Serum factors potentiate hypoxia-induced hepatotoxicity in vitro through increasing transforming growth factor-β1 activation and release

Cytokine

Volumn 47, Issue 1, 2009, Pages 11-22

  Kao, Ying Hsien ^a   Jawan, Bruno ^a   Goto, Shigeru ^a,b   Pan, Mei Chun ^a   Lin, Yu Chun ^a   Sun, Cheuk Kwan ^a   Hsu, Li Wen ^a   Tai, Ming Hong ^c   Cheng, Yu Fan ^a   Nakano, Toshiaki ^a   Wang, Chih Shien ^a   Huang, Chia Jung ^a   Chen, Chao Long ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b Iwao Hospital   (Japan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

CD44; Hepatotoxicity; Matrix metalloproteinases; Smad2 phosphorylation; TGF receptors

Indexed keywords

FLUORESCENT DYE; GELATINASE A; GELATINASE B; HERMES ANTIGEN; LACTATE DEHYDROGENASE; NEUTRALIZING ANTIBODY; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; AUTOCRINE EFFECT; CELL CLONE; CELL CULTURE; CELL MEMBRANE; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; LIVER CELL; LIVER ISCHEMIA; LIVER TOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD44; APOPTOSIS; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; GENE EXPRESSION; HEPATOCYTES; L-LACTATE DEHYDROGENASE; MATRIX METALLOPROTEINASE 9; NITROIMIDAZOLES; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SERUM; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 67549086101     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2009.03.004     Document Type: Article

References (44)

