메뉴 건너뛰기




Volumn 19, Issue 6, 2009, Pages 827-845

Improving antidepressant drugs: Update on recently patented compounds

Author keywords

2 adrenoceptor antagonist; 5 HT antagonist; Antidepressants; Fluoxetine; Glycinergic system; Melatonin; Mirtazapine; Multi target drugs; Schizophrenia; SNRI; SSRI

Indexed keywords

AGOMELATINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; BENZODIOXAN DERIVATIVE; CANNABINOID 1 RECEPTOR ANTAGONIST; DESIPRAMINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; FLUOXETINE; HALOPERIDOL; IDAZOXAN; IMIPRAMINE; ISOXAZOLINE DERIVATIVE; MELATONIN; MIRTAZAPINE; MONOAMINE; MONOAMINE OXIDASE INHIBITOR; MU OPIATE RECEPTOR AGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROLEPTIC AGENT; OLANZAPINE; OPIATE; PAROXETINE; PHOSPHODIESTERASE IV INHIBITOR; SEROTONIN ANTAGONIST; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; UNINDEXED DRUG; VENLAFAXINE;

EID: 67649337310     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543770902932934     Document Type: Review
Times cited : (11)

References (191)
  • 1
    • 67649310256 scopus 로고    scopus 로고
    • Available from
    • Available from: http://www.who.int/mental-health/management/depression/ definition/en/
  • 2
    • 41349100425 scopus 로고    scopus 로고
    • Mental Health Global Action Programme. Geneva: World Health Organization
    • Mental Health Global Action Programme. Close the gap, dare to care. Geneva: World Health Organization; 2002
    • (2002) Close the Gap, Dare to Care
  • 3
  • 4
    • 0030754230 scopus 로고    scopus 로고
    • Antidepressants
    • Frazer A. Antidepressants. J Clin Psychiatr 1997;58:9-25
    • (1997) J Clin Psychiatr , vol.58 , pp. 9-25
    • Frazer, A.1
  • 5
    • 4644353199 scopus 로고    scopus 로고
    • The role of monoamines in the actions of established and «novel» antidepressant agents: A critical review
    • DOI 10.1016/j.ejphar.2004.07.038, PII S0014299904007472
    • Millan MJ. The role of monoamines in the actions of established and «novel» antidepressant agents: a critical review. Eur J Pharmacol 2004;500:371-384 (Pubitemid 39304021)
    • (2004) European Journal of Pharmacology , vol.500 , Issue.1 SPEC. ISS , pp. 371-384
    • Millan, M.J.1
  • 6
    • 4444355123 scopus 로고    scopus 로고
    • 2-adrenoceptors in antidepressant action: Recent findings from microdialysis studies
    • DOI 10.1016/j.pnpbp.2004.05.026, PII S0278584604000831
    • Invernizzi RW, Garattini S. Role of presynaptic α2-adrenoceptors in antidepressant action: recent findings from microdialysis studies. Prog Neuro Psychopharmacol Biol Psychiatry 2004;28:819-827 •• This review reports the multi-target strategies to improve the treatement of depression from the neuronal substrates to the development of drugs. (Pubitemid 39195273)
    • (2004) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.28 , Issue.5 , pp. 819-827
    • Invernizzi, R.W.1    Garattini, S.2
  • 7
    • 52449098689 scopus 로고    scopus 로고
    • Recent development in the design of anti-depressive therapies: Targeting the serotonin transporter
    • Butler SG, Meegan MJ. Recent development in the design of anti-depressive therapies: targeting the serotonin transporter. Curr Med Chem 2008;15:1737-1761
    • (2008) Curr Med Chem , vol.15 , pp. 1737-1761
    • Butler, S.G.1    Meegan, M.J.2
  • 8
    • 31444441701 scopus 로고    scopus 로고
    • New approaches to antidepressant drug discovery: Beyond monoamines
    • DOI 10.1038/nrn1846, PII NRN1846
    • Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006;7:137-151 •• This review gives an excellent overview of the problems on the development of non-monoamine-based antidepressants, and of the most promising current strategies. (Pubitemid 43151600)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.2 , pp. 137-151
    • Berton, O.1    Nestler, E.J.2
  • 9
    • 33645452696 scopus 로고    scopus 로고
    • Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
    • Millan MJ. Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 2006;110:135-370
    • (2006) Pharmacol Ther , vol.110 , pp. 135-370
    • Millan, M.J.1
  • 10
    • 57749090403 scopus 로고    scopus 로고
    • Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: Novel concepts, new drugs
    • Millan MJ. Dual- and triple-acting agents for treating core and co-morbid symptoms of major depression: novel concepts, new drugs. Neurotherapeutics 2009;6:53-77
    • (2009) Neurotherapeutics , vol.6 , pp. 53-77
    • Millan, M.J.1
  • 11
    • 33745220505 scopus 로고    scopus 로고
    • Creating more effective antidepressants: Clues from the clinic
    • DOI 10.1016/j.drudis.2006.05.004, PII S135964460600170X
    • Rasmussen K. Creating more effective antidepressants: clues from the clinic. Drug Discov Today 2006;11:623-631 (Pubitemid 43912496)
    • (2006) Drug Discovery Today , vol.11 , Issue.13-14 , pp. 623-631
    • Rasmussen, K.1
  • 12
    • 2342459611 scopus 로고    scopus 로고
    • Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: Involvement of melatonin and serotonin receptors
    • Bourin M, Mocaer E, Porsolt R. Antidepressant-like activity of S 20098 (agomelatine) in the forced swimming test in rodents: involvement of melatonin and serotonin receptors. J Psychiatry Neurosci 2004;29:126-133 (Pubitemid 38570217)
    • (2004) Journal of Psychiatry and Neuroscience , vol.29 , Issue.2 , pp. 126-133
    • Bourin, M.1    Mocaer, E.2    Porsolt, R.3
  • 13
    • 0031811285 scopus 로고    scopus 로고
    • Dopaminergic agents and stimulants as antidepressant augmentation strategies
    • Nierenberg AA, Dougherty D, Rosenbaum JF. Dopaminergic agents and stimulants as antidepressant augementation strategies. J Clin Psychiatry 1998;59(Suppl 5):60-63 (Pubitemid 28249108)
    • (1998) Journal of Clinical Psychiatry , vol.59 , Issue.SUPPL. 5 , pp. 60-64
    • Nierenberg, A.A.1    Dougherty, D.2    Rosenbaum, J.F.3
  • 14
    • 0030867369 scopus 로고    scopus 로고
    • The mesolimbic dopamine system as a target for rapid antidepressant action
    • DOI 10.1097/00004850-199705002-00003
    • Willner P. The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol 1997;12(Suppl 3):S7-14 (Pubitemid 27414585)
    • (1997) International Clinical Psychopharmacology , vol.12 , Issue.SUPPL. 3
    • Willner, P.1
  • 15
    • 61849083112 scopus 로고    scopus 로고
    • Future antidepressant targets: Neurotrophic factors and related signaling cascades
    • Schmidt HD, Banasr M, Duman RS. Future antidepressant targets: neurotrophic factors and related signaling cascades. Drug Discov Today Ther Strateg 2008;5:151-156
    • (2008) Drug Discov Today Ther Strateg , vol.5 , pp. 151-156
    • Schmidt, H.D.1    Banasr, M.2    Duman, R.S.3
  • 16
    • 67649315583 scopus 로고    scopus 로고
    • Available from
    • EPO searching engine. Available from: http://ep.espacenet.com/
    • EPO Searching Engine
  • 17
    • 67649315576 scopus 로고    scopus 로고
    • 4-Arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of CNS disorders
    • WO2006106432
    • Nencetti S, Lapucci A. 4-Arylpiperidine derivatives and use thereof for preparing a medicament for the treatment of CNS disorders. WO2006106432; 2006
    • (2006)
    • Nencetti, S.1    Lapucci, A.2
  • 18
    • 67649335009 scopus 로고    scopus 로고
    • Enantiomers of 2′-fluoralkyl-6-nitroquipazine as Serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics
    • WO2007127262
    • Gerdes JM, Bolstad DB. Enantiomers of 2′-fluoralkyl-6- nitroquipazine as Serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics. WO2007127262; 2007
    • (2007)
    • Gerdes, J.M.1    Bolstad, D.B.2
  • 19
    • 67649310257 scopus 로고    scopus 로고
    • Aralkyl-alcohol piperazine derivatives adn their uses as antgyepressant
    • Shanghai INST. Pharm. Industry. US2005267121
    • Shanghai INST. Pharm. Industry. Aralkyl-alcohol piperazine derivatives adn their uses as antgyepressant. US2005267121; 2005
    • (2005)
  • 20
    • 67649339572 scopus 로고    scopus 로고
    • New substituted 1-oxo-3,8-diazospiro(4.5)-decan-2-one compounds are 5-hydroxy tryptamine uptake receptor inhibitors, useful to treat and/or prevent e.g. pain, migraine, chronic paroxysomal hemicrania, depression and asthma
    • Gruenenthal GMBH. DE102005030051
    • Gruenenthal GMBH. New substituted 1-oxo-3,8-diazospiro(4.5)-decan-2-one compounds are 5-hydroxy tryptamine uptake receptor inhibitors, useful to treat and/or prevent e.g. pain, migraine, chronic paroxysomal hemicrania, depression and asthma. DE102005030051; 2006
    • (2006)
  • 21
    • 67649335008 scopus 로고    scopus 로고
    • 2-(1H-indolylsulfanyl)-benzyl amine derivative
    • Lundbeck & Co As. P2007277254
