Cellular effects of extremely low frequency (ELF) electromagnetic fields

International Journal of Radiation Biology

Volumn 85, Issue 4, 2009, Pages 294-313

  Santini, Maria T ^a   Rainaldi, Gabriella ^a   Indovina, Pietro L ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Cell biology; Extremely low frequency electromagnetic fields; Non ionising radiations

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CELL ADHESION MOLECULE; CELL DNA; HEAT SHOCK PROTEIN 70; MELATONIN; MYC PROTEIN; NERVE GROWTH FACTOR; PLACEBO; TAMOXIFEN; VERY LATE ACTIVATION ANTIGEN 2; VERY LATE ACTIVATION ANTIGEN 5;

ANALGESIA; ARTICLE; BONE CELL; BONE DEVELOPMENT; BONE MATRIX; BREAST CANCER; CALCIUM HOMEOSTASIS; CANCER RISK; CARCINOGENESIS; CARCINOGENICITY; CELL DIFFERENTIATION; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC PAIN; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DNA DAMAGE; DRUG ACTIVITY; ELECTROMAGNETIC FIELD; EXTREMELY LOW FREQUENCY ELECTROMAGNETIC FIELD; FIBROMYALGIA; FRACTURE HEALING; GENETIC TRANSCRIPTION; HUMAN; IMMUNOCOMPETENT CELL; ISCHEMIA; LEG ULCER; LYMPHOCYTE; MYALGIA; NERVE CELL; NERVE FIBER GROWTH; NONHUMAN; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RADIATION EXPOSURE; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; RHEUMATOID ARTHRITIS; SISTER CHROMATID EXCHANGE; TUMOR CELL; WOUND HEALING; ANIMAL; BONE; CELL; CYTOLOGY; IMMUNE SYSTEM; NEOPLASM; PATHOLOGY; REVIEW;

ANIMALS; BONE AND BONES; CELLS; ELECTROMAGNETIC FIELDS; HUMANS; IMMUNE SYSTEM; NEOPLASMS; NEURONS;

EID: 67649214820     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000902781097     Document Type: Article

References (188)

1. Aaron RK, Ciombor D McK, Jolly G. 1989. Stimulation of experimental endochondral ossification by low-energy pulsing electromagnetic fields. Journal of Bone and Mineral Research 2:227-233.
2. Adey WR. 1971. Evidence for cerebral membrane effects of calcium, derived from direct-current gradient, impedance, and intracellular records. Experimental Neurology 30:78-102.
3. Adey WR. 1988a. Cell membranes: the electromagnetic environment and cancer promotion. Neurochemical Research 13:671-677.
4. Adey WR. 1988b. The cellular microenvironment and signaling through cell membranes. Progress in Clinical Biological Research 257:81-106.
5. Adey WR. 1993. Biological effects of electromagnetic fields. Journal of Cellular Biochemistry 51:410-416.
6. Ahlbom A, Day N, Feychting M, Roman E, Skinner J, Dockerty J, Linet M, McBride M, Michaelis J, Olsen JH, Tynes T, Verkasalo PK. 2000. A pooled analysis of magnetic fields and childhood leukaemia. British Journal of Cancer 83:692-698.
7. Ahlbom A, Feychting M. 1993. EMF and cancer. Science 260: 13-16.
8. Ahlbom IC, Cardis E, Green A, Linet M, Savitz D, Swerdlow A. 2001. Review of the epidemiologic literature on EMF and health. Environmental Health Perspectives 109:911-933.
9. Allis JW, Sinha-Robinson BL. 1987. Temperature-specific inhibition of human red cell Na"/K"-ATPase by 2,450-MHz microwave radiation. Bioelectromagnetics 8:203-212.
10. Anderson LE, Boorman GA, Morris JE, Sasser LB, Mann PC, Grumbein SL, Hailey JR, McNally A, Sills RC, Haseman JK. 1999. Effect of 13 week magnetic field exposures on the DMBA-initiated mammary gland carcinomas in female Sprague-Dawley rats. Carcinogenesis 20:1615-1620.
11. Anderson LE, Morris JE, Sasser LB, Löscher W. 2000. Effects of 50- or 60-Hz, 100 μT magnetic field exposure in the DMBA mammary cancer model in Sprague-Dawley rats: Possible explanations for different results from two laboratories. Environmental Health Perspectives 108:792-802.
12. Antonopoulos A, Yang B, Stamm, A, Heller WD, Obe G. 1995. Cytological effects of 50 Hz electromagnetic fields on human lymphocytes in vitro. Mutation Research 346:151-157.
13. Bassett CAL. 1965. Electrical effects in bone. Scientific American 213:18-25.
14. Bassett CAL. 1968. Review: Biological significance of piezoelectricity. Calcified Tissue Research 1:252-272.
15. Bassett CAL, Becker RO. 1962. Generation of electrical potentials by bone in response to mechanical stress. Science 137:1063-1064.
16. Bassett CAL, Pawluk RJ, Pilla AA. 1974. Augmentation of bone repair by inductively coupled electromagnetic fields. Science 184:575-577.
17. Bawin SM, Adey WR. 1976. Sensitivity of calcium binding in cerebral tissue to weak environmental electric fields oscillating at low frequency. Annals of the New York Academy of Science 73:1999-2003.
18. Bawin SM, Kaczmarek LK, Adey WR. 1975. Effects of modulated VHF fields on the central nervous system. Annals of the New York Academy of Science 247:74-81.
