-
1
-
-
67649310256
-
-
Available from
-
Available from: http://www.who.int/mental-health/management/depression/ definition/en/
-
-
-
-
2
-
-
41349100425
-
-
Mental Health Global Action Programme. Geneva: World Health Organization
-
Mental Health Global Action Programme. Close the gap, dare to care. Geneva: World Health Organization; 2002
-
(2002)
Close the Gap, Dare to Care
-
-
-
3
-
-
1842861600
-
Central monoamines and their role in major depression
-
DOI 10.1016/j.pnpbp.2003.11.018, PII S0278584603003233
-
Elhwuegi AS. Central monoamines and their role in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2004;28:435-451 (Pubitemid 38490755)
-
(2004)
Progress in Neuro-Psychopharmacology and Biological Psychiatry
, vol.28
, Issue.3
, pp. 435-451
-
-
Elhwuegi, A.S.1
-
4
-
-
0030754230
-
Antidepressants
-
Frazer A. Antidepressants. J Clin Psychiatr 1997;58:9-25
-
(1997)
J Clin Psychiatr
, vol.58
, pp. 9-25
-
-
Frazer, A.1
-
5
-
-
4644353199
-
The role of monoamines in the actions of established and «novel» antidepressant agents: A critical review
-
DOI 10.1016/j.ejphar.2004.07.038, PII S0014299904007472
-
Millan MJ. The role of monoamines in the actions of established and «novel» antidepressant agents: a critical review. Eur J Pharmacol 2004;500:371-384 (Pubitemid 39304021)
-
(2004)
European Journal of Pharmacology
, vol.500
, Issue.1 SPEC. ISS
, pp. 371-384
-
-
Millan, M.J.1
-
6
-
-
4444355123
-
2-adrenoceptors in antidepressant action: Recent findings from microdialysis studies
-
DOI 10.1016/j.pnpbp.2004.05.026, PII S0278584604000831
-
Invernizzi RW, Garattini S. Role of presynaptic α2-adrenoceptors in antidepressant action: recent findings from microdialysis studies. Prog Neuro Psychopharmacol Biol Psychiatry 2004;28:819-827 •• This review reports the multi-target strategies to improve the treatement of depression from the neuronal substrates to the development of drugs. (Pubitemid 39195273)
-
(2004)
Progress in Neuro-Psychopharmacology and Biological Psychiatry
, vol.28
, Issue.5
, pp. 819-827
-
-
Invernizzi, R.W.1
Garattini, S.2
-
7
-
-
52449098689
-
Recent development in the design of anti-depressive therapies: Targeting the serotonin transporter
-
Butler SG, Meegan MJ. Recent development in the design of anti-depressive therapies: targeting the serotonin transporter. Curr Med Chem 2008;15:1737-1761
-
(2008)
Curr Med Chem
, vol.15
, pp. 1737-1761
-
-
Butler, S.G.1
Meegan, M.J.2
-
8
-
-
31444441701
-
New approaches to antidepressant drug discovery: Beyond monoamines
-
DOI 10.1038/nrn1846, PII NRN1846
-
Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006;7:137-151 •• This review gives an excellent overview of the problems on the development of non-monoamine-based antidepressants, and of the most promising current strategies. (Pubitemid 43151600)
-
(2006)
Nature Reviews Neuroscience
, vol.7
, Issue.2
, pp. 137-151
-
-
Berton, O.1
Nestler, E.J.2
-
9
-
-
33645452696
-
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
-
Millan MJ. Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 2006;110:135-370
-
(2006)
Pharmacol Ther
, vol.110
, pp. 135-370
-
-
Millan, M.J.1
-
10
-
-
57749090403
-
Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: Novel concepts, new drugs
-
Millan MJ. Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs. Neurotherapeutics 2009;6:53-77
-
(2009)
Neurotherapeutics
, vol.6
, pp. 53-77
-
-
Millan, M.J.1
-
11
-
-
33745220505
-
Creating more effective antidepressants: Clues from the clinic
-
DOI 10.1016/j.drudis.2006.05.004, PII S135964460600170X
-
Rasmussen K. Creating more effective antidepressants: clues from the clinic. Drug Discov Today 2006;11:623-631 (Pubitemid 43912496)
-
(2006)
Drug Discovery Today
, vol.11
, Issue.13-14
, pp. 623-631
-
-
Rasmussen, K.1
-
12
-
-
2342459611
-
Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: Involvement of melatonin and serotonin receptors
-
Bourin M, Mocaer E, Porsolt R. Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors. J Psychiatry Neurosci 2004;29:126-133 (Pubitemid 38570217)
-
(2004)
Journal of Psychiatry and Neuroscience
, vol.29
, Issue.2
, pp. 126-133
-
-
Bourin, M.1
Mocaer, E.2
Porsolt, R.3
-
13
-
-
0031811285
-
Dopaminergic agents and stimulants as antidepressant augmentation strategies
-
Nierenberg AA, Dougherty D, Rosenbaum JF. Dopaminergic agents and stimulants as antidepressant augementation strategies. J Clin Psychiatry 1998;59(Suppl 5):60-63 (Pubitemid 28249108)
-
(1998)
Journal of Clinical Psychiatry
, vol.59
, Issue.SUPPL. 5
, pp. 60-64
-
-
Nierenberg, A.A.1
Dougherty, D.2
Rosenbaum, J.F.3
-
14
-
-
0030867369
-
The mesolimbic dopamine system as a target for rapid antidepressant action
-
DOI 10.1097/00004850-199705002-00003
-
Willner P. The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol 1997;12(Suppl 3):S7-14 (Pubitemid 27414585)
-
(1997)
International Clinical Psychopharmacology
, vol.12
, Issue.SUPPL. 3
-
-
Willner, P.1
-
15
-
-
61849083112
-
Future antidepressant targets: Neurotrophic factors and related signaling cascades
-
Schmidt HD, Banasr M, Duman RS. Future antidepressant targets: neurotrophic factors and related signaling cascades. Drug Discov Today Ther Strateg 2008;5:151-156
-
(2008)
Drug Discov Today Ther Strateg
, vol.5
, pp. 151-156
-
-
Schmidt, H.D.1
Banasr, M.2
Duman, R.S.3
-
16
-
-
67649315583
-
-
Available from
-
EPO searching engine. Available from: http://ep.espacenet.com/
-
EPO Searching Engine
-
-
-
17
-
-
67649315576
-
4-Arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of CNS disorders
-
WO2006106432
-
Nencetti S, Lapucci A. 4-Arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of CNS disorders. WO2006106432; 2006
-
(2006)
-
-
Nencetti, S.1
Lapucci, A.2
-
18
-
-
67649335009
-
Enantiomers of 2′-fluoralkyl-6-nitroquipazine as Serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics
-
WO2007127262
-
Gerdes JM, Bolstad DB. Enantiomers of 2′-fluoralkyl-6- nitroquipazine as Serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics. WO2007127262; 2007
-
(2007)
-
-
Gerdes, J.M.1
Bolstad, D.B.2
-
19
-
-
67649310257
-
Aralkyl-alcohol piperazine derivatives adn their uses as antgyepressant
-
Shanghai INST. Pharm. Industry. US2005267121
-
Shanghai INST. Pharm. Industry. Aralkyl-alcohol piperazine derivatives adn their uses as antgyepressant. US2005267121; 2005
-
(2005)
-
-
-
20
-
-
67649339572
-
New substituted 1-oxo-3,8-diazospiro(4.5)-decan-2-one compounds are 5-hydroxy tryptamine uptake receptor inhibitors, useful to treat and/or prevent e.g. pain, migraine, chronic paroxysomal hemicrania, depression and asthma
-
Gruenenthal GMBH. DE102005030051
-
Gruenenthal GMBH. New substituted 1-oxo-3,8-diazospiro(4.5)-decan-2-one compounds are 5-hydroxy tryptamine uptake receptor inhibitors, useful to treat and/or prevent e.g. pain, migraine, chronic paroxysomal hemicrania, depression and asthma. DE102005030051; 2006
-
(2006)
-
-
-
21
-
-
67649335008
-
2-(1H-indolylsulfanyl)-benzyl amine derivative
-
Lundbeck & Co As. P2007277254
-
Lundbeck & Co As. 2-(1H-indolylsulfanyl)-benzyl amine derivative. P2007277254; 2007
-
(2007)
-
-
-
22
-
-
67649335010
-
3-Aryloxy 3-Substituted Propanamines
-
Natco Pharma Ltd. WO2008081477
-
Natco Pharma Ltd. 3-Aryloxy 3-Substituted Propanamines. WO2008081477; 2008
-
(2008)
-
-
-
23
-
-
0342894667
-
Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment
-
DOI 10.1016/S0140-6736(96)08007-5
-
Perez V, Gilaberte I, Faries D, et al. Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment. Lancet 1997;349:1594-1597 (Pubitemid 27229140)
-
(1997)
Lancet
, vol.349
, Issue.9065
, pp. 1594-1597
-
-
Perez, V.1
Gilaberte, I.2
Faries, D.3
Alvarez, E.4
Artigas, F.5
-
24
-
-
67649307937
-
Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxan methylamines
-
Wyeth Corp. KR20050061470
