Intermittent extremely low frequency electromagnetic fields cause DNA damage in a dose-dependent way

International Archives of Occupational and Environmental Health

Volumn 76, Issue 6, 2003, Pages 431-436

  Ivancsits, Sabine ^a,b   Diem, Elisabeth ^b   Jahn, Oswald ^b   Rüdiger, Hugo W ^b  

^a Klinische Abteilung für Arbeitsmedizin   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

50 Hz sinusoidal; Comet assay; ELF EMF; Intermittent exposure

Indexed keywords

DNA; DOUBLE STRANDED DNA; SINGLE STRANDED DNA;

ADULT; ALKALINITY; ARTICLE; CELL STRAIN; COMET ASSAY; CONTROLLED STUDY; DIPLOIDY; DNA DAMAGE; DNA STRAND BREAKAGE; DOSE TIME EFFECT RELATION; ELECTROMAGNETIC FIELD; ENVIRONMENTAL FACTOR; FEMALE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIZING RADIATION; MALE; NORMAL VALUE; PRACTICE GUIDELINE; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION; RADIOFREQUENCY; SKIN BIOPSY; SKIN FIBROBLAST; THERMAL EXPOSURE; VALIDATION PROCESS;

ADULT; CELLS, CULTURED; CHILD; COMET ASSAY; DIPLOIDY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTROMAGNETIC FIELDS; FEMALE; FIBROBLASTS; HUMANS; MALE;

EID: 0041425190     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-003-0446-5     Document Type: Article

References (27)

1. Anderson D, Yu TW, Phillips BJ, Schmerzer P (1994) The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the comet assay. Mutat Res 307:261-271
2. Diem E, Ivancsits S, Rüdiger HW (2002) Basal levels of DNA strand breaks in human leukocytes determined by comet assay. J Toxicol Environ Health A 65:641-648
3. Fairbairn JJ, Khan MW, Ward KJ, Loveridge BW, Fairbairn DW, O'Neill KL (1995) Induction of apoptotic cell DNA fragmentation in human cells after treatment with hyperthermia. Cancer Lett 89:183-188
4. Feychting M, Forssen U, Floderus B (1997) Occupational and residential magnetic field exposure and leukemia and central nervous system tumors. Epidemiology 8:384-389
5. International Agency for Research on Cancer. (2002) Non-ionizing radiation, part 1: Static and extremely low-frequency (ELF) electric and magnetic fields. IARC Monogr Eval Carcinog Risks Hum 80:1-395
6. International Commission on Non-Ionizing Radiation Protection (1998) Guidelines for limiting exposure to time-varying, magnetic, and electromagnetic fields up to 300 GHz. Health Phys 74:494-522
7. Ivancsits S, Diem E, Pilger A, Rüdiger HW, Jahn O (2002a) Induction of DNA strand breaks by exposure to extremely-low-frequency electromagnetic fields in human diploid fibroblasts. Mutat Res 519:1-13
8. Ivancsits S, Pilger A, Diem E, Schaffer A, Rüdiger HW (2002b) Vanadate induces DNA strand breaks in cultured human fibroblasts at doses relevant to occupational exposure. Mutat Res 519:25-35
9. Lai H, Singh N (1997) Acute exposure to a 60 Hz magnetic field increases DNA strand breaks in rat brain cells. Bioelectromagnetics 18:156-165
10. Li CY, Theriault G, Lin RS (1997) Residential exposure to 60 Hz magnetic fields and adult cancers in Taiwan. Epidemiology 8:25-30
11. McCann J, Dietrich F, Rafferty C, Martin AO (1993) A critical review of the genotoxic potential of electric and magnetic fields. Mutat Res 297:61-95
12. McCann J, Dietrich F, Rafferty C (1998) The genotoxic potential of electric and magnetic fields: An update. Mutat Res 411:45-86
13. Moulder JE (1998) Power-frequency fields and cancer. Crit Rev Biomed Eng 26:1-116
14. Murphy JC, Kaden DA, Warren J, Sivak A (1993) Power frequency electric and magnetic fields: A review of genetic toxicology. Mutat Res 296:221-240
15. Östling O, Johanson KJ (1984) Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Biophys Res Commun 123:291-298
16. Savitz DA, Wachtel H, Barnes FA, John EM, Tvrdik JG (1988) Case control study of childhood cancer and exposure to 60 Hz magnetic fields. Am J Epidemiol 128:21-38
17. Schreibner GH, Swaen GMH, Meijers JMM, Slangen JJM, Sturmans F (1993) Cancer mortality and residence near electricity transmission equipment: A retrospective cohort study. Int J Epidemiol 22:9-15
18. Singh N, Lai H (1998) 60 Hz magnetic field exposure induces DNA crosslinks in rat brain cells. Mutat Res 400:313-320
19. Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191
20. Singh NP, Tice RR, Stephens RE, Schneider EL (1991) A microgelelectrophoresis technique for direct quantitation of DNA damage and repair in individual fibroblasts cultured on microscope slides. Mutat Res 252:289-296
21. Svedenstal BM, Johanson KJ, Mild KH (1999a) DNA damage induced in brain cells of CBA mice exposed to magnetic fields. In Vivo 13:551-552
22. Svedenstal BM, Johanson KJ, Mattsson MO, Paulsson LE (1999b) DNA damage, cell kinetics and ODC activities studied in CBA mice exposed to electromagnetic fields generated by transmission lines. In Vivo 13:507-513
23. Tomenius L (1986) 50 Hz electromagnetic environment and the incidence of childhood tumors in Stockholm County. Bioelectromagnetics 7:191-207
24. Van Den Bosch M, Lohman PHM, Pastink (2002) A DNA double strand break repair by homologous recombination. Rev Biol Chem 383:873-892
25. Van Gent DC, Hoeijmakers JH, Kanaar R (2001) Chromosomal stability and the DNA double-strand break connection. Nat Rev Genet 2:196-206
26. Verkasalo PK, Pukkala E, Hongisto MY, Valjus JE, Järvinen PJ, Heikkilä KV, Koskenvuo M (1993) Risk of cancer in Finnish children living close to power lines. Br Med J 307:895-899
27. Wertheimer N, Leeper E (1979) Electrical wiring configurations and childhood cancer. Am J Epidemiol 109: 273-284