19. Benfante R, Antonini RA, Kustner N, Schuderer J, Maercker C, Adlkofer F, Clementi F, Fornasari D. 2008. The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase(DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model. Toxicology In Vitro 22:1489-1495.
20. Berridge M, Lipp P, Bootman M. 1999. Calcium signaling. Current Biology 9:R157-159.
21. Blackman CF, Benane SG, House DE. 1993. Evidence for direct effect of magnetic fields on neurite outgrowth. FASEB Journal 7:801-806.
22. Blackman CF, Benane SG, House DE. 2001. The influence of 1.2 microT, 60 Hz magnetic fields on melatonin- and tamoxifen-induced inhibition of MCF-7 cell growth. Bioelectromagnetics 22:122-128.
23. Blackman CF, Benane SG, House DE, Elliott DJ. 1990. Importance of alignment between local DC magnetic field and an oscillating magnetic field in response of brain tissue in vitro and in vivo. Bioelectromagnetics 11:159-167.
24. Blackman CF, Benane SG, House DE, Joines WT. 1985. Effects of ELF (1-120 Hz) and modulated (50 Hz) RF fields on the efflux of calcium ions from brain tissue in vitro. Bioelectromagnetics 6:1-11.
25. Blackman CF, Benane SG, Joines WT, Hollis MA, House DE. 1980. Calcium-ion efflux from brain tissue: power-density versus internal field-intensity dependencies at 50 MHz RF radiation. Bioelectromagnetics 1:277-283.
26. Blackman CF, Blanchard JP, Benane SG, House DE. 1994. Empirical test of an ion parametric resonance model for magnetic field interaction with PC-12 cells. Bioelectromag-netics 15:239-260.
27. Blackman CF, House DE, Benane SG, Joines WT, Spiegel RJ. 1988. Effect of ambient levels of power-line-frequency electric fields on a developing vertebrate. Bioelectromagnetics 9:129-140.
28. Blackman CF, Kinney LS, House DE, Joines WT. 1989. Multiple power-density windows and their possible origin. Bioelectromagnetics 10:115-128.
29. Blank M, Goodman R. 1997. Do electromagnetic fields interact directly with DNA? Bioelectromagnetics 18:111-115.
30. Blank M, Goodman R. 1999. Electromagnetic fields may act directly on DNA. Journal of Cell Biochemistry 75:369-374.
31. Blank M, Goodman R. 2000. Stimulation of the cellular stress response by low frequency electromagnetic fields: Possibility of direct interaction with DNA. IEEE Transactions on Plasma Sciences 28:168-172.
32. Blank M, Soo L. 1996. The threshold of Na,K-ATPase stimulation by electromagnetic fields. Bioelectrochemistry and Bioenergetics 40:63-65.
33. Blank M, Soo L. 1998a. Enhancement of cytochrome oxidase activity in 60 Hz magnetic fields. Bioelectrochemistry and Bioenergetics 45:253-259.
34. Blank M, Soo L. 1998b. Frequency dependence of cytochrome oxidase activity in magnetic fields. Bioelectrochemistry and Bioenergetics 46:139-143.
35. Blank M, Soo L. 2001. Optimal frequencies for magnetic acceleration of cytochrome oxidase and Na,K-ATPase reactions. Bioelectrochemistry 53:171-174.
36. Bodamyali T, Bhatt B, Hughes FJ, Winrow VR, Kanczier JM, Simon B, Abbott J, Blake DR, Stevens CR. 1998. Pulsed electromagnetic fields simultaneously induce osteogenesis and upregulate transcription of bone morphogenetic proteins 2 and 4 in rat osteoblasts in vitro. Biochemical and Biophysical Research Communications 250:458-461.
37. Brzezinski A. 1997. Melatonin in humans. New England Journal of Medicine 336:186-195.
38. Callaghan MJ, Chang EI, Seiser N, Aarabi S, Ghali S, Kinnucan ER, Simon BJ, Gurtner GC. 2008. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plastic Reconstruction Surgery 121:130-141.
39. Cañ edo-Dorantes L, García-Cantú R, Barrera R, Méndez-Ramírez I, Navarro VH, Serrano G. 2002. Healing of chronic arterial and venous leg ulcers through systemic effects of electromagnetic fields. Archives in Medical Research 33:281-289.
40. California Department of Health Services (CDHS). 2002. An evaluation of the possible risks from electric and magnetic fields (EMFs) from power lines, internal wiring, electrical occupations, and appliances, California EMF Program, Final Report June 2002. Oakland, CA: CDHS. Accessed from the website: http://www.dhs.ca.gov/eheb/emf/RiskEvaluation/riskeval.html
41. Chiabrera A, Bianco B, Moggia E, Kaufman JJ. 2000. Zeeman-Stark modeling of the RF EMF interaction with ligand binding. Bioelectromagnetics 21:312-324.
42. Cleary SF, Garber F, Liu LM. 1982. Effects of X-band microwave exposure on rabbit erythrocytes. Bioelectromagnetics 3:453-466.
43. Cohen MM, Kunska A, Astemborski JA, McCulloch D, Paskewitz DA. 1986. Effect of low-level, 60-Hz electromagnetic fields on human lymphoid cells: I. Mitotic rate and chromosome breakage in human peripheral lymphocytes. Bioelectromag-netics 7:415-423.
44. Conti P, Gigante GE, Alesse E, Cifone MG, Fieschi C, Reale M, Angeletti PU. 1985. A role for calcium in the effect of very low frequency electromagnetic field on the blastogenesis of human lymphocytes. FEBS Letters 181:28-32.