    • Lundbeck & Co As. 2-(1H-indolylsulfanyl)-benzyl amine derivative. P2007277254; 2007
    • (2007)
  • 22
    • 67649335010 scopus 로고    scopus 로고
    • 3-Aryloxy 3-Substituted Propanamines
    • Natco Pharma Ltd. WO2008081477
    • Natco Pharma Ltd. 3-Aryloxy 3-Substituted Propanamines. WO2008081477; 2008
    • (2008)
  • 23
    • 0342894667 scopus 로고    scopus 로고
    • Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment
    • DOI 10.1016/S0140-6736(96)08007-5
    • Perez V, Gilaberte I, Faries D, et al. Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment. Lancet 1997;349:1594-1597 (Pubitemid 27229140)
    • (1997) Lancet , vol.349 , Issue.9065 , pp. 1594-1597
    • Perez, V.1    Gilaberte, I.2    Faries, D.3    Alvarez, E.4    Artigas, F.5
  • 24
    • 67649307937 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxan methylamines
    • Wyeth Corp. KR20050061470
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxan methylamines. KR20050061470; 2005
    • (2005)
  • 25
    • 67649335001 scopus 로고    scopus 로고
    • Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. KR20050042192
    • Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. KR20050042192; 2005
    • (2005)
  • 26
    • 67649335001 scopus 로고    scopus 로고
    • Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. KR20050042187
    • Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. KR20050042187; 2005
    • (2005)
  • 27
    • 67649345210 scopus 로고    scopus 로고
    • Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
    • Wyeth Corp. KR20050042176
    • Wyeth Corp. Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines. KR20050042176; 2005
    • (2005)
  • 28
    • 67649335001 scopus 로고    scopus 로고
    • Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. MXPA05002743
    • Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. MXPA05002743; 2005
    • (2005)
  • 29
    • 67649347438 scopus 로고    scopus 로고
    • Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
    • Wyeth Corp. MXPA05002740
    • Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan. MXPA05002740; 2005
    • (2005)
  • 30
    • 67649319956 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9- dioxa-3-azacyclopenta[a]naphtalene
    • Wyeth Corp. MXPA03009829
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-dioxa-3-azacyclopenta[a]naphtalene. MXPA03009829; 2005
    • (2005)
  • 31
    • 67649345213 scopus 로고    scopus 로고
    • Antidepressant (SSRI) azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1, 3-diazacyclopenta[a]naphtalene
    • Wyeth Corp. MXPA03009828
    • Wyeth Corp. Antidepressant (SSRI) azaheterocyclylmethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1, 3-diazacyclopenta[a]naphtalene. MXPA03009828; 2005
    • (2005)
  • 32
    • 67649356432 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4- dioxino[2,3-f ]quinaxoline
    • Wyeth Corp. MXPA03009826
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f ]quinaxoline. MXPA03009826; 2005
    • (2005)
  • 33
    • 67649307937 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused- [1,4]-benzodioxans
    • Wyeth Corp. MXPA03009825
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans. MXPA03009825; 2005
    • (2005)
  • 34
    • 67649347438 scopus 로고    scopus 로고
    • Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4- benzodioxans
    • Wyeth Corp. EP1537103
    • Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxans. EP1537103; 2005
    • (2005)
  • 35
    • 67649302604 scopus 로고    scopus 로고
    • Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole
    • Wyeth Corp. WO02088146
    • Wyeth Corp. Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole. WO02088146; 2005
    • (2005)
  • 36
    • 67649332676 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa- 1-aza-phenanthrene
    • Wyeth Corp. US2005228010
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene. US2005228010; 2005
    • (2005)
  • 37
    • 67649368787 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa- phenanthrene
    • Wyeth Corp. US2005004209
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene. US2005004209; 2005
    • (2005)
  • 38
    • 67649302597 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. ZA200502043
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. ZA200502043; 2006
    • (2006)
  • 39
    • 67649351461 scopus 로고    scopus 로고
    • Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. ZA200502047
    • Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. ZA200502047; 2006
    • (2006)
  • 40
    • 67649351461 scopus 로고    scopus 로고
    • Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. ZA200502042
    • Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. ZA200502042; 2006
    • (2006)
  • 41
    • 67649319957 scopus 로고    scopus 로고
    • Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines
    • Wyeth Corp. ZA200502040
    • Wyeth Corp. Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines. ZA200502040; 2006
    • (2006)
  • 42
    • 67649302597 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. US2006293301
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. US2006293301; 2006
    • (2006)
  • 43
    • 67649351461 scopus 로고    scopus 로고
    • Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. US2006276481
    • Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. US2006276481; 2006
    • (2006)
  • 44
    • 67649351461 scopus 로고    scopus 로고
    • Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. NZ539253
    • Wyeth Corp. Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans. NZ539253; 2006
    • (2006)
  • 45
    • 67649324150 scopus 로고    scopus 로고
    • Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan
    • Wyeth Corp. US2006160881
    • Wyeth Corp. Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan. US2006160881; 2006
    • (2006)
  • 46
    • 67649375849 scopus 로고    scopus 로고
    • Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. US2007004702
    • Wyeth Corp. Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans. US2007004702; 2007
    • (2007)
  • 47
    • 67649302598 scopus 로고    scopus 로고
    • Antidepressant heteroaryl derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. WO2008150848
    • Wyeth Corp. Antidepressant heteroaryl derivatives of heterocycle-fused benzodioxans. WO2008150848; 2008
    • (2008)
  • 48
    • 67649345214 scopus 로고    scopus 로고
    • Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines
    • Wyeth Corp. CN101143867
    • Wyeth Corp. Antidepressant indolealkyl derivatives of heterocyclefused benzodioxan methylamines. CN101143867; 2008
    • (2008)
  • 49
    • 67649302598 scopus 로고    scopus 로고
    • Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. CN101239953
    • Wyeth Corp. Antidepressant arylpiperazine derivatives of heterocycle-fused benzodioxans. CN101239953; 2008
    • (2008)
  • 50
    • 67649302598 scopus 로고    scopus 로고
    • Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
    • Wyeth Corp. CN101230066
    • Wyeth Corp. Antidepressant piperidine derivatives of heterocycle-fused benzodioxans. CN101230066; 2008
    • (2008)
  • 51
    • 0027337616 scopus 로고
    • 3H]5-HT uptake: Effect of administration of various antidepressant treatments
    • DOI 10.1016/0028-3908(93)90181-2
    • Cheetham SC, Viggers JA, Slater NA, et al. [3H]Paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: effect of administration of various antidepressant treatments. Neuropharmacology 1993;32:737-743 (Pubitemid 23227658)
    • (1993) Neuropharmacology , vol.32 , Issue.8 , pp. 737-743
    • Cheetham, S.C.1    Viggers, J.A.2    Slater, N.A.3    Heal, D.J.4    Buckett, W.R.5
  • 52
    • 0021892571 scopus 로고
    • 3H]8-hydroxy-2-(di-n-propylamino)tetralin binding to pre- And postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain
    • DOI 10.1111/j.1471-4159.1985.tb07155.x
    • Hall MD, El Mestikawy S, Emerit MB, et al. [3H]8-Hydroxy-2-(di-n- propylamino) tetraline binding to pre- and postsynaptic 5-Hydroxytryptamine sites in various regions of the rat brain. J Neurochem 1985;44:1685-1696 (Pubitemid 15000270)
    • (1985) Journal of Neurochemistry , vol.44 , Issue.6 , pp. 1685-1696
    • Hall, M.D.1    El Mestikawy, S.2    Emerit, M.B.3
  • 53
    • 67649318787 scopus 로고    scopus 로고
    • Derivatives of pyridinalkyl-amonoalkyl-1h-indole inhibiting receptors 5-ht and recapture of serotonin which can be used as antidepressant and anxiolitic
    • Merck Patent GmbH. KR20050085038
    • Merck Patent GmbH. Derivatives of pyridinalkyl-amonoalkyl-1h-indole inhibiting receptors 5-ht and recapture of serotonin which can be used as antidepressant and anxiolitic. KR20050085038; 2005