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxan methylamines. KR20050061470; 2005
-
(2005)
-
-
-
25
-
-
67649335001
-
Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. KR20050042192
-
Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. KR20050042192; 2005
-
(2005)
-
-
-
26
-
-
67649335001
-
Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. KR20050042187
-
Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. KR20050042187; 2005
-
(2005)
-
-
-
27
-
-
67649345210
-
Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
-
Wyeth Corp. KR20050042176
-
Wyeth Corp. Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines. KR20050042176; 2005
-
(2005)
-
-
-
28
-
-
67649335001
-
Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. MXPA05002743
-
Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. MXPA05002743; 2005
-
(2005)
-
-
-
29
-
-
67649347438
-
Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
-
Wyeth Corp. MXPA05002740
-
Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan. MXPA05002740; 2005
-
(2005)
-
-
-
30
-
-
67649319956
-
Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9- dioxa-3-azacyclopenta[a]naphtalene
-
Wyeth Corp. MXPA03009829
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-dioxa-3-azacyclopenta[a]naphtalene. MXPA03009829; 2005
-
(2005)
-
-
-
31
-
-
67649345213
-
Antidepressant (SSRI) azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1, 3-diazacyclopenta[a]naphtalene
-
Wyeth Corp. MXPA03009828
-
Wyeth Corp. Antidepressant (SSRI) azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1, 3-diazacyclopenta[a]naphtalene. MXPA03009828; 2005
-
(2005)
-
-
-
32
-
-
67649356432
-
Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4- dioxino[2,3-f ]quinaxoline
-
Wyeth Corp. MXPA03009826
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f ]quinaxoline. MXPA03009826; 2005
-
(2005)
-
-
-
33
-
-
67649307937
-
Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused- [1,4]-benzodioxans
-
Wyeth Corp. MXPA03009825
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans. MXPA03009825; 2005
-
(2005)
-
-
-
34
-
-
67649347438
-
Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4- benzodioxans
-
Wyeth Corp. EP1537103
-
Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxans. EP1537103; 2005
-
(2005)
-
-
-
35
-
-
67649302604
-
Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole
-
Wyeth Corp. WO02088146
-
Wyeth Corp. Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole. WO02088146; 2005
-
(2005)
-
-
-
36
-
-
67649332676
-
Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa- 1-aza-phenanthrene
-
Wyeth Corp. US2005228010
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene. US2005228010; 2005
-
(2005)
-
-
-
37
-
-
67649368787
-
Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa- phenanthrene
-
Wyeth Corp. US2005004209
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene. US2005004209; 2005
-
(2005)
-
-
-
38
-
-
67649302597
-
Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. ZA200502043
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. ZA200502043; 2006
-
(2006)
-
-
-
39
-
-
67649351461
-
Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. ZA200502047
-
Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. ZA200502047; 2006
-
(2006)
-
-
-
40
-
-
67649351461
-
Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. ZA200502042
-
Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. ZA200502042; 2006
-
(2006)
-
-
-
41
-
-
67649319957
-
Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines
-
Wyeth Corp. ZA200502040
-
Wyeth Corp. Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines. ZA200502040; 2006
-
(2006)
-
-
-
42
-
-
67649302597
-
Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. US2006293301
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. US2006293301; 2006
-
(2006)
-
-
-
43
-
-
67649351461
-
Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. US2006276481
-
Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. US2006276481; 2006
-
(2006)
-
-
-
44
-
-
67649351461
-
Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. NZ539253
-
Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. NZ539253; 2006
-
(2006)
-
-
-
45
-
-
67649324150
-
Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
-
Wyeth Corp. US2006160881
-
Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan. US2006160881; 2006
-
(2006)
-
-
-
46
-
-
67649375849
-
Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. US2007004702
-
Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. US2007004702; 2007
-
(2007)
-
-
-
47
-
-
67649302598
-
Antidepressant heteroaryl derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. WO2008150848
-
Wyeth Corp. Antidepressant heteroaryl derivatives of heterocycle-fused benzodioxans. WO2008150848; 2008
-
(2008)
-
-
-
48
-
-
67649345214
-
Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines
-
Wyeth Corp. CN101143867
-
Wyeth Corp. Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines. CN101143867; 2008
-
(2008)
-
-
-
49
-
-
67649302598
-
Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. CN101239953
-
Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. CN101239953; 2008
-
(2008)
-
-
-
50
-
-
67649302598
-
Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
-
Wyeth Corp. CN101230066
-
Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. CN101230066; 2008
-
(2008)
-
-
-
51
-
-
0027337616
-
3H]5-HT uptake: Effect of administration of various antidepressant treatments
-
DOI 10.1016/0028-3908(93)90181-2
-
Cheetham SC, Viggers JA, Slater NA, et al. [3H]Paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments. Neuropharmacology 1993;32:737-743 (Pubitemid 23227658)
-
(1993)
Neuropharmacology
, vol.32
, Issue.8
, pp. 737-743
-
-
Cheetham, S.C.1
Viggers, J.A.2
Slater, N.A.3
Heal, D.J.4
Buckett, W.R.5
-
52
-
-
0021892571
-
3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to pre- And postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain
-
DOI 10.1111/j.1471-4159.1985.tb07155.x
-
Hall MD, El Mestikawy S, Emerit MB, et al. [3H]8-Hydroxy-2-(di-n- propylamino) tetraline binding to pre- and postsynaptic 5-Hydroxytryptamine sites in various regions of the rat brain. J Neurochem 1985;44:1685-1696 (Pubitemid 15000270)
-
(1985)
Journal of Neurochemistry
, vol.44
, Issue.6
, pp. 1685-1696
-
-
Hall, M.D.1
El Mestikawy, S.2
Emerit, M.B.3
-
53
-
-
67649318787
-
Derivatives of pyridinalkyl-amonoalkyl-1h-indole inhibiting receptors 5-ht and recapture of serotonin which can be used as antidepressant and anxiolitic
-
Merck Patent GmbH. KR20050085038
-
Merck Patent GmbH. Derivatives of pyridinalkyl-amonoalkyl-1h-indole inhibiting receptors 5-ht and recapture of serotonin which can be used as antidepressant and anxiolitic. KR20050085038; 2005
-
(2005)
-
-
-
54
-
-
67649328948
-
Benzofuran oxyethylamines serving as antidepressant drugs and anxiolytic drugs
-
Merck Patent GmbH. PL377618
-
Merck Patent GmbH. Benzofuran oxyethylamines serving as antidepressant drugs and anxiolytic drugs. PL377618; 2006
-
(2006)
-
-
-
55
-
-
67649328956
-
Indole derivatives as serotonin reuptake inhibitors
-
Merck Patent GmbH. MXPA05013538
-
Merck Patent GmbH. Indole derivatives as serotonin reuptake inhibitors. MXPA05013538; 2006
-
(2006)
-
-
-
56
-
-
67649324155
-
4-Aminopiperidine derivatives, processes for their preparation and their use as medicaments
-
UCB SA. MXPA05003290
-
UCB SA. 4-Aminopiperidine derivatives, processes for their preparation and their use as medicaments. MXPA05003290; 2005
-
(2005)
-
-
-
57
-
-
67649339569
-
Use of 4-aminoderivatives for the preparation of a medicament for treating neurological diseases
-
UCB SA. EP1693061
-
UCB SA. Use of 4-aminoderivatives for the preparation of a medicament for treating neurological diseases. EP1693061; 2006
-
(2006)
-
-
-
58
-
-
