SMAD-proteins as a molecular switch from hypertrophy to apoptosis induction in adult ventricular cardiomyocytes

Journal of Cellular Physiology

Volumn 220, Issue 2, 2009, Pages 515-523

  Heger, Jacqueline ^a   Peters, Saskia C ^a   Piper, Hans Michael ^a   Euler, Gerhild ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; ISOPROTEIN; PHENYLEPHRINE; PROTEIN BAX; PROTEIN BCL 2; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HYPERTROPHY; IMMUNOBLOTTING; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; ANIMAL; CELL CULTURE; CYTOLOGY; GENETICS; HEART VENTRICLE; METABOLISM; PATHOLOGY; PHYSIOLOGY; WISTAR RAT;

ADENOVIRIDAE; RATTUS;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELLS, CULTURED; HEART VENTRICLES; HYPERTROPHY; MALE; MYOCYTES, CARDIAC; PROTEIN ISOFORMS; RATS; RATS, WISTAR; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 67649378995     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21805     Document Type: Article

References (42)

1. Aries A, Paradis P, Lefebvre C, Schwartz RJ, Nemer M. 2004. Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity. Proc Natl Acad Sci USA 101:6975-6980.
2. Arimura T, Helbling-Leclerc A, Massart C, Varnous S, Niel F, Lacéne E, Fromes Y, Toussaint M, Mura AM, Keller DI, Amthor H, Isnard R, Malissen M, Schwartz K, Bonne G. 2005. Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies. Hum Mol Genet 14:155-169.
3. Atfi A, Buisine M, Mazars A, Gespach C. 1997. Induction of apoptosis by DPC4, a transcriptional factor regulated by transforming growth factor-beta through stressactivated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling pathway. J Biol Chem 272:24731-24734.
4. Biasi F, Vizio B, Mascia C, Gaia E, Zarkovic N, Chiarpotto E, Leonarduzzi G, Poli G. 2006. c-JunN-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-beta1 and 4-hydroxynonenal in colon mucosa. Free Radic Biol Med 41:443-454.
5. Brown CO III, Chi X, Garcia-Gras E, Shirai M, Feng XH, Schwartz RJ. 2004. The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem 279:10659-10669.
6. Dai JL, Bansal RK, Kern SE. 1999. G1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation. Proc Natl Acad Sci USA 96:1427-1432.
7. de Boer RA, Pokharel S, Flesch M, van Kampen DA, Suurmeijer AJ, Boomsma F, van Gilst WH, van Veldhuisen DJ, Pinto YM. 2004. Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27. J Mol Med 82:678-687.
8. Derynck R, Zhang Y, Feng XH. 1998. Smads: Transcriptional activators of TGF-beta responses. Cell 95:737-740.
9. Dixon IM, Hao J, Reid NL, Roth JC. 2000. Effect of chronic AT(1) receptor blockade on cardiac Smad overexpression in hereditary cardiomyopathic hamsters. Cardiovasc Res 46:286-297.
10. Euler-Taimor G, Heger J. 2006. The complex pattern ofSMADsignaling in the cardiovascular system. Cardiovasc Res 69:15-25.
11. Godfrey K. 1985. Statistics in practice. Comparing the means of several groups.NEngl J Med 313:1450-1456.
12. Hao J, Ju H, Zhao S, Junaid A, Scammell-La Fleur T, Dixon IM. 1999. Elevation of expression of Smads 2,3 and 4, decorin and TGF-beta in the chronic phase of myocardial infarct scar healing. J Mol Cell Cardiol 31:667-678.
13. Hao J,Wang B, Jones SC, Jassal DS,Dixon IM. 2000. Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Am J Physiol Heart Circ Physiol 279:H3020-H3030.
14. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. 1998. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 95:2509-2514.
15. Hirotani S, Otsu K, Nishida K, Higuchi Y, Morita T, Nakayama H, Yamaguchi O, Mano T, Matsumura Y, Ueno H, Tada M, Hori M. 2002. Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation 105:509-515.
16. Ikeuchi M, Tsutsui H, Shiomi T, Matsusaka H,Matsushima S,Wen J, Kubota T, Takeshita A. 2004. Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction. Cardiovasc Res 64:526-535.