1. Jenkins G. The role of proteases in transforming growth factor-beta activation. Int J Biochem Cell Biol 40 (2008) 1068-1078
2. Bursch W., Oberhammer F., Jirtle R.L., Askari M., Sedivy R., Grasl-Kraupp B., et al. Transforming growth factor-beta 1 as a signal for induction of cell death by apoptosis. Br J Cancer 67 (1993) 531-536
3. Javelaud D., and Mauviel A. Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-beta: implications for carcinogenesis. Oncogene 24 (2005) 5742-5750
4. Derynck R., Akhurst R.J., and Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 29 (2001) 117-129
5. Yang H.K., Kang S.H., Kim Y.S., Won K., Bang Y.J., and Kim S.J. Truncation of the TGF-beta type II receptor gene results in insensitivity to TGF-beta in human gastric cancer cells. Oncogene 18 (1999) 2213-2219
6. Park K., Kim S.J., Bang Y.J., Park J.G., Kim N.K., Roberts A.B., et al. Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta. Proc Natl Acad Sci USA 91 (1994) 8772-8776
7. Kim I.Y., Ahn H.J., Zelner D.J., Shaw J.W., Sensibar J.A., Kim J.H., et al. Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells. Cancer Res 56 (1996) 44-48
8. Oberhammer F., Bursch W., Parzefall W., Breit P., Erber E., Stadler M., et al. Effect of transforming growth factor beta on cell death of cultured rat hepatocytes. Cancer Res 51 (1991) 2478-2485
9. Sanchez A., Alvarez A.M., Benito M., and Fabregat I. Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates. J Biol Chem 271 (1996) 7416-7422
10. Bissell D.M., Wang S.S., Jarnagin W.R., and Roll F.J. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 96 (1995) 447-455
11. Ramm G.A., Nair V.G., Bridle K.R., Shepherd R.W., and Crawford D.H. Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia. Am J Pathol 153 (1998) 527-535
12. De Bleser P.J., Niki T., Rogiers V., and Geerts A. Transforming growth factor-beta gene expression in normal and fibrotic rat liver. J Hepatol 26 (1997) 886-893
13. Nelson D.R., Gonzalez-Peralta R.P., Qian K., Xu Y., Marousis C.G., Davis G.L., et al. Transforming growth factor-beta 1 in chronic hepatitis C. J Viral Hepat 4 (1997) 29-35
14. Hellerbrand C., Stefanovic B., Giordano F., Burchardt E.R., and Brenner D.A. The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. J Hepatol 30 (1999) 77-87
15. Jeong W.I., Do S.H., Yun H.S., Song B.J., Kim S.J., Kwak W.J., et al. Hypoxia potentiates transforming growth factor-beta expression of hepatocyte during the cirrhotic condition in rat liver. Liver Int 24 (2004) 658-668
16. Qi Z., Atsuchi N., Ooshima A., Takeshita A., and Ueno H. Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci USA 96 (1999) 2345-2349
17. Yata Y., Gotwals P., Koteliansky V., and Rockey D.C. Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy. Hepatology 35 (2002) 1022-1030
18. Chandel N.S., Budinger G.R., Choe S.H., and Schumacker P.T. Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes. J Biol Chem 272 (1997) 18808-18816
19. Corpechot C., Barbu V., Wendum D., Kinnman N., Rey C., Poupon R., et al. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 35 (2002) 1010-1021
20. Herrera B., Alvarez A.M., Beltran J., Valdes F., Fabregat I., and Fernandez M. Resistance to TGF-beta-induced apoptosis in regenerating hepatocytes. J Cell Physiol 201 (2004) 385-392
21. Kakihara N., Takeshita K., Ishibashi H., Tani T., and Kodama M. Hypoxic conditions restore lost sensitivity to the growth inhibitory effect of transforming growth factor beta-1 (TGF beta-1) in proliferating rat hepatocytes in vitro. Life Sci 67 (2000) 2929-2940
22. Papakonstantinou E., Aletras A.J., Roth M., Tamm M., and Karakiulakis G. Hypoxia modulates the effects of transforming growth factor-beta isoforms on matrix-formation by primary human lung fibroblasts. Cytokine 24 (2003) 25-35
23. Jawan B., Kao Y.H., Goto S., Pan M.C., Lin Y.C., Hsu L.W., et al. Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation. Toxicol Appl Pharmacol 229 (2008) 362-373
24. Shah B.H., Alberto Olivares-Reyes J., Yesilkaya A., and Catt K.J. Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes. Mol Endocrinol 16 (2002) 610-620
25. Gressner A.M., Lahme B., Mannherz H.G., and Polzar B. TGF-beta-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes. J Hepatol 26 (1997) 1079-1092
26. Baer H.U., Friess H., Abou-Shady M., Berberat P., Zimmermann A., Gold L.I., et al. Transforming growth factor betas and their receptors in human liver cirrhosis. Eur J Gastroenterol Hepatol 10 (1998) 1031-1039
27. Yu Q., and Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14 (2000) 163-176
28. Acharya P.S., Majumdar S., Jacob M., Hayden J., Mrass P., Weninger W., et al. Fibroblast migration is mediated by CD44-dependent TGF beta activation. J Cell Sci 121 (2008) 1393-1402
29. Faassen A.E., Mooradian D.L., Tranquillo R.T., Dickinson R.B., Letourneau P.C., Oegema T.R., et al. Cell surface CD44-related chondroitin sulfate proteoglycan is required for transforming growth factor-beta-stimulated mouse melanoma cell motility and invasive behavior on type I collagen. J Cell Sci 105 Pt. 2 (1993) 501-511
30. Del Castillo G., Murillo M.M., Alvarez-Barrientos A., Bertran E., Fernandez M., Sanchez A., et al. Autocrine production of TGF-beta confers resistance to apoptosis after an epithelial-mesenchymal transition process in hepatocytes: role of EGF receptor ligands. Exp Cell Res 312 (2006) 2860-2871
31. Graeber T.G., Osmanian C., Jacks T., Housman D.E., Koch C.J., Lowe S.W., et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379 (1996) 88-91
32. Minchenko A., Bauer T., Salceda S., and Caro J. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab Invest 71 (1994) 374-379
33. Donovan D., Harmey J.H., Toomey D., Osborne D.H., Redmond H.P., and Bouchier-Hayes D.J. TGF beta-1 regulation of VEGF production by breast cancer cells. Ann Surg Oncol 4 (1997) 621-627
34. McMahon S., Charbonneau M., Grandmont S., Richard D.E., and Dubois C.M. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J Biol Chem 281 (2006) 24171-24181
35. Yoshiji H., Kuriyama S., Yoshii J., Ikenaka Y., Noguchi R., Hicklin D.J., et al. Vascular endothelial growth factor and receptor interaction is a prerequisite for murine hepatic fibrogenesis. Gut 52 (2003) 1347-1354
36. Rosmorduc O., Wendum D., Corpechot C., Galy B., Sebbagh N., Raleigh J., et al. Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis. Am J Pathol 155 (1999) 1065-1073
37. Romero-Gallo J., Sozmen E.G., Chytil A., Russell W.E., Whitehead R., Parks W.T., et al. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy. Oncogene 24 (2005) 3028-3041
38. Ambalavanan N., Nicola T., Hagood J., Bulger A., Serra R., Murphy-Ullrich J.E., et al. Transforming growth factor-beta signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung. Am J Physiol Lung Cell Mol Physiol 295 (2008) L86-L95
39. Kalo E., Buganim Y., Shapira K.E., Besserglick H., Goldfinger N., Weisz L., et al. Mutant p53 attenuates the Smad-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II. Mol Cell Biol 27 (2007) 8228-8242
40. Oklü R., and Hesketh R. The latent transforming growth factor beta binding protein (LTBP) family. Biochem J 352 (2000) 601-610
41. Ahrens T., Assmann V., Fieber C., Termeer C., Herrlich P., Hofmann M., et al. CD44 is the principal mediator of hyaluronic-acid-induced melanoma cell proliferation. J Invest Dermatol 116 (2001) 93-101
42. Koyama T., Yashiro M., Inoue T., Nishimura S., and Hirakawa Y.S.C.K. TGF-beta1 secreted by gastric fibroblasts up-regulates CD44H expression and stimulates the peritoneal metastatic ability of scirrhous gastric cancer cells. Int J Oncol 16 (2000) 355-362
43. Nakashio T., Narita T., Akiyama S., Kasai Y., Kondo K., Ito K., et al. Adhesion molecules and TGF-beta1 are involved in the peritoneal dissemination of NUGC-4 human gastric cancer cells. Int J Cancer 70 (1997) 612-618
44. Romaris M., Bassols A., and David G. Effect of transforming growth factor-beta 1 and basic fibroblast growth factor on the expression of cell surface proteoglycans in human lung fibroblasts. Enhanced glycanation and fibronectin-binding of CD44 proteoglycan, and down-regulation of glypican. Biochem J 310 Pt. 1 (1995) 73-81