    • (2005)
  • 54
    • 67649328948 scopus 로고    scopus 로고
    • Benzofuran oxyethylamines serving as antidepressant drugs and anxiolytic drugs
    • Merck Patent GmbH. PL377618
    • Merck Patent GmbH. Benzofuran oxyethylamines serving as antidepressant drugs and anxiolytic drugs. PL377618; 2006
    • (2006)
  • 55
    • 67649328956 scopus 로고    scopus 로고
    • Indole derivatives as serotonin reuptake inhibitors
    • Merck Patent GmbH. MXPA05013538
    • Merck Patent GmbH. Indole derivatives as serotonin reuptake inhibitors. MXPA05013538; 2006
    • (2006)
  • 56
    • 67649324155 scopus 로고    scopus 로고
    • 4-Aminopiperidine derivatives, processes for their preparation and their use as medicaments
    • UCB SA. MXPA05003290
    • UCB SA. 4-Aminopiperidine derivatives, processes for their preparation and their use as medicaments. MXPA05003290; 2005
    • (2005)
  • 57
    • 67649339569 scopus 로고    scopus 로고
    • Use of 4-aminoderivatives for the preparation of a medicament for treating neurological diseases
    • UCB SA. EP1693061
    • UCB SA. Use of 4-aminoderivatives for the preparation of a medicament for treating neurological diseases. EP1693061; 2006
    • (2006)
  • 58
    • 0029670162 scopus 로고    scopus 로고
    • 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo
    • Ge JA, Barnes NM. 5-HT4 receptor-mediated modulation of 5-HT release in the rat hippocampus in vivo. Br J Pharmacol 1996;117:1475-1480 (Pubitemid 3040750)
    • (1996) British Journal of Pharmacology , vol.117 , Issue.7 , pp. 1475-1480
    • Ge, J.1    Barnes, N.M.2
  • 59
    • 0036025214 scopus 로고    scopus 로고
    • 4 receptors exert a frequency-related facilitatory control on dorsal raphe nucleus 5-HT neuronal activity
    • DOI 10.1046/j.1460-9568.2002.02150.x
    • Lucas G, Debonnel G. 5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphe nucleus 5-HT neuronal activity. Eur J Neurosci 2002;16:817-822 (Pubitemid 35463573)
    • (2002) European Journal of Neuroscience , vol.16 , Issue.5 , pp. 817-822
    • Lucas, G.1    Debonnel, G.2
  • 61
    • 34548246547 scopus 로고    scopus 로고
    • Serotonin(4) (5-HT4) receptor agonists are putative antidepressants with a rapid onset of action
    • Lucas G, Rymar VV, Du J, et al. Serotonin(4) (5-HT4) receptor agonists are putative antidepressants with a rapid onset of action. Neuron 2007;55:712-725
    • (2007) Neuron , vol.55 , pp. 712-725
    • Lucas, G.1    Rymar, V.V.2    Du, J.3
  • 62
    • 67649356433 scopus 로고    scopus 로고
    • Stimulators of 5-ht4 receptors and uses thereof
    • WO2006029520
    • Debonnel G, Lucas G. Stimulators of 5-ht4 receptors and uses thereof. WO2006029520; 2006
    • (2006)
    • Debonnel, G.1    Lucas, G.2
  • 63
    • 67649328956 scopus 로고    scopus 로고
    • Indole derivatives as serotonin reuptake inhibitors
    • US2006160824
    • Heinrich T, Bottcher H. Indole derivatives as serotonin reuptake inhibitors. US2006160824; 2006
    • (2006)
    • Heinrich, T.1    Bottcher, H.2
  • 64
    • 67649310252 scopus 로고    scopus 로고
    • Serotonin reuptake inhibitors
    • WO2005094896
    • Pinney KG, Miranda MG. Serotonin reuptake inhibitors. WO2005094896; 2005
    • (2005)
    • Pinney, K.G.1    Miranda, M.G.2
  • 65
    • 67649356434 scopus 로고    scopus 로고
    • Serotonin reuptake inhibitors
    • US2008132514
    • Pinney KG, Miranda MG. Serotonin reuptake inhibitors. US2008132514; 2008
    • (2008)
    • Pinney, K.G.1    Miranda, M.G.2
  • 66
    • 67649328950 scopus 로고    scopus 로고
    • C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants
    • Janssen Pharmaceutica. US2005256119
    • Janssen Pharmaceutica. C-substituted tricyclic isoxazoline derivatives and their use as anti-depressants. US2005256119; 2005
    • (2005)
  • 67
    • 67649335007 scopus 로고    scopus 로고
    • Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor
    • Alpha 2 Pharmaceutical. WO2006083204
    • Alpha 2 Pharmaceutical. Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor. WO2006083204; 2006
    • (2006)
  • 68
    • 67649384294 scopus 로고    scopus 로고
    • Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor
    • Alpha 2 Pharmaceutical. US2008269306
    • Alpha 2 Pharmaceutical. Antidepressant Medicament Comprising Idazoxan and a Selective Serotonin Reuptake Inhibitor. US2008269306; 2008
    • (2008)
  • 69
    • 0032771114 scopus 로고    scopus 로고
    • Neurochemical brain imaging investigations of schizophrenia
    • DOI 10.1016/S0006-3223(99)00015-3, PII S0006322399000153
    • Soares JC, Innis RB. Neurochemical brain imaging investigations of schizophrenia. Biol Psychiatry 1999;46:600-615 (Pubitemid 29401858)
    • (1999) Biological Psychiatry , vol.46 , Issue.5 , pp. 600-615
    • Soares, J.C.1    Innis, R.B.2
  • 70
    • 67649345216 scopus 로고    scopus 로고
    • Combination therapy for treatment of psychoses
    • Lilly Co. Eli. EP830864
    • Lilly Co. Eli. Combination therapy for treatment of psychoses. EP830864; 1997
    • (1997)
  • 72
    • 67649335003 scopus 로고    scopus 로고
    • New phenylpiperazines useful for treating central nervous system disorders caused by dopaminergic or serotonergic systems
    • Solvay Pharmaceuticals BV. NZ523135
    • Solvay Pharmaceuticals BV. New phenylpiperazines useful for treating central nervous system disorders caused by dopaminergic or serotonergic systems. NZ523135; 2005
    • (2005)
  • 73
    • 67649335002 scopus 로고    scopus 로고
    • Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
    • Solvay Pharmaceuticals BV. US2006122189, US2006122190, US2006247256
    • Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. US2006122189, US2006122190, US2006247256; 2006
    • (2006)
  • 74
    • 67649302599 scopus 로고    scopus 로고
    • Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
    • Solvay Pharmaceuticals BV. US2006122175, CA2587940
    • Solvay Pharmaceuticals BV. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. US2006122175, CA2587940; 2006
    • (2006)
  • 75
    • 67649318783 scopus 로고    scopus 로고
    • Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptakesites
    • Solvay Pharmaceuticals BV. US2006122177. CA2587928
    • Solvay Pharmaceuticals BV. Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptakesites. US2006122177. CA2587928; 2006
    • (2006)
  • 76
    • 67649326709 scopus 로고    scopus 로고
    • Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
    • Solvay Pharmaceuticals BV. US2006122206, CA2587936
    • Solvay Pharmaceuticals BV. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. US2006122206, CA2587936; 2006
    • (2006)
  • 77
    • 67649335002 scopus 로고    scopus 로고
    • Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
    • Solvay Pharmaceuticals BV. US2006122247
    • Solvay Pharmaceuticals BV. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. US2006122247; 2006
    • (2006)
  • 78
    • 67649375853 scopus 로고    scopus 로고
    • Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
    • Solvay Pharmaceuticals BV. EP1824479, EP1824480, EP1827426, EP1828161, MX2007006818
    • Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. EP1824479, EP1824480, EP1827426, EP1828161, MX2007006818; 2007
    • (2007)
  • 79
    • 67649328947 scopus 로고    scopus 로고
    • Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
    • Solvay Pharmaceuticals BV. EP1824486, MX2007006758
    • Solvay Pharmaceuticals BV. Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. EP1824486, MX2007006758; 2007
    • (2007)
  • 80
    • 67649307938 scopus 로고    scopus 로고
    • Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
    • Solvay Pharmaceuticals BV. EP1828168, MX2007006757
    • Solvay Pharmaceuticals BV. Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. EP1828168, MX2007006757; 2007
    • (2007)
  • 81
    • 67649318786 scopus 로고    scopus 로고
    • 8-{4-[3-(5-fluoro-1H-indol-3-YLl)-propyl]- Piperazin-1-YL-2-methyl-4H- benzo[1,4]. oxazin-3-one mesylate with high affinity for the dopamine D2 receptor and the serotonin reuptake site
    • Solvay Pharmaceuticals BV. AU2002250983
    • Solvay Pharmaceuticals BV. 8-{4-[3-(5-fluoro-1H-indol-3-YLl)-propyl]- piperazin-1-YL)-2-methyl-4H-benzo[1,4]. oxazin-3-one mesylate with high affinity for the dopamine D2 receptor and the serotonin reuptake site. AU2002250983; 2006
    • (2006)
  • 82
    • 67649384299 scopus 로고    scopus 로고
    • Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
    • Solvay Pharmaceuticals BV. SI1827427
    • Solvay Pharmaceuticals BV. Aryloxyethylamine and phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. SI1827427; 2008
    • (2008)
  • 83
    • 67649328947 scopus 로고    scopus 로고
    • Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
    • Solvay Pharmaceuticals BV. MX2007006756
    • Solvay Pharmaceuticals BV. Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites. MX2007006756; 2007
    • (2007)
  • 84
    • 67649328951 scopus 로고    scopus 로고
    • Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
    • Solvay Pharmaceuticals BV. HR20090015
    • Solvay Pharmaceuticals BV. Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition. HR20090015; 2009
    • (2009)
  • 86
    • 67649351463 scopus 로고    scopus 로고
    • Yaksh TL, Lynch C, Zapol W, et al. Philadelphia: Lippincott-Raven
    • Sindrup J. Anesthesia: Biological foundations. In: Yaksh TL, Lynch C, Zapol W, et al. Philadelphia: Lippincott-Raven; 1997
    • (1997) Anesthesia: Biological Foundations
    • Sindrup, J.1
  • 87
    • 67649339566 scopus 로고    scopus 로고
    • C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorder
    • Gruenenthal GmbH. US2006258741
    • Gruenenthal GmbH. C-(2-phenyl-cyclohexyl)-methylamine compounds for the treatment of anxiety disorder. US2006258741; 2006
    • (2006)
  • 88
    • 0034192260 scopus 로고    scopus 로고
    • The troubled story of tachykinins and neurokinins
    • DOI 10.1016/S0165-6147(00)01463-2, PII S0165614700014632
    • Maggi CA. The troubled story of tachykinins and neurokinins. Trends Pharmacol Sci 2000;21:173-175 (Pubitemid 30243198)
    • (2000) Trends in Pharmacological Sciences , vol.21 , Issue.5 , pp. 173-175
    • Maggi, C.A.1
  • 90
    • 67649384295 scopus 로고    scopus 로고
    • Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists
    • Servier Lab. EP1710240
    • Servier Lab. Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists. EP1710240; 2006
    • (2006)
  • 91
    • 67649347437 scopus 로고    scopus 로고
    • Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them
    • Sanofi Aventis. EP1707564
    • Sanofi Aventis. Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them. EP1707564; 2006
    • (2006)
  • 92
    • 0026508416 scopus 로고
    • A potent and selective non-peptide antagonist of the neurokinin a (NH2) receptor
    • Edmonds-Alt X, Vilain P, Goulaouic P, et al. A potent and selective non-peptide antagonist of the neurokinin a (NH2) receptor. Life Sci 1992;50:PL101-6
    • (1992) Life Sci , vol.50
    • Edmonds-Alt, X.1    Vilain, P.2    Goulaouic, P.3
  • 93
    • 67649328955 scopus 로고    scopus 로고
    • Composition useful to treat e.g. anxiety disorder comprises (S)-(-)-N-(4-(4-acetamido-4-phenyl- 1-piperidyl)-2-(3, 4-dichlorophenyl) butyl)-N-methylbenzamide, (+/-)-N-methyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy) -propan- 1-amine
    • Sanofi Aventis. FR2904221
    • Sanofi Aventis. Composition useful to treat e.g. anxiety disorder comprises (S)-(-)-N-(4-(4-acetamido-4-phenyl- 1-piperidyl)-2-(3, 4-dichlorophenyl) butyl)-N-methylbenzamide, (+/-)-N-methyl-3-phenyl-3-(4- (trifluoromethyl)phenoxy)-propan- 1-amine. FR2904221; 2008
    • (2008)
  • 94
    • 23144460515 scopus 로고    scopus 로고
    • Recent developments in cannabinoid ligands
    • DOI 10.1016/j.lfs.2005.05.020, PII S0024320505005084, Yargeted Lipidomics: Endocannabinoids and other Endolipid Modulators
    • Padgett LW. Recent developments in cannabinoid ligands. Life Sci 2005;77:1767-1798 (Pubitemid 41078745)
    • (2005) Life Sciences , vol.77 , Issue.14 , pp. 1767-1798
    • Padgett, L.W.1
  • 95
    • 21044458324 scopus 로고    scopus 로고
    • Current knowledge on the antagonists and inverse agonists of cannabinoid receptors
    • DOI 10.2174/0929867054020891
    • Muccioli GG, Lambert DM. Current knowledge on the antagonists and inverse agonists of cannabinoid receptors. Curr Med Chem 2005;12:1361-1394 (Pubitemid 40872582)
    • (2005) Current Medicinal Chemistry , vol.12 , Issue.12 , pp. 1361-1394
    • Muccioli, G.G.1    Lambert, D.M.2
  • 96
    • 23444432920 scopus 로고    scopus 로고
    • The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
    • DOI 10.1021/jm058183t
    • Lambert DM, Fowler CJ. The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 2005;48:5059-5087 (Pubitemid 41113892)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.16 , pp. 5059-5087
    • Lambert, D.M.1    Fowler, C.J.2
  • 97
    • 20444379218 scopus 로고    scopus 로고
    • Endocannabinoid system and stress and anxiety responses
    • DOI 10.1016/j.pbb.2005.01.029, PII S0091305705001346
    • Viveros MP, Marco EM, File SE. Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav 2005;81:331-342 (Pubitemid 40807131)
    • (2005) Pharmacology Biochemistry and Behavior , vol.81 , Issue.2 SPEC. ISS , pp. 331-342
    • Viveros, M.P.1    Marco, E.M.2    File, S.E.3
  • 98
    • 67649345217 scopus 로고    scopus 로고
    • Compounds with a combination of cannabinoid cb1 antagonism and serotonin reuptake inhibition
    • Solvay Pharmaceuticals BV. US2008214559, WO2008084057
    • Solvay Pharmaceuticals BV. Compounds with a combination of cannabinoid cb1 antagonism and serotonin reuptake inhibition. US2008214559, WO2008084057; 2008
    • (2008)
  • 99
    • 0030961840 scopus 로고    scopus 로고
    • 5-HT receptor classification and nomenclature: Towards a harmonization with the human genome
    • DOI 10.1016/S0028-3908(97)00036-1, PII S0028390897000361
    • Hoyer D, Martin G. 5-HT receptor classification and nomenclature: towards a harmonization with the human genome. Neuropharmacology 1997;36:419-428 (Pubitemid 27272086)
    • (1997) Neuropharmacology , vol.36 , Issue.4-5 , pp. 419-428
    • Hoyer, D.1    Martin, G.2
  • 100
    • 67649351462 scopus 로고
    • Composition containing 5-HT1A and 5-HTID antagonists
    • SmithKline Beecham PLC, WO9531988
    • SmithKline Beecham PLC, Jones BJ, Routledge C. Composition containing 5-HT1A and 5-HTID antagonists. WO9531988; 1995
    • (1995)
    • Jones, B.J.1    Routledge, C.2
  • 101
    • 0029671030 scopus 로고    scopus 로고
    • Serotonin 5-HT1d and 5-HT1a receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro
    • Maura G. Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate and inhibition of cyclic GMP production in rat cerebellum in vitro. J Neurochem 1996;66:203-209 (Pubitemid 3015803)
    • (1996) Journal of Neurochemistry , vol.66 , Issue.1 , pp. 203-209
    • Maura, G.1    Raiteri, M.2
  • 102
    • 67649315578 scopus 로고    scopus 로고
    • 5HT1 antagonists for antidepressant therapy
    • Pfizer Prod., Inc. OA11742
    • Pfizer Prod., Inc. 5HT1 antagonists for antidepressant therapy. OA11742; 2005
    • (2005)
  • 103
    • 67649356435 scopus 로고    scopus 로고
    • New 3-oxo-1-propenyl azo compounds useful as 5-HT receptor antagonists e.g. for treating psychoses, neurological disorders, amyotrophic lateral sclerosis and eating disorders
    • Merck Patent GmbH. DE10360151
    • Merck Patent GmbH. New 3-oxo-1-propenyl azo compounds useful as 5-HT receptor antagonists e.g. for treating psychoses, neurological disorders, amyotrophic lateral sclerosis and eating disorders. DE10360151; 2005
    • (2005)
  • 104
    • 67649332671 scopus 로고    scopus 로고
    • New quinolonyl- or benzopyranonyl-substituted indole derivatives are 5HT(1A)- and/or 5HT(1D)-agonists useful e.g. as anxiolytic, antidepressant, neuroleptic and/or antihypertensive agents
    • Merck Patent GmbH. DE10353657
    • Merck Patent GmbH. New quinolonyl- or benzopyranonyl-substituted indole derivatives are 5HT(1A)- and/or 5HT(1D)-agonists useful e.g. as anxiolytic, antidepressant, neuroleptic and/or antihypertensive agents. DE10353657; 2005
    • (2005)
  • 105
    • 67649324156 scopus 로고    scopus 로고
    • New tetrahydroisoquinoline substituted sulfonamide compounds useful as 5-HT7 receptor antagonist in the treatment of e.g. central nervous system disorders
    • Esteve Labor Dr. ES2257168
    • Esteve Labor Dr. New tetrahydroisoquinoline substituted sulfonamide compounds useful as 5-HT7 receptor antagonist in the treatment of e.g. central nervous system disorders. ES2257168; 2006
    • (2006)
  • 106
    • 67649345218 scopus 로고    scopus 로고
    • New dihydro-1H-isoquinoline compounds are 5-hydroxytryptamine-7 inhibitors useful for the treatment of e.g. sleep disorder, shift worker syndrome, depression, migraine, anxiety, psychosis, schizophrenia and pain
    • Esteve Labor Dr. ES2257167
    • Esteve Labor Dr. New dihydro-1H-isoquinoline compounds are 5-hydroxytryptamine-7 inhibitors useful for the treatment of e.g. sleep disorder, shift worker syndrome, depression, migraine, anxiety, psychosis, schizophrenia and pain. ES2257167; 2006
    • (2006)
  • 107
    • 0000553358 scopus 로고    scopus 로고
    • The 5HT7 receptor: A target for novel therapeutic avenues?
