Environmental Magnetic Fields Inhibit the Antiproliferative Action of Tamoxifen and Melatonin in a Human Breast Cancer Cell Line

Bioelectromagnetics

Volumn 18, Issue 8, 1997, Pages 555-562

  Harland, Joan D ^a   Liburdy, Robert P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell proliferation; Human breast cancer cells; Magnetic fields; MCF 7; Melatonin; Tamoxifen

Indexed keywords

CANCER CELLS; CELL CULTURE; DISEASES; DRUG INTERACTIONS; ELECTRIC FIELDS; ENVIRONMENTAL REGULATIONS; HORMONES; MAGNETIC FIELDS;

ANTI-PROLIFERATIVE; CANCER CELL LINES; ENVIRONMENTAL LEVELS; ENVIRONMENTAL MAGNETIC FIELDS; GROWTH INHIBITION; HUMAN BREAST CANCER CELLS; MAGNETIC-FIELD; MCF-7; MELATONIN; TAMOXIFEN;

CELL PROLIFERATION;

MINK CELL FOCUS-FORMING VIRUS;

ANTINEOPLASTIC AGENT; GROWTH INHIBITOR; MELATONIN; TAMOXIFEN;

ARTICLE; BREAST TUMOR; CELL CULTURE; CELL DIVISION; DRUG EFFECT; ELECTROMAGNETIC FIELD; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; PATHOLOGY; RADIATION EXPOSURE; RADIATION RESPONSE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTROMAGNETIC FIELDS; ENVIRONMENTAL EXPOSURE; FEMALE; GROWTH INHIBITORS; HUMANS; MELATONIN; TAMOXIFEN; TUMOR CELLS, CULTURED;

EID: 0030631568     PISSN: 01978462     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-186X(1997)18:8<555::AID-BEM4>3.0.CO;2-1     Document Type: Article

References (63)