45. Cook CM, Saucier DM, Thomas AW, Prato FS. 2006. Exposure to ELF-modulated radiofrequency fields: The time course of physiological and cognitive effects observed in recent studies (2001-2005).
46. Cook CM, Saucier DM, Thomas AW, Prato FS. 2009. Changes in human EEG alpha activity following exposure to two different pulsed magnetic field sequences. Bioelectromagnetics 30:9-20.
47. Cossarizza A, Monti D, Bersani F, Cantini M, Cadossi R, Sacchi A, Franceschi C. 1989. Extremely low frequency pulsed electromagnetic fields increase cell proliferation in lymphocytes from young and aged subjects. Biochemical and Biophysical Research Communications 160:692-698.
48. Craviso GL, Chatterjee, Publicover NG. 2003. Catecholamine release from cultured bovine adrenal medullary chromaffin cells in the presence of 60-Hz magnetic fields. Bioelectrochemistry 59:57-64.
49. Craviso GL, Poss J, Lanctot C, Lundback SS, Chatterjee I, Publicover NG. 2002. Intracellular calcium activity in isolated bovine adrenal chromaffin cells in the presence and absence of 60 Hz magnetic fields. Bioelectromagnetics 23:557-567.
50. Crumpton MJ, Collins AR. 2004. Are environmental electromagnetic fields genotoxic? DNA Repair 3:1385-1387.
51. Delle Monache S, Alessandro R, Iorio R, Gualtieri G, Colonna R. 2008. Extremely low frequency electromagnetic fields (ELF-EMFs) induce in vitro angiogenesis process in human endothelial cells. Bioelectromagnetics 29:640-648.
52. De Mattei M, Gagliano N, Moscheni C, Dellavia C, Calastrini C, Pellati A, Gioia M, Caruso A, Stabellini G. 2005. Changes in polyamines, c-myc and c-fos gene expression in osteoblast-like cells exposed to pulsed electromagnetic fields. Bioelectromagnetics 26:207-214.
53. Di Carlo AL, Farrell JM, Litovitz TA. 1998. A simple experiment to study electromagnetic field effects: protection induced by short-term exposures to 60 Hz magnetic fields. Bioelectromagnetics 19:498-500.
54. Di Carlo AL, Farrell JM, Litovitz TA. 1999b. Myocardial protection conferred by electromagnetic fields. Circulation 99:813-816.
55. Di Carlo AL, Litovitz TA. 1999a. Is genetics the unrecognized confounding factor in bioelectromagnetics? Flock-dependence of field-induced anoxia protection in chick embryos. Bioelectrochemistry and Bioenergetics 48:209-215.
56. Dixey R, Rein G. 1982. 3H-noradrenaline release potentionated in a clonal nerve cell line by low-intensity pulsed magnetic fields. Nature 296:253-256.
57. Dutta SK, Das K, Ghosh B, Blackman CF. 1992. Dose dependence of acetylcholinesterase activity in neuroblastoma cells exposed to modulated radiofrequency electromagnetic radiation. Bioelectromagnetics 13:317-322.
58. Dutta SK, Ghosh B, Blackman CF. 1989. Radiofrequency radiation-induced calcium ion efflux enhancement from human and other neuroblastoma cells in culture. Bioelectromagnetics 10:197-202.
59. Fedrowitz M, Westermann J, Löscher W. 2002. Magnetic field exposure increases cell proliferation but does not affect melatonin levels in the mammary gland of female Sprague-Dawley rats. Cancer Research 6:1356-1363.
60. Fedrowitz M, Kamino K, Löscher W. 2004. Significant differences in the effects of magnetic field exposure on 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in two substrains of Sprague-Dawley rats. Cancer Research 64:243-251.
61. 24Na+ efflux from human erythrocytes. Radiation Research 92:411-422.
62. Fitzsimmons RJ, Farley J, Adey WR, Baylink DJ. 1986. Embryonic bone matrix formation is increased after exposure to a low-amplitude capacitively coupled electric field, in vitro. Biochimica et Biophysica Acta 882:51-56.
63. Frankenhaeuser B, Hodgkin AL. 1957. The action of calcium on the electrical properties of squid axons. Journal of Physiology 137:218-244.
64. Fukada E, Yasuda I. 1957. On the piezoelectric effect of bone. Journal of the Physics Society of Japan 12:1158-1162.
65. 2+ oscillations in human leukemia T-cells are reduced by 50 Hz magnetic fields. Bioelectromag-netics 20:269-276.
66. Gavalas RJ, Walter DO, Hamer J, Adey WR. 1970. Effect of low-level, low-frequency electric fields on EEG behavior in Macaca nemestrina. Brain Research 18: 491-501.
67. Gavalas-Medici R, Day-Magdaleno SR. 1976. Effects of weak electric fields on behavior and EEG of laboratory animals. Nature 261:256-258.
68. George I, Geddis MS, Lill Z, Lin H, Gomez T, Blank M, Oz MC, Goodman R. 2008. Myocardial function improved by electromagnetic field induction of stress protein hsp70. Journal of Cell Physiology 216:816-823.
69. Girgert R, Schimming H, Körner W, Gründker C, Hanf V. 2005. Induction of tamoxifen resistance in breast cancer cells by ELF electromagnetic fields. Biochemical and Biophysical Research Communications 336:1144-1149.
