Mitochondrial DNA-deficient models and aging

Annals of the New York Academy of Sciences

Volumn 1100, Issue , 2007, Pages 241-245

  Olgun, Abdullah ^a   Akman, Serif ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Aging; Longevity; Mitochondrial DNA; Model

Indexed keywords

ANTIBIOTIC AGENT; CELL NUCLEUS DNA; CHLORAMPHENICOL; CYTOCHROME C OXIDASE; DOXYCYCLINE; ETHIDIUM BROMIDE; FREE RADICAL; MITOCHONDRIAL DNA; OXIDOREDUCTASE; PROTEIN SUBUNIT; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PYRIMIDINE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SILENT INFORMATION REGULATOR PROTEIN 2; UBIQUINOL CYTOCHROME C REDUCTASE; URIDINE; ETHIDIUM; OXYGEN;

AGING; CAENORHABDITIS ELEGANS; CELL CULTURE; CELL NUCLEUS; CELL SURVIVAL; CONFERENCE PAPER; DEVELOPMENTAL STAGE; DNA DAMAGE; DNA REPLICATION; DOWNSTREAM PROCESSING; EXPERIMENTAL MODEL; GENETIC SCREENING; GENOME; HUMAN; KNOCKOUT GENE; LACTIC ACIDOSIS; LARVA; LIFESPAN; LONGEVITY; MUTANT; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PHYSIOLOGY; PROTEIN FUNCTION; RESPIRATORY CHAIN; RNA TRANSLATION; YEAST; ANIMAL; DISEASE MODEL; GENETICS; METABOLISM; MOUSE; MUTATION; PHOSPHORYLATION; REVIEW;

ANIMALIA; CAENORHABDITIS ELEGANS;

AGING; ANIMALS; CAENORHABDITIS ELEGANS; CELL NUCLEUS; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; ETHIDIUM; FREE RADICALS; HUMANS; LONGEVITY; MICE; MUTATION; OXYGEN; PHENOTYPE; PHOSPHORYLATION;

EID: 34249671069     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1395.025     Document Type: Conference Paper

References (13)

1. INGMAN, M., H. KAESSMANN, S. PAABO & U. GYLLENSTEN. 2000. Mitochondrial genome variation and the origin of modern humans. Nature 408: 708-713. Erratum in: Nature 2001. 410: 611.
2. OLGUN, A., S. AKMAN, M.A. SERDAR & T. KUTLUAY. 2002. Oxidative phosphorylation enzyme complexes in caloric restriction. Exp. Gerontol. 37: 639-645.
3. TSANG, W.Y. & B.D. LEMIRE. 2002. Mitochondrial genome content is regulated during nematode development. Biochem. Biophys. Res. Commun. 291: 8-16.
4. KING, M.P. 1996. Use of ethidium bromide to manipulate ratio of mutated and wild-type mitochondrial DNA in cultured cells. Methods Enzymol. 264: 339-344.
5. TSANG, W.Y., L.C. SAYLES, L.I. GRAD, et al. 2001. Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span. J. Biol. Chem. 276: 32240-32246.
6. SEIDEL-ROGOL, B.L. & G.S. SHADEL. 2002. Modulation of mitochondrial transcription in response to mtDNA depletion and repletion in HeLa cells. Nucleic Acids Res. 30: 1929-1934.
7. ARMAND, R., J.Y. CHANNON, J. KINTNER, et al. 2004. The effects of ethidium bromide induced loss of mitochondrial DNA on mitochondrial phenotype and ultrastructure in a human leukemia T-cell line (MOLT-4 cells). Toxicol. Appl. Pharmacol. 196: 68-79.
8. GARCIA, R.A., L. LIU, Z. HU, et al. 2005. Severe cytochrome c oxidase inhibition in vivo does not induce a pyrimidine deficiency; neuroprotective action of oral uridine prodrug PN401 requires supraphysiological levels of uridine. Brain Res. 1066: 164-171.
9. SAYDOFF, J.A., L.S. LIU, R.A. GARCIA, et al. 2003. Oral uridine pro-drug PN401 decreases neurodegeneration, behavioral impairment, weight loss and mortality in the 3-nitropropionic acid mitochondrial toxin model of Huntington's disease. Brain Res. 994: 44-54.
10. LEE, S.S., R.Y. LEE, A.G. FRASER, et al. 2003. A systematic RNAi screen identifies a critical role for mitochondria in C.elegans longevity. Nat. Genet. 33: 40-48.
11. FABRIZIO, P., C. GATTAZZO, L. BATTISTELLA, et al. 2005. Sir2 blocks extreme lifespan extension. Cell 123: 655-667.
12. TRIFUNOVIC, A., A. WREDENBERG, M. FALKENBERG, et al. 2004. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429: 417-423.
13. TRIFUNOVIC, A., A. HANSSON, A. WREDENBERG, et al. 2005. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc. Natl. Acad. Sci. USA 102: 17993-17998.