1. Acuna-Costroviejo D, Reiter RJ, Menendez-Pelaez A, Pablos MI, Burgos A (1994): Characterization of high-affinity melatonin binding sites in purified cell nuclei of rat liver. J Pineal Res 16:100-112.
2. Bassen H, Litovitz T, Penafiel M, Meister R (1992): ELF in vitro exposure systems for inducing uniform electric and magnetic fields in cell culture media. Bioelectromagnetics 13:183-198.
3. Becker-Andre M, Wiesenberg I, Schaeren-Wiemers N, et al. (1994): Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor family. J Biol Chem 269:28531-28534.
4. Benitez-King G, Anton-Tay F (1993): Calmodulin mediates melatonin cytoskeletal effects. Experientia 49:635-641.
5. Blackman CF, Blanchard JP, Benane SG, House DE (1995): The ion parametric resonance model predicts magnetic field parameters that affect nerve cells. FASEB J 9:547-551.
6. Blackman CF, Benane SG, House DE (1996): Independent replication of the 12 mG magnetic field effect on melatonin and MCF-7 cells in vitro. Abstract A-12, 18th Annual Meeting of the Bioelectromagnetics Society, June 9-14, Vancouver, Canada.
7. Blask DE, Wilson ST, Saffer JD, Wilson MA, Anderson LE, Wilson BW (1993a): Culture conditions influence the effects of weak magnetic fields on the growth-response of MCF-7 human breast cancer cells to melatonin in vitro. Abstract P-45, Annual D.O.E. Contractors Meeting, October 31-November 4, Savannah, GA.
8. Blask, D.E., Wilson, S.T., and Valenta (1993b): Alterations in the growth response of human breast cancer cells to the inhibitory action of a physiological concentration of melatonin in incubators with different ambient 60 Hz magnetic fields. Abstract A-28, Annual D.O.E. Contractors Meeting, October 31-November 4, Savannah, GA.
9. Brzezinski A (1997): Melatonin in humans. N Engl J Med 336:186-195.
10. Cos S, Blask DE (1990): Effects of the pineal hormone melatonin in the anchorage-independent growth of human breast cancer cells (MCF-7) in a clonogenic culture system. Cancer Lett. 50:115-119.
11. Cos S, Blask DE, Lemus-Wilson A, Hill AB (1991): Effects of melatonin on the cell cycle kinetics and estrogen rescue of MCF-7 human breast cancer cells in culture. J Pineal Res 10:36-42.
12. Dubocovich ML (1995): Melatonin receptors: are there multiple subtypes? Trends Pharmacol Sci 16:50-56.
13. Ebisawa T, Karne S, Lerner MR, Reppert SM (1994): Expression cloning of a high affinity melatonin receptor from Xenopus dermal melanophores. Proc Natl Acad Sci USA 91:6133-6137.
14. Engstrom S (1996): Dynamic properties of Lednev's parametric resonance mechanism. Bioelectromagnetics 17:58-70.
15. Frankel RB, Liburdy RP (1995): Biological effects of static magnetic fields. In Polk C, Postow E (eds): "CRC Handbook of Biological Effects of Electromagnetic Fields, 2nd ed." Boca Raton, FL: CRC Press, pp 149-183.
16. Fujimoto N, Katzenellenbogen BS (1994): Alteration in the agonist/antagonist balance of antiestrogens by activation of protein kinase A signaling pathways in breast cancer cells: Antiestrogen selectivity and promoter dependence. Mol Endocrinol 8:296-304.
17. Graham C, Cook MR, Cohen HD, Riffle DW, Hoffman SJ, McClernon FJ, Smith D, Gerkovich MM (1993): EMF suppression of nocturnal melatonin in human volunteers. Abstract A-31, Annual D.O.E. Contractor's Meeting, October 31-November 4, Savannah, GA.
18. Graham C, Cook MR, Cohen HD, Riffle DW (1994): Nocturnal melatonin levels in men exposed to magnetic fields. Abstract A-51, Annual D.O.E. Contractor's Meeting, November 6-10, Albuquerque, NM.
19. 12 ethanolamine ammonia lyase: Evidence for a radical mechanism. Science 263:958-960.
20. Harland JD, Engstrom S, Liburdy RP (1996): Timescale hypothesis of magnetic field interaction with biological systems: Application to tamoxifen model. Abstract P-103A, 18th Annual Meeting of the Bioelectromagnetics Society, June 9-14, Vancouver, Canada.
21. Hill SM, Blask DE (1988): Effects of pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res 48:6121-6126.
22. Kirschvink JL (1992a): Uniform magnetic fields and double-wrapped coil systems: Improved techniques for the design ot bioelectromagnetic experiments. Bioelectromagnetics 13:401-411.