70. Goodman R, Bassett CA, Henderson AS. 1983. Pulsing electromagnetic fields induce cellular transcription. Science 220:1283-1285.
71. Goodman R, Blank M. 1998. Magnetic field stress induces expression of hsp70. Cell Stress Chaperones 3:79-88.
72. Goodman R, Blank M, Lin H, Khorkova O, Soo L, Weisbrot D, Henderson A. 1994. Increased levels of hsp transcripts are induced when cells are exposed to low frequency electromagnetic fields. Bioelectrochemistry and Bioenergetics 33:115-120.
73. Goodman R, Wei LX, Xu JC, Henderson A. 1989. Exposure of human cells to low-frequency electromagnetic fields results in quantitative changes in transcripts. Biochimica et Biophysica Acta 1009:216-220.
74. Greene JJ, Pearson SL, Skowronski WJ, Nardone RM, Mullins JM, Krause D. 1993. Gene-specific modulation of RNA synthesis and degradation by extremely low frequency electromagnetic fields. Cellular and Molecular Biology (Noisy-le-grand) 39:261-268.
75. Greene L, Tischler A. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proceedings of the National Academy of Sciences of the USA 73:2424-2426.
76. Greenebaum B, Sutton CH, Subramanian Vadula M, Battocletti JH, Swiontek T, De Keiser J, Sisken BF. 1996. Effects of pulsed magnetic fields on neurite outgrowth from chick embryo dorsal root ganglia. Bioelectromagnetics 17:293-302.
77. Greenland S, Sheppard AR, Kaune WT, Poole C, Kelsh MA. 2000. A pooled analysis of magnetic fields, wire codes, and childhood leukemia. Epidemiology 11:624-634.
78. Hamer J. 1968. Effects of low level, low frequency electric fieds on human reaction time. Communications in Biohavioral Biology 2(5) Part A: 217-222.
79. Han L, Lin H, Head M, Jin M, Blank M, Goodman R. 1998. Application of magnetic field-induced Hsp70 for presurgical cytoprotection. Journal of Cellular Biochemistry 71:577-583.
80. Harland JD, Liburdy RP. 1997. Environmental magnetic fields inhibit the antiproliferative action of tamoxifen and melatonin in a human breast cancer cell line. Bioelectromagnetics 18:555-562.
81. Henshaw DL, Reiter RJ. 2005. Do magnetic fields cause increased risk of childhood leukemia via melatonin disruption? Bioectromagnetics Supplement 7:S86-S97.
82. Heredia-Rojas JA, Rodríguez-De La Fuente AO, del Roble Velazco-Campos M, Leal-Garza CH, Rodríguez-Flores LE, de La Fuente-Cortez B. 2001. Cytological effects of 60 Hz magnetic fields on human lymphocytes in vitro: Sisterchromatid exchanges, cell kinetics and mitotic rate. Bioelectromagnetics 22:145-149.
83. Hill SM, Blask DE. 1988. Effects of pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Research 48:6121-6126.
84. Hodgkin AL, Huxley AF. 1952. A quantitative description of membrane current and its application to conduction and excitation in nerve. Journal of Physiology 117:500-544.
85. Holmberg B. 1995. Magnetic fields and cancer: Animal and cellular evidence - an overview. Environmental Health Perspectives 103(Suppl. 2): 63-67.
86. Huang L, Dong L, Chen Y, Qi H, Xiao D. 2006. Effects of sinusoidal magnetic field observed on cell proliferation, ion concentration, and osmolarity in two human cancer cell lines. Electromagnetic Biology and Medicine 25:113-126.
87. International Agency for Research on Cancer (IARC). 2002. IARC monographs on the evaluation of carcinogenic risks to humans. Vol. 80. Non-ionizing radiation, part 1: Static and extremely low frequency (ELF) electric and magnetic fields. France: IARC Press. pp 19-26.
88. International Commission on Non-Ionising Radiation Protection (ICNIRP). 1998. Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz). Health Physics 74:494-522.
89. Ikeda K, Shinmura Y, Mizoe H, Yoshizawa H, Yoshida A, Kanao S, Sumitani H, Hasebe S, Motomura T, Yamakawa T, Mizuno F, Otaka Y, Hirose H. 2003. No effects of extremely low frequency magnetic fields found on cytotoxic activities and cytokine production of human peripheral blood mononuclear cells in vitro. Bioelectromagnetics 24:21-31.
90. Ishido M, Nitta H, Kabuto M. 2001. Magnetic fields (MF) of 50 Hz at 1.2 μT as well as 100 μT cause uncoupling of inhibitory pathways of adenylyl cyclase mediated by melatonin 1a receptor in MF-sensitive MCF-7 cells. Carcinogenesis 22:1043-1048.
91. Ito H, Bassett CA. 1983. Effect of weak, pulsing electromagnetic fields on neuronal regeneration in the rat. Clinical Orthopaedics and Related Research 181:283-290.
92. Ivancsits S, Diem E, Jahn O, Rüdiger HW. 2003. Intermittent extremely low frequency electromagnetic fields cause damage in a dose-dependent way. International Archives of Occupational and Environmental Health 76:431-436.
93. Ivancsits S, Diem E, Pilger A, Rüdiger HW, Jahn O. 2002. Induction of DNA strand breaks by intermittent exposure to extremely low frequency electromagnetic fields in human diploid fibroblasts. Mutation Research 519:1-13.
