Converting NADH to NAD+ by nicotinamide nucleotide transhydrogenase as a novel strategy against mitochondrial pathologies during aging

Biogerontology

Volumn 10, Issue 4, 2009, Pages 531-534

  Olgun, Abdullah ^a  

^a Erzincan Military Hospital   (Turkey)

Author keywords

Aging; Dihydroorotate dehydrogenase; Mitochondrial DNA; NADH; Nicotinamide nucleotide transhydrogenase; Ubiquinone

Indexed keywords

ALTERNATIVE OXIDASE; DIHYDROOROTATE DEHYDROGENASE; FREE RADICAL; HISTONE DEACETYLASE; MITOCHONDRIAL DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; NUCLEOTIDE; OXIDOREDUCTASE; QUINONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SILENT INFORMATION REGULATOR PROTEIN 2; UBIQUINOL; UBIQUINONE; UNCLASSIFIED DRUG; URIDINE;

AGING; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CELL AGING; CHEMICAL REACTION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; GENE MUTATION; GENE OVEREXPRESSION; LONGEVITY; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN METABOLISM; PYRIMIDINE SYNTHESIS; RESPIRATORY CHAIN;

AGING; ANIMALS; DNA DAMAGE; DNA, MITOCHONDRIAL; HUMANS; MICE; MITOCHONDRIA; NAD; NADP TRANSHYDROGENASE; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; UBIQUINONE;

EID: 67649646948     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-008-9190-2     Document Type: Article

References (31)

