Significant Differences in the Effects of Magnetic Field Exposure on 7,12-Dimethylbenz(a)anthracene-Induced Mammary Carcinogenesis in Two Substrains of Sprague-Dawley Rats

Cancer Research

Volumn 64, Issue 1, 2004, Pages 243-251

  Fedrowitz, Maren ^a   Kamino, Kenji ^b   Löscher, Wolfgang ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; DIMETHYLBENZ[A]ANTHRACENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREEDING; CELL PROLIFERATION; CONTROLLED STUDY; EVIDENCE BASED MEDICINE; FEMALE; HEREDITY; LABORATORY; MAGNETIC FIELD; MAMMARY GLAND; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; TUMOR GROWTH; UNITED STATES;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; CARCINOGENS; CELL DIVISION; DISEASE MODELS, ANIMAL; ELECTROMAGNETIC FIELDS; FEMALE; MAMMARY NEOPLASMS, EXPERIMENTAL; NEOPLASMS, RADIATION-INDUCED; ORNITHINE DECARBOXYLASE; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

EID: 1642535577     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2808     Document Type: Article

References (70)

1. Moulder, J. E., and Foster, K. R. Biological effects of power-frequency fields as they relate to carcinogenesis. Proc. Soc. Exp. Biol. Med., 209: 309-324, 1995.
2. Löscher, W., and Liburdy, R. P. Animal and cellular studies on carcinogenic effects of low frequency (50/60-Hz) magnetic fields. Mutat. Res., 410: 185-220, 1998.
3. Portier, C. J., and Wolfe, M. S. Assessment of health effects from exposure to power-line frequency electric and magnetic fields. NIEHS Working Group Report. Research Triangle Park, NC: National Institute of Environmental Health Sciences, NIH, 1998.
4. Ahlbom, I. C., Cardis, E., Green, A., Linet, M., Savitz, D., and Swerdlow, A. Review of the epidemiologic literature on EMF and Health. Environ. Health Perspect., 109(Suppl. 6): 911-933, 2001.
5. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans Non-ionizing radiation, Part I: static and extremely low-frequency (ELF) electric and magnetic fields. IARC. Monogr. Eval. Carcinog. Risks. Hum., 80: 1-395, 2002.
6. Brainard, G. C., Kavet, R., and Kheifets, L. I. The relationship between electromagnetic field and light exposures to melatonin and breast cancer risk: a review of the relevant literature. J. Pineal Res., 26: 65-100, 1999.
7. Caplan, L. S., Schoenfeld, E. R., O'Leary, E. S., and Leske. M. C. Breast cancer and electromagnetic fields - a review. Ann. Epidemiol., 10: 31-44, 2000.
8. Erren, T. C. A meta-analysis of epidemiologic studies of electric and magnetic fields and breast cancer in women and men. Bioelectromagnetics, 5 (Suppl.): S105-S119, 2001.
9. Stevens, R. G., and Davis, S. The melatonin hypothesis: Electric power and breast cancer. Environ. Health Perspect., 104: 135-140, 1996.
10. Fedrowitz, M., Westermann, J., and Löscher, W. Magnetic field exposure increases cell proliferation but does not affect melatonin levels in the mammary gland of female Sprague-Dawley rats. Cancer Res., 62: 1356-1363, 2002.
11. Löscher, W., and Mevissen, M. Magnetic fields and breast cancer: Experimental studies on the melatonin hypothesis. In: R. G. Stevens, B. W. Wilson, and L. E. Anderson (eds.), The Melatonin Hypothesis - Breast Cancer and Use of Electric Power, pp. 555-584. Columbus: Battelle Press, 1997.
12. Thun-Battersby, S., Mevissen, M., and Löscher, W. Exposure of Sprague-Dawley rats to a 50-Hertz, 100-μ Tesla magnetic field for 27 weeks facilitates mammary tumorigenesis in the 7, 12-dimethylbenz[a]anthracene model of breast cancer. Cancer Res., 59: 3627-3633, 1999.
13. Löscher, W. Breast cancer and use of electric power: Experimental studies on the melatonin hypothesis. In: C. Bartsch, H. Bartsch, D. E. Blask, D. P. Cardinali, W. J. M. Hrushesky and D. Mecke (eds.), The Pineal Gland and Cancer: Neuroimmunoendocrine Mechanisms in Malignancy, pp. 518-533. Heidelberg: Springer, 2001.
14. National Toxicology Program. NTP Studies of Magnetic Field Promotion (DMBA Initiation) in Female Sprague-Dawley Rats (Whole-body Exposure/Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser., 489: 1-148, 1999.