17. Jang CW, Chen CH, Chen CC, Chen JY, Su YH, Chen RH. 2002. TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase. Nat Cell Biol 4:51-58.
18. Kon A, Vindevoghel L, Kouba DJ, Fujimura Y, Uitto J, Mauviel A. 1999. Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expression. Oncogene 18:1837-1844.
19. Lee KH, Evans S, Ruan TY, Lassar AB. 2004. SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer. Development 131:4709-4723.
20. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408.
21. Lopez-Rovira T, Chalaux E, Rosa JL, Bartrons R, Ventura F. 2000. Interaction and functional cooperation of NF-kappa B with Smads. Transcriptional regulation of the junB promoter. J Biol Chem 275:28937-28946.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
23. Massague J. 1998. TGF-beta signal transduction. Annu Rev Biochem 67:753-791.
24. Molkentin JD. 2000. The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. J Biol Chem 275:38949-38952.
25. Moustakas A, Souchelnytskyi S, Heldin CH. 2001. Smad regulation in TGF-beta signal transduction. J Cell Sci 114:4359-4369.
26. Pikkarainen S, Tokola H, Kerkela R, Ruskoaho H. 2004. GATA transcription factors in the developing and adult heart. Cardiovasc Res 63:196-207.
27. Pinson A, Schlüter KD, Zhou XJ, Schwartz P, Kessler-Icekson G, Piper HM. et al. 1993. Alpha- and beta-adrenergic stimulation of protein synthesis in cultured adult ventricular cardiomyocytes. J Mol Cell Cardiol 25:477-490.
28. Piper HM, Probst I, Schwartz P, Hutter FJ, Spieckermann PG. 1982. Culturing of calcium stable adult cardiac myocytes. J Mol Cell Cardiol 14:397-412.
29. Samuel W, Nagineni CN, Kutty RK, Parks WT, Gordon JS, Prouty SM, et al. 2002. Transforming growth factor-beta regulates stearoyl coenzyme A desaturase expression through a Smad signaling pathway. J Biol Chem 277:59-66.
30. Schäfer M, Pönicke K, Heinroth-Hoffmann I, Brodde OE, Piper HM, Schlüter KD. 2001. Beta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes. J Am Coll Cardiol 37:300-307.
31. Schneiders D, Heger J, Best P, Michael Piper H, Taimor G. 2005. SMAD proteins are involved in apoptosis induction in ventricular cardiomyocytes. Cardiovasc Res 67:87-96.
32. Shi Y, Massague J. 2003. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113:685-700.
33. Shi Y,Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP. 1998. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling. Cell 94:585-594.
34. Taimor G, Rakow A, Piper HM. 2001a. Transcription activator protein 1 (AP-1) mediates NO-induced apoptosis of adult cardiomyocytes. FASEB J 15:2518-2520.
35. Taimor G, Schluter K, Piper HM. 2001b. Hypertrophy-associated gene induction after betaadrenergic stimulation in adult cardiomyocytes. J Mol Cell Cardiol 33:503-511.
36. Taimor G, Schluter KD, Best P,Helmig S, Piper HM. 2004. Transcription activator protein 1 mediates alpha- but not beta-adrenergic hypertrophic growth responses in adult cardiomyocytes. Am J Physiol Heart Circ Physiol 286:H2369-H2375.
37. Verrecchia F, Vindevoghel L, Lechleider RJ, Uitto J, Roberts AB, Mauviel A. 2001. Smad3/ AP-1 interactions control transcriptional responses to TGF-beta in a promoter-specific manner. Oncogene 20:3332-3340.
38. Wang J, Xu N, Feng X, Hou N, Zhang J, Cheng X, Chen Y, Zhang Y,Yang X. 2005. Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ Res 97:821-828.
39. Watanabe H, deCaestecker MP, Yamada Y. 2001. Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5cells. J Biol Chem 276:14466-14473.
40. Xu L, Kang Y, Col S, Massague J. 2002. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell 10:271-282.
41. Yamamura Y, Hua X, Bergelson S, Lodish HF. 2000. Critical role of Smads and AP-1 complex in transforming growth factor-beta-dependent apoptosis. J Biol Chem 275:36295-36302.
42. Zhang Y, Feng X,We R, Derynck R. 1996. Receptor-associatedMad homologues synergize as effectors of the TGF-beta response. Nature 383:168-172.