    • Terrón JA. The 5HT7 receptor: a target for novel therapeutic avenues? IDrugs 1998;1:302-310
    • (1998) IDrugs , vol.1 , pp. 302-310
    • Terrón, J.A.1
  • 110
    • 0032445751 scopus 로고    scopus 로고
    • Central distribution and function of 5-HT(6) receptor subtype in the rat brain
    • Yoshioka M, Matsumoto M, Togashi H, et al. Central distribution and function of 5-HT(6) receptor subtype in the rat brain. Ann NY Acad Sci 1998;861:244
    • (1998) Ann NY Acad Sci , vol.861 , pp. 244
    • Yoshioka, M.1    Matsumoto, M.2    Togashi, H.3
  • 112
    • 0002628683 scopus 로고    scopus 로고
    • Cognitive enhancement effects of the selective 5-HT6 antagonist SB-271046
    • Rogers DC, Robinson TL, Quilter CA, et al. Cognitive enhancement effects of the selective 5-HT6 antagonist SB-271046. Br J Pharmacol Suppl S 1999;127:22P
    • (1999) Br J Pharmacol Suppl S , vol.127
    • Rogers, D.C.1    Robinson, T.L.2    Quilter, C.A.3
  • 116
    • 0029295914 scopus 로고
    • Clozapine - Selective labeling of sites resembling 5ht(6) serotonin receptors may reflect psychoactive profile
    • Glatt CE, Snowman AM, Sibley DR, et al. Clozapine - selective labeling of sites resembling 5ht(6) serotonin receptors may reflect psychoactive profile. Mol Med 1995;1:398-406
    • (1995) Mol Med , vol.1 , pp. 398-406
    • Glatt, C.E.1    Snowman, A.M.2    Sibley, D.R.3
  • 117
    • 0027481384 scopus 로고
    • Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs
    • Monsma FJ, Shen Y, Ward RP, et al. Cloning and expression of a novel serotonin receptor with high-affinity for tricyclic psychotropic-drugs. Mol Pharmacol 1993;43:320-327 (Pubitemid 23081986)
    • (1993) Molecular Pharmacology , vol.43 , Issue.3 , pp. 320-327
    • Monsma Jr., F.J.1    Shen, Y.2    Ward, R.P.3    Hamblin, M.W.4    Sibley, D.R.5
  • 119
    • 67649384296 scopus 로고    scopus 로고
    • Pyridine derivatives of alkyloxindoles as 5-HT7 receptor active agents
    • Egis Gyogyszergyar Nyilvanosan. HU0500462
    • Egis Gyogyszergyar Nyilvanosan. Pyridine derivatives of alkyloxindoles as 5-HT7 receptor active agents. HU0500462; 2007
    • (2007)
  • 120
    • 67649339568 scopus 로고    scopus 로고
    • Pyperazine derivatives of alkyl-oxindoles
    • Egis Gyogyszergyar Nyilvanosan. HU0500461
    • Egis Gyogyszergyar Nyilvanosan. Pyperazine derivatives of alkyl-oxindoles. HU0500461; 2007
    • (2007)
  • 121
    • 67649368788 scopus 로고    scopus 로고
    • Pyridine derivatives of dialkyl-oxindoles
    • Egis Gyogyszergyar Nyilvanosan. HU0500463
    • Egis Gyogyszergyar Nyilvanosan. Pyridine derivatives of dialkyl-oxindoles. HU0500463; 2007
    • (2007)
  • 122
    • 67649368788 scopus 로고    scopus 로고
    • Piperazine derivatives of dialkyl-oxindoles
    • Egis Gyogyszergyar Nyilvanosan. HU0500464
    • Egis Gyogyszergyar Nyilvanosan. Piperazine derivatives of dialkyl-oxindoles. HU0500464; 2007
    • (2007)
  • 123
    • 67649310255 scopus 로고    scopus 로고
    • New 1-hydroxy- 3-oxo-propen-1-yl-hexahydro-pyrroloindole compounds are 5-hydroxy tryptamine-2 receptor antagonists useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's diseases, cancer, skin diseases and anxiety
    • FR2912747
    • Fourtillan SNC. New 1-hydroxy- 3-oxo-propen-1-yl-hexahydro-pyrroloindole compounds are 5-hydroxy tryptamine-2 receptor antagonists useful to treat e.g. depression, anxiety, Parkinson's disease, Alzheimer's diseases, cancer, skin diseases and anxiety. FR2912747; 2008
    • (2008)
    • Fourtillan, S.N.C.1
  • 124
    • 67649302600 scopus 로고    scopus 로고
    • New 3H,11Hoxazolo(3′,4′:1,2)pyrido(3,4-b)indole derivatives are 5-hydroxytryptamine-2 receptor activators useful e.g. to treat insomnia, jet lag, anxiety, depression and Alzheimers
    • FR2908767
    • Fourtillan SNC. New 3H,11Hoxazolo(3′,4′:1,2)pyrido(3,4-b) indole derivatives are 5-hydroxytryptamine-2 receptor activators useful e.g. to treat insomnia, jet lag, anxiety, depression and Alzheimers. FR2908767; 2008
    • (2008)
    • Fourtillan, S.N.C.1
  • 126
    • 0036373345 scopus 로고    scopus 로고
    • 2A-adrenoceptors
    • DOI 10.1038/sj.mp.4001067
    • Gonzalez-Maeso J, Rodriguez-Puertas R, Meana JJ, et al. Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: Selective supersensitivity of alpha2A-adrenoceptors. Mol Psychiatry 2002;7:755-767 •• This article presents evidence of the imvolvement of alpha2-adrenoceptors in depression. (Pubitemid 34984953)
    • (2002) Molecular Psychiatry , vol.7 , Issue.7 , pp. 755-767
    • Gonzalez-Maeso, J.1    Rodriguez-Puertas, R.2    Meana, J.J.3    Garcia-Sevilla, J.A.4    Guimon, J.5
  • 127
    • 0034866318 scopus 로고    scopus 로고
    • 2-adrenoceptors regulating noradrenergic transmission in the rat brain: A dual-probe microdialysis study
    • Mateo Y, Fernandez-Pastor B, Meana JJ. Acute and chronic effects of desipramine and clorgyline on alpha2-adrenoceptors regulating noradrenergic transmission in the rat brain: a dual-probe microdialysis study. Br J Pharmacol 2001;133:1362-1370 (Pubitemid 32783498)
    • (2001) British Journal of Pharmacology , vol.133 , Issue.8 , pp. 1362-1370
    • Mateo, Y.1    Fernandez-Pastor, B.2    Meana, J.J.3
  • 128
    • 0037053089 scopus 로고    scopus 로고
    • In vivo tonic modulation of the noradrenaline release in the rat cortex by locus coeruleus somatodendritic alpha2-adrenoceptors
    • Fernandez-Pastor B, Meana JJ. In vivo tonic modulation of the noradrenaline release in the rat cortex by locus coeruleus somatodendritic alpha2-adrenoceptors. Eur J Pharmacol 2002;442:225-229
    • (2002) Eur J Pharmacol , vol.442 , pp. 225-229
    • Fernandez-Pastor, B.1    Meana, J.J.2
  • 129
    • 0034749996 scopus 로고    scopus 로고
    • Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex
    • DOI 10.1038/sj.mp.4000904
    • Devoto P, Flore G, Pani L, Gessa GL. Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex. Mol Psychiatry 2001;6:657-664 (Pubitemid 33020584)
    • (2001) Molecular Psychiatry , vol.6 , Issue.6 , pp. 657-664
    • Devoto, P.1    Flore, G.2    Pani, L.3    Gessa, G.L.4
  • 130
    • 0031595284 scopus 로고    scopus 로고
    • 2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine
    • Mateo Y, Pineda J, Meana JJ. Somatodendritic alpha2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine. J Neurochem 1998;71:790-798 (Pubitemid 28480428)
    • (1998) Journal of Neurochemistry , vol.71 , Issue.2 , pp. 790-798
    • Mateo, Y.1    Pineda, J.2    Meana, J.J.3
  • 131
    • 57849108929 scopus 로고    scopus 로고
    • Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - Findings from the Munich Antidepressant Response Signature (MARS) project
    • Hennings JM, Owashi T, Binder EB, et al. Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project. J Psychiatr Res 2009;43:215-229
    • (2009) J Psychiatr Res , vol.43 , pp. 215-229
    • Hennings, J.M.1    Owashi, T.2    Binder, E.B.3
  • 132
    • 67649356438 scopus 로고    scopus 로고
    • Guanidine based Compounds
    • EP2008068199
    • Rozas I, Rodriguez F, et al. Guanidine based Compounds. EP2008068199; 2008
    • (2008)
    • Rozas, I.1    Rodriguez, F.2
  • 133
    • 67649332674 scopus 로고    scopus 로고
    • α2-Adrenoceptor Ligands
    • UK08234205
    • Rozas I, Rodriguez F, et al. α2-Adrenoceptor Ligands. UK08234205; 2008
    • (2008)
    • Rozas, I.1    Rodriguez, F.2
  • 135
    • 67649331238 scopus 로고    scopus 로고
    • New N-substituted 1-benzyl-1H-(1,2,3)-triazole-4-carboxamides, are dopamine and alpha-1 adrenergic receptor ligands useful for treating diseases of the urinary tract, vascular system or CNS
    • DE102004039065
    • Gmeiner P, Huebner H. New N-substituted 1-benzyl-1H-(1,2,3)-triazole-4- carboxamides, are dopamine and alpha-1 adrenergic receptor ligands useful for treating diseases of the urinary tract, vascular system or CNS. DE102004039065; 2006
    • (2006)
    • Gmeiner, P.1    Huebner, H.2
  • 137
    • 0034026318 scopus 로고    scopus 로고
    • Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha(2)-adrenergic and serotonin(2C) receptors: A comparison with citalopram
    • Millan MJ, Gobert A, Rivet JM, et al. Mirtazapine enhances frontocortical dopaminergic and corticolimbic adrenergic, but not serotonergic, transmission by blockade of alpha(2)-adrenergic and serotonin(2C) receptors: a comparison with citalopram. Eur J Neurosci 2000;12:1079-1095
    • (2000) Eur J Neurosci , vol.12 , pp. 1079-1095
    • Millan, M.J.1    Gobert, A.2    Rivet, J.M.3
  • 138
    • 0037382089 scopus 로고    scopus 로고
    • 2A- adrenoceptors: A dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors
    • DOI 10.1124/jpet.102.046383
    • Gobert A, Di Cara B, Cistarelli L, et al. Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha(2A)-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors. J Pharmacol Exp Ther 2003;305:338-346 (Pubitemid 36373869)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.305 , Issue.1 , pp. 338-346
    • Gobert, A.1    Di Cara, B.2    Cistarelli, L.3    Millan, M.J.4
  • 140
    • 67649331235 scopus 로고    scopus 로고
    • Benzoindoline derivatives with adrenergic activity
    • Servier Lab. EP1516871
    • Servier Lab. Benzoindoline derivatives with adrenergic activity. EP1516871; 2005
    • (2005)
  • 141
    • 13844298553 scopus 로고    scopus 로고
    • Glycine site modulators and glycine transporter-1 inhibitors as novel therapeutic targets for the treatment of schizophrenia
    • DOI 10.2174/1570159052773387
    • Kinney GG, Sur C. Glycine site modulators and glycine transporter-1 inhibitors as novel therapeutic targets for the treatment of schizophrenia. Curr Neuropharmacol 2005;3:35-43 (Pubitemid 40246717)
    • (2005) Current Neuropharmacology , vol.3 , Issue.1 , pp. 35-43
    • Kinney, G.G.1    Sur, C.2
  • 142
    • 67649302601 scopus 로고    scopus 로고
    • Combating stress states or nervous system or metabolic disorders, using glycine as neurotransmission modulator showing antistress, stress protective, nootropic and toxin binding actions
    • Tech Egon. DE102005027905
    • Tech Egon. Combating stress states or nervous system or metabolic disorders, using glycine as neurotransmission modulator showing antistress, stress protective, nootropic and toxin binding actions. DE102005027905; 2005
    • (2005)
  • 143
    • 67649324152 scopus 로고    scopus 로고
    • New N-heterocyclylmethyl benzamide derivatives useful as glycine transporter inhibitors for e.g. treating dementia-associated behavioral problems, psychoses, anxiety, depression and alcohol abuse
    • Sanofi Aventis. FR2861076
    • Sanofi Aventis. New N-heterocyclylmethyl benzamide derivatives useful as glycine transporter inhibitors for e.g. treating dementia-associated behavioral problems, psychoses, anxiety, depression and alcohol abuse. FR2861076; 2005
    • (2005)
  • 144
    • 67649302603 scopus 로고    scopus 로고
    • Use of tricyclic compounds as glycine transport inhibitors
    • Sanofi Aventis. CN1882587
    • Sanofi Aventis. Use of tricyclic compounds as glycine transport inhibitors. CN1882587; 2006
    • (2006)
  • 146
    • 67649326711 scopus 로고    scopus 로고
    • 6-Fluorobicyclo[3.1.0]hexane derivatives
    • US2005119345
    • Nazakato A, Chaki S. 6-Fluorobicyclo[3.1.0]hexane derivatives. US2005119345; 2005
    • (2005)
    • Nazakato, A.1    Chaki, S.2
  • 147
    • 67649384298 scopus 로고    scopus 로고
    • Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators
    • Servier Lab. EP1557412
    • Servier Lab. Fluorinated benzothiadiazine derivatives and their use as AMPA receptor modulators. EP1557412; 2005
    • (2005)
  • 148
    • 67649345220 scopus 로고    scopus 로고
    • Benzothiazine and benzothiadiazine derivatives, process for their preparation and phamaceutical compositions containing them
    • Servier Lab. EP1669072
    • Servier Lab. Benzothiazine and benzothiadiazine derivatives, process for their preparation and phamaceutical compositions containing them. EP1669072; 2006
    • (2006)
  • 149
    • 67649368790 scopus 로고    scopus 로고
    • Benzothiadiazine derivatives, method for preparing them and pharmaceutical compositions containing them
    • Servier Lab. EP1655030
    • Servier Lab. Benzothiadiazine derivatives, method for preparing them and pharmaceutical compositions containing them. EP1655030; 2006
    • (2006)
  • 150
    • 67649368790 scopus 로고    scopus 로고
    • Benzothiadiazine derivatives, process of preparation thereof and pharmaceutical compositions containing them
    • Servier Lab. EP1655299
    • Servier Lab. Benzothiadiazine derivatives, process of preparation thereof and pharmaceutical compositions containing them. EP1655299; 2006
    • (2006)