15. Anderson, L. E., Boorman, G. A., Morris, J. E., Sasser, L. B., Mann, P. C., Grumbein, S. L., Hailey, J. R., McNally, A., Sills, R. C., and Haseman, J. K. Effect of 13 week magnetic field exposures on DMBA-initiated mammary gland carcinoma in female Sprague-Dawley rats. Carcinogenesis (Lond.), 20: 1615-1620, 1999.
16. Boorman, G. A., Anderson, L. E., Morris, J. E., Sasser, L. B., Mann, P. C., Grumbein, S. L., Hailey, J. R., McNally, A., Sills, R. C., and Haseman, J. K. Effect of 26 week magnetic field exposures in a DMBA initiation-promotion mammary gland model in Sprague-Dawley rats. Carcinogenesis (Lond.), 20: 899-904, 1999.
17. Anderson, L. E., Morris, J. E., Sasser, L. B., and Löscher, W. Effects of 50 or 60 Hertz, 100 μT magnetic field exposure in the DMBA mammary cancer model in Sprague-Dawley rats: possible explanations for different results from two laboratories. Environ. Health Perspect., 108: 797-802, 2000.
18. van Zwieten, M. J., Shellabarger, C. J., Hollander, C. F., Cramer, D. V., Stone, J. P., Holtzman, S., and Broerse, J. J. Differences in DMBA-induced mammary neoplastic responses in two lines of Sprague-Dawley rats. Eur. J. Cancer Clin. Oncol., 20: 1199-1204, 1984.
19. Mevissen, M., Kietzmann, M., and Löscher, W. In vivo exposure of rats to a weak alternating magnetic field increases ornithine decarboxylase activity in the mammary gland by a similar extent as the carcinogen DMBA. Cancer Lett., 90: 207-214, 1995.
20. Mevissen, M., Häußler, M., and Löscher, W. Alterations in ornithine decarboxylase activity in the rat mammary gland after different periods of 50 Hertz magnetic field exposure. Bioelectromagnetics, 20: 338-346, 1999.
21. Westermann, J., Michel, S., Lopez-Kostka, S., Bode, U., Rothkotter, H. J., Bette, M., Weihe, E., Straub, R. H., and Pabst, R. Regeneration of implanted splenic tissue in the rat: re-innervation is host age-dependent and necessary for tissue development. J. Neuroimmunol., 88: 67-76, 1998.
22. Luettig, B., Pape, L., Bode, U., Bell, E. B., Sparshott, S. M., Wagner, S., and Westermann, J. Naive and memory T lymphocytes migrate in comparable numbers through normal rat liver: activated T cells accumulate in the periportal field. J. Immunol., 163: 4300-4307, 1999.
23. 14C-carboxyl-labeled amino acids. Anal. Biochem., 84: 638-641, 1978.
24. Baum, A., Mevissen, M., Kamino, K., Mohr, U., and Löscher, W. A histopathological study on alterations in DMBA-induced mammary carcinogenesis in rats with 50 Hz, 100 μT magnetic field exposure. Carcinogenesis (Lond.), 16: 119-125, 1995.
25. Mevissen, M., Häußler, M., Lerchl, A., and Löscher, W. Acceleration of mammary tumorigenesis by exposure of 7, 12-dimethylbenz[a]anthracene-treated female rats in a 50-Hz, 100 μT magnetic field: replication study. J. Toxicol. Environ. Health, 53: 401-418, 1998.
26. Löscher, W., Mevissen, M., and Häußle, M. Seasonal influence on 7, 12-dimethyl-[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats under controlled laboratory conditions. Pharmacol. Toxicol., 81: 265-270, 1997.
27. Mevissen, M., Stamm, A., Buntenkötter, S., Zwingelberg, R., Wahnschaffe, U., and Löscher, W. Effects of magnetic fields on mammary tumor development induced by 7, 12-dimethylbenz(a)anthracene in rats. Bioelectromagnetics, 14: 131-143, 1993.
28. Boorman, G. A., Wilson, J. T., van Zwieten, M. J., and Eustis, S. L. Mammary gland. In: G. A. Boorman, S. L. Eustis, M. R. Elwell, C. A. Montgomery, and W. F. MacKenzie (eds.), Pathology of the Fischer Rat, pp. 295-314. San Diego: Academic Press, 1990.
29. Löscher, W., Mevissen, M., Lehmacher, W., and Stamm, A. Tumor promotion in a breast cancer model by exposure to a weak alternating magnetic field. Cancer Lett., 71: 75-81, 1993.
30. Isaacs, J. T. Inheritance of a genetic factor from the Copenhagen rat and the suppression of chemically induced mammary adenocarcinogenesis. Cancer Res., 48: 2204-2213, 1988.
