Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways

Journal of Cell Biology

Volumn 148, Issue 3, 2000, Pages 465-479

  Noda, Takeshi ^a   Kim, John ^b   Huang, Wei Pang ^b   Baba, Misuzu ^c   Tokunaga, Chikara ^a   Ohsumi, Yoshinori ^a   Klionsky, Daniel J ^b  

^a NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JAPAN WOMEN'S UNIVERSITY   (Japan)

Author keywords

Aminopeptidase I; Lysosome; Protein targeting; Vacuole; Yeast

Indexed keywords

AMINOPEPTIDASE I; MEMBRANE PROTEIN;

ALLELE; ARTICLE; AUTOPHAGY; CELL VACUOLE; CYTOSOL; INTRACELLULAR TRANSPORT; LYSOSOME; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING; SACCHAROMYCES CEREVISIAE; STARVATION;

ANIMALS; AUTOPHAGY; BIOLOGICAL TRANSPORT; CENTRIFUGATION, DENSITY GRADIENT; FUNGAL PROTEINS; MEMBRANE PROTEINS; RABBITS; SACCHAROMYCES CEREVISIAE; SUBCELLULAR FRACTIONS; VACUOLES;

EID: 0034614934     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.148.3.465     Document Type: Article

References (60)

1. Ultrastructural analysis of the autophagic process in yeast: Detection of autophagosomes and their characterization
2. Analysis of the membrane structures involved in autophagy in yeast by freeze-replica method
3. Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome
4. Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p
5. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function
6. Identification of tubulin from the yeast Saccharomyces cerevisiae
7. Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast
8. Autophagic proteolysis: Control and specificity
9. The transcriptional program of sporulation in budding yeast
10. A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole
11. Exploring the metabolic and genetic control of gene expression on a genomic scale
12. Studies on the mechanisms of autophagy: Formation of the autophagic vacuole
13. The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment
14. The Saccharomyces cerevisiae vesicle-associated soluble NSF attachment protein receptor Vti1p is required for multiple membrane transport pathways to the vacuole
15. Apg5p functions in the sequestration step in the cytoplasm to vacuole targeting and macroautophagy pathways
16. Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway
17. Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway
18. Two syntaxin homologues in the TGN/endosomal system of yeast
19. The syntaxin Tlg1p mediates trafficking of chitin synthase III to polarized growth sites in yeast
20. The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways
21. Mechanism of autophagy in permeabilized hepatocytes: Evidence for regulation by GTP binding proteins
22. Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae
23. Transport of a large oligomerie protein by the cytoplasm to vacuole protein targeting pathway
24. Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways
25. Alternative protein sorting pathways
26. Formation process of autophagosome is traced with Apg8/Aut7p in yeast
27. Vacuolar import of proteins and organelles from the cytoplasm
28. Intracellular sorting and processing of a yeast vacuolar hydrolase: Proteinase A propeptide contains vacuolar targeting information
29. Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway
30. A simple method for displaying the hydropathic character of a protein
31. Aut2p and Aut7p, two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole
32. The autophagic and endocytic pathways converge at the nascent autophagic vacuoles
33. Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
34. A protein conjugation system essential for autophagy
35. Apg16p is required for the function of the Apg12p-Apg5p conjugate in the yeast autophagy pathway
36. Autophagy
37. A rapid method for localized mutagenesis of yeast genes
38. Acidification of vacuole is required for the autophagic degradation in the yeast Saccharomyces cerevisiae
39. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
40. Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae
41. Protein sorting in Saccharomyces cerevisiae: Isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
42. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector
43. Peroxisome degradation by microautophagy in P. pastoris: Identification of specific steps and morphological intermediates
44. Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking
45. In vitro reconstitution of cytoplasm to vacuole protein transport in yeast
46. Cytoplasm to vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole
47. Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism
48. Structural aspects of autophagy
49. Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast
50. Mutational analysis of Csc1/ Vps4p: Involvement of endosome in regulation of autophagy in yeast
51. Purification and characterization of autophagosomes from rat hepatocytes
52. Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction
53. Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy
54. Isolation of autophagocytosis mutants of Saccharomyces cerevisiae
55. In exocrine pancreas, the basolateral endocytic pathway converges with the autophagic pathway immediately after the early endosome
56. Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
57. Divergent modes of autophagy in the methylotrophic yeast Pichia pastoris
58. A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast
59. Formation of autophagosomes during degradation of excess peroxisomes induced by di-(2-ethylhexyl)phthalate treatment. II. Immunocytochemical analysis of early and late autophagosomes
60. Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein