The clinicopathological significance of tissue levels of hypoxia-inducible factor-1α and vascular endothelial growth factor in gastric cancer

Gut and Liver

Volumn 3, Issue 2, 2009, Pages 88-94

  Kim, Seong Eun ^a,b   Shim, Ki Nam ^a   Jung, Sung Ae ^a   Yoo, Kwon ^a   Joo, Ho Lee ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Mokdong Hospital   (South Korea)

Author keywords

Hypoxia inducible factor 1, alpha; Stomach neoplasms; Vascular endothelial growth factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; VASCULOTROPIN;

ADULT; AGED; ARTICLE; CLINICAL FEATURE; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN EXPRESSION; RECURRENT CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH BIOPSY; STOMACH CANCER;

EID: 67649300463     PISSN: 19762283     EISSN: None     Source Type: Journal    
DOI: 10.5009/gnl.2009.3.2.88     Document Type: Article

References (36)

1. Kuwai T, Kitadai Y, Tanaka S, et al. Expression of hypoxia inducible factor 1alpha is associated with tumor vascularization in human colorectal carcinoma. Int J Cancer 2003;105:176-181. (Pubitemid 36505317)
2. Stoeltzing O, McCarty MF, Wey JS, et al. Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst 2004;96:946-956. (Pubitemid 38868141)
3. Livingston DM, Shivdasani R. Toward mechanism-based cancer care. JAMA 2001;285:588-593. (Pubitemid 32656329)
4. Takahashi R, Tanaka S, Hiyama T, et al. Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol Rep 2003;10:797-802.
5. Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000;157:411-421. (Pubitemid 30626905)
6. Chun YS, Kim MS, Park JW. Oxygen-dependent and -independent regulation of HIF-1alpha. J Korean Med Sci 2002;17:581-588.
7. Shi YH, Fang WG. Hypoxia-inducible factor-1 in tumor angiogenesis. World J Gastroenterol 2004;10:1082-1087.
8. Zhong H, Agani F, Baccala AA, et al. Increased expression of hypoxia inducible factor-1 alpha in rat and human prostate cancer. Cancer Res 1998;58:5280-5284. (Pubitemid 28551099)
9. Stroka DM, Burkhardt T, Desbaillets I, et al. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J 2001;15:2445-2453. (Pubitemid 33063172)
10. Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002;64:993-998. (Pubitemid 35232274)
11. Chen WT, Huang CJ, Wu MT, Yang SF, Su YC, Chai CY. Hypoxia-inducible factor-1alpha is associated with risk of aggressive behavior and tumor angiogenesis in gastrointestinal stromal tumor. Jpn J Clin Oncol 2005;35:207-213. (Pubitemid 40796855)
12. Mizokami K, Kakeji Y, Oda S, et al. Clinicopathologic significance of hypoxia-inducible factor 1alpha overexpression in gastric carcinomas. J Surg Oncol 2006;94:149-154. (Pubitemid 44267197)
13. Yoshikawa T, Tsuburaya A, Miyagi Y, et al. Up-regulation of hypoxia-inducible factor-1 alpha and VEGF mRNAs in peritoneal dissemination of patients with gastric cancer. Anticancer Research 2006;26:3849-3854. (Pubitemid 44701470)
14. Fukuda R, Kelly B, Semenza GL. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res 2003;63:2330-2334. (Pubitemid 36538645)
15. Koshikawa N, Iyozumi A, Gassmann M, Takenaga K. Constitutive upregulation of hypoxia-inducible factor-1alpha mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure. Oncogene 2003;22:6717-6724. (Pubitemid 37372212)
16. Iyer NV, Kotch LE, Agani F, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1alpha. Genes Dev 1998;12:149-162. (Pubitemid 28060446)
17. Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394:485-490. (Pubitemid 28373960)
18. Reinmuth N, Parikh AA, Ahmad SA, et al. Biology of angiogenesis in tumors of the gastrointestinal tract. Microsc Res Tech 2003;60:199-207. (Pubitemid 36125708)
19. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR, Ellis LM. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995;55:3964-3968.
20. Aoyagi K, Kouhuji K, Yano S, et al. VEGF significance in peritoneal recurrence from gastric cancer. Gastric Cancer 2005;8:155-163. (Pubitemid 41176094)
21. Sumiyoshi Y, Kakeji Y, Egashira A, Mizokami K, Orita H, Maehara Y. Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer. Clin Cancer Res 2006;12:5112-5117. (Pubitemid 44453338)
22. Urano N, Fujiwara Y, Doki Y, et al. Overexpression of hypoxia-inducible factor-1alpha in gastric adenocarcinoma. Gastric Cancer 2006;9:44-49.
23. Griffiths EA, Pritchard SA, Valentine HR, et al. Hypoxiainducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas. Br J Cancer 2007;96:95-103. (Pubitemid 46094645)
24. Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Relation of hypoxia inducible factor 1alpha and 2alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001;85:881-890. (Pubitemid 33010557)
25. Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999;59:5830-5835.
26. Matsuyama T, Nakanishi K, Hayashi T, et al. Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma. Cancer Sci 2005;96:176-182. (Pubitemid 40575919)
27. Kitadai Y, Kodama M, Cho S, et al. Quantitative analysis of lymphangiogenic markers for predicting metastasis of human gastric carcinoma to lymph nodes. Int J Cancer 2005;115:388-392. (Pubitemid 40663742)
28. Mori M, Mimori K, Inoue H, et al. Detection of cancer micrometastases in lymph nodes by reverse transcriptasepolymerase chain reaction. Cancer Res 1995;55:3417-3420.
29. Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC. Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer. Cancer Res 2004;64:1765-1772. (Pubitemid 38428700)
30. Griffiths EA, Pritchard SA, Welch IM, Price PM, West CM. Is the hypoxia-inducible factor pathway important in gastric cancer? Eur J Cancer 2005;41:2792-2805.
31. Krishnamachary B, Berg-Dixon S, Kelly B, et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res 2003;63:1138-1143. (Pubitemid 36278449)
32. Beasley NJ, Leek R, Alam M, et al. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res 2002;62:2493-2497. (Pubitemid 34462724)
33. Hachisuka T, Narikiyo M, Yamada Y, et al. High lymphatic vessel density correlates with overexpression of VEGF-C in gastric cancer. Oncol Rep 2005;13:733-737.
34. Onogawa S, Kitadai Y, Amioka T, et al. Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with clinicopathological parameters. Cancer Lett 2005;226:85-90. (Pubitemid 40943433)
35. Takahashi Y, Cleary KR, Mai M, Kitadai Y, Bucana CD, Ellis LM. Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer. Clin Cancer Res 1996;2:1679-1684. (Pubitemid 26356351)
36. Hong SS, Lee H, Kim KW. HIF-1alpha: a valid therapeutic target for tumor therapy. Cancer Res Treat 2004;36:343-353.