  • 152
    • 0346461630 scopus 로고    scopus 로고
    • Glutamate and Depression: Clinical and Preclinical Studies
    • DOI 10.1196/annals.1300.016
    • Paul IA, Skolnick P. Glutamate and depression: clinical and preclinical studies. Ann NY Acad Sci 2003;1003:250-272 (Pubitemid 38083061)
    • (2003) Annals of the New York Academy of Sciences , vol.1003 , pp. 250-272
    • Paul, I.A.1    Skolnick, P.2
  • 153
    • 67649315582 scopus 로고    scopus 로고
    • Novel neuroprotective compounds and uses thereof
    • WO2006077597
    • Gozin M, Weiner HL. Novel neuroprotective compounds and uses thereof. WO2006077597; 2006
    • (2006)
    • Gozin, M.1    Weiner, H.L.2
  • 154
    • 67649339571 scopus 로고    scopus 로고
    • Use of S-(+)-ketamine for treating depression, which is therapy-refractive depression, preferably depressive episode, relapsing disorder and bipolar affective disorder
    • DE102007009888
    • Hermann HL. Use of S-(+)-ketamine for treating depression, which is therapy-refractive depression, preferably depressive episode, relapsing disorder and bipolar affective disorder. DE102007009888; 2008
    • (2008)
    • Hermann, H.L.1
  • 155
    • 67649307942 scopus 로고    scopus 로고
    • Use of 1,3-dioxane derivatives to enhance the activity of gamma-aminobutyric acid (GABA) on GABA-A receptors
    • DE102007010077
    • Hatt H, Kragler A. Use of 1,3-dioxane derivatives to enhance the activity of gamma-aminobutyric acid (GABA) on GABA-A receptors. DE102007010077; 2008
    • (2008)
    • Hatt, H.1    Kragler, A.2
  • 156
    • 67649328953 scopus 로고    scopus 로고
    • Ferrocenecarboxamide derivatives for use as dopamine D3 ligands for the treatment of CNS disorders
    • Sanol Arznei Schwarz GmbH. EP1733727
    • Sanol Arznei Schwarz GmbH. Ferrocenecarboxamide derivatives for use as dopamine D3 ligands for the treatment of CNS disorders. EP1733727; 2006
    • (2006)
  • 157
    • 67649384297 scopus 로고    scopus 로고
    • New arylpiperazine derivatives, useful to prevent and/or treat neuropsychiatric disorders e.g. disorders of drug dependence, sexual disorders and motor disturbance, are dopamine D3 receptor ligands
    • Bioproject Soc Civ Ile. FR2878524
    • Bioproject Soc Civ Ile. New arylpiperazine derivatives, useful to prevent and/or treat neuropsychiatric disorders e.g. disorders of drug dependence, sexual disorders and motor disturbance, are dopamine D3 receptor ligands. FR2878524; 2006
    • (2006)
  • 158
    • 67649319961 scopus 로고    scopus 로고
    • Arylpiperazuine derivatives as selective ligand for the dopamine D3 receptor
    • Bioproject Soc Civ Ile. EP1659112
    • Bioproject Soc Civ Ile. Arylpiperazuine derivatives as selective ligand for the dopamine D3 receptor. EP1659112; 2006
    • (2006)
  • 159
    • 7444253542 scopus 로고    scopus 로고
    • High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation
    • DOI 10.1016/j.biopsych.2004.08.010, PII S0006322304008960
    • Caldarone BJ, Harrist A, Cleary MA, et al. High affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation. Biol Psychiatry 2004;56:657-664 (Pubitemid 39446847)
    • (2004) Biological Psychiatry , vol.56 , Issue.9 , pp. 657-664
    • Caldarone, B.J.1    Harrist, A.2    Cleary, M.A.3    Beech, R.D.4    King, S.L.5    Picciotto, M.R.6
  • 160
    • 67649310254 scopus 로고    scopus 로고
    • New enantiomerically pure hexahydro-pyrrolo-cyclopenta-pyridine derivatives, useful as central nicotine receptor subtype agonists for e.g. treating Alzheimer's or Parkinson's disease, anxiety and depression
    • Binder Eva Dkfm. AT414305
    • Binder Eva Dkfm. New enantiomerically pure hexahydro-pyrrolo-cyclopenta- pyridine derivatives, useful as central nicotine receptor subtype agonists for e.g. treating Alzheimer's or Parkinson's disease, anxiety and depression. AT414305; 2006
    • (2006)
  • 161
    • 67649375851 scopus 로고    scopus 로고
    • New spiro-isoxazole-cycloalkane compounds, useful as vanilloid receptor 1 ligands for treating e.g. pain, depression and neurodegeneration
    • Gruenenthal GmbH. DE102005044814
    • Gruenenthal GmbH. New spiro-isoxazole-cycloalkane compounds, useful as vanilloid receptor 1 ligands for treating e.g. pain, depression and neurodegeneration. DE102005044814; 2006
    • (2006)
  • 162
    • 67649319959 scopus 로고    scopus 로고
    • New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
    • Abbott GmbH & Co. KG. DE102005015957
    • Abbott GmbH & Co. KG. New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders. DE102005015957; 2006
    • (2006)
  • 163
    • 67649319959 scopus 로고    scopus 로고
    • New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders
    • Abbott GmbH & Co. KG. DE102005014628
    • Abbott GmbH & Co. KG. New substituted oxindole derivatives are vasopressin receptor binders useful to treat e.g. diabetes insipidus, enuresis nocturna, incontinence, hypertonia, heart failure, myocardial infarction, coronary spasm and renal disorders. DE102005014628; 2006
    • (2006)
  • 164
    • 67649368791 scopus 로고    scopus 로고
    • New fused pyrazole derivatives, useful for treatment of psychosis and pain, are sigma receptor inhibitors
    • Esteve Labor. Dr. ES2251317
    • Esteve Labor. Dr. New fused pyrazole derivatives, useful for treatment of psychosis and pain, are sigma receptor inhibitors. ES2251317; 2006
    • (2006)
  • 165
    • 67649324153 scopus 로고    scopus 로고
    • Substituted 2 amino imidazoles, method for their manufacture and their use as a drug or diagnostic and drug containing them
    • Sanofi Aventis Deutschland. EP1857445
    • Sanofi Aventis Deutschland. Substituted 2 amino imidazoles, method for their manufacture and their use as a drug or diagnostic and drug containing them. EP1857445; 2007
    • (2007)
  • 166
    • 23144443533 scopus 로고    scopus 로고
    • Antidepressant action of agomelatine (S 20098) in a transgenic mouse model
    • This article gives evidence of the antidepressant activity of agomelatine, a new drug that act through different mechanisms
    • Barden N, Shink E, Labbe M, et al. Antidepressant action of agomelatine (S 20098) in a transgenic mouse model. Prog Neuropsychopharmacol Biol Psychiatry 2005;29:908-916 • This article gives evidence of the antidepressant activity of agomelatine, a new drug that act through different mechanisms.
    • (2005) Prog Neuropsychopharmacol Biol Psychiatry , vol.29 , pp. 908-916
    • Barden, N.1    Shink, E.2    Labbe, M.3
  • 167
    • 67649347434 scopus 로고    scopus 로고
    • Novel melatonin ligands having antidepressant activity as well as sleep inducing properties
    • CA2636601
    • Lucini V, Spadoni G. Novel melatonin ligands having antidepressant activity as well as sleep inducing properties. CA2636601; 2007
    • (2007)
    • Lucini, V.1    Spadoni, G.2
  • 168
    • 67649375852 scopus 로고    scopus 로고
    • Novel elatonin ligands having antidepressant activity as well as sleep inducing properties
    • EP1973868
    • Gobbi G, Mor M. Novel elatonin ligands having antidepressant activity as well as sleep inducing properties. EP1973868; 2008
    • (2008)
    • Gobbi, G.1    Mor, M.2
  • 169
    • 67649339570 scopus 로고    scopus 로고
    • New 3-acylaminoethyl-3-phenylthio-benzothiophene derivatives, are melatonin receptor ligands useful e.g. for treating sleeping disorders, anxiety, depression, jet lag or appetite disorders
    • Servier Lab. FR2857011
    • Servier Lab. New 3-acylaminoethyl-3-phenylthio-benzothiophene derivatives, are melatonin receptor ligands useful e.g. for treating sleeping disorders, anxiety, depression, jet lag or appetite disorders. FR2857011; 2005
    • (2005)
  • 170
    • 67649315580 scopus 로고    scopus 로고
    • New indole derivatives are melatonin receptor binders useful to treat e.g. sleep disturbance, stress, anxiety, depression, cardiovascular diseases, digestive system disorders, schizophrenia, panic attack, obesity and insomnia
    • Servier Lab. FR2907452
    • Servier Lab. New indole derivatives are melatonin receptor binders useful to treat e.g. sleep disturbance, stress, anxiety, depression, cardiovascular diseases, digestive system disorders, schizophrenia, panic attack, obesity and insomnia. FR2907452; 2008
    • (2008)
  • 171
    • 67649331237 scopus 로고    scopus 로고
    • New naphthalene derivatives, method of preparing same and pharmaceutical compositions containing them
    • Servier Lab. EP1873140
    • Servier Lab. New naphthalene derivatives, method of preparing same and pharmaceutical compositions containing them. EP1873140; 2008
    • (2008)
  • 172
    • 67649302602 scopus 로고    scopus 로고
    • Use of agomelatin in the manufacture of a medicament for the treatment of bipolar disorders
    • Servier Lab. EP1714647
    • Servier Lab. Use of agomelatin in the manufacture of a medicament for the treatment of bipolar disorders. EP1714647; 2006
    • (2006)
  • 173
    • 67649345219 scopus 로고    scopus 로고
    • Use of agomelatine to obtain a medication aimed at treating generalised anxiety disorder
    • Servier Lab. EP1842535
    • Servier Lab. Use of agomelatine to obtain a medication aimed at treating generalised anxiety disorder. EP1842535; 2007
    • (2007)
  • 174
    • 67649347435 scopus 로고    scopus 로고
    • Use of agomelatine to obtain a drug to treat Smith Magenis syndrome, major depression, seasonal depression, sleep disorder, cardiovascular disease, digestive system disorder, insomnia, shiftlag, appetite disorders and obesity
    • Servier Lab. FR2908995
    • Servier Lab. Use of agomelatine to obtain a drug to treat Smith Magenis syndrome, major depression, seasonal depression, sleep disorder, cardiovascular disease, digestive system disorder, insomnia, shiftlag, appetite disorders and obesity. FR2908995; 2008
    • (2008)
  • 175
    • 25144449526 scopus 로고    scopus 로고
    • Involvement of melanocortin-4 receptor in anxiety and depression
    • DOI 10.1016/j.peptides.2004.11.029, PII S019697810500241X, The Melanocortin Pathway 2005
    • Chaki S, Okuyama S. Involvement of melanocortin-4 receptor in anxiety and depression. Peptides 2005;26:1952-1964 (Pubitemid 41354554)
    • (2005) Peptides , vol.26 , Issue.10 , pp. 1952-1964
    • Chaki, S.1    Okuyama, S.2
  • 176
    • 67649356436 scopus 로고    scopus 로고
    • New 1,2,6-trisubstituted benzimidazole derivatives and imidazo-pyridine analogs, are melanocortin receptor ligands useful for treating e.g. obesity, cachexia, anxiety, depression or neuropathic pain
    • FR2862971
    • Poitout L, Brault V. New 1,2,6-trisubstituted benzimidazole derivatives and imidazo-pyridine analogs, are melanocortin receptor ligands useful for treating e.g. obesity, cachexia, anxiety, depression or neuropathic pain. FR2862971; 2005
    • (2005)
    • Poitout, L.1    Brault, V.2
  • 178
    • 67649351468 scopus 로고    scopus 로고
    • Antidepressant
    • Takeda Pharmaceutical. PL371366
    • Takeda Pharmaceutical. Antidepressant. PL371366; 2005
    • (2005)
  • 179
    • 67649319960 scopus 로고    scopus 로고
    • Antidepressant
    • Takeda Pharmaceutical. US2006241168
    • Takeda Pharmaceutical. Antidepressant. US2006241168; 2006
    • (2006)
  • 180
    • 67649328954 scopus 로고    scopus 로고
    • Use of hyperforin derivatives as an antidepressant agent
    • EP1607099
    • Bombardelli E, Morazzoni P. Use of hyperforin derivatives as an antidepressant agent. EP1607099; 2005
    • (2005)
    • Bombardelli, E.1    Morazzoni, P.2
  • 181
    • 67649318785 scopus 로고    scopus 로고
    • New 2-amino-imidazo(4,5-d)pyridazin-4-one derivatives are dipeptidyl-peptidase IV inhibitors useful in the treatment of e.g. diabetes mellitus, autoimmune disease, rheumatoid arthritis, and multiple sclerosis
    • Boehringer Ingelheim Pharma. DE102004025552
    • Boehringer Ingelheim Pharma. New 2-amino-imidazo(4,5-d)pyridazin-4-one derivatives are dipeptidyl-peptidase IV inhibitors useful in the treatment of e.g. diabetes mellitus, autoimmune disease, rheumatoid arthritis, and multiple sclerosis. DE102004025552; 2005
    • (2005)
  • 182
    • 37349122437 scopus 로고    scopus 로고
    • Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling
    • DOI 10.1039/b714136j
    • Lodola A, Mor M, Rivara S, et al. Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modeling. Chem Commun 2008;214-216 (Pubitemid 350294105)
    • (2008) Chemical Communications , Issue.2 , pp. 214-216
    • Lodola, A.1    Mor, M.2    Rivara, S.3    Christov, C.4    Tarzia, G.5    Piomelli, D.6    Mulholland, A.J.7
  • 183
    • 67649351467 scopus 로고    scopus 로고
    • New 1-alkyl-(homo) piperazine-4-carboxylate ester derivatives, are fatty acid amidohydrolase inhibitors useful e.g. for treating pain, cancer or neurodegenerative, cardiovascular, inflammatory or allergic disease
    • Sanofi Synthelabo. FR2866888
    • Sanofi Synthelabo. New 1-alkyl-(homo) piperazine-4-carboxylate ester derivatives, are fatty acid amidohydrolase inhibitors useful e.g. for treating pain, cancer or neurodegenerative, cardiovascular, inflammatory or allergic disease. FR2866888; 2005
    • (2005)
  • 184
    • 67649332675 scopus 로고    scopus 로고
    • Derivatives of arylalkylcarbamates, process for their preparation and therapeutic application thereof
    • Sanofi Synthelabo. EP1972616
    • Sanofi Synthelabo. Derivatives of arylalkylcarbamates, process for their preparation and therapeutic application thereof. EP1972616; 2008
    • (2008)
  • 185
    • 35148895860 scopus 로고    scopus 로고
    • PDE inhibitors in psychiatry - Future options for dementia, depression and schizophrenia?
    • Halene TB, Siegel SJ. PDE inhibitors in psychiatry - future options for dementia, depression and schizophrenia? Drug Discov Today 2007;12:870-878
    • (2007) Drug Discov Today , vol.12 , pp. 870-878
    • Halene, T.B.1    Siegel, S.J.2
  • 186
    • 67649347433 scopus 로고    scopus 로고
    • New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease
    • Boehringer Ingelheim Pharma. DE102005023207
    • Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005023207; 2006
    • (2006)
  • 187
    • 67649347433 scopus 로고    scopus 로고
    • New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease
    • Boehringer Ingelheim Pharma. DE102005019718
    • Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005019718; 2006
    • (2006)
  • 188
    • 67649307941 scopus 로고    scopus 로고
    • New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or
    • Boehringer Ingelheim Pharma. DE102005035575
    • Boehringer Ingelheim Pharma. New heteroaryl derivatives are phosphodiesterase-4 enzyme inhibitors useful for the treatment of e.g. respiratory or gastrointestinal complaints or diseases, depression, Alzheimer's disease and Parkinson's disease. DE102005035575; 2007
    • (2007)
  • 189
    • 67649324154 scopus 로고    scopus 로고
    • New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia
    • Boehringer Ingelheim Pharma. DE102004057645
    • Boehringer Ingelheim Pharma. New substituted pteridine compounds, useful as phosphodiesterase 4 inhibitors for treating e.g. inflammatory diseases, cancer, asthma, ulcerative colitis, depression and schizophrenia. DE102004057645; 2006;
    • (2006)
  • 190
    • 67649335005 scopus 로고    scopus 로고
    • New triazabenzo(a) naphtho(2,1,8-cde)azulene derivatives useful as tyrosine hydroxylase inducers, e.g. for treating depression or anxiety
    • Servier Lab. FR2911141
    • Servier Lab. New triazabenzo(a) naphtho(2,1,8-cde)azulene derivatives useful as tyrosine hydroxylase inducers, e.g. for treating depression or anxiety. FR2911141; 2008
    • (2008)
  • 191
    • 67649335006 scopus 로고    scopus 로고
    • Available from: Life Science Analytics, Inc
    • Medtrack. Available from: http://www.medtrack.com/research/default.asp, Life Science Analytics, Inc
    • Medtrack


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.