0029670162
-
5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo
-
Ge JA, Barnes NM. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. Br J Pharmacol 1996;117:1475-1480 (Pubitemid 3040750)
-
(1996)
British Journal of Pharmacology
, vol.117
, Issue.7
, pp. 1475-1480
-
-
Ge, J.1
Barnes, N.M.2
-
59
-
-
0036025214
-
4 receptors exert a frequency-related facilitatory control on dorsal raphe nucleus 5-HT neuronal activity
-
DOI 10.1046/j.1460-9568.2002.02150.x
-
Lucas G, Debonnel G. 5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphe nucleus 5-HT neuronal activity. Eur J Neurosci 2002;16:817-822 (Pubitemid 35463573)
-
(2002)
European Journal of Neuroscience
, vol.16
, Issue.5
, pp. 817-822
-
-
Lucas, G.1
Debonnel, G.2
-
60
-
-
16844371069
-
4 agonists
-
DOI 10.1016/j.biopsych.2004.12.023
-
Lucas G, Compan V, Charnay Y, et al. Frontocortical 5-HT4 receptors exert positive feedback on serotonergic activity: viral transfections, subacute and chronic treatments with 5-HT4 agonists. Biol Psychiatry 2005;57:918-925 (Pubitemid 40488361)
-
(2005)
Biological Psychiatry
, vol.57
, Issue.8
, pp. 918-925
-
-
Lucas, G.1
Compan, V.2
Charnay, Y.3
Neve, R.L.4
Nestler, E.J.5
Bockaert, J.6
Barrot, M.7
Debonnel, G.8
-
61
-
-
34548246547
-
Serotonin(4) (5-HT4) receptor agonists are putative antidepressants with a rapid onset of action
-
Lucas G, Rymar VV, Du J, et al. Serotonin(4) (5-HT4) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 2007;55:712-725
-
(2007)
Neuron
, vol.55
, pp. 712-725
-
-
Lucas, G.1
Rymar, V.V.2
Du, J.3
-
62
-
-
67649356433
-
Stimulators of 5-ht4 receptors and uses thereof
-
WO2006029520
-
Debonnel G, Lucas G. Stimulators of 5-ht4 receptors and uses thereof. WO2006029520; 2006
-
(2006)
-
-
Debonnel, G.1
Lucas, G.2
-
63
-
-
67649328956
-
Indole derivatives as serotonin reuptake inhibitors
-
US2006160824
-
Heinrich T, Bottcher H. Indole derivatives as serotonin reuptake inhibitors. US2006160824; 2006
-
(2006)
-
-
Heinrich, T.1
Bottcher, H.2
-
64
-
-
67649310252
-
Serotonin reuptake inhibitors
-
WO2005094896
-
Pinney KG, Miranda MG. Serotonin reuptake inhibitors. WO2005094896; 2005
-
(2005)
-
-
Pinney, K.G.1
Miranda, M.G.2
-
65
-
-
67649356434
-
Serotonin reuptake inhibitors
-
US2008132514
-
Pinney KG, Miranda MG. Serotonin reuptake inhibitors. US2008132514; 2008
-
(2008)
-
-
Pinney, K.G.1
Miranda, M.G.2
-
66
-
-
67649328950
-
C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants
-
Janssen Pharmaceutica. US2005256119
-
Janssen Pharmaceutica. C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants. US2005256119; 2005
-
(2005)
-
-
-
67
-
-
67649335007
-
Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor
-
Alpha 2 Pharmaceutical. WO2006083204
-
Alpha 2 Pharmaceutical. Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor. WO2006083204; 2006
-
(2006)
-
-
-
68
-
-
67649384294
-
Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor
-
Alpha 2 Pharmaceutical. US2008269306
-
Alpha 2 Pharmaceutical. Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor. US2008269306; 2008
-
(2008)
-
-
-
69
-
-
0032771114
-
Neurochemical brain imaging investigations of schizophrenia
-
DOI 10.1016/S0006-3223(99)00015-3, PII S0006322399000153
-
Soares JC, Innis RB. Neurochemical brain imaging investigations of schizophrenia. Biol Psychiatry 1999;46:600-615 (Pubitemid 29401858)
-
(1999)
Biological Psychiatry
, vol.46
, Issue.5
, pp. 600-615
-
-
Soares, J.C.1
Innis, R.B.2
-
70
-
-
67649345216
-
Combination therapy for treatment of psychoses
-
Lilly Co. Eli. EP830864
-
Lilly Co. Eli. Combination therapy for treatment of psychoses. EP830864; 1997
-
(1997)
-
-
-
71
-
-
0035058871
-
1a agonist
-
DOI 10.1358/dof.2001.026.02.608830
-
Feenstra R, Ronken E, Koopman T, et al. SLV308. antiparkinsonian, antidepressant, anxiolytic, dopamine D2 partial agonist, 5-HT1A agonist. Drugs Future 2001;26:128-132 (Pubitemid 32367072)
-
(2001)
Drugs of the Future
, vol.26
, Issue.2
, pp. 128-132
-
-
Feenstra, R.1
Ronken, E.2
Koopman, T.3
De Vries, M.4
McCreary, A.5
Stoker, M.6
Van Charldorp, K.7
Long, S.8
Van Scharrenburg, G.9
-
72
-
-
67649335003
-
New phenylpiperazines useful for treating central nervous system disorders caused by dopaminergic or serotonergic systems
-
Solvay Pharmaceuticals BV. NZ523135
-
Solvay Pharmaceuticals BV. New phenylpiperazines useful for treating central nervous system disorders caused by dopaminergic or serotonergic systems. NZ523135; 2005
-
(2005)
-
-
-
73
-
-
67649335002
-
Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
-
Solvay Pharmaceuticals BV. US2006122189, US2006122190, US2006247256
-
Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. US2006122189, US2006122190, US2006247256; 2006
-
(2006)
-
-
-
74
-
-
67649302599
-
Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
-
Solvay Pharmaceuticals BV. US2006122175, CA2587940
-
Solvay Pharmaceuticals BV. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. US2006122175, CA2587940; 2006
-
(2006)
-
-
-
75
-
-
67649318783
-
Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptakesites
-
Solvay Pharmaceuticals BV. US2006122177. CA2587928
-
Solvay Pharmaceuticals BV. Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptakesites. US2006122177. CA2587928; 2006
-
(2006)
-
-
-
76
-
-
67649326709
-
Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
-
Solvay Pharmaceuticals BV. US2006122206, CA2587936
-
Solvay Pharmaceuticals BV. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. US2006122206, CA2587936; 2006
-
(2006)
-
-
-
77
-
-
67649335002
-
Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
-
Solvay Pharmaceuticals BV. US2006122247
-
Solvay Pharmaceuticals BV. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. US2006122247; 2006
-
(2006)
-
-
-
78
-
-
67649375853
-
Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
-
Solvay Pharmaceuticals BV. EP1824479, EP1824480, EP1827426, EP1828161, MX2007006818
-
Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. EP1824479, EP1824480, EP1827426, EP1828161, MX2007006818; 2007
-
(2007)
-
-
-
79
-
-
67649328947
-
Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
-
Solvay Pharmaceuticals BV. EP1824486, MX2007006758
-
Solvay Pharmaceuticals BV. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. EP1824486, MX2007006758; 2007
-
(2007)
-
-
-
80
-
-
67649307938
-
Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
-
Solvay Pharmaceuticals BV. EP1828168, MX2007006757
-
Solvay Pharmaceuticals BV. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. EP1828168, MX2007006757; 2007
-
(2007)
-
-
-
81
-
-
67649318786
-
8-{4-[3-(5-fluoro-1H-indol-3-YLl)-propyl]- Piperazin-1-YL-2-methyl-4H- benzo[1,4]. oxazin-3-one mesylate with high affinity for the dopamine D2 receptor and the serotonin reuptake site
-
Solvay Pharmaceuticals BV. AU2002250983
-
Solvay Pharmaceuticals BV. 8-{4-[3-(5-fluoro-1H-indol-3-YLl)-propyl]- piperazin-1-YL)-2-methyl-4H-benzo[1,4]. oxazin-3-one mesylate with high affinity for the dopamine D2 receptor and the serotonin reuptake site. AU2002250983; 2006
-
(2006)
-
-
-
82
-
-
67649384299
-
Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
-
Solvay Pharmaceuticals BV. SI1827427
-
Solvay Pharmaceuticals BV. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. SI1827427; 2008
-
(2008)
-
-
-
83
-
-
67649328947
-
Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
-
Solvay Pharmaceuticals BV. MX2007006756
-
Solvay Pharmaceuticals BV. Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. MX2007006756; 2007
-
(2007)
-
-
-
84
-
-
67649328951
-
Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
-
Solvay Pharmaceuticals BV. HR20090015
-
Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. HR20090015; 2009
-
(2009)
-
-
-
86
-
-
67649351463
-
-
Yaksh TL, Lynch C, Zapol W, et al. Philadelphia: Lippincott-Raven
-