1. Arkblad EL, Tuck S, Pestov NB, Dmitriev RI, Kostina MB, Stenvall J, Tranberg M, Rydstrom J (2005) A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress. Free Radic Biol Med 38:1518-1525. doi: 10.1016/j.freeradbiomed.2005.02.012
2. Armand R, Channon JY, Kintner J, White KA, Miselis KA, Perez RP, Lewis LD (2004) The effects of ethidium bromide induced loss of mitochondrial DNA on mitochondrial phenotype and ultrastructure in a human leukemia T-cell line (MOLT-4 cells). Toxicol Appl Pharmacol 196:68-79. doi: 10.1016/j.taap.2003.12.001
3. Desjardins P, Frost E, Morais R (1985) Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts. Mol Cell Biol 5:1163-1169
4. Desjardins P, de Muys JM, Morais R (1986) An established avian fibroblast cell line without mitochondrial DNA. Somat Cell Mol Genet 12:133-139. doi: 10.1007/BF01560660
5. Freeman H, Shimomura K, Cox RD, Ashcroft FM (2006) Nicotinamide nucleotide transhydrogenase: A link between insulin secretion, glucose metabolism and oxidative stress. Biochem Soc Trans 34:806-810. doi: 10.1042/BST0340806
6. Garcia RA, Liu L, Hu Z, Gonzalez A, von Borstel RW, Saydoff JA (2005) Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine. Brain Res 1066:164-171. doi: 10.1016/j.brainres.2005.10.056
7. Gregoire M, Morais R, Quilliam MA, Gravel D (1984) On auxotrophy for pyrimidines of respiration-deficient chick embryo cells. Eur J Biochem 142:49-55. doi: 10.1111/j.1432-1033.1984.tb08249.x
8. Haigis MC, Guarente LP (2006) Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev 20:2913-2921. doi: 10.1101/gad.1467506
9. Hakkaart GA, Dassa EP, Jacobs HT, Rustin P (2006) Allotopic expression of a mitochondrial alternative oxidase confers cyanide resistance to human cell respiration. EMBO Rep 7:341-345. doi: 10.1038/sj.embor.7400601
10. Howell N, Sager R (1979) Cytoplasmic genetics of mammalian cells: conditional sensitivity to mitochondrial inhibitors and isolation of new mutant phenotypes. Somat Cell Genet 5:833-845. doi: 10.1007/BF01542645
11. Ishii N, Ishii T, Hartman PS (2007) The role of the electron transport SDHC gene on lifespan and cancer. Mitochondrion 7:24-28. doi: 10.1016/ j.mito.2006.11.012
12. Kayo T, Allison DB, Weindruch R, Prolla TA (2001) Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci USA 98:5093-5098. doi: 10.1073/pnas.081061898
13. Kayser EB, Sedensky MM, Morgan PG, Hoppel CL (2004) Mitochondrial oxidative phosphorylation is defective in the long-lived mutant clk-1. J Biol Chem 279:54479-54486. doi: 10.1074/jbc.M403066200
14. King MP, Attardi G (1989) Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation. Science 246:500-503. doi: 10.1126/science.2814477
15. Larm JA, Vaillant F, Linnane AW, Lawen A (1994) Up-regulation of the plasma membrane oxidoreductase as a prerequisite for the viability of human Namalwa rho 0 cells. J Biol Chem 269:30097-30100
16. Malik SG, Vaillant F, Lawen A (2004) Plasma membrane NADH-oxidoreductase in cells carrying mitochondrial DNA G11778A mutation and in cells devoid of mitochondrial DNA (rho0). Biofactors 20:189-198
17. Martinus RD, Linnane AW, Nagley P (1993) Growth of rho 0 human Namalwa cells lacking oxidative phosphorylation can be sustained by redox compounds potassium ferricyanide or coenzyme Q10 putatively acting through the plasma membrane oxidase. Biochem Mol Biol Int 31:997-1005
18. Morais R, Gregoire M, Jeannotte L, Gravel D (1980) Chick embryo cells rendered respiration-deficient by chloramphenicol and ethidium bromide are auxotrophic for pyrimidines. Biochem Biophys Res Commun 94:71-77. doi: 10.1016/S0006-291X(80)80189-6
19. Ohta S (2006) Contribution of somatic mutations in the mitochondrial genome to the development of cancer and tolerance against anticancer drugs. Oncogene 25:4768-4776. doi: 10.1038/sj.onc.1209602
20. Olgun A, Akman S (2007) Mitochondrial DNA-deficient models and aging. Ann N Y Acad Sci 1100:241-245. doi: 10.1196/annals.1395.025
21. Olgun A, Akman S, Serdar MA, Kutluay T (2002) Oxidative phosphorylation enzyme complexes in caloric restriction. Exp Gerontol 37:639-645. doi: 10.1016/S0531-5565(02)00009-8
22. Pelicano H, Xu RH, Du M, Feng L, Sasaki R, Carew JS, Hu Y, Ramdas L, Hu L, Keating MJ, Zhang W, Plunkett W, Huang P (2006) Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol 175:913-923. doi: 10.1083/jcb.200512100
23. Rydstrom J (2006) Mitochondrial NADPH, transhydrogenase and disease. Biochim Biophys Acta 1757:721-726. doi: 10.1016/j.bbabio.2006.03.010
24. Saydoff JA, Liu LS, Garcia RA, Hu Z, Li D, von Borstel RW (2003) Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease. Brain Res 994:44-54. doi: 10.1016/j.brainres.2003.09.049
25. Seidel-Rogol BL, Shadel GS (2002) Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Res 30:1929-1934. doi: 10.1093/nar/30.9.1929
26. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder CE, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, Tornell J, Jacobs HT, Larsson NG (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417-423. doi: 10.1038/ nature02517
27. Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG (2005) Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA 102:17993-17998. doi: 10.1073/ pnas.0508886102
28. Walker UA, Venhoff N (2005) Uridine in the prevention and treatment of NRTI-related mitochondrial toxicity. Antivir Ther 10(Suppl 2):M117-M123
29. Walker UA, Venhoff N, Koch EC, Olschewski M, Schneider J, Setzer B (2003) Uridine abrogates mitochondrial toxicity related to nucleoside analogue reverse transcriptase inhibitors in HepG2 cells. Antivir Ther 8:463-470
30. Walker UA, Auclair M, Lebrecht D, Kornprobst M, Capeau J, Caron M (2006) Uridine abrogates the adverse effects of antiretroviral pyrimidine analogues on adipose cell functions. Antivir Ther 11:25-34
31. Yagi T, Seo BB, Nakamaru-Ogiso E, Marella M, Barber-Singh J, Yamashita T, Matsuno-Yagi A (2006) Possibility of transkingdom gene therapy for complex I diseases. Biochim Biophys Acta 1757:708-714. doi: 10.1016/ j.bbabio.2006.01.011