23. Kirschvink JL (1992b): Constraints on biological effects of weak extremely low frequency electromagnetic fields: comment. Phys. Rev. A 46:2178-2184.
24. Kirschvink JL, Kobayashi-Kirschvink A, Diaz-Ricci JC, Kirschvink SJ (1992): Magnetite in human tissues: A mechanism for the biological effects of weak ELF magnetic fields. Bioelectromagnetics (Suppl. 1): 101-113.
25. Kirschvink JL, Diaz Ricci J, Nesson MH, Kirschvink SJ (1993): Magnetite based magnetoreceptors: Ultrastructural, behavioral, and biophysical studies. Electric Power Research Institute (EPRI), Palo Alto, California, USA. Technical Report TR-102008,.
26. Liburdy RP (1992a): Biological interactions of cellular systems with time-varying magnetic fields. Ann N Y Acad Sci 649:74-95.
27. Liburdy RP (1992b): Calcium signalling in lymphocytes and ELF fields: Evidence for an electric field metric and a site of interaction involving the calcium ion channel. FEBS Lett 301:53-59.
28. Liburdy RP (1992c): ELF fields and the immune system: Signal transduction, calcium metabolism, and mitogenesis in lymphocytes with relevance to carcinogenesis. In Norden B, Ramel C (eds): "Interaction Mechanisms of Low-Level Electromagnetic Fields in Living Systems." New York: Oxford University Press, pp 217-239.
29. Liburdy RP (1994): Cell culture incubators, ELF fields, and important considerations for cell culture exposure and propagation: An exposure system for in vitro bioelectromagnetics research. Abstract P-198, 16th Annual Meeting of the Bioelectromagnetics Society, June 12-17, Copenhagen, Denmark.
30. Liburdy RP (1995): Cellular studies and interaction mechanisms of extremely low frequency fields. Radio Sci 30:179-203.
31. Liburdy RP, Callahan DE, Harland J, Dunham E, Sloma TR Yaswen P (1993a): Experimental evidence for 60 Hz magnetic fields operating through the signal transduction cascade: Effects on calcium influx and c-MYC mRNA induction. FEBS Lett, 334: 301-308.
32. Liburdy RP, Callahan DE, Sloma TR, Yaswen P (1993b): Intracellular calcium, calcium transport, and c-MYC mRNA induction in lymphocytes exposed to 60 Hz magnetic fields: The cell membrane and the signal transduction pathway. In Blank M (ed): "Electricity and Magnetism in Biology and Medicine." San Francisco, CA: San Francisco Press, pp311-314.
33. Liburdy RP, Sloma TS, Sokolic R, and Yaswen P (1993c) ELF magnetic fields, breast cancer, and melatonin: 60 Hz fields block melatonin's oncostatic action on ER+ breast cancer cell proliferation. J. Pineal Res 14:89-97.
34. + breast cancer cells. In Blank M (ed): "Electricity and Magnetism in Biology and Medicine." San Francisco: San Francisco Press, pp 398-399.
35. Lippman ME, Bolan G, Huff K (1976): The effects of estrogen and antiestrogen on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res 36:4595-4601.
36. Loscher W, Mevissen M, Lehmacher W, Stamm A (1993): Tumor promotion in a breast cancer model by exposure to a weak alternating magnetic field. Cancer Lett 71:75-81.
37. Luben RA, Saraiya S, Morgan AP (1996): Replication of 12 mG EMF effects on melatonin responses of MCF-7 breast cancer cells in vitro. Abstract A-1, D.O.E. Annual Review of Research on the Biological Effects of Electric and Magnetic Fields from the Generation, Delivery, & Use of Electricity, November 17-21, San Antonio, TX.
38. Martin PM, Berthois Y, Jensen EV (1988): Binding of antiestrogens exposes an occult antigenic determinant in the human estrogen receptor. Proc Natl Acad Sci USA 85:2533-2537.
39. Merritt R, Purcell G, Stroink G (1983): Uniform magnetic field produced by three, four, and five square coils. Rev Sci Instrum 54:879-882.
40. Mevissen M, Stamm A, Burtenkotter S, Zwingelberg R, Wahnschaffe U, and Loscher W (1993): Effects of magnetic fields on mammary tumor development induced by 7,12-dimethylbenz(a)-anthracene in rats. Bioelectromagnetics 14:131-143.
41. Morgan PJ, Barrett P, Howell HE, Helliwell R (1994): Melatonin receptors: Localization, molecular pharmacology and physiological significance. Neurochem Int 24:101-146.