31. Moore, C. J., Tricomi, W. A., and Gould, M. N. Comparison of 7, 12-dimethylbenz[a]anthracene metabolism and DNA binding in mammary epithelial cells from three rat strains with differing susceptibilities to mammary carcinogenesis. Carcinogenesis (Lond.), 9: 2099-102, 1988.
32. Gould, M. N., Wang, B. C., and Moore, C. J. The modulation of mammary carcinogenesis by enhancer and suppressor genes. In: N. Colbum (ed.), Genes and Signal Transduction in Multistage Carcinogenesis, pp. 19-38. New York: Marcel Dekker, 1989.
33. Rogers, A. E. Factors that modulate chemical carcinogenesis in the mammary gland of the female rat. In: T. C. Jones, U. Mohr, and R. D. Hunt (eds.), Integument and Mammary Glands, pp. 304-314. Berlin: Springer-Verlag, 1989.
34. Gould, M. N., and Zhang, R. Genetic regulation of mammary carcinogenesis in the rat by susceptibility and suppressor genes. Environ. Health Perspect., 93: 161-167, 1991.
35. Russo, J., and Russo, I. H. Experimentally induced mammary tumors in rats. Breast Cancer Res. Treat., 39: 7-20, 1996.
36. Goldman, P. R., and Vogel, W. H. Striatal dopamine-stimulated adenylate cyclase activity reflects susceptibility of rats to 7, 12-dimethylbenz[a]anthracene-induced mammary tumor development. Carcinogenesis (Lond.), 5: 971-973, 1984.
37. Matthys, L., Castello, R., Zilz, A., and Widmaier, E. P. Differential sensitivity to ACTH, but not stress, in two sources of outbred Sprague-Dawley rats. Neuroendocrinology., 67: 403-411, 1998.
38. Yoon, Y. W., Lee, D. H., Lee, B. H., Chung, K., and Chung, J. M. Different strains and substrains of rats show different levels of neuropathic pain behaviors. Exp. Brain Res., 129: 167-171, 1999.
39. Graham, B. A., Hammond, D. L., and Proudfit, H. K. Synergistic interactions between two a(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats. Pain, 85: 135-143, 2000.
40. Fuller, D. D., Baker, T. L., Behan, M., and Mitchell, G. S. Expression of hypoglossal long-term facilitation differs between substrains of Sprague-Dawley rat. Physiol. Genomics, 4: 175-181, 2001.
41. Kelder, D., and Ross, S. B. Differential sensitivity to 8-hydroxy-2-(di-n-propylamino)tetralin-induced corticosterone secretion and hypothermia between Sprague-Dawley rats from different breeding colonies. Pharmacol. Toxicol., 89: 295-300, 2001.
42. Bulka, A., Wiesenfeld-Hallin, Z., and Xu, X. J. Differential antinociception by morphine and methadone in two sub-strains of Sprague-Dawley rats and its potentiation by dextromethorphan. Brain Res., 942: 95-100, 2002.
43. Festing, M. F. Genetic variation in outbred rats and mice and its implications for toxicological screening. J. Exp. Anim. Sci., 35: 210-220, 1993.
44. Kacew, S., and Festing, M. F. Role of rat strain in the differential sensitivity to pharmaceutical agents and naturally occurring substances. J. Toxicol. Environ. Health, 47: 1-30, 1996.
45. Rapp, K. G., Kluge, R., and Burow, K. Genetische Steuerung von Auszuchtstämmen am Beispiel der Han:NMR1-Mäusepopulationen. In: K. Gärtner (ed.), Qualitätskriterien der Versuchstierforschung, pp. 149-174. Weinheim: VCH, 1991.
46. Torgersen, O. Regional distribution of DMBA-induced mammary tumours in the rat. Acta path. microbiol. scand., 83: 639-644, 1975.
47. Russo, J., Saby, J., Isenberg, W. M., and Russo, I. H. Pathogenesis of mammary carcinoma induced in rats by 7, 12-dimethylbenz[a]anthracene. J. Nat. Cancer Inst., 59: 435-445, 1977.
48. Russo, I. H., and Russo, J. Mammary gland neoplasia in long-term rodent studies. Environ. Health Perspect., 104: 938-967, 1996.
49. Stevens, R. G. Electric power use and breast cancer: a hypothesis. Am. J. Epidemiol., 125: 556-561, 1987.
50. Stevens, R. G., Davis, S., Thomas, D. B., Anderson, L. E., and Wilson, B. W. Electric power, pineal function, and the risk of breast cancer. FASEB J., 6: 853-860, 1992.
