Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release

Plastic and Reconstructive Surgery

Volumn 121, Issue 1, 2008, Pages 130-141

  Callaghan, Matthew J ^b   Chang, Edward I ^b   Seiser, Natalie ^b   Aarabi, Shahram ^b   Ghali, Shadi ^b   Kinnucan, Elspeth R ^b   Simon, Bruce J ^b   Gurtner, Geoffrey C ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; STREPTOZOCIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; ELECTROMAGNETIC FIELD; ENDOTHELIUM CELL; MOUSE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PULSED ELECTRIC FIELD; SKIN FLAP; STREPTOZOCIN DIABETES; TISSUE NECROSIS; UMBILICAL VEIN; UPREGULATION; VASCULARIZATION; WOUND CLOSURE; WOUND HEALING;

ANIMALS; DIABETES COMPLICATIONS; ELECTROMAGNETIC FIELDS; FIBROBLAST GROWTH FACTOR 2; HUMANS; ISCHEMIA; MICE; MICE, INBRED STRAINS; NECROSIS; NEOVASCULARIZATION, PHYSIOLOGIC; SURGICAL FLAPS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 38049088774     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000293761.27219.84     Document Type: Article

References (37)

1. Amos, A. F., McCarty, D. J., and Zimmet, P. The rising global burden of diabetes and its complications: Estimates and projections to the year 2010. Diabet. Med. 14 (Suppl. 5): S1, 1997.
2. Kannel, W. B., and McGee, D. L. Update on some epidemiologic features of intermittent claudication: The Framingham Study. J. Am. Geriatr. Soc. 33: 13, 1985.
3. Calle-Pascual, A. L., Duran, A., Diaz, A., et al. Comparison of peripheral arterial reconstruction in diabetic and non-diabetic patients: A prospective clinic-based study. Diabetes Res. Clin. Pract. 53: 129, 2001.
4. Falanga, V. Wound healing and its impairment in the diabetic foot. Lancet 366: 1736, 2005.
5. Poornima, I. G., Parikh, P., and Shannon, R. P. Diabetic cardiomyopathy: The search for a unifying hypothesis. Circ. Res. 98: 596, 2006.
6. Sullivan, K. A., and Feldman, E. L. New developments in diabetic neuropathy. Curr. Opin. Neurol. 18: 586, 2005.
7. Wetzler, C., Kampfer, H., Stallmeyer, B., et al. Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: Prolonged persistence of neutrophils and macrophages during the late phase of repair. J. Invest. Dermatol. 115: 245, 2000.
8. Beer, H. D., Longaker, M. T., and Werner, S. Reduced expression of PDGF and PDGF receptors during impaired wound healing. J. Invest. Dermatol. 109: 132, 1997.
9. Bitar, M. S., and Labbad, Z. N. Transforming growth factorbeta and insulin-like growth factor-I in relation to diabetesinduced impairment of wound healing. J. Surg. Res. 61: 113, 1996.
10. Brown, D. L., Kane, C. D., Chernausek, S. D., et al. Differential expression and localization of insulin-like growth factors I and II in cutaneous wounds of diabetic and nondiabetic mice. Am. J. Pathol. 151: 715, 1997.
11. Cao, R., Eriksson, A., Kubo, H., et al. Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability. Circ. Res. 94: 664, 2004.
12. Galiano, R. D., Tepper, O. M., Pelo, C. R., et al. Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells. Am. J. Pathol. 164: 1935, 2004.
13. Li, H., Fredriksson, L., Li, X., et al. PDGF-D is a potent transforming and angiogenic growth factor. Oncogene 22: 1501, 2003.
14. Werner, S., Breeden, M., Hubner, G., et al. Induction of keratinocyte growth factor expression is reduced and delayed during wound healing in the genetically diabetic mouse. J. Invest. Dermatol. 103: 469, 1994.
15. Carmeliet, P. VEGF gene therapy: Stimulating angiogenesis or angioma-genesis? Nat. Med. 6: 1102, 2000.
16. Drake, C. J., and Little, C. D. Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization. Proc. Natl. Acad. Sci. U.S.A. 92: 7657, 1995.
17. Lee, R. J., Springer, M. L., Blanco-Bose, W. E., et al. VEGF gene delivery to myocardium: Deleterious effects of unregulated expression. Circulation 102: 898, 2000.
18. Lee, S. U., Wykrzykowska, J. J., and Laham, R. J. Angiogenesis: Bench to bedside, have we learned anything? Toxicol. Pathol. 34: 3, 2006.
19. Bassett, C. A., Pawluk, R. J., and Pilla, A. A. Augmentation of bone repair by inductively coupled electromagnetic fields. Science 184: 575, 1974.
20. Ryaby, J. T. Clinical effects of electromagnetic and electric fields on fracture healing. Clin. Orthop. Relat. Res. 355 (Suppl.): S205, 1998.
21. Scott, G., and King, J. B. A prospective, double-blind trial of electrical capacitive coupling in the treatment of non-union of long bones. J. Bone Joint Surg. (Am.) 76: 820, 1994.
22. Sharrard, W. J. A double-blind trial of pulsed electromagnetic fields for delayed union of tibial fractures. J. Bone Joint Surg. (Br.) 72: 347, 1990.
23. Tepper, O. M., Callaghan, M. J., Chang, E. I., et al. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. F.A.S.E.B. J. 18: 1231, 2004.
24. Martin, A., Komada, M. R., and Sane, D. C. Abnormal angiogenesis in diabetes mellitus. Med. Res. Rev. 23: 117, 2003.
25. Galiano, R. D., Michaels, J., Dobryansky, M., et al. Quantitative and reproducible murine model of excisional wound healing. Wound Repair Regen. 12: 485, 2004.
26. Asahara, T., Murohara, T., Sullivan, A., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275: 964, 1997.
27. Isner, J. M., and Asahara, T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J. Clin. Invest. 103: 1231, 1999.
28. Kalka, C., Masuda, H., Takahashi, T., et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc. Natl. Acad. Sci. U.S.A. 97: 3422, 2000.
29. Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat. Med. 10: 858, 2004.
30. Tsuboi, R., Shi, C. M., Rifkin, D. B., et al. A wound healing model using healing-impaired diabetic mice. J. Dermatol. 19: 673, 1992.
31. Eyries, M., Collins, T., and Khachigian, L. M. Modulation of growth factor gene expression in vascular cells by oxidative stress. Endothelium 11: 133, 2004.
32. Tepper, O. M., Galiano, R. D., Capla, J. M., et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation 106: 2781, 2002.
33. Lerman, O. Z., Galiano, R. D., Armour, M., et al. Cellular dysfunction in the diabetic fibroblast: Impairment in migration, vascular endothelial growth factor production, and response to hypoxia. Am. J. Pathol. 162: 303, 2003.
34. Brighton, C. T., Wang, W., Seldes, R., et al. Signal transduction in electrically stimulated bone cells. J. Bone Joint Surg. (Am.) 83: 1514, 2001.
35. Nie, K., and Henderson, A. MAP kinase activation in cells exposed to a 60 Hz electromagnetic field. J. Cell. Biochem. 90: 1197, 2003.
36. Phillips, J. L. Effects of electromagnetic field exposure on gene transcription. J. Cell. Biochem. 51: 381, 1993.
37. Roland, D., Ferder, M., Kothuru, R., et al. Effects of pulsed magnetic energy on a microsurgically transferred vessel. Plast. Reconstr. Surg. 105: 1371, 2000.