Sindrup J. Anesthesia: Biological foundations. In: Yaksh TL, Lynch C, Zapol W, et al. Philadelphia: Lippincott-Raven; 1997
-
(1997)
Anesthesia: Biological Foundations
-
-
Sindrup, J.1
-
87
-
-
67649339566
-
C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorder
-
Gruenenthal GmbH. US2006258741
-
Gruenenthal GmbH. C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorder. US2006258741; 2006
-
(2006)
-
-
-
88
-
-
0034192260
-
The troubled story of tachykinins and neurokinins
-
DOI 10.1016/S0165-6147(00)01463-2, PII S0165614700014632
-
Maggi CA. The troubled story of tachykinins and neurokinins. Trends Pharmacol Sci 2000;21:173-175 (Pubitemid 30243198)
-
(2000)
Trends in Pharmacological Sciences
, vol.21
, Issue.5
, pp. 173-175
-
-
Maggi, C.A.1
-
89
-
-
18244364895
-
1 antagonists-serotonin reuptake inhibitors: Synthesis and SAR of a new class of potential antidepressants
-
DOI 10.1016/S0960-894X(01)00727-2, PII S0960894X01007272
-
Ryckmans T, Balançon L, Berton O, et al. First dual NK1 antagonists serotonin reuptake inhibitors: synthesis and SAR of a new class off potential antidepressants. Bioorg Med Chem Lett 2002;12:261-264 (Pubitemid 34037980)
-
(2002)
Bioorganic and Medicinal Chemistry Letters
, vol.12
, Issue.2
, pp. 261-264
-
-
Ryckmans, T.1
Balancon, L.2
Berton, O.3
Genicot, C.4
Lamberty, Y.5
Lallemand, B.6
Pasau, P.7
Pirlot, N.8
Quere, L.9
Talaga, P.10
-
90
-
-
67649384295
-
Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists
-
Servier Lab. EP1710240
-
Servier Lab. Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists. EP1710240; 2006
-
(2006)
-
-
-
91
-
-
67649347437
-
Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them
-
Sanofi Aventis. EP1707564
-
Sanofi Aventis. Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them. EP1707564; 2006
-
(2006)
-
-
-
92
-
-
0026508416
-
A potent and selective non-peptide antagonist of the neurokinin a (NH2) receptor
-
Edmonds-Alt X, Vilain P, Goulaouic P, et al. A potent and selective non-peptide antagonist of the neurokinin a (NH2) receptor. Life Sci 1992;50:PL101-6
-
(1992)
Life Sci
, vol.50
-
-
Edmonds-Alt, X.1
Vilain, P.2
Goulaouic, P.3
-
93
-
-
67649328955
-
Composition useful to treat e.g. anxiety disorder comprises (S)-(-)-N-(4-(4-acetamido-4-phenyl- 1-piperidyl)-2-(3, 4-dichlorophenyl) butyl)-N-methylbenzamide, (+/-)-N-methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy) -propan- 1-amine
-
Sanofi Aventis. FR2904221
-
Sanofi Aventis. Composition useful to treat e.g. anxiety disorder comprises (S)-(-)-N-(4-(4-acetamido-4-phenyl- 1-piperidyl)-2-(3, 4-dichlorophenyl) butyl)-N-methylbenzamide, (+/-)-N-methyl-3-phenyl-3-(4- (trifluoromethyl)phenoxy)-propan- 1-amine. FR2904221; 2008
-
(2008)
-
-
-
94
-
-
23144460515
-
Recent developments in cannabinoid ligands
-
DOI 10.1016/j.lfs.2005.05.020, PII S0024320505005084, Yargeted Lipidomics: Endocannabinoids and other Endolipid Modulators
-
Padgett LW. Recent developments in cannabinoid ligands. Life Sci 2005;77:1767-1798 (Pubitemid 41078745)
-
(2005)
Life Sciences
, vol.77
, Issue.14
, pp. 1767-1798
-
-
Padgett, L.W.1
-
95
-
-
21044458324
-
Current knowledge on the antagonists and inverse agonists of cannabinoid receptors
-
DOI 10.2174/0929867054020891
-
Muccioli GG, Lambert DM. Current knowledge on the antagonists and inverse agonists of cannabinoid receptors. Curr Med Chem 2005;12:1361-1394 (Pubitemid 40872582)
-
(2005)
Current Medicinal Chemistry
, vol.12
, Issue.12
, pp. 1361-1394
-
-
Muccioli, G.G.1
Lambert, D.M.2
-
96
-
-
23444432920
-
The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
-
DOI 10.1021/jm058183t
-
Lambert DM, Fowler CJ. The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 2005;48:5059-5087 (Pubitemid 41113892)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.16
, pp. 5059-5087
-
-
Lambert, D.M.1
Fowler, C.J.2
-
97
-
-
20444379218
-
Endocannabinoid system and stress and anxiety responses
-
DOI 10.1016/j.pbb.2005.01.029, PII S0091305705001346
-
Viveros MP, Marco EM, File SE. Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav 2005;81:331-342 (Pubitemid 40807131)
-
(2005)
Pharmacology Biochemistry and Behavior
, vol.81
, Issue.2 SPEC. ISS
, pp. 331-342
-
-
Viveros, M.P.1
Marco, E.M.2
File, S.E.3
-
98
-
-
67649345217
-
Compounds with a combination of cannabinoid cb1 antagonism and serotonin reuptake inhibition
-
Solvay Pharmaceuticals BV. US2008214559, WO2008084057
-
Solvay Pharmaceuticals BV. Compounds with a combination of cannabinoid cb1 antagonism and serotonin reuptake inhibition. US2008214559, WO2008084057; 2008
-
(2008)
-
-
-
99
-
-
0030961840
-
5-HT receptor classification and nomenclature: Towards a harmonization with the human genome
-
DOI 10.1016/S0028-3908(97)00036-1, PII S0028390897000361
-
Hoyer D, Martin G. 5-HT receptor classification and nomenclature: towards a harmonization with the human genome. Neuropharmacology 1997;36:419-428 (Pubitemid 27272086)
-
(1997)
Neuropharmacology
, vol.36
, Issue.4-5
, pp. 419-428
-
-
Hoyer, D.1
Martin, G.2
-
100
-
-
67649351462
-
Composition containing 5-HT1A and 5-HTID antagonists
-
SmithKline Beecham PLC, WO9531988
-
SmithKline Beecham PLC, Jones BJ, Routledge C. Composition containing 5-HT1A and 5-HTID antagonists. WO9531988; 1995
-
(1995)
-
-
Jones, B.J.1
Routledge, C.2
-
101
-
-
0029671030
-
Serotonin 5-HT1d and 5-HT1a receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro
-
Maura G. Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate and inhibition of cyclic GMP production in rat cerebellum in vitro. J Neurochem 1996;66:203-209 (Pubitemid 3015803)
-
(1996)
Journal of Neurochemistry
, vol.66
, Issue.1
, pp. 203-209
-
-
Maura, G.1
Raiteri, M.2
-
102
-
-
67649315578
-
5HT1 antagonists for antidepressant therapy
-
Pfizer Prod., Inc. OA11742
-
Pfizer Prod., Inc. 5HT1 antagonists for antidepressant therapy. OA11742; 2005
-
(2005)
-
-
-
103
-
-
67649356435
-
New 3-oxo-1-propenyl azo compounds useful as 5-HT receptor antagonists e.g. for treating psychoses, neurological disorders, amyotrophic lateral sclerosis and eating disorders
-
Merck Patent GmbH. DE10360151
-
Merck Patent GmbH. New 3-oxo-1-propenyl azo compounds useful as 5-HT receptor antagonists e.g. for treating psychoses, neurological disorders, amyotrophic lateral sclerosis and eating disorders. DE10360151; 2005
-
(2005)
-
-
-
104
-
-
67649332671
-
New quinolonyl- or benzopyranonyl-substituted indole derivatives are 5HT(1A)- and/or 5HT(1D)-agonists useful e.g. as anxiolytic, antidepressant, neuroleptic and/or antihypertensive agents
-
Merck Patent GmbH. DE10353657
-
Merck Patent GmbH. New quinolonyl- or benzopyranonyl-substituted indole derivatives are 5HT(1A)- and/or 5HT(1D)-agonists useful e.g. as anxiolytic, antidepressant, neuroleptic and/or antihypertensive agents. DE10353657; 2005
-
(2005)
-
-
-
105
-
-
67649324156
-
New tetrahydroisoquinoline substituted sulfonamide compounds useful as 5-HT7 receptor antagonist in the treatment of e.g. central nervous system disorders
-
Esteve Labor Dr. ES2257168
-
Esteve Labor Dr. New tetrahydroisoquinoline substituted sulfonamide compounds useful as 5-HT7 receptor antagonist in the treatment of e.g. central nervous system disorders. ES2257168; 2006
-
(2006)
-
-
-
106
-
-
67649345218
-
New dihydro-1H-isoquinoline compounds are 5-hydroxytryptamine-7 inhibitors useful for the treatment of e.g. sleep disorder, shift worker syndrome, depression, migraine, anxiety, psychosis, schizophrenia and pain
-
Esteve Labor Dr. ES2257167
-
Esteve Labor Dr. New dihydro-1H-isoquinoline compounds are 5-hydroxytryptamine-7 inhibitors useful for the treatment of e.g. sleep disorder, shift worker syndrome, depression, migraine, anxiety, psychosis, schizophrenia and pain. ES2257167; 2006
-
(2006)
-
-
-
107
-
-
0000553358
-
The 5HT7 receptor: A target for novel therapeutic avenues?