51. Löscher, W., Mevissen, M., and Lerchl, A. Exposure of female rats to a 100-μT 50 Hz magnetic field does not induce consistent changes in nocturnal levels of melatonin. Radiat. Res., 150: 557-567, 1998.
52. Hill, S. M., and Blask, D. E. Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res., 48: 6121-6126, 1988.
53. Sanchez-Barcelo, E. J., Mediavilla, M. D., and Tucker, H. A. Influence of melatonin on mammary gland growth: in vivo and in vitro studies. Proc. Soc. Exp. Biol. Med., 194: 103-107, 1990.
54. Hill, S. M., Spriggs, L. L., Simon, M. A., Muraoka, H., and Blask, D. E. The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system. Cancer Lett., 64: 249-256, 1992.
55. Cos, S., and Sanchez-Barcelo, E. J. Melatonin and mammary pathological growth. Front. Neuroendocrinol., 21: 133-170, 2000.
56. Blask, D. E. Systemic, cellular, and molecular aspects of melatonin action on experimental breast carcinogenesis. In: R. G. Stevens, B. W. Wilson and L. E. Anderson (eds.), The melatonin hypothesis. Breast cancer and use of electric power, pp. 189-232. Columbus: Battelle Press, 1997.
57. Molis, T. M., Spriggs, L. L., and Hill, S. M. Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. Mol. Endocrinol., 8: 1681-1690, 1994.
58. Cos, S., Fernandez, F., and Sanchez-Barcelo, E. J. Melatonin inhibits DNA synthesis in MCF-7 human breast cancer cells in vitro. Life Sci., 58: 2447-2453, 1996.
59. Mediavilla, M. D., Cos, S., and Sanchez-Barcelo, E. J. Melatonin increases p53 and p21WAF1 expression in MCF-7 human breast cancer cells in vitro. Life Sci., 65: 415-420, 1999.
60. Liburdy, R. P., Sloma, T. R., Sokolic, R., and Yaswen, P. ELF magnetic fields, breast cancer, and melatonin: 60 Hz fields block melatonin's oncostatic action on ER and breast cancer cell proliferation. J. Pineal Research, 14: 89-97, 1993.
61. Blackman, C. F., Benane, S. G., and House, D. E. The influence of 1.2 microT, 60 Hz magnetic fields on melatonin- and tamoxifen-induced inhibition of MCF-7 cell growth. Bioelectromagnetics, 22: 122-128, 2001.
62. Ishido, M., Nitta, H., and Kabuto, M. Magnetic fields (MF) of 50 Hz at 1.2 microT as well as 100 microT cause uncoupling of inhibitory pathways of adenylyl cyclase mediated by melatonin 1a receptor in MF-sensitive MCF-7 cells. Carcinogenesis (Lond.), 22: 1043-1048, 2001.
63. Blask, D. E., Wilson, S. T., Saffer. J. D., Wilson, M. A., Anderson, L. E., and Wilson, B. W. Culture conditions influence the effects of weak magnetic fields on the growth-response of MCF-7 human breast cancer cells to melatonin in vitro. The Annual Review of Research on Biological Effects of Electric and Magnetic Fields from the Generation, Delivery & Use of Electricity, Savannah, Georgia, Project Abstracts, 651993.
64. Phillips, J. L. Effects of electromagnetic field exposure on gene transcription. J. Cell Biochem., 51: 381-386, 1993.
65. Lin. H., Blank, M., Rossol-Haseroth, K., and Goodman, R. Regulating genes with electromagnetic response elements. J. Cell Biochem., 81: 143-148, 2001.
66. Marcu, K. B., Bossome, S. A., and Patel, A. J. MYC function and regulation. Annu. Rev. Biochem., 61: 809-860, 1992.
67. Lacy-Hulbert, A., Wilkins, R. C., Hesketh, T. R., and Metcalfe, J. C. Cancer risk and electromagnetic fields. Nature, 375: 231995.
68. Saffer, J. D., and Thurston, S. J. Cancer risk and electromagnetic fields. Nature (Lond.), 375: 221995.
69. Jahreis, G. P., Johnson, P. G., Zhao, Y. L., and Hui, S. W. Absence of 60-Hz, 0.1-mT magnetic field-induced changes in oncogene transcription rates or levels in CEM-CM3 cells. Biochim. Biophys. Acta, 1443: 334-342, 1998.
70. Loberg, L. I., Gauger, J. R., Buthod, J. L., Engdahl, W. R., and McConnick, D. L. Gene expression in human breast epithelial cells exposed to 60 Hz magnetic fields. Carcinogenesis (Lond.), 20: 1633-1636, 1999.