Receipt of the C-terminal tail from a neighboring λ Int protomer allosterically stimulates Holliday junction resolution

Journal of Molecular Biology

Volumn 351, Issue 5, 2005, Pages 948-955

  Hazelbaker, Dane ^a   Radman Livaja, Marta ^a   Landy, Arthur ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Bacteriophage lambda; Holliday junction; Integrase; Peptide; Site specific recombination

Indexed keywords

DNA; DNA TOPOISOMERASE; INTEGRASE; LAMBDA INTEGRASE; MONOMER; MUTANT PROTEIN; TETRAMER; UNCLASSIFIED DRUG;

ACCURACY; ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; ENZYME BINDING; ENZYME SUBUNIT; GENE DELETION; HOLLIDAY JUNCTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN FUNCTION; WILD TYPE;

BACTERIOPHAGE LAMBDA;

EID: 23644448115     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.06.077     Document Type: Article

References (23)

1. A. Campbell Episomes Advan. Genet. 11 1962 104 145
2. M. Tekle, D.J. Warren, T. Biswas, T. Ellenberger, A. Landy, and S.E. Nunes-Duby Attenuating functions of the C terminus of lambda integrase J. Mol. Biol. 324 2002 649 665
3. R.A. Kazmierczak, B.M. Swalla, A.B. Burgin, R.I. Gumport, and J.F. Gardner Regulation of site-specific recombination by the C-terminus of lambda integrase Nucl. Acids Res. 30 2002 5193 5204
4. H. Aihara, H.J. Kwon, S.E. Nunes-Duby, A. Landy, and T. Ellenberger A conformational switch controls the DNA cleavage activity of lambda integrase Mol. Cell. 12 2003 187 198
5. S.Y. Lee, H. Aihara, T. Ellenberger, and A. Landy Two structural features of lambda integrase that are critical for DNA cleavage by multimers but not by monomers Proc. Natl Acad. Sci. USA 101 2004 2770 2775
6. Y.W. Han, R.I. Gumport, and J.F. Gardner Mapping the functional domains of bacteriophage lambda integrase protein J. Mol. Biol. 235 1994 908 925
7. M. Azaro, and A. Landy Lambda integrase and the lambda Int family N.L. Craig R. Craigie M. Gellert A. Lambovitz Mobile DNA II 2002 ASM Press Washington DC 118 148
8. H. Nash Site-specific recombination: integration, excision, resolution, and inversion of defined DNA segments F.C. Neidhardt R.I. Curtiss J.L. Ingraham E.C.C. Lin K.B. Low B. Magasanik W.S. Reznikoff M. Riley M. Schaechter H.E. Umbarger Escherichia coli and Salmonella: Cellular and Molecular Biology 1996 ASM Press Washington, DC 2363 2376
9. G.D. Van Duyne A structural view of tyrosine recombinase site-specific recombination N.L. Craig R. Craigie M. Gellert A. Lambovitz Mobile DNA II 2002 ASM Press Washington DC 93 113
10. L.W. Enquist, and R.A. Weisberg A genetic analysis of the att-int-xis region of coliphage lambda J. Mol. Biol. 111 1977 97 120
11. S.E. Bear, J.B. Clemens, L.W. Enquist, and R.J. Zagursky Mutational analysis of the lambda int gene: DNA sequence of dominant mutations J. Bacteriol. 169 1987 5880 5883
12. H.J. Kwon, R. Tirumalai, A. Landy, and T. Ellenberger Flexibility in DNA recombination: structure of the lambda integrase catalytic core Science 276 1997 126 131
13. T. Biswas, H. Aihara, M. Radman-Livaja, D. Filman, A. Landy, and T. Ellenberger A structural basis for allosteric control of DNA recombination by lambda integrase Nature 435 2005 1059 1066
14. M. Radman-Livaja, C. Shaw, M. Azaro, T. Biswas, T. Ellenberger, and A. Landy Arm sequences contribute to the architecture and catalytic function of a lambda integrase-Holliday junction complex Mol. Cell. 11 2003 783 794
15. P.L. Hsu, and A. Landy Resolution of synthetic att-site Holliday structures by the integrase protein of bacteriophage lambda Nature 311 1984 721 726
16. B. Franz, and A. Landy Interactions between lambda Int molecules bound to sites in the region of strand exchange are required for efficient Holliday junction resolution J. Mol. Biol. 215 1990 523 535
17. W. Keller, and I. Wendel Stepwise relaxation of supercoiled SV40 DNA Cold Spring Harbor Symp. Quant. Biol. 39 1975 199 208
18. B. Hallet, L.K. Arciszewska, and D.J. Sherratt Reciprocal control of catalysis by the tyrosine recombinases XerC and XerD: an enzymatic switch in site-specific recombination Mol. Cell. 4 1999 949 959
19. H. Ferreira, B. Butler-Cole, A. Burgin, R. Baker, D.J. Sherratt, and L.K. Arciszewska Functional analysis of the C-terminal domains of the site-specific recombinases XerC and XerD J. Mol. Biol. 330 2003 15 27
20. S. Subramaniam, A.K. Tewari, S.E. Nunes-Duby, and M.P. Foster Dynamics and DNA substrate recognition by the catalytic domain of lambda integrase J. Mol. Biol. 329 2003 423 439
21. B.O. Krogh, and S. Shuman Proton relay mechanism of general acid catalysis by DNA topoisomerase IB J. Biol. Chem. 277 2002 5711 5714
22. T. Bankhead, and A.M. Segall Characterization of a mutation of bacteriophage lambda integrase. Putative role in core binding and strand exchange for a conserved residue J. Biol. Chem. 275 2000 36949 36956
23. D. Sarkar, M. Radman-Livaja, and A. Landy The small DNA binding domain of lambda integrase is a context-sensitive modulator of recombinase functions EMBO J. 20 2001 1203 1212