-
Terrón JA. The 5HT7 receptor: a target for novel therapeutic avenues? IDrugs 1998;1:302-310
-
(1998)
IDrugs
, vol.1
, pp. 302-310
-
-
Terrón, J.A.1
-
108
-
-
0027368668
-
7) implicated in the regulation of mammalian circadian rhythms
-
DOI 10.1016/0896-6273(93)90149-L
-
Lovenberg TW, Baron BM, de Lecea L, et al. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of circadian rhythms. Neuron 1993;11:449-458 (Pubitemid 23287072)
-
(1993)
Neuron
, vol.11
, Issue.3
, pp. 449-458
-
-
Lovenberg, T.W.1
Baron, B.M.2
De Lecea, L.3
Miller, J.D.4
Prosser, R.A.5
Rea, M.A.6
Foye, P.E.7
Racke, M.8
Slone, A.L.9
Siegel, B.W.10
Danielson, P.E.11
Sutcliffe, J.G.12
Erlander, M.G.13
-
109
-
-
67649315581
-
-
Esteve Labor Dr. ES2274725
-
Esteve Labor Dr. New indene derivatives useful for treating e.g. obesity, bulimia, anorexia, cachexia, diabetes, anxiety, panic attacks, depression and bipolar disorders. ES2274725; 2007
-
(2007)
New Indene Derivatives Useful for Treating E.g. Obesity, Bulimia, Anorexia, Cachexia, Diabetes, Anxiety, Panic Attacks, Depression and Bipolar Disorders.
-
-
-
110
-
-
0032445751
-
Central distribution and function of 5-HT(6) receptor subtype in the rat brain
-
Yoshioka M, Matsumoto M, Togashi H, et al. Central distribution and function of 5-HT(6) receptor subtype in the rat brain. Ann NY Acad Sci 1998;861:244
-
(1998)
Ann NY Acad Sci
, vol.861
, pp. 244
-
-
Yoshioka, M.1
Matsumoto, M.2
Togashi, H.3
-
111
-
-
0031593618
-
6 receptors in nigro-striatal function in rodents
-
Bourson A, Boess FG, Bos M, et al. Involvement of 5-HT6 receptors in nigro-striatal function in rodents. Br J Pharmacol 1998;125:1562-1566 (Pubitemid 28548569)
-
(1998)
British Journal of Pharmacology
, vol.125
, Issue.7
, pp. 1562-1566
-
-
Bourson, A.1
Boess, F.G.2
Bos, M.3
Sleight, A.J.4
-
112
-
-
0002628683
-
Cognitive enhancement effects of the selective 5-HT6 antagonist SB-271046
-
Rogers DC, Robinson TL, Quilter CA, et al. Cognitive enhancement effects of the selective 5-HT6 antagonist SB-271046. Br J Pharmacol Suppl S 1999;127:22P
-
(1999)
Br J Pharmacol Suppl S
, vol.127
-
-
Rogers, D.C.1
Robinson, T.L.2
Quilter, C.A.3
-
114
-
-
0033854822
-
6 receptor antagonist
-
Routledge C, Bromidge SM, Moss SF, et al. Characterization of SB-271046: A potent, selective and orally active 5-HT6 receptor antagonist. Br J Pharmacol 2000;130:1606-1612 (Pubitemid 30611938)
-
(2000)
British Journal of Pharmacology
, vol.130
, Issue.7
, pp. 1606-1612
-
-
Routledge, C.1
Bromidge, S.M.2
Moss, S.F.3
Price, G.W.4
Hirst, W.5
Newman, H.6
Riley, G.7
Gager, T.8
Stean, T.9
Upton, N.10
Clarke, S.E.11
Brown, A.M.12
Middlemiss, D.N.13
-
115
-
-
0028261434
-
Binding of typical and atypical antipsychotic agents to 5- Hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
-
Roth BL, Craigo SC, Choudhary MS, et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J Pharmacol Exp Ther 1994;268:1403-1410 (Pubitemid 24100360)
-
(1994)
Journal of Pharmacology and Experimental Therapeutics
, vol.268
, Issue.3
, pp. 1403-1410
-
-
Roth, B.L.1
Craigo, S.C.2
Choudhary, M.S.3
Uluer, A.4
Monsma Jr., F.J.5
Shen, Y.6
Meltzer, H.Y.7
Sibley, D.R.8
-
116
-
-
0029295914
-
Clozapine - Selective labeling of sites resembling 5ht(6) serotonin receptors may reflect psychoactive profile
-
Glatt CE, Snowman AM, Sibley DR, et al. Clozapine - selective labeling of sites resembling 5ht(6) serotonin receptors may reflect psychoactive profile. Mol Med 1995;1:398-406
-
(1995)
Mol Med
, vol.1
, pp. 398-406
-
-
Glatt, C.E.1
Snowman, A.M.2
Sibley, D.R.3
-
117
-
-
0027481384
-
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
-
Monsma FJ, Shen Y, Ward RP, et al. Cloning and expression of a novel serotonin receptor with high-affinity for tricyclic psychotropic-drugs. Mol Pharmacol 1993;43:320-327 (Pubitemid 23081986)
-
(1993)
Molecular Pharmacology
, vol.43
, Issue.3
, pp. 320-327
-
-
Monsma Jr., F.J.1
Shen, Y.2
Ward, R.P.3
Hamblin, M.W.4
Sibley, D.R.5
-
118
-
-
0033574643
-
6 receptor gene in schizophrenia
-
DOI 10.1002/(SICI)1096-8628(19990416)88:2<120::AID-AJMG4>3.0.CO;2-Y
-
Shinkai T, Ohmori O, Kojima H, et al. et al. Association study of the 5-HT6 receptor gene in schizophrenia. Am J Med Genet 1999;88:120-122 (Pubitemid 29156446)
-
(1999)
American Journal of Medical Genetics - Neuropsychiatric Genetics
, vol.88
, Issue.2
, pp. 120-122
-
-
Shinkai, T.1
Ohmori, O.2
Kojima, H.3
Terao, T.4
Suzuki, T.5
Abe, K.6
-
119
-
-
67649384296
-
Pyridine derivatives of alkyloxindoles as 5-HT7 receptor active agents
-
Egis Gyogyszergyar Nyilvanosan. HU0500462
-
Egis Gyogyszergyar Nyilvanosan. Pyridine derivatives of alkyloxindoles as 5-HT7 receptor active agents. HU0500462; 2007
-
(2007)
-
-
-
120
-
-
67649339568
-
Pyperazine derivatives of alkyl-oxindoles
-
Egis Gyogyszergyar Nyilvanosan. HU0500461
-
Egis Gyogyszergyar Nyilvanosan. Pyperazine derivatives of alkyl-oxindoles. HU0500461; 2007
-
(2007)
-
-
-
121
-
-
67649368788
-
Pyridine derivatives of dialkyl-oxindoles
-
Egis Gyogyszergyar Nyilvanosan. HU0500463
-
Egis Gyogyszergyar Nyilvanosan. Pyridine derivatives of dialkyl-oxindoles. HU0500463; 2007
-
(2007)
-
-
-
122
-
-
67649368788
-
Piperazine derivatives of dialkyl-oxindoles
-
Egis Gyogyszergyar Nyilvanosan. HU0500464
-
Egis Gyogyszergyar Nyilvanosan. Piperazine derivatives of dialkyl-oxindoles. HU0500464; 2007
-
(2007)
-
-
-
123
-
-
67649310255
-
New 1-hydroxy- 3-oxo-propen-1-yl-hexahydro-pyrroloindole compounds are 5-hydroxy tryptamine-2 receptor antagonists useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's diseases, cancer, skin diseases and anxiety
-
FR2912747
-
Fourtillan SNC. New 1-hydroxy- 3-oxo-propen-1-yl-hexahydro-pyrroloindole compounds are 5-hydroxy tryptamine-2 receptor antagonists useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's diseases, cancer, skin diseases and anxiety. FR2912747; 2008
-
(2008)
-
-
Fourtillan, S.N.C.1
-
124
-
-
67649302600
-
New 3H,11Hoxazolo(3′,4′:1,2)pyrido(3,4-b)indole derivatives are 5-hydroxytryptamine-2 receptor activators useful e.g. to treat insomnia, jet lag, anxiety, depression and Alzheimers
-
FR2908767
-
Fourtillan SNC. New 3H,11Hoxazolo(3′,4′:1,2)pyrido(3,4-b) indole derivatives are 5-hydroxytryptamine-2 receptor activators useful e.g. to treat insomnia, jet lag, anxiety, depression and Alzheimers. FR2908767; 2008
-
(2008)
-
-
Fourtillan, S.N.C.1
-
125
-
-
0031594755
-
Selective increase of α(2A)-adrenoceptor agonist binding sites in brains of depressed suicide victims
-
Callado LF, Meana JJ, Grijalba B, et al. Selective increase of alpha2a-adrenoceptor agonist binding sites in brains of depressed suicide victims. J Neurochem 1998;70:1114-1123 (Pubitemid 28113645)
-
(1998)
Journal of Neurochemistry
, vol.70
, Issue.3
, pp. 1114-1123
-
-
Callado, L.F.1
Meana, J.J.2
Grijalba, B.3
Pazos, A.4
Sastre, M.5
Garcia-Sevilla, J.A.6
-
126
-
-
0036373345
-
2A-adrenoceptors
-
DOI 10.1038/sj.mp.4001067
-
Gonzalez-Maeso J, Rodriguez-Puertas R, Meana JJ, et al. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: Selective supersensitivity of alpha2A-adrenoceptors. Mol Psychiatry 2002;7:755-767 •• This article presents evidence of the imvolvement of alpha2-adrenoceptors in depression. (Pubitemid 34984953)