94. Ivancsits S, Pilger A, Diem E, Jahn O, Rüdiger HW. 2005. Cell type-specific genotoxic effects of intermittent extremely low frequency electromagnetic fields. Mutation Research 583:184-188.
95. 3H]gamma-aminobutyric acid from cerebral cortex. Brain Research 63:331-342.
96. Kaczmarek LK, Adey WR. 1974. Weak electric gradients change ionic and transmitter fluxes in cortex. Brain Research 66:537-540.
97. Kanje M, Rusovan A, Sisken B, Lundborg G. 1993. Pretreatment of the rats with pulsed electromagnetic fields enhances regeneration of the sciatic nerve. Bioelectromagnetics 14:353-359.
98. Kato M, Honma K, Shigemitsum T, Shiga Y. 1993. Effects of exposure to a circularly polarized 50 Hz magnetic field on plasma and pineal melatonin levels in rats. Bioelectromagnetics 14:97-106.
99. Kheifets LI, Afifi AA, Buffler PA, Zhang ZW, Matkin CC. 1997. Occupational electric and magnetic field exposure and leukemia. A meta-analysis. Journal of Occupational Environmental Medicine 39:1074-101091.
100. Lai H, Carino M. 1999. 60 Hz magnetic fields and central cholinergic activity: Effects of exposure intensity and duration. Bioelectromagnetics 20:284-289.
101. Lai H, Carino MA, Horita A, Guy AW. 1993. Effects of a 60 Hz magnetic field on central cholinergic system of the rat. Bioelectromagnetics 14:5-15.
102. Lai H, Singh NP. 1997. Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells. Bioelectromagnetics 18:156-165.
103. Lai H, Singh NP. 2004. Magnetic-field-induced DNA strand breaks in brain cells of the rat. Environmental Health Perspectives 112:687-694.
104. Lednev VV. 1991. Possible mechanism for the influence of weak magnetic fields on biological systems. Bioelectromagnetics 12:71-75.
105. Liboff AR. 1985. A geomagnetic cyclotron resonance in living cells. Journal of Biological Physics 13:99-102.
106. Liburdy RP, Callahan DE, Harland J, Dunham E, Sloma TR, Yaswen P. 1993b. Experimental evidence for 60 Hz magnetic fields operating through the signal transduction cascade. Effects on calcium influx and c-MYC mRNA induction. FEBS Letters 334:301-308.
107. 2 dependent: Cation permeability and protein shedding occur at the membrane phase transition. Bioelectromagnetics 5:283-291.
108. Liburdy RP, Sloma TS, Sokolic R, Yaswen P. 1993a. ELF magnetic fields, breast cancer, and melatonin: 60 Hz fields block melatonin's oncostatic action on ER+ breast cancer cell proliferation. Journal of Pineal Research 14:89-97.
109. Liburdy RP, Vanek PF Jr. 1985. Microwaves and the cell membrane. II. Temperature, plasma, and oxygen mediate microwave-induced membrane permeability in the erythrocyte. Radiation Research 102:190-205.
110. Lin H, Blank M, Goodman R. 1999. A magnetic field-responsive domain in the human HSP70 promoter. Journal of Cell Biochemistry 75:170-176.
111. Lin H, Blank M, Jin M, Goodman R. 1996. Electromagnetic field stimulation of biosynthesis: Changes in c-myc transcript levels during continuous and intermittent exposure. Bioelectrochem-istry and Bioenergetics 39:215-220.
112. Lin H, Blank M, Rossol-Haseroth K, Goodman R. 2001. Regulating genes with electromagnetic response elements. Journal of Cell Biochemistry 81:143-148.
113. Lin H, Goodman R, Shirley-Henderson A. 1994. Specific region of the c-myc promoter is responsive to electric and magnetic fields. Journal of Cell Biochemistry 54:281-288.
114. Lin H, Han L, Blank M, Head M, Goodman R. 1998b. Magnetic field activation of protein-DNA binding. Journal of Cell Biochemistry 70:297-303.
115. Lin H, Head M, Blank M, Han L, Jin M, Goodman R. 1998a. Myc-mediated transactivation of HSP70 expression following exposure to magnetic fields. Journal of Cell Biochemistry 69:181-188.
116. Lin H, Opler M, Head M, Blank M, Goodman R. 1997. Electromagnetic field exposure induces rapid, transitory heat shock factor activation in human cells. Journal of Cell Biochemistry 66:482-488.
117. Lindström E, Berglund A, Mild KH, Lindström P, Lundgren E. 1995b. CD45 phosphatase in Jurkat cells is necessary for response to applied ELF magnetic fields. FEBS Letters 370:118-122.
118. Lindström E, Lindström P, Berglund A, Lundgren E, Mild KH. 1995a. Intracellular calcium oscillations in a T-cell line after exposure to extremely-low-frequency magnetic fields with variable frequencies and flux densities. Bioelectromagnetics 16:41-47.
119. Lindström E, Lindström P, Berglund A, Mild KH, Lundgren E. 1993. Intracellular calcium oscillations induced in a T-cell line by a weak 50 Hz magnetic field. Journal of Cell Physiology 156:395-398.
120. London SJ, Thomas DC, Bowman JD, Sobel E, Cheng TC, Peters JM. 1991. Exposure to residential electric and magnetic fields and risk of childhood leukemia. American Journal of Epidemiology 131:923-937.
121. Longo FM, Young T, Hamilton S, Hyde JF, Walker J, Jennes L, Stack R, Sisken BF. 1999. Electromagnetic fields influence NGF activity and levels following sciatic nerve transection. Journal of Neuroscience Research 55:230-237.
