Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling

Journal of Biological Chemistry

Volumn 284, Issue 19, 2009, Pages 12956-12965

  Zhang, Yaqin ^a   Rosado, Leslie A Rivera ^a   Moon, Sun Young ^a   Zhang, Baolin ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANOIKIS; APOPTOSIS; BREAST CANCER; BREAST CANCER CELLS; CELL FUNCTIONS; CELLULAR MEMBRANES; CULTURE CONDITIONS; CYTOSOL; HUMAN BREAST CANCER CELLS; KINASE ACTIVITY; LUNG METASTASIS; RAC GTPASES; RHO GTPASES; RNA INTERFERENCE; SUSTAINED ACTIVATION; THERAPEUTIC INTERVENTION; TUMOR GROWTH; TUMORIGENESIS;

CELL CULTURE; CELL DEATH; NUCLEIC ACIDS; PATHOLOGY; RNA;

CELL MEMBRANES;

MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN D4 GDI; RAC1 PROTEIN; RAC3 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CARCINOGENESIS; CELL FUNCTION; CELL INVASION; CELL MEMBRANE; CELL STRAIN; CELL STRAIN MDA MB 231; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TRANSLOCATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR GROWTH;

ANIMALS; ANOIKIS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; GENE SILENCING; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; HUMANS; IMMUNOPRECIPITATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RAC1 GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 67649675530     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807845200     Document Type: Article

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