-
(2002)
Molecular Psychiatry
, vol.7
, Issue.7
, pp. 755-767
-
-
Gonzalez-Maeso, J.1
Rodriguez-Puertas, R.2
Meana, J.J.3
Garcia-Sevilla, J.A.4
Guimon, J.5
-
127
-
-
0034866318
-
2-adrenoceptors regulating noradrenergic transmission in the rat brain: A dual-probe microdialysis study
-
Mateo Y, Fernandez-Pastor B, Meana JJ. Acute and chronic effects of desipramine and clorgyline on alpha2-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis study. Br J Pharmacol 2001;133:1362-1370 (Pubitemid 32783498)
-
(2001)
British Journal of Pharmacology
, vol.133
, Issue.8
, pp. 1362-1370
-
-
Mateo, Y.1
Fernandez-Pastor, B.2
Meana, J.J.3
-
128
-
-
0037053089
-
In vivo tonic modulation of the noradrenaline release in the rat cortex by locus coeruleus somatodendritic alpha2-adrenoceptors
-
Fernandez-Pastor B, Meana JJ. In vivo tonic modulation of the noradrenaline release in the rat cortex by locus coeruleus somatodendritic alpha2-adrenoceptors. Eur J Pharmacol 2002;442:225-229
-
(2002)
Eur J Pharmacol
, vol.442
, pp. 225-229
-
-
Fernandez-Pastor, B.1
Meana, J.J.2
-
129
-
-
0034749996
-
Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex
-
DOI 10.1038/sj.mp.4000904
-
Devoto P, Flore G, Pani L, Gessa GL. Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex. Mol Psychiatry 2001;6:657-664 (Pubitemid 33020584)
-
(2001)
Molecular Psychiatry
, vol.6
, Issue.6
, pp. 657-664
-
-
Devoto, P.1
Flore, G.2
Pani, L.3
Gessa, G.L.4
-
130
-
-
0031595284
-
2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine
-
Mateo Y, Pineda J, Meana JJ. Somatodendritic alpha2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine. J Neurochem 1998;71:790-798 (Pubitemid 28480428)
-
(1998)
Journal of Neurochemistry
, vol.71
, Issue.2
, pp. 790-798
-
-
Mateo, Y.1
Pineda, J.2
Meana, J.J.3
-
131
-
-
57849108929
-
Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - Findings from the Munich Antidepressant Response Signature (MARS) project
-
Hennings JM, Owashi T, Binder EB, et al. Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project. J Psychiatr Res 2009;43:215-229
-
(2009)
J Psychiatr Res
, vol.43
, pp. 215-229
-
-
Hennings, J.M.1
Owashi, T.2
Binder, E.B.3
-
132
-
-
67649356438
-
Guanidine based Compounds
-
EP2008068199
-
Rozas I, Rodriguez F, et al. Guanidine based Compounds. EP2008068199; 2008
-
(2008)
-
-
Rozas, I.1
Rodriguez, F.2
-
133
-
-
67649332674
-
α2-Adrenoceptor Ligands
-
UK08234205
-
Rozas I, Rodriguez F, et al. α2-Adrenoceptor Ligands. UK08234205; 2008
-
(2008)
-
-
Rozas, I.1
Rodriguez, F.2
-
135
-
-
67649331238
-
New N-substituted 1-benzyl-1H-(1,2,3)-triazole-4-carboxamides, are dopamine and alpha-1 adrenergic receptor ligands useful for treating diseases of the urinary tract, vascular system or CNS
-
DE102004039065
-
Gmeiner P, Huebner H. New N-substituted 1-benzyl-1H-(1,2,3)-triazole-4- carboxamides, are dopamine and alpha-1 adrenergic receptor ligands useful for treating diseases of the urinary tract, vascular system or CNS. DE102004039065; 2006
-
(2006)
-
-
Gmeiner, P.1
Huebner, H.2
-
136
-
-
0028062125
-
Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat R(alpha-2A) adrenergic receptors in the control of nociception, motor behavior and hippocampal synthesis of noradrenaline
-
Millan MJ, Bervoets K, Rivet JM, et al. Multiple alpha-2-adrenergic receptor subtypes .2. Evidence for a role of rat r(alpha-2a), adrenergic-receptors in the control of nociception, motor behavior and hippocampal synthesis of nor adrenaline. J Pharmacol Exp Ther 1994;270:958-972 (Pubitemid 24315208)
-
(1994)
Journal of Pharmacology and Experimental Therapeutics
, vol.270
, Issue.3
, pp. 958-972
-
-
Millan, M.J.1
Bervoets, K.2
Rivet, J.-M.3
Widdowson, P.4
Renouard, A.5
Le Marouille- Girardon, S.6
Gobert, A.7
-
137
-
-
0034026318
-
Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha(2)-adrenergic and serotonin(2C) receptors: A comparison with citalopram
-
Millan MJ, Gobert A, Rivet JM, et al. Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha(2)-adrenergic and serotonin(2C) receptors: a comparison with citalopram. Eur J Neurosci 2000;12:1079-1095
-
(2000)
Eur J Neurosci
, vol.12
, pp. 1079-1095
-
-
Millan, M.J.1
Gobert, A.2
Rivet, J.M.3
-
138
-
-
0037382089
-
2A- adrenoceptors: A dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors
-
DOI 10.1124/jpet.102.046383
-
Gobert A, Di Cara B, Cistarelli L, et al. Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha(2A)-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors. J Pharmacol Exp Ther 2003;305:338-346 (Pubitemid 36373869)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.305
, Issue.1
, pp. 338-346
-
-
Gobert, A.1
Di Cara, B.2
Cistarelli, L.3
Millan, M.J.4
-
139
-
-
0030610867
-
SE 242084, a selective and brain penetrant 5-HT(2C) receptor antagonist
-
DOI 10.1016/S0028-3908(97)00038-5, PII S0028390897000385
-
Kennett GA, Wood MD, Bright F, et al. SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 1997;36:609-620 (Pubitemid 27272106)
-
(1997)
Neuropharmacology
, vol.36
, Issue.4-5
, pp. 609-620
-
-
Kennett, G.A.1
Wood, M.D.2
Bright, F.3
Trail, B.4
Riley, G.5
Holland, V.6
Avenell, K.Y.7
Stean, T.8
Upton, N.9
Bromidge, S.10
Forbes, I.T.11
Brown, A.M.12
Middlemiss, D.N.13
Blackburn, T.P.14
-
140
-
-
67649331235
-
Benzoindoline derivatives with adrenergic activity
-
Servier Lab. EP1516871
-
Servier Lab. Benzoindoline derivatives with adrenergic activity. EP1516871; 2005
-
(2005)
-
-
-
141
-
-
13844298553
-
Glycine site modulators and glycine transporter-1 inhibitors as novel therapeutic targets for the treatment of schizophrenia
-
DOI 10.2174/1570159052773387
-
Kinney GG, Sur C. Glycine site modulators and glycine transporter-1 inhibitors as novel therapeutic targets for the treatment of schizophrenia. Curr Neuropharmacol 2005;3:35-43 (Pubitemid 40246717)
-
(2005)
Current Neuropharmacology
, vol.3
, Issue.1
, pp. 35-43
-
-
Kinney, G.G.1
Sur, C.2
-
142
-
-
67649302601
-
Combating stress states or nervous system or metabolic disorders, using glycine as neurotransmission modulator showing antistress, stress protective, nootropic and toxin binding actions
-
Tech Egon. DE102005027905
-
Tech Egon. Combating stress states or nervous system or metabolic disorders, using glycine as neurotransmission modulator showing antistress, stress protective, nootropic and toxin binding actions. DE102005027905; 2005
-
(2005)
-
-
-
143
-
-
67649324152
-
New N-heterocyclylmethyl benzamide derivatives useful as glycine transporter inhibitors for e.g. treating dementia-associated behavioral problems, psychoses, anxiety, depression and alcohol abuse
-
Sanofi Aventis. FR2861076
-
Sanofi Aventis. New N-heterocyclylmethyl benzamide derivatives useful as glycine transporter inhibitors for e.g. treating dementia-associated behavioral problems, psychoses, anxiety, depression and alcohol abuse. FR2861076; 2005
-
(2005)
-
-
-
144
-
-
67649302603
-
Use of tricyclic compounds as glycine transport inhibitors
-
Sanofi Aventis. CN1882587
-
Sanofi Aventis. Use of tricyclic compounds as glycine transport inhibitors. CN1882587; 2006
-
(2006)
-
-
-
145
-
-
14044258729
-
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
-
DOI 10.1038/nrd1630
-