122. Lyle DB, Fuchs TA, Casamento JP, Davis CC, Swicord ML. 1997. Intracellular calcium signalling by Jurkat T-lymphocytes exposed to a 60 Hz magnetic field. 1997. Bioelectromagnetics 18:439-445.
123. Lyle DB, Wang XH, Ayotte RD, Sheppard AR, Adey WR. 1991. Calcium uptake by leukemic and normal T-lymphocytes exposed to low frequency magnetic fields. Bioelectromagnetics 12:145-156.
124. Macias MY, Battocletti JH, Sutton CH, Pintar FA, Maiman DJ. 2000. Directed and enhanced neurite growth with pulsed magnetic field stimulation. Bioelectromagnetics 21:272-286.
125. Mairs RJ, Hughes K, Fitzsimmons S, Prise KM, Livingstone A, Wilson L, Baig N, Clark AM, Timpson A, Patel G, Folkard M, Angerson WJ, Boyd M. 2007. Microsatellite analysis for determination of the mutagenicity of extremely low-frequency electromagnetic fields and ionizing radiation in vitro. Mutation Research 626:34-41.
126. Mangiacasale R, Tritarelli A, Sciamanna I, Cannone M, Lavia P, Barberis MC, Lorenzini R, Cundari E. 2001. Normal and cancer-prone human cells respond differently to extremely low frequency magnetic fields. FEBS Letters 487:397-403.
127. McBride ML, Gallagher RP, Theriault G, Armstrong BG, Tamaro S, Spinelli JJ, Deadman JE, Fincham S, Robson D, Choi W. 1999. Power-frequency electric and magnetic fields and risk of childhood leukemia in Canada. American Journal of Epidemiology 149:831-842.
128. McCreary CR, Dixon SJ, Fraher LJ, Carson JJ, Prato FS. 2006. Realtime measurement of cytosolic free calcium concentration in Jurkat cells during ELF magnetic field exposure and evaluation of the role of cell cycle. Bioelectromagnetics 27:354-364.
129. McFarlane E, Dawe GS, Marks M, Campbell IC. 2000. Changes in neurite outgrowth but not in cell division by low EMF exposure: Influence of field strength and culture conditions on responses in rat PC12 pheochromocytoma cells. Bioelectrochemistry 52:23-28.
130. McKay JC, Prato FS, Thomas AW. 2007. A literature review: The effects of magnetic field exposure on blood flow and blood vessels in the microvasculature. Bioelectromagnetics 28:81-98.
131. Mevissen M, Stamm A, Burtenkotter S, Zwingelberg R, Wahnschaffe U, Loscher W. 1993. Effects of magnetic fields on mammary tumor development induced by 7,12-dimethylbenz(a)-anthracene in rats. Bioelectromagnetics 14: 131-143.
132. Murdoch C, Finn A. 2000. Chemokine receptors and their role in inflammation and infectious diseases. Blood 10:3032-3043.
133. Murphy JC, Kaden DA, Warren J, Sivak A. 1993. International commission for protection against environmental mutagens and carcinogens. Power frequency and magnetic fields: a review of genetic toxicology. Mutation Research 296: 221-240.
134. National Institute of Environmental Health (NIEH). 1999. EMF Rapid Program report on "Health effects from exposure to power-line frequency electric and magnetic fields". NIH Publication No. 99-4493.
135. New York Academy of Sciences. 1974. Proceedings of the conference on "Electrically mediated growth mechanisms in living systems". New York. 1973. Annals of the New York Academy of Sciences 238.
136. Nindl G, Balcavage WX, Vesper DN, Swez JA, Wetzel BJ, Chamberlain JK, Fox MT. 2000. Experiments showing that electromagnetic fields can be used to treat inflammatory diseases. Biomedicine and Scientific Instruments 36:7-13.
137. Nindl G, Swez JA, Miller JM, Balcavage WX. 1997. Growth stage dependent effects of electromagnetic fields on DNA synthesis of Jurkat cells. FEBS Letters 414:501-506.
138. Okano H, Onmori R, Tomita N, Ikada Y. 2006. Effects of a moderate-intensity static magnetic field on VEGF-A stimulated endothelial capillary tubule formation in vitro. Bioelectromagnetics 27:628-640.
139. Olcerst RB, Belman S, Eisenbud M, Mumford WW, Rabinowitz JR. 1980. Increased passive efflux of sodium and rubidium from rabbit erythrocytes by microwave radiation. Radiation Research 82:244-256.
140. Opler M, Rukenstein A, Cote L, Goodman R. 1997. Reduced dopamine levels in PC12 cells exposed to low frequency electromagnetic field. Bioelectrochemistry and Bioenergetics 42:235-239.
141. Ottani V, De Pasquale V, Govoni P, Franchi M, Zaniol P, Ruggeri A. 1988. Effects of pulsed extremely-low-frequency magnetic fields on skin wounds in the rat. Bioelectromagnetics 9:53-62.
142. Reese JA, Jostes RF, Frazier ME. 1988. Exposure of mammalian cells to 60-Hz magnetic or electric fields: Analysis for DNA single-stand breaks. Bioelectromagnetics 9: 237-247.
143. Reiter RJ. 1998. Melatonin in the context of the reported bioeffects of environmental electromagnetic fields. Bioelectrochemistry and Bioenergetics 47:135-142.
