Trivalent methylated arsenical-induced phosphatidylserine exposure and apoptosis in platelets may lead to increased thrombus formation

Toxicology and Applied Pharmacology

Volumn 239, Issue 2, 2009, Pages 144-153

  Bae, Ok Nam ^a   Lim, Kyung Min ^a,b   Noh, Ji Yoon ^a   Chung, Seung Min ^a   Kim, Se Hwan ^a   Chung, Jin Ho ^a  

^a Seoul National University   (South Korea)

^b AmorePacific Corporation   (South Korea)

Author keywords

Apoptosis; Phosphatidylserine; Platelets; Procoagulant activity; Thrombosis; Trivalent methylated arsenicals

Indexed keywords

ADENOSINE TRIPHOSPHATE; CACODYLIC ACID; CALCIUM; CASPASE 3; CYTOCHROME C; FLIPPASE; MEMBRANE ENZYME; METHANEARSONIC ACID; ORGANOARSENIC DERIVATIVE; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; THIOL; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARSENIC POISONING; ARTICLE; BLOOD CLOTTING; CARDIOTOXICITY; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; HYPERCOAGULABILITY; IN VIVO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PROTEIN DEPLETION; RAT; THROMBOCYTE; THROMBOGENESIS; VEIN THROMBOSIS;

ADOLESCENT; ADULT; ANIMALS; APOPTOSIS; BLOOD COAGULATION; BLOOD PLATELETS; CACODYLIC ACID; CALCIUM; CASPASE 3; CELLS, CULTURED; CYTOCHROMES C; DISEASE MODELS, ANIMAL; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; ORGANOMETALLIC COMPOUNDS; PHOSPHATIDYLSERINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; VENOUS THROMBOSIS; YOUNG ADULT;

ANIMALIA; RATTUS;

EID: 67649552179     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2008.12.020     Document Type: Article

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