Swanson CJ, Bures M, Johnson MP, et al. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nature Rev Drug Discov 2005;4:131-144 (Pubitemid 40277494)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.2
, pp. 131-144
-
-
Swanson, C.J.1
Bures, M.2
Johnson, M.P.3
Linden, A.-M.4
Monn, J.A.5
Schoepp, D.D.6
-
146
-
-
67649326711
-
6-Fluorobicyclo[3.1.0]hexane derivatives
-
US2005119345
-
Nazakato A, Chaki S. 6-Fluorobicyclo[3.1.0]hexane derivatives. US2005119345; 2005
-
(2005)
-
-
Nazakato, A.1
Chaki, S.2
-
147
-
-
67649384298
-
Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators
-
Servier Lab. EP1557412
-
Servier Lab. Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators. EP1557412; 2005
-
(2005)
-
-
-
148
-
-
67649345220
-
Benzothiazine and benzothiadiazine derivatives, process for their preparation and phamaceutical compositions containing them
-
Servier Lab. EP1669072
-
Servier Lab. Benzothiazine and benzothiadiazine derivatives, process for their preparation and phamaceutical compositions containing them. EP1669072; 2006
-
(2006)
-
-
-
149
-
-
67649368790
-
Benzothiadiazine derivatives, method for preparing them and pharmaceutical compositions containing them
-
Servier Lab. EP1655030
-
Servier Lab. Benzothiadiazine derivatives, method for preparing them and pharmaceutical compositions containing them. EP1655030; 2006
-
(2006)
-
-
-
150
-
-
67649368790
-
Benzothiadiazine derivatives, process of preparation thereof and pharmaceutical compositions containing them
-
Servier Lab. EP1655299
-
Servier Lab. Benzothiadiazine derivatives, process of preparation thereof and pharmaceutical compositions containing them. EP1655299; 2006
-
(2006)
-
-
-
152
-
-
0346461630
-
Glutamate and Depression: Clinical and Preclinical Studies
-
DOI 10.1196/annals.1300.016
-
Paul IA, Skolnick P. Glutamate and depression: clinical and preclinical studies. Ann NY Acad Sci 2003;1003:250-272 (Pubitemid 38083061)
-
(2003)
Annals of the New York Academy of Sciences
, vol.1003
, pp. 250-272
-
-
Paul, I.A.1
Skolnick, P.2
-
153
-
-
67649315582
-
Novel neuroprotective compounds and uses thereof
-
WO2006077597
-
Gozin M, Weiner HL. Novel neuroprotective compounds and uses thereof. WO2006077597; 2006
-
(2006)
-
-
Gozin, M.1
Weiner, H.L.2
-
154
-
-
67649339571
-
Use of S-(+)-ketamine for treating depression, which is therapy-refractive depression, preferably depressive episode, relapsing disorder and bipolar affective disorder
-
DE102007009888
-
Hermann HL. Use of S-(+)-ketamine for treating depression, which is therapy-refractive depression, preferably depressive episode, relapsing disorder and bipolar affective disorder. DE102007009888; 2008
-
(2008)
-
-
Hermann, H.L.1
-
155
-
-
67649307942
-
Use of 1,3-dioxane derivatives to enhance the activity of gamma-aminobutyric acid (GABA) on GABA-A receptors
-
DE102007010077
-
Hatt H, Kragler A. Use of 1,3-dioxane derivatives to enhance the activity of gamma-aminobutyric acid (GABA) on GABA-A receptors. DE102007010077; 2008
-
(2008)
-
-
Hatt, H.1
Kragler, A.2
-
156
-
-
67649328953
-
Ferrocenecarboxamide derivatives for use as dopamine D3 ligands for the treatment of CNS disorders
-
Sanol Arznei Schwarz GmbH. EP1733727
-
Sanol Arznei Schwarz GmbH. Ferrocenecarboxamide derivatives for use as dopamine D3 ligands for the treatment of CNS disorders. EP1733727; 2006
-
(2006)
-
-
-
157
-
-
67649384297
-
New arylpiperazine derivatives, useful to prevent and/or treat neuropsychiatric disorders e.g. disorders of drug dependence, sexual disorders and motor disturbance, are dopamine D3 receptor ligands
-
Bioproject Soc Civ Ile. FR2878524
-
Bioproject Soc Civ Ile. New arylpiperazine derivatives, useful to prevent and/or treat neuropsychiatric disorders e.g. disorders of drug dependence, sexual disorders and motor disturbance, are dopamine D3 receptor ligands. FR2878524; 2006
-
(2006)
-
-
-
158
-
-
67649319961
-
Arylpiperazuine derivatives as selective ligand for the dopamine D3 receptor
-
Bioproject Soc Civ Ile. EP1659112
-
Bioproject Soc Civ Ile. Arylpiperazuine derivatives as selective ligand for the dopamine D3 receptor. EP1659112; 2006
-
(2006)
-
-
-
159
-
-
7444253542
-
High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation
-
DOI 10.1016/j.biopsych.2004.08.010, PII S0006322304008960
-
Caldarone BJ, Harrist A, Cleary MA, et al. High affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation. Biol Psychiatry 2004;56:657-664 (Pubitemid 39446847)
-
(2004)
Biological Psychiatry
, vol.56
, Issue.9
, pp. 657-664
-
-
Caldarone, B.J.1
Harrist, A.2
Cleary, M.A.3
Beech, R.D.4
King, S.L.5
Picciotto, M.R.6
-
160
-
-
67649310254
-
New enantiomerically pure hexahydro-pyrrolo-cyclopenta-pyridine derivatives, useful as central nicotine receptor subtype agonists for e.g. treating Alzheimer's or Parkinson's disease, anxiety and depression
-
Binder Eva Dkfm. AT414305
-
Binder Eva Dkfm. New enantiomerically pure hexahydro-pyrrolo-cyclopenta- pyridine derivatives, useful as central nicotine receptor subtype agonists for e.g. treating Alzheimer's or Parkinson's disease, anxiety and depression. AT414305; 2006
-
(2006)
-
-
-
161
-
-
67649375851
-
New spiro-isoxazole-cycloalkane compounds, useful as vanilloid receptor 1 ligands for treating e.g. pain, depression and neurodegeneration
-
Gruenenthal GmbH. DE102005044814
-
Gruenenthal GmbH. New spiro-isoxazole-cycloalkane compounds, useful as vanilloid receptor 1 ligands for treating e.g. pain, depression and neurodegeneration. DE102005044814; 2006
-
(2006)
-
-
-
162
-
-
67649319959
-
New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
-
Abbott GmbH & Co. KG. DE102005015957
-
Abbott GmbH & Co. KG. New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders. DE102005015957; 2006
-
(2006)
-
-
-
163
-
-
67649319959
-
New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
-
Abbott GmbH & Co. KG. DE102005014628
-
Abbott GmbH & Co. KG. New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders. DE102005014628; 2006
-
(2006)
-
-
-
164
-
-
67649368791
-
New fused pyrazole derivatives, useful for treatment of psychosis and pain, are sigma receptor inhibitors
-
Esteve Labor. Dr. ES2251317
-
Esteve Labor. Dr. New fused pyrazole derivatives, useful for treatment of psychosis and pain, are sigma receptor inhibitors. ES2251317; 2006
-
(2006)
-
-
-
165
-
-
67649324153
-
Substituted 2 amino imidazoles, method for their manufacture and their use as a drug or diagnostic and drug containing them
-
Sanofi Aventis Deutschland. EP1857445
-
Sanofi Aventis Deutschland. Substituted 2 amino imidazoles, method for their manufacture and their use as a drug or diagnostic and drug containing them. EP1857445; 2007
-
(2007)
-
-
-
166
-
-
23144443533
-
Antidepressant action of agomelatine (S 20098) in a transgenic mouse model
-
This article gives evidence of the antidepressant activity of agomelatine, a new drug that act through different mechanisms
-
Barden N, Shink E, Labbe M, et al. Antidepressant action of agomelatine (S 20098) in a transgenic mouse model. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:908-916 • This article gives evidence of the antidepressant activity of agomelatine, a new drug that act through different mechanisms.
