Bovine insulin filaments induced by reducing disulfide bonds show a different morphology, secondary structure, and cell toxicity from intact insulin amyloid fibrils

Biophysical Journal

Volumn 96, Issue 8, 2009, Pages 3331-3340

  Zako, Tamotsu ^a   Sakono, Masafumi ^a   Hashimoto, Naomi ^a   Ihara, Masaki ^a   Maeda, Mizuo ^a  

^a RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; BOVINE INSULIN; PEPTIDE HORMONE; TRIS(2 CARBOXYETHYL)PHOSPHINE; CONGO RED; INSULIN; PHOSPHINE DERIVATIVE; THIAZOLE DERIVATIVE; THIOFLAVINE; TRIS(2-CARBOXYETHYL)PHOSPHINE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BETA SHEET; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; MORPHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN ASSEMBLY; PROTEIN SECONDARY STRUCTURE; RAT; REDUCTION; ANIMAL; CATTLE; CELL DEATH; CHEMISTRY; CIRCULAR DICHROISM; INFRARED SPECTROSCOPY; METABOLISM; RAMAN SPECTROMETRY; SPECTROFLUOROMETRY; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET RADIATION;

BOVINAE;

AMYLOID; ANIMALS; CATTLE; CELL DEATH; CIRCULAR DICHROISM; CONGO RED; INSULIN; MICROSCOPY, ELECTRON, TRANSMISSION; PHOSPHINES; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTRUM ANALYSIS, RAMAN; THIAZOLES; ULTRAVIOLET RAYS;

EID: 67649397928     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2008.12.3957     Document Type: Article

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