Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination

EMBO Journal

Volumn 28, Issue 12, 2009, Pages 1745-1756

  Ma, Chien Hui ^a   Rowley, Paul A ^a   MacIeszak, Anna ^b   Guga, Piotr ^b   Jayaram, Makkuni ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b CENTRE OF MOLECULAR AND MACROMOLECULAR STUDIES   (Poland)

Author keywords

Active site electrostatics; Methylphosphonate; Type I Flp endonuclease; Type II Flp endonuclease; Tyrosine recombinases

Indexed keywords

ALANINE; DNA; ENDONUCLEASE; METHYLPHOSPHONIC ACID; PHOSPHOTYROSINE; RECOMBINASE; WATER; AMINO ACID; DNA POLYMERASE; ORGANOPHOSPHORUS COMPOUND;

ARTICLE; DNA CONFORMATION; DNA RECOMBINATION; DNA TRANSPOSITION; HYDROLYSIS; INTRON; ISOMERIZATION; PRIORITY JOURNAL; RNA SPLICING; TRANSESTERIFICATION; AMINO ACID SUBSTITUTION; BIOLOGICAL MODEL; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ESTERIFICATION; GENETIC RECOMBINATION; GENETICS; GENOME; KINETICS; METABOLISM; STATIC ELECTRICITY; STEREOISOMERISM;

AMINO ACID SUBSTITUTION; AMINO ACIDS; CATALYTIC DOMAIN; DNA; DNA NUCLEOTIDYLTRANSFERASES; ENDONUCLEASES; ESTERIFICATION; GENOME; HYDROLYSIS; KINETICS; MODELS, BIOLOGICAL; ORGANOPHOSPHORUS COMPOUNDS; RECOMBINATION, GENETIC; STATIC ELECTRICITY; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 67649512575     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2009.131     Document Type: Article

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