144. Robertson JA, Thomas AW, Bureau Y, Prato FS. 2007. The influence of extremely low frequency magnetic fields on cytoprotection and repair. Bioelectromagnetics 28:16-30.
145. Rosenthal M, Obe G. 1989. Effects of 50-Hertz electromagnetic fields on proliferation and chromosomal alterations in human peripheral lymphocytes untreated or pretreated with chemical mutagens. Mutation Research 210:329-335.
146. Rusovan A, Kanje M. 1991. Stimulation of regeneration of the rat sciatic nerve by 50 Hz sinusoidal magnetic fields. Experimental Neurology 112:312-316.
147. Rusovan A, Kanje M. 1992. Magnetic fields stimulate peripheral nerve regeneration in hypophysectiomized rats. Neuroreport 3:1039-1041.
148. Rusovan A, Kanje M, Mild KD. 1992. The stimulatory effect of magnetic fields on regeneration of the rat sciatic nerve is frequency dependent. Experimental Neurology 117:81-84.
149. Sanders AP, Joines WT, Allis JW. 1984. The differential effects of 200, 591, and 2,450 MHz radiation on rat brain energy metabolism. Bioelectromagnetics 5:419-433.
150. Sanders AP, Joines WT, Allis JW. 1985. Effects of continuous-wave, pulsed, and sinusoidal-amplitude-modulated microwaves on brain energy metabolism. Bioelectromagnetics 6:89-97.
151. 1H-NMR study reveals apoptosis-like behavior in human K562 erythroleukemic cells exposed to a 50 Hz sinusoidal magnetic field. International Journal of Radiation Biology 81:97-113.
152. Santini MT, Rainaldi G, Ferrante A, Indovina P, Donelli G, Indovina PL. 2006. A 50 Hz sinusoidal magnetic field does not damage MG-63 three-dimensional tumor spheroids but induces changes in their invasive properties. Bioelectromagnetics 27:132-141.
153. Santini MT, Rainaldi G, Ferrante A, Indovina PL, Vecchia P, Donelli G. 2003. Effects of a 50 Hz sinusoidal magnetic field on cell adhesion molecule expression in two human osteosarcoma cell lines (MG-63 and Saos-2). Bioelectromagnetics 24:327-338.
154. Santoro MM, Gaudino G. 2005. Cellular and molecular facets of keratinocyte reepithelization during wound healing. Experimental Cell Research 304:274-286.
155. Savitz DA, Cai J, van Wijngaarden E, Loomies D, Mihlan G, Dufort V, Kleckner RC, Nylander-French L, Kromhout H, Zhou H. 2000. Case-cohort analysis of brain cancer and leukemia in electric utility workers using a refined magnetic field job-exposure matrix. American Journal of Industrial Medicine 38:417-425.
156. Schwartz JL, House DE, Mealing GAR. 1990. Exposure of frog hearts to CW or amplitude-modulated VHF fields: Selective efflux of calcium ions at 16 Hz. Bioelectromagnetics 11:349-358.
157. Selvam R, Ganesan K, Narayana Raju KV, Gangadharan AC, Manohar BM, Puvanakrishnan R. 2007. Low frequency and low intensity pulsed electromagnetic field exerts its antiin-flammatory effect through restoration of plasma membrane calcium ATPase activity. Life Sciences 80:2403-2410.
158. Selvamurugan N, Kwok S, Vasilov A, Jefcoat SC, Partridge NC. 2007. Effects of BMP-2 and pulsed electromagnetic field (PEMF) on rat primary osteoblastic cell proliferation and gene expression. Journal of Orthopedic Research 25:1213-1220.
159. Shah JP, Midkiff P, Brandt PC, Sisken BF. 2001. Growth and differentiation of PC6 cells: The effects of pulsed electromagnetic fields (PEMF). Bioelectromagnetics 22:267-271.
160. Shupak NM, Marzano MW, McKay JC, Nielson WR, Rollman GB, Prato FS, Thomas AW. 2006. Exposure to a specific pulsed low-frequency magnetic field: A double-blind placebocontrolled study of effects on pain ratings in rheumatoid arthritis and fibromyalgia patients. Pain Research and Management 11:85-90.
161. Shupak NM, Prato FS, Thomas AW. 2004. Human exposure to a specific pulsed magnetic field: Effects on thermal sensory and pain thresholds. Neuroscience Letters 363:157-162.
162. Simkó M. 2004. Induction of cell activation processes by low frequency electromagnetic fields. Scientific World Journal 4(suppl. 2):4-22.
163. Simkó M. 2007. Cell type specific redox status is responsible for diverse electromagnetic field effects. Current Medicinal Chemistry 14:1141-1152.
164. Simkó M, Mattsson MO. 2004. Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: Possible immune cell activation. Journal of Cell Biochemistry 93:83-92.
165. Sivamani RK, Garcia MS, Isseroff RR. 2007. Wound reepithelialization: Modulating keratinocyte migration in wound healing. Frontiers in Bioscience 12:2849-2868.
166. Sorahan T, Hamilton L, Gardiner K, Hodgson JT, Harrington JM. 1999. Maternal occupational exposure to electromagnetic fields before, during, and after pregnancy in relation to risks of childhood cancers: Findings from the Oxford survey of childhood cancers, 1953-1981 deaths. American Journal of Industrial Medicine 35:348-357.