-
(2005)
Prog Neuropsychopharmacol Biol Psychiatry
, vol.29
, pp. 908-916
-
-
Barden, N.1
Shink, E.2
Labbe, M.3
-
167
-
-
67649347434
-
Novel melatonin ligands having antidepressant activity as well as sleep inducing properties
-
CA2636601
-
Lucini V, Spadoni G. Novel melatonin ligands having antidepressant activity as well as sleep inducing properties. CA2636601; 2007
-
(2007)
-
-
Lucini, V.1
Spadoni, G.2
-
168
-
-
67649375852
-
Novel elatonin ligands having antidepressant activity as well as sleep inducing properties
-
EP1973868
-
Gobbi G, Mor M. Novel elatonin ligands having antidepressant activity as well as sleep inducing properties. EP1973868; 2008
-
(2008)
-
-
Gobbi, G.1
Mor, M.2
-
169
-
-
67649339570
-
New 3-acylaminoethyl-3-phenylthio-benzothiophene derivatives, are melatonin receptor ligands useful e.g. for treating sleeping disorders, anxiety, depression, jet lag or appetite disorders
-
Servier Lab. FR2857011
-
Servier Lab. New 3-acylaminoethyl-3-phenylthio-benzothiophene derivatives, are melatonin receptor ligands useful e.g. for treating sleeping disorders, anxiety, depression, jet lag or appetite disorders. FR2857011; 2005
-
(2005)
-
-
-
170
-
-
67649315580
-
New indole derivatives are melatonin receptor binders useful to treat e.g. sleep disturbance, stress, anxiety, depression, cardiovascular diseases, digestive system disorders, schizophrenia, panic attack, obesity and insomnia
-
Servier Lab. FR2907452
-
Servier Lab. New indole derivatives are melatonin receptor binders useful to treat e.g. sleep disturbance, stress, anxiety, depression, cardiovascular diseases, digestive system disorders, schizophrenia, panic attack, obesity and insomnia. FR2907452; 2008
-
(2008)
-
-
-
171
-
-
67649331237
-
New naphthalene derivatives, method of preparing same and pharmaceutical compositions containing them
-
Servier Lab. EP1873140
-
Servier Lab. New naphthalene derivatives, method of preparing same and pharmaceutical compositions containing them. EP1873140; 2008
-
(2008)
-
-
-
172
-
-
67649302602
-
Use of agomelatin in the manufacture of a medicament for the treatment of bipolar disorders
-
Servier Lab. EP1714647
-
Servier Lab. Use of agomelatin in the manufacture of a medicament for the treatment of bipolar disorders. EP1714647; 2006
-
(2006)
-
-
-
173
-
-
67649345219
-
Use of agomelatine to obtain a medication aimed at treating generalised anxiety disorder
-
Servier Lab. EP1842535
-
Servier Lab. Use of agomelatine to obtain a medication aimed at treating generalised anxiety disorder. EP1842535; 2007
-
(2007)
-
-
-
174
-
-
67649347435
-
Use of agomelatine to obtain a drug to treat Smith Magenis syndrome, major depression, seasonal depression, sleep disorder, cardiovascular disease, digestive system disorder, insomnia, shiftlag, appetite disorders and obesity
-
Servier Lab. FR2908995
-
Servier Lab. Use of agomelatine to obtain a drug to treat Smith Magenis syndrome, major depression, seasonal depression, sleep disorder, cardiovascular disease, digestive system disorder, insomnia, shiftlag, appetite disorders and obesity. FR2908995; 2008
-
(2008)
-
-
-
175
-
-
25144449526
-
Involvement of melanocortin-4 receptor in anxiety and depression
-
DOI 10.1016/j.peptides.2004.11.029, PII S019697810500241X, The Melanocortin Pathway 2005
-
Chaki S, Okuyama S. Involvement of melanocortin-4 receptor in anxiety and depression. Peptides 2005;26:1952-1964 (Pubitemid 41354554)
-
(2005)
Peptides
, vol.26
, Issue.10
, pp. 1952-1964
-
-
Chaki, S.1
Okuyama, S.2
-
176
-
-
67649356436
-
New 1,2,6-trisubstituted benzimidazole derivatives and imidazo-pyridine analogs, are melanocortin receptor ligands useful for treating e.g. obesity, cachexia, anxiety, depression or neuropathic pain
-
FR2862971
-
Poitout L, Brault V. New 1,2,6-trisubstituted benzimidazole derivatives and imidazo-pyridine analogs, are melanocortin receptor ligands useful for treating e.g. obesity, cachexia, anxiety, depression or neuropathic pain. FR2862971; 2005
-
(2005)
-
-
Poitout, L.1
Brault, V.2
-
177
-
-
31844449063
-
MCL0042: A nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- And antidepressant-like activity
-
DOI 10.1016/j.pbb.2005.11.001, PII S0091305705003515
-
Chaki S, Oshida Y, Ogawa S, et al. MCL0042: a nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity. Pharmacol Biochem Behav 2005;82:621-626 (Pubitemid 43184037)
-
(2005)
Pharmacology Biochemistry and Behavior
, vol.82
, Issue.4
, pp. 621-626
-
-
Chaki, S.1
Oshida, Y.2
Ogawa, S.-I.3
Funakoshi, T.4
Shimazaki, T.5
Okubo, T.6
Nakazato, A.7
Okuyama, S.8
-
178
-
-
67649351468
-
Antidepressant
-
Takeda Pharmaceutical. PL371366
-
Takeda Pharmaceutical. Antidepressant. PL371366; 2005
-
(2005)
-
-
-
179
-
-
67649319960
-
Antidepressant
-
Takeda Pharmaceutical. US2006241168
-
Takeda Pharmaceutical. Antidepressant. US2006241168; 2006
-
(2006)
-
-
-
180
-
-
67649328954
-
Use of hyperforin derivatives as an antidepressant agent
-
EP1607099
-
Bombardelli E, Morazzoni P. Use of hyperforin derivatives as an antidepressant agent. EP1607099; 2005
-
(2005)
-
-
Bombardelli, E.1
Morazzoni, P.2
-
181
-
-
67649318785
-
New 2-amino-imidazo(4,5-d)pyridazin-4-one derivatives are dipeptidyl-peptidase IV inhibitors useful in the treatment of e.g. diabetes mellitus, autoimmune disease, rheumatoid arthritis, and multiple sclerosis
-
Boehringer Ingelheim Pharma. DE102004025552
-
Boehringer Ingelheim Pharma. New 2-amino-imidazo(4,5-d)pyridazin-4-one derivatives are dipeptidyl-peptidase IV inhibitors useful in the treatment of e.g. diabetes mellitus, autoimmune disease, rheumatoid arthritis, and multiple sclerosis. DE102004025552; 2005
-
(2005)
-
-
-
182
-
-
37349122437
-
Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling
-
DOI 10.1039/b714136j
-
Lodola A, Mor M, Rivara S, et al. Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modeling. Chem Commun 2008;214-216 (Pubitemid 350294105)
-
(2008)
Chemical Communications
, Issue.2
, pp. 214-216
-
-
Lodola, A.1
Mor, M.2
Rivara, S.3
Christov, C.4
Tarzia, G.5
Piomelli, D.6
Mulholland, A.J.7
-
183
-
-
67649351467
-
New 1-alkyl-(homo) piperazine-4-carboxylate ester derivatives, are fatty acid amidohydrolase inhibitors useful e.g. for treating pain, cancer or neurodegenerative, cardiovascular, inflammatory or allergic disease
-
Sanofi Synthelabo. FR2866888
-
Sanofi Synthelabo. New 1-alkyl-(homo) piperazine-4-carboxylate ester derivatives, are fatty acid amidohydrolase inhibitors useful e.g. for treating pain, cancer or neurodegenerative, cardiovascular, inflammatory or allergic disease. FR2866888; 2005
-
(2005)
-
-
-
184
-
-
67649332675
-
Derivatives of arylalkylcarbamates, process for their preparation and therapeutic application thereof
-
Sanofi Synthelabo. EP1972616
-
Sanofi Synthelabo. Derivatives of arylalkylcarbamates, process for their preparation and therapeutic application thereof. EP1972616; 2008
-
(2008)
-
-
-
185
-
-
35148895860
-
PDE inhibitors in psychiatry - Future options for dementia, depression and schizophrenia?
-
Halene TB, Siegel SJ. PDE inhibitors in psychiatry - future options for dementia, depression and schizophrenia? Drug Discov Today 2007;12:870-878
-
(2007)
Drug Discov Today
, vol.12
, pp. 870-878
-
-
Halene, T.B.1
Siegel, S.J.2
-
186
-
-
67649347433
-
New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease
-
Boehringer Ingelheim Pharma. DE102005023207
-
Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005023207; 2006
-
(2006)
-
-
-
187
-
-
67649347433
-
New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease
-
Boehringer Ingelheim Pharma. DE102005019718
-
Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005019718; 2006
-
(2006)
-
-
-
188
-
-
67649307941
-
New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or
-
Boehringer Ingelheim Pharma. DE102005035575
-
Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005035575; 2007
-
(2007)
-
-
-
189
-
-
67649324154
-
New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia
-
Boehringer Ingelheim Pharma. DE102004057645
-
Boehringer Ingelheim Pharma. New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia. DE102004057645; 2006;
-
(2006)
-
-
-
190
-
-
67649335005
-
New triazabenzo(a) naphtho(2,1,8-cde)azulene derivatives useful as tyrosine hydroxylase inducers, e.g. for treating depression or anxiety
-
Servier Lab. FR2911141
-
Servier Lab. New triazabenzo(a) naphtho(2,1,8-cde)azulene derivatives useful as tyrosine hydroxylase inducers, e.g. for treating depression or anxiety. FR2911141; 2008
-
(2008)
-
-
-
191
-
-
67649335006
-
-
Available from: Life Science Analytics, Inc
-
Medtrack. Available from: http://www.medtrack.com/research/default.asp, Life Science Analytics, Inc
-
Medtrack
-
-
|