42. Nair I, Liburdy RP (1996): Biological electron transfer: A possible framework for some of the biological effects of ELF magnetic fields. Abstract B-6-2, 18th Annual Meeting of the Bioelectromagnetics Society, June 9-14, Vancouver, Canada.
43. Polk C (1994): Effects of extremely low frequency magnetic fields on biological magnetite. Bioelectromagnetics 15:261-270.
44. Prato FS, Carson JJ, Ossenkopp KP, Kavaliers M (1995): Possible mechanisms by which extremely low frequency magnetic fields affect opioid function. FASEB J 9:807-814.
45. Reiter RJ, Poeggeler B, Tan D, Chen L, Manchester LC, Guerrero JM (1993): Antioxidant capacity of melatonin: A novel action not requiring a receptor. Neuroendocrinol Lett 15:103-116.
46. Ree AH, Landmark BF, Walaas SI, Lahooti W, Eikvar L, Eskild W, Hansson V. (1991): Down-regulation of messenger ribonucleic acid and protein levels for estrogen receptors by phorbol ester and calcium in MCF-7 cells. Endocrinology 129:339-344.
47. Roy S, Noda Y, Eckert V, Traber MG, Mon A, Liburdy RP, Packer L (1995): The phorbol 12-myristate 13-acetate(PMA)-induced oxidative burst in rat peritoneal neutrophils is increased by a 0.1 mT (60 Hz) magnetic field. FEBS Lett 376:164-166.
48. Scaiano JC, Mohat N, Cozens FL, McClean J, Thansandote A (1994): Application of the radical pair mechanism to free radicals in organized systems: Can the effects of 60 Hz be predicted from studies under static fields? Bioelectromagnetics 15:549-554.
49. Soule HD, Vasquez J, Long A, Albert S, Brennan M (1973): A human cell line from a pleural effusion derived from a breast carcinoma. J Natl Cancer Inst 51:1409-1416.
50. Stevens RG, Davis S, Thomas DB, Anderson LE, Wilson BW (1992): Electric power, pineal function, and the risk of breast cancer. FASEB J 6:853-860.
51. Stuchly M, Xi W (1994): Modeling induced currents in biological cells exposed to low frequency magnetic fields. Phys Med Biol 39:1319-1330. The calculated electric fields in our petri dishes do not take into account the presence of cell proximity effects as described by Drs. Stuchly and Xi.
52. Subramanian A, Kothari L (1991): Suppressive effect by melatonin on different phases of 9,10-dimethyl-1-2,-benzanthracene (DMBA)-induced rat mammary gland. Carcinogenesis. Anticancer Drugs 2:297-303.
53. Swain SM, Lippman ME (1990): Endocrine therapies of cancer, Chapter 4, In (ed): "Cancer Chemotherapy: Principles and Practice." Philadelphia: J.B. Lippincott Co., p 84.
54. Taylor CM, Blanchard B, Zava DT (1984): Estrogen receptor-mediated and cytotoxic effects of the antiestrogens tamoxifen and 4-hydroxytamoxifen. Cancer Res 44:1409-1414.
55. Walleczek J, Liburdy RP (1990): Nonthermal 60 Hz sinusoidal magnetic field exposure enhances 45-calcium uptake in rat thymocytes: Dependence on mitogen activation. FEBS Lett 271:157-160.
56. Weaver JC, Astumian RD (1990): The response of living cells to very weak electric fields: The thermal noise limit. Science 247:459-462.
57. Welker HA, Semm P, Willig RP, Commentz JC, Wiltschko W, Volrath L (1983): Effects of an artificial magnetic field on serotonin N-acetyl transferase activity and melatonin content of the rat pineal gland. Exp Brain Res 50:426-432.
58. Wiesenfeld K, Moss F (1994): Stochastic resonance and the benefits of noise: From ice ages to crayfish and SQUIDs. Nature 373:33-36.
59. Wilson BW, Anderson LE, Hilton DI, Phillips RD (1981): Chronic exposure to 60 Hz electric fields: Evidence on pineal function in the rat. Bioelectromagnetics 2:371-380.
60. Wilson BW, Anderson LE, Hilton DI, Phillips RD (1983): Chronic exposure to 60 Hz electric fields: Evidence on pineal function in the rat (erratum). Bioelectromagnetics 4:293.
61. Wilson BW, Chess EK, Anderson LE (1986): 60 Hz electric field effects on pineal melatonin rhythms: Time course of onset and recovery. Bioelectromagnetics 7:239-242.
62. Yellon SM (1994): Acute 60 Hz magnetic field exposure effects on the melatonin rhythm in the pineal gland and circulation of the adult Djungarian hamster. J Pineal Res 16:136-144.
63. Yu H.-S, Reiter R (1993): Melatonin: Biosynthesis, Physiological Effects, and Clinical Applications. Boca Raton, FL: CRC Press.