167. Stronati L, Testa A, Villani P, Marino C, Lovisolo GA, Conti D, Russo F, Fresegna AM, Cordelli E. 2004. Absence of genotoxicity in human blood cells exposed to 50 Hz magnetic fields as assessed by comet assay, chromosome aberration, micronucleus and sister chromatid exchange analyses. Bioelectromagnetics 25:41-48.
168. Subramanian A, Kothari L. 1991. Suppressive effect by melatonin on different phases of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced rat mammary gland. Carcinogenesis and Anticancer Drugs 2:297-303.
169. Thomas AW, Graham K, Prato FS, McKay J, Morley Foster P, Moulin DE, Chari S. 2007. A randomized, double-blind, placebo-controlled clinical trial using a low-frequency magnetic field in the treatment of musculoskeletal chronic pain. Pain Research and Management 12:249-258.
170. Tofani S, Barone D, Cintorino M, de Santi MM, Ferrara A, Orlassino R, Ossola P, Peroglio F, Rolfo K, Ronchetto F. 2001. Static and ELF magnetic fields induce tumor growth and inhibition and apoptosis. Bioelectromagnetics 22:419-428.
171. Tofani S, Cintorino M, Barone D, Berardelli M, de Santi MM, Ferrara A, Orlassino R, Ossola P, Rolfo K, Ronchetto F, Tripodi SA, Tosi P. 2002. Increased mouse survival, tumor growth inhibition and decreased immunoreactive p53 after exposure to magnetic fields. Bioelectromagnetics 23:230-238.
172. Touitou Y, Bogdan A, Lambrozo J, Selmaoui B. 2006. Is melatonin the hormonal missing link between magnetic field effects and human diseases? Cancer Causes and Control 17:547-552.
173. Trillo MA, Ubeda A, Blanchard JP, House DE, Blackman CF. 1996. Magnetic fields at resonant conditions for the hydrogen ion affect neurite outgrowth in PC-12 cells: A test of the ion paramagnetic resonance model. Bioelectromagnetics 17: 10-20.
174. Türközer Z, Gü ler G, Sevhan N. 2008. Effects of exposure to 50 Hz electric field at different strengths on oxidative stress and antioxidant enzyme activities in the brain tissue of guinea pigs. International Journal of Radiation Biology 84:581-590.
175. Vianale G, Reale M, Amerio P, Stefanachi M, Di Luzio S, Muraro R. 2008. Extremely low frequency electromagnetic field enhances human keratinocyte cell growth and decreases proinflammatory chemokine production. British Journal of Dermatology 158:1189-1196.
176. Wahab MA, Podd JV, Rapley BI, Rowland RE. 2007. Elevated sister chromatid exchange frequencies in dividing human peripheral blood lymphocytes exposed to 50 Hz magnetic fields. Bioelectromagnetics 28:281-288.
177. Walker JL, Evans JM, Resig P, Guarnieri S, Meade P, Sisken BF. 1994. Enhancement of functional recovery following a crush lesion to the rat sciatic nerve by exposure to pulsed electromagnetics fields. Experimental Neurology 125:302-305.
178. 2+ uptake in rat thymocytes: Dependence on mitogen activation. FEBS Letters 271:157-160.
179. Wertheimer N, Leeper E. 1979. Electrical wiring configurations and childhood cancer. American Journal of Epidemiology 109:273-284.
180. Wetzel BJ, Nindl G, Vesper DN, Swez JA, Jasti AC, Johnson MT. 2001. Electromagnetic field effects: Changes in protein phosphorylation in the Jurkat E6.1 cell line. Biomedicine and Scientific Instruments 37:203-208.
181. Whitson GL, Carrier WL, Francis AA, Shih CC, Georghiou S, Regan JD. 1986. Effects of extremely low frequency (ELF) electric fields on cell growth and DNA repair in human skin fibroblasts. Cell and Tissue Kinetics 19:39-47.
182. Wilson BW, Chess EK, Anderson LE. 1986. 60 Hz electric field effects on pineal melatonin rhythms: Time course of onset and recovery. Bioelectromagnetics 7:239-242.
183. Winker R, Ivancsits S, Pilger A, Adlkofer F, Rüdiger HW. 2005. Chromosomal damage in human diploid fibroblasts by intermittent exposure to extremely low-frequency electromagnetic fields. Mutation Research 585:43-49.
184. Wolf FI, Torsello A, Tedesco B, Fasanella S, Boninsegna A, D'Ascenzo M, Grassi C, Azzena GB, Cittadini A. 2005. 50-Hz extremely low frequency electromagnetic fields enhance cell proliferation and DNA damage: Possible involvement of a redox mechanism. Biochimica et Biophysica Acta 1743:120-129.
185. Yellon SM. 1994. Acute 60 Hz magnetic field exposure effects on the melatonin rhythm in the pineal gland and circulation of the adult Djungarian hamster. Journal of Pineal Research 16:136-144.
186. Zhang Y, Ding J, Duan W, Fan W. 2005. Influence of pulsed electromagnetic field with different pulse duty cycles on neurite outgrowth on PC12 rat pheochromocytoma cells. Bioelectro-magnetics 26:406-411.
187. Zlotnick A, Yoshie O. 2000. Chemokines: A new classification and their role in immunity. Immunity 12:121-127.
188. Zwingelberg R, Obe G, Rosenthal M, Mevissen M, Buntenkötter S, Löscher W. 1993. Exposure of rats to a 50 Hz, 30 mT magnetic field influences neither the frequencies of sister chromatid exchanges nor proliferation characteristics of cultured peripheral lymphocytes. Mutation Research 302: 39-44.