First dual NK1 antagonists-serotonin reuptake inhibitors: Synthesis and SAR of a new class of potential antidepressants

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 2, 2002, Pages 261-264

  Ryckmans, Thomas ^a   Balançon, Laurent ^a   Berton, Olivier ^a   Genicot, Christophe ^a   Lamberty, Yves ^a   Lallemand, Benedicte ^a   Pasau, Patrick ^a   Pirlot, Nathalie ^a   Quéré, Luc ^a   Talaga, Patrice ^a  

^a UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; ANTIDEPRESSANT AGENT; APREPITANT; IMIPRAMINE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; SEROTONIN UPTAKE INHIBITOR;

ANXIETY NEUROSIS; ARTICLE; CLINICAL TRIAL; DEPRESSION; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; INHIBITION KINETICS; LIPOPHILICITY; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANTIDEPRESSIVE AGENTS; RECEPTORS, NEUROKININ-1; SEROTONIN UPTAKE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 18244364895     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00727-2     Document Type: Article

References (35)