser, A. S., Teo, S. S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., and Skoda, R. C. (2005) N. Engl. J. Med. 352, 1779-1790
13. Kratz, C. P., Böll, S., Kontny, U., Schrappe, M., Niemeyer, C. M., and Stanulla, M. (2006) Leukemia 20, 381-383
14. Funakoshi-Tago, M., Pelletier, S., Moritake, H., Parganas, E., and Ihle, J. N. (2008) Mol. Cell. Biol. 28, 1792-1801
15. Funakoshi-Tago, M., Tago, K., Nishizawa, C., Takahashi, K., Mashino, T., Iwata, S., Inoue, H., Sonoda, Y., and Kasahara, T. (2008) Biochem. Pharmacol. 76, 1681-1693
16. Funakoshi-Tago, M., Sonoda, Y., Tanaka, S., Hashimoto, K., Tago, K., Tominaga, S., and Kasahara, T. (2003) J. Biol. Chem. 278, 29359-29365
17. Onishi, M., Nosaka, T., Misawa, K., Mui, A. L., McMahon, G. D., Miyajima, A., and Kitamura, T. (1998) Mol. Cell. Biol. 18, 3871-3879
18. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., and Reed, J. C. (1997) Nature 388, 300-304
19. Roy, N., Deveraux, Q. L., Takahashi, R., Salvesen, G. S., and Reed, J. C. (1997) EMBO J. 16, 6914-6925
20. Boise, L. H., González-García, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nuñez, G., and Thompson, C. B. (1993) Cell 74, 597-608
21. Gottschalk, A. R., Boise, L. H., Thompson, C. B., and Quintáns, J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 7350-7354
22. Meydan, N., Grunberger, T., Dadi, H., Shahar, M. A., Arpaia, E., Lapidot, Z., Leeder, J. S., Freedman, M., Cohen, A., Gazit, A., Levitzki, A., and Roifman, C. M. (1996) Nature 379, 645-648
23. Blume-Jensen, P., and Hunter, T. (2001) Nature 411, 355-365
24. You, M., Ku, P. T., Hrdlicková, R., and Bose, H. R., Jr. (1997) Mol. Cell. Biol. 17, 7328-7341
25. Stehlik, C., de Martin, R., Kumabashiri, I., Schmid, J. A., Binder, B. R., and Lipp, J. (1998) J. Exp. Med. 188, 211-216
26. Khoshnan, A., Tindell, C., Laux, I., Bae, D., Bennett, B., and Nel, A. E. (2000) J. Immunol. 165, 1743-1754
27. Feldman, G. M., Rosenthal, L. A., Liu, X., Hayes, M. P., Wynshaw-Boris, A., Leonard, W. J., Hennighausen, L., and Finbloom, D. S. (1997) Blood 90, 1768-1776
28. Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernández-Luna, J. L., Nuñez, G., Dalton, W. S., and Jove, R. (1999) Immunity 10, 105-115
29. Danilkovitch-Miagkova, A., and Zbar, B. (2002) J. Clin. Investig. 109, 863-867
30. Fidler, I. J. (2002) Semin. Cancer Biol. 12, 89-96
31. Grant, S. (2008) J. Clin. Investig. 118, 3003-3006
32. Kinkade, C. W., Castillo-Martin, M., Puzio-Kuter, A., Yan, J., Foster, T. H., Gao, H., Sun, Y., Ouyang, X., Gerald, W. L., Cordon-Cardo, C., and Abate-Shen, C. (2008) J. Clin